Health 3.0: A Discussion about Medicine at the Cutting Edge with the Mayo Clinic's Dr. Nicholas LaRusso
Nicholas F. LaRusso, M.D., Charles H. Weinman Endowed Professor of Medicine, is Director of the Center for Innovation at Mayo and a Distinguished Investigator of the Mayo Foundation.
Prior to becoming Center Director in 2008, he was Vice Chair for Research of the Department of Medicine (DOM), Chair of the Division of Gastroenterology and Hepatology, and Chair of the DOM at Mayo Clinic. Before assuming a faculty position at Mayo in 1977, he was a guest investigator at the Rockefeller University in the laboratory of the Noble laureate, Christian de Duve. A member of the American Association of Clinical Investigation and the Association of American Physicians, he is the former editor of GASTROENTEROLOGY and past president of the American Association for the Study of Liver Diseases (AASLD). Among other honors, he is a recipient of a MERIT Award and the Principle Investigator on two R01s from the NIH; he also received Distinguished Achievement Awards from both the American Gastroenterological Association (AGA) and the AASLD, and the Distinguished Mentor Award of the AGA. He is currently President of the AGA.
He received his undergraduate degree (magna cum laude) from Boston College, his M.D. degree from New York Medical College, and his training in internal medicine and gastroenterology at Mayo, the latter as an NIH fellow in the laboratory of Alan Hofmann.
Question: What initiatives are you working on at Mayo?
Nicholas LaRusso: We now have active pilot projects testing the ability to provide what we call eConsoles, or virtual consoles, electronically to providers all over the country, primary care providers. We believe that the initial effort should not be directly to patients but the patients to their primary care provider because we think that patients are ultimately going to need a continuous relationship with a team of providers in their own community. That’s a second initiative that we have. It’s something called the Advanced Medical Home where we’re organizing teams of providers to maintain a continuous relationship with patients within their community.
The third initiative, that gets to the genetic profiling, is we’re trying to understand through designer-centered research. This is available commercially. There are three companies out there that will provide you with a genetic analysis if you provide them with the biological specimen, whether it’s a blood sample or a spit sample or a hair sample. We’re trying to find out what do patients expect when they do this, and when they get the information that says they have, based on your genetic profile, 40% increased chance of getting type II diabetes or threefold increase in the chance of getting Alzheimer’s disease. How do they understand that? How does that affect the way they think about their health? What do they do with that information? What do the primary care providers that they may go to with that information, how do they understand it? How does this affect their ability to modify their lifestyle? And so, that will be a third concrete project that we’re engaged in.
Question: What is the future of organ transplantation?
Nicholas LaRusso: One of the great things about the liver is that it regenerates. So, if you cut half of someone’s liver, it grows back. That’s why we can now not only use cadaver livers, but we can use portions of living donors. It’s entirely possible, and there’s work being done in this area, that in the future a liver transplant will be no more than an injection of a number of cells that will implant somewhere in the body and will grow and form an entire new liver. This is the whole area of stem cell transplantation
Then I think the last area, and this is a fairly controversial area, but I think has great potential, and the background here is, that as you maybe aware, there are many people particularly with liver disease, many more people that need livers than we currently have livers for.
There’s a whole area called xenotransplantation in which the idea is that we would take animals, pigs are currently the preferred animal, and be able to modify them genetically in such a way that a human would not only not reject a pig liver, but that any potential diseases that would be unique to animals would not be able to be contracted by a human. This is a big concern right now.
You can envision 20 years from now everyone who needs a liver having access to one because you walk in to a facility, you take out a pig and you use the pig liver for the patient.
Technical advances, leading to minimally increasingly, minimally evasive surgery, new drugs and ultimately sufficient understanding of the immune system that no drugs would be necessary, the use of cells rather than whole organs, and potentially the use of animal organs--are probably the four areas of the future when it comes to solid organ transplantation.
Topic: Apple CEO Steve Jobs’ liver transplant.
Nicholas LaRusso: I guess there are at least two aspects to his situation that have caught the public’s attention. One is the whole issue of whether or not someone of his prominence was given special attention in terms of access to a liver. And the other has to do with the indication for his liver transplantation.
With regard to the former, let me say that the distribution system for solid organs has advanced, particularly livers, has advanced tremendously to a more fair and equitable system with the evolution of the MELD system [the Model for End-Stage Liver Disease (MELD) system] of scoring. So, the system allocates organs based generally on the severity of the liver disease. It’s organized on a regional basis.
Some areas of the country have better access to more livers than other areas of the country. According to the press, he got his transplant in Tennessee. Based on what I know, the availabilities of livers in Tennessee might be better than say on either coast. If that was the case, there was nothing inappropriate about that. He was not “gaming” in the system in any way. Many people will have themselves listed in more than one region in an attempt to get access to a liver. That’s how I would comment on that aspect of.
With regards to the indication, again it’s not clear what he--he had a pancreatic tumor. There are number of different kinds of pancreatic tumors. The most common is what’s called an adenocarcinoma of the pancreas, and this is a devastating disease with very poor prognosis that has a five years survival, in general less than 5%. It would be highly, highly unlikely that that was the kind of tumor that he had, or that anyone would consider a liver transplant for that kind of a tumor when the tumor went to the liver. The likelihood is that he had some type of a neuroendocrine tumor, which are generally slow growing tumors. And the likelihood is from what I’ve read that the tumor was receptive but probably had metastasized to the liver, and that was the indication for a liver transplant. In fact, at many centers a transplant for a neuroendocrine tumor that’s metastasized to the liver is considered appropriate.
Question: How should healthcare be overhauled?
Nicholas LaRusso: Our new president [Barack Obama] has identified as one of his three major areas of attention, health care which by the way I personally applaud and Mayo has worked through its health policy institute to articulate the four pillars that are necessary for transforming healthcare. Those 4 pillars then provide the environment with which the Center for Innovation, and innovation across the country in health care delivery can evolve.
Those pillars are pretty simple. Conceptually, they include creating value, coordinating care, restructuring the payment system, and providing universal access. Those are the four pillars.
For the innovations that we envision helping to catalyze through our Center activities, to be maximally effective, there needs to be policy changes that address those four areas. Care coordination, value, payment reform and universal access.
Topic: An example of healthcare reform.
Nicholas LaRusso: If you’re in charge of a delivery system, and you’re being reimbursed because of the quality or value of the care that you provide, and because of the coordination that you provide, rather than on the number of tests that are done, then that provides a whole different set of incentives for you to reorganize the way you deliver health care.
This gets back to one of the four pillars of our policy initiative, and that is payment reform. Right now the payment system results in just what you expected it to do. That is, if people get paid because they do a lot of stuff, they’re going to keep doing more and more stuff to get more and more pay. But if you pay people for the quality of what they deliver, and you define quality or value, and you have metrics for value, and you make those metrics publicly available so the consumer knows where to go to get the highest value care, and you coordinate things.
Question: How can hospitals improve health outcomes?
Nicholas LaRusso: Increasingly we’re going to have a much more demanding set of consumers in health care. That’s going to result in, and that’s the good thing, that’s going to result in the need for us to be able to make transparent to them the concrete outcomes of what it is we’re providing.
For example, if a patient needs a liver transplant, they’re going to be able to go online and find out who does the most transplants? Who does the most transplants from my particular condition? What they should be able to find out is, what’s the approximate range of cost? And what’s the likelihood that I’m going to get out of the hospital in a week, two weeks, three weeks? How many patients that have this kind of a transplant need another operation?
These are the outcomes that we have to be accountable for, and that we need to make transparent to the public. I think that’s the right thing to do.
If we believe, and we do at Mayo, the Mayo mantra which is the needs of the patient come first. They have to be fully informed and we have to be held accountable for the outcomes of the things that we do.
Recorded on: June 24, 2009.
A conversation with Professor of Medicine at Mayo Medical School, and Medical Director of the Center for Innovation at Mayo Clinic.
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Beards and perceptions of masculinity<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMjU5OTg0MC9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0NzkxMjM3N30.cH-GqNwP5GVqvstgJWAhBPn1B_lYpVEAI0I7iax7EQw/img.jpg?width=1245&coordinates=0%2C1900%2C0%2C849&height=700" id="caae6" class="rm-shortcode" data-rm-shortcode-id="cb0a355a4e8e1899789bc45f3f7aef56" data-rm-shortcode-name="rebelmouse-image" />
Photo Credit: Wikimedia<p>The study used 919 American (mostly white) women ages 18-70 who rated 30 pictures of men they were shown with various stages of facial hair growth. The photographs depicted men with faces that had been digitally altered to look more feminine or more masculine, with a beard and without a beard. The women rated the men according to perceived attractiveness for long-term and short-term relationships. The study found that the more facial hair the men had, the higher the men were rated on their attractiveness, particularly for their suitability for a long-term relationship.</p><p>Part of this might be attributed to facial masculinity — i.e. protruding brow ridge, wide cheekbones, thick jawline, and deeply set narrow eyes — which conveys information to a woman about a man's underlying health and formidability. Women tend to associate more masculine faces with physical strength and social assertiveness. It can also indicate a man with a superior immune response. The researchers suggested that their findings favoring bearded men could be due to the fact that facial hair enhances the masculine facial features on a man's face, like creating the illusion of a thicker jaw line. This could communicate direct benefits to women like resources and protection that would enhance survival among mothers and their infants. In other words, while a beard doesn't mean superior genetics in and of itself, it might be a primitive, ornamental way of saying, "Hey girl, I'm a testosterone-fueled lean, mean, pathogen fighting machine." <br></p><p>It could also be that a beard becomes its own destiny. The researchers in this study cite prior research that found that by growing a beard, men felt more masculine and had higher levels of serum testosterone, which was linked to a higher level of social dominance. They also tended to subscribe to more old-school beliefs about gender roles in their relationships with women as compared to men with clean-shaven faces.<span></span><br></p>
What does disgust have to do with beard preference?<p>Obviously, not all women dig beards. The researchers were particularly interested in what traits make a women prefer bearded men over clean-shaven faces. They looked into several factors including a woman's disgust levels on various concepts, her desire to become pregnant, and her exposure to facial hair in her personal life. </p><p>According to the study, women who were not into facial hair were turned-off by potential parasites or other critters they imagined could be in the hair or skin. Women ranking high on this "ectoparasite disgust" scale might have viewed beards as a sign of poor grooming habits. However, women who ranked higher in levels of "pathogen" did find the bearded men to be desirable, possibly because they perceived beards as a signal of good health and immune function. An intriguing discovery in the study was links to morality. Women who displayed higher levels of "moral disgust," or feelings of repugnance toward taboo behaviors, were more likely to prefer hairy faces. The authors opined that this could reflect a link between beardedness, politically conservative outlooks, and traditional views regarding performances of masculinity in heterosexual relationships.</p>
Additional findings<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMjU5OTg1My9vcmlnaW4uZ2lmIiwiZXhwaXJlc19hdCI6MTYyNDI1NjUyOX0.P9B8WbmJR0q4nfzYZKbuNSA-2SAigVWJgrQE-_Gxlds/img.gif?width=980" id="49143" class="rm-shortcode" data-rm-shortcode-id="2ed3b1d6f20fc170bf2974646e565e8d" data-rm-shortcode-name="rebelmouse-image" />Giphy<p>The correlations that existed between married and single women's rating on the attractiveness of beards were not particularly clear, although the researchers noted that single and married women who wanted children tended to find beards more attractive than the women who didn't want children. They also found that women with bearded husbands found beards to be more attractive, which might indicate that social exposure to beards influences how desirable they are perceived of as being. Or it could be that men with wives who like beards grow beards.</p><p>It's important to note that culture plays a huge role in how attractive women perceive certain male characteristics as being. This study looked at a small, culturally specific group of American women, so no big, universal claims should be made about masculinity, facial hair, and male desirability to women. However, research like this is important in highlighting how human grooming decisions are driven by much more than fashion trends. Sociobiological, economic, and ecological factors all play a part in the way we choose to present ourselves.</p>
Yet 80 percent of respondents want to reduce their risk of dementia.
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Credit: logika600 / Shutterstock<p>Remaining healthy requires regular screenings. Here again we see a disassociation between risk reduction and proactivity. Seventy-seven percent of respondents don't talk to their doctors about lifestyle habits that support brain health; 51 percent have never been screened for depression; 44 percent have never had a neurological exam; and 32 percent have never been screened for hearing problems. </p><p>Common early warning signs of dementia, <a href="https://news.yahoo.com/americans-worry-alzheimers-disease-survey-140644803.html" target="_blank" rel="noopener noreferrer">according to</a> Dr. Jason Karlawish, co-director of the Penn Memory Center, include repetitive questions and stories, difficulties with complex daily tasks, and trouble with orientation. </p><p>In terms of intervention, <a href="https://bigthink.com/21st-century-spirituality/does-lack-of-exercise-lead-to-dementia" target="_self">exercise</a>, <a href="https://bigthink.com/surprising-science/obesity-dementia" target="_self">diet</a>, building a <a href="https://bigthink.com/mind-brain/brain-reserve" target="_self">brain reserve</a>, and challenging your brain (such as learning a new language or musical instrument) are all proven methods for staving off the ravages of Alzheimer's. Oxytocin has also <a href="https://bigthink.com/mind-brain/alzheimers-oxytocin" target="_self">showed promise</a> in brain-addled mice, while researchers found positive results for a <a href="https://bigthink.com/mind-brain/intermittent-fasting" target="_self">group of intermittent fasters</a> in promoting neurogenesis. </p><p>Epidemiologist Bryan James says that dementia is <a href="https://www.npr.org/sections/health-shots/2013/04/15/176920391/how-exercise-and-other-activities-beat-back-dementia" target="_blank">not an inevitable result</a> of aging. </p><p style="margin-left: 20px;">"It's simply not pre-destined for all human beings. Lots of people live into their 90s and even 100s with no symptoms of dementia." </p><p>Professor of neurology at Boston University School of Medicine, Andrew Budson, <a href="https://news.yahoo.com/americans-worry-alzheimers-disease-survey-140644803.html" target="_blank" rel="noopener noreferrer">recommends</a> aerobic exercise and the Mediterranean diet. As has long been known, whole grains, fruits and vegetables, fish and shellfish, and healthy fasts like nuts and olive oil seem to have brain-boosting properties. </p><p>To learn more, take the <a href="https://www.mdvip.com/brain-health-iq-quiz" target="_blank">Brain Health IQ quiz</a>.</p><p><span></span>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a>, <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank">Facebook</a> and <a href="https://derekberes.substack.com/" target="_blank" rel="noopener noreferrer">Substack</a>. His next book is</em> "<em>Hero's Dose: The Case For Psychedelics in Ritual and Therapy."</em></p>