In the novel, technicians in charge of the hatcheries manipulate the nutrients they give the fetuses to make the newborns fit the desires of society. Two recent scientific developments suggest that Huxley's imagined world of functionally manufactured people is no longer far-fetched.
On March 17, 2021, an Israeli team announced that it had grown mouse embryos for 11 days – about half of the gestation period – in artificial wombs that were essentially bottles. Until this experiment, no one had grown a mammal embryo outside a womb this far into pregnancy. Then, on April 15, 2021, a U.S. and Chinese team announced that it had successfully grown, for the first time, embryos that included both human and monkey cells in plates to a stage where organs began to form.
As both a philosopher and a biologist I cannot help but ask how far researchers should take this work. While creating chimeras – the name for creatures that are a mix of organisms – might seem like the more ethically fraught of these two advances, ethicists think the medical benefits far outweigh the ethical risks. However, ectogenesis could have far-reaching impacts on individuals and society, and the prospect of babies grown in a lab has not been put under nearly the same scrutiny as chimeras.
Mouse embryos were grown in an artificial womb for 11 days, and organs had begun to develop.
Growing in an artificial womb
When in vitro fertilization first emerged in the late 1970s, the press called IVF embryos “test-tube babies," though they are nothing of the sort. These embryos are implanted into the uterus within a day or two after doctors fertilize an egg in a petri dish.
Before the Israeli experiment, researchers had not been able to grow mouse embryos outside the womb for more than four days – providing the embryos with enough oxygen had been too hard. The team spent seven years creating a system of slowly spinning glass bottles and controlled atmospheric pressure that simulates the placenta and provides oxygen.
This development is a major step toward ectogenesis, and scientists expect that it will be possible to extend mouse development further, possibly to full term outside the womb. This will likely require new techniques, but at this point it is a problem of scale – being able to accommodate a larger fetus. This appears to be a simpler challenge to overcome than figuring out something totally new like supporting organ formation.
The Israeli team plans to deploy its techniques on human embryos. Since mice and humans have similar developmental processes, it is likely that the team will succeed in growing human embryos in artificial wombs.
To do so, though, members of the team need permission from their ethics board.
CRISPR – a technology that can cut and paste genes – already allows scientists to manipulate an embryo's genes after fertilization. Once fetuses can be grown outside the womb, as in Huxley's world, researchers will also be able to modify their growing environments to further influence what physical and behavioral qualities these parentless babies exhibit. Science still has a way to go before fetus development and births outside of a uterus become a reality, but researchers are getting closer. The question now is how far humanity should go down this path.
Chimeras evoke images of mythological creatures of multiple species – like this 15th-century drawing of a griffin – but the medical reality is much more sober. (Martin Schongauer/WikimediaCommons)
Human-monkey hybrids
Human–monkey hybrids might seem to be a much scarier prospect than babies born from artificial wombs. But in fact, the recent research is more a step toward an important medical development than an ethical minefield.
If scientists can grow human cells in monkeys or other animals, it should be possible to grow human organs too. This would solve the problem of organ shortages around the world for people needing transplants.
But keeping human cells alive in the embryos of other animals for any length of time has proved to be extremely difficult. In the human-monkey chimera experiment, a team of researchers implanted 25 human stem cells into embryos of crab-eating macaques – a type of monkey. The researchers then grew these embryos for 20 days in petri dishes.
After 15 days, the human stem cells had disappeared from most of the embryos. But at the end of the 20-day experiment, three embryos still contained human cells that had grown as part of the region of the embryo where they were embedded. For scientists, the challenge now is to figure out how to maintain human cells in chimeric embryos for longer.
Regulating these technologies
Some ethicists have begun to worry that researchers are rushing into a future of chimeras without adequate preparation. Their main concern is the ethical status of chimeras that contain human and nonhuman cells – especially if the human cells integrate into sensitive regions such as a monkey's brain. What rights would such creatures have?
However, there seems to be an emerging consensus that the potential medical benefits justify a step-by-step extension of this research. Many ethicists are urging public discussion of appropriate regulation to determine how close to viability these embryos should be grown. One proposed solution is to limit growth of these embryos to the first trimester of pregnancy. Given that researchers don't plan to grow these embryos beyond the stage when they can harvest rudimentary organs, I don't believe chimeras are ethically problematic compared with the true test–tube babies of Huxley's world.
Few ethicists have broached the problems posed by the ability to use ectogenesis to engineer human beings to fit societal desires. Researchers have yet to conduct experiments on human ectogenesis, and for now, scientists lack the techniques to bring the embryos to full term. However, without regulation, I believe researchers are likely to try these techniques on human embryos – just as the now-infamous He Jiankui used CRISPR to edit human babies without properly assessing safety and desirability. Technologically, it is a matter of time before mammal embryos can be brought to term outside the body.
While people may be uncomfortable with ectogenesis today, this discomfort could pass into familiarity as happened with IVF. But scientists and regulators would do well to reflect on the wisdom of permitting a process that could allow someone to engineer human beings without parents. As critics have warned in the context of CRISPR-based genetic enhancement, pressure to change future generations to meet societal desires will be unavoidable and dangerous, regardless of whether that pressure comes from an authoritative state or cultural expectations. In Huxley's imagination, hatcheries run by the state grew a large numbers of identical individuals as needed. That would be a very different world from today.
Sahotra Sarkar, Professor of Philosophy and Integrative Biology, The University of Texas at Austin College of Liberal Arts
This article is republished from The Conversation under a Creative Commons license. Read the original article.
Sometimes, when you are looking for something ordinary, you find the unexpected. This is definitely the case with the strange 'Oumuamua, which made international headlines as a potential interstellar visitor. Its true identity remained obscure for a while, as scientists proposed different explanations for its puzzling behavior. This is the usual scientific approach of testing hypotheses to make sense of a new discovery.
What captured the popular imagination was the claim that the object was no piece of rock or comet, but an alien artifact, designed by a superior intelligence.
Do you remember the black monolith tumbling through space in the classic Stanley Kubrick movie 2001: A Space Odyssey? The one that "inspired" our ape-like ancestors to develop technology and followed humanity and its development since then? What made this claim amazing is that it wasn't coming from the usual UFO enthusiasts but from a respected astrophysicist from Harvard University, Avi Loeb, and his collaborator Shmuel Bialy. Does their claim really hold water? Were we really visited by an alien artifact? How would we know?
A mystery at 200,000 miles per hour
Before we dive into the controversy, let's examine some history. 'Oumuamua was discovered accidentally by Canadian astronomer Robert Weryk while he was routinely reviewing images captured by the telescope Pan-STARRS1 (Panoramic Survey and Rapid Response System 1), situated atop the ten-thousand-foot Haleakala volcanic peak on the Hawaiian island of Maui. The telescope scans the skies in search of near-Earth objects, mostly asteroids and possibly comets that come close to Earth. The idea is to monitor the solar system to learn more about such objects and their orbits and, of course, to sound the alarm in case of a potential collision course with Earth. Contrary to the objects Weryk was used to seeing, mostly moving at about 40,000 miles per hour, this one was moving almost five times as fast — nearly 200,000 miles per hour, definitely an anomaly.
Hyperbolic trajectory of ʻOumuamua through the inner Solar System.Credit: nagualdesign / Tomruen / JPL Horizons via Wikipedia and licensed under CC BY-SA 4.0
Intrigued, astronomers tracked the visitor while it was visible, concluding that it indeed must have come from outside our solar system, the first recognized interstellar visitor. Contrary to most known asteroids that move in elliptical orbits around the sun, 'Oumuamua had a bizarre path, mostly straight. Also, its brightness varied by a factor of ten as it tumbled across space, a very unusual property that could be caused either by an elongated cigar shape or by it being flat, like a CD, one side with a different reflectivity than the other. The object, 1I/2017 U1, became popularly known as 'Oumuamua, from the Hawaiian for "scout."
In their paper, Loeb and Bialy argue that the only way the object could be accelerated to the speeds observed was if it were extremely thin and very large, like a sail. They estimated that its thickness had to be between 0.3 to 0.9 millimeters, which is extremely thin. After confirming that such an object is robust enough to withstand the hardships of interstellar travel (e.g., collision with gas particles and dust grains, tensile stresses, rotation, and tidal forces), Loeb and Bialy conclude that it couldn't possibly be a solar system object like an asteroid or comet. Being thus of interstellar origin, the question is whether it is a natural or artificial object. This is where the paper ventures into interesting but far-fetched speculation.
I'm not saying it was aliens, but it was aliens
First, the authors consider that it might be garbage "floating in interstellar space as debris from advanced technological equipment," ejected from its own stellar system due to its non-functionality; essentially, alien space junk. Then, they suggest that a "more exotic scenario is that 'Oumuamua may be a fully operational probe sent intentionally to Earth vicinity by an alien civilization," [italicized as in the original] concluding that a "survey for lightsails as technosignatures in the solar system is warranted, irrespective of whether 'Oumuamua is one of them."
You can shoot down as many hypotheses as you want to vindicate yours, but this doesn't prove yours is the right one.
I have known Avi Loeb for decades and consider him a serious and extremely talented astrophysicist. His 2018 paper includes a suggestive interpretation of strange data that obviously sparks the popular imagination. Theoretical physicists routinely suggest the existence of traversable wormholes, multiverses, and parallel quantum universes. Not surprisingly, Loeb was highly in demand by the press to fill in the details of his idea. A book followed, Extraterrestrial: The First Sign of Intelligent Life Beyond Earth, and its description tells all: "There was only one conceivable explanation: the object was a piece of advanced technology created by a distant alien civilization."
It came from outer space.Credit: Scott Barbour via Getty Images
This is where most of the scientific establishment began to cringe. One thing is to discuss the properties of a strange natural phenomenon and rule out more prosaic hypotheses while suggesting a daring one. Another is to declare to the public that the only conceivable explanation is one that is also speculative. An outsider will conclude that a reliable scientist has confirmed not only the existence of extraterrestrial life but of intelligent and technologically sophisticated extraterrestrial life with an interest in our solar system. I wonder if Loeb considered the impact of his words and how they reflect on the scientific community as a whole.
This is why aliens won't talk to us
Earlier this year, in a live public lecture hosted by the Catholic University of Chile, Avi Loeb locked horns with Jill Tarter, the scientist that is perhaps most identifiable as someone who spent her career looking for signs of extraterrestrial intelligence. (Coincidentally, I was the speaker that followed Loeb the next week in the same seminar series and was cautioned — along with the other panelists — to behave myself to avoid another showdown. I smiled, knowing that my topic was pretty tame in comparison. I mean, how can the limits of human knowledge compare with alien surveillance?)
The Loeb-Tarter exchange was awful and, it being a public debate, was picked up by the press. Academics can be rough like anyone else. But the issue goes deeper.
What scientists say matters. When should a scientist make public declarations about a cutting-edge topic with absolute certainty? I'd say never. There is no clear-cut certainty in cutting-edge science. There are hypotheses that should be tested more until there is community consensus. Even then, consensus is not guaranteed proof. The history of science is full of examples where leading scientists were convinced of something, only to be proven wrong later.
The epistemological mistake Loeb committed was to make an assertion that publicly amounted to certainty by using a process of elimination of other competing hypotheses. You can shoot down as many hypotheses as you want to vindicate yours, but this doesn't prove yours is the right one. It only means that the other hypotheses are wrong. I do, however, agree with Loeb when he says that 'Oumuamua should be the trigger for an increase in funding for the search for technosignatures, a way of detecting intelligent extraterrestrial life.
One of the oldest activities carried out by humans has been identified in a cave in South Africa. A team of geologists and archaeologists found evidence that our ancestors were making fire and tools in the Wonderwerk Cave in the country's Kalahari Desert some 1.8 million years ago.
A new study published in the journal Quaternary Science Reviews from researchers at the Hebrew University of Jerusalem and the University of Toronto proposes that Wonderwerk — which means "miracle" in Afrikaans — contains the oldest evidence of human activity discovered.
"We can now say with confidence that our human ancestors were making simple Oldowan stone tools inside the Wonderwerk Cave 1.8 million years ago," shared the study's lead author Professor Ron Shaar from Hebrew University.
Oldowan stone tools are the earliest type of tools that date as far back as 2.6 million years ago. An Oldowan tool, which was useful for chopping, was made by chipping flakes off of one stone by hitting it with another stone.
An Oldowan stone toolCredit: Wikimedia / Public domain
Professor Shaar explained that Wonderwerk is different from other ancient sites where tool shards have been found because it is a cave and not in the open air, where sample origins are harder to pinpoint and contamination is possible.
Studying the cave, the researchers were able to pinpoint the time over one million years ago when a shift from Oldowan tools to the earliest handaxes could be observed. Investigating deeper in the cave, the scientists also established that a purposeful use of fire could be dated to one million years back.
This is significant because examples of early fire use usually come from sites in the open air, where there is the possibility that they resulted from wildfires. The remnants of ancient fires in a cave — including burned bones, ash, and tools — contain clear clues as to their purpose.
To precisely date their discovery, the researchers relied on paleomagnetism and burial dating to measure magnetic signals from the remains hidden within a sedimentary rock layer that was 2.5 meters thick. Prehistoric clay particles that settled on the cave floor exhibit magnetization and can show the direction of the ancient earth's magnetic field. Knowing the dates of magnetic field reversals allowed the scientists to narrow down the date range of the cave layers.
The Kalahari desert Wonderwerk CaveCredit: Michael Chazan / Hebrew University of Jerusalem
Professor Ari Matmon of Hebrew University used another dating method to solidify their conclusions, focusing on isotopes within quartz particles in the sand that "have a built-in geological clock that starts ticking when they enter a cave." He elaborated that in their lab, the scientists were "able to measure the concentrations of specific isotopes in those particles and deduce how much time had passed since those grains of sand entered the cave."
Finding the exact dates of human activity in the Wonderwerk Cave could lead to a better understanding of human evolution in Africa as well as the way of life of our early ancestors.
The asteroid 2021 PDC was first spotted on April 19, 2021 by the Pan-STARRS project at the University of Hawaii. By May 2, astronomers were 100% certain it was going to strike Earth somewhere in Europe or northern Africa. On October 20, 2021, the asteroid plowed into Europe, taking countless lives.
There was absolutely nothing anyone could do to deflect it from its deadly course. Experts could only warn a panicking population to get out of the way as soon as possible, if it was possible.
The above scenario is the result of a recently concluded NASA thought experiment.
The question the agency sought to answer was this: If we discovered a potentially deadly asteroid destined to hit Earth in six months, was there anything we could do to prevent a horrifying catastrophe? The disturbing answer is "no," not with currently available technology.
While Europe can breathe easy for now, the simulation conducted by NASA/JPL's Center for Near Earth Object Studies and presented at the 7th IAA Planetary Defense Conference is troubling. Space agencies spot "near-Earth objects" (NEOs) all the time. Many are larger than 140 meters in size, which means they're potentially deadly.
Sitting Ducks
Credit: ImageBank4U / Adobe Stock
"The level [at] which we're finding the 140-meter and larger asteroids remains pretty stable, at about 500 a year. Our projection of the number of these objects out there is about 25,000, and we've only found a little over one-third of those so far, maybe 38% or so," NASA's Planetary Defense Office Lindley Johnson tells Space.com.
With our current technology, spotting an NEO comes down to whether we just happen to have a telescope pointing in its direction. To remove humanity's blind spot, the Planetary Society — the same organization that deployed Earth's first light sails — is developing the NEO Surveyor spacecraft, which they plan to deploy in 2025. According to the Planetary Society, it will be able to detect 90 percent of NEOs of 140 meters or larger, a vast improvement.
How to move an asteroid
The DART spacecraft will attempt to deflect an asteroid.Credit: NASA
The NASA/JPL exercise made clear that six months is just not enough time with our current technology to prepare and launch a mission in time to nudge an NEO off its course. (Small course adjustments become significant over great distances, which is why "nudging" an asteroid is a potential strategy.)
What would such a mission look like? Hollywood aside — remember Armageddon?— we know of no good way to redirect an NEO headed our way. Experts believe that shooting laser beams at an incoming rock, exciting as it might look, is not a realistic possibility. Targeted nuclear blasts might work, but forget about landing Bruce Willis, Ben Affleck, and Liv Tyler on an asteroid to set off a course-altering bomb, especially just a month after its discovery (as was the case in the movie).
Another thing that might work is crashing a spacecraft into an NEO hard enough to shift its course. That's the idea behind NASA's Double Asteroid Redirection Test (DART). This mission will shoot a spacecraft at the (non-threatening) asteroid Dimorphos in the fall of 2022 in the hope of changing its trajectory.
The deadly asteroid's journey
The asteroid "2021 PDC" hit Europe in NASA's simulation.Credit: NASA/JPL
The harrowing "tabletop exercise," as NASA/JPL called it, took place across four days at the conference:
- Day 1, "April 19" — The asteroid named "2021 PDC" is discovered 35 million miles away. Scientists calculate it has a 1-in-20 chance of striking Earth.
- Day 2, "May 2" — Now certain that 2021 PDC will hit Earth, space mission designers attempt to dream up a response. They conclude that with less than six months to impact, there's not enough time to realistically mount a mission to disrupt the NEO's course.
- Day 3, "June 30" — Images from the world's four largest telescopes reveal the area in Europe that will be hit. Space-based infrared measurements narrow the object's size to between 35 and 700 meters. This would pack a similar punch as a 1.2-megaton nuclear bomb.
- Day 4, "October 14" — Six days before impact, the asteroid is just 6.3 million km from Earth. Finally, the Goldstone Solar System Radar has been able to assess the size of 2021 PDC. Scientists calculate the blast from the asteroid will be primarily confined to the border region between Germany, Czechia, Austria, Slovenia, and Croatia. Disaster response experts develop plans for addressing the human toll.
"Each time we participate in an exercise of this nature," says Johnson, "we learn more about who the key players are in a disaster event, and who needs to know what information, and when."
Practically speaking, little can be done to hurry technological development along other than budgeting more money toward that goal. Maybe we should have Bruce Willis on call, just in case.
