The Remarkable History of Infectious Disease, with Anthony Fauci
Anthony Fauci is the head of the National Institute of Allergy and Infectious Diseases. He is an immunologist who has made substantial contributions to research on AIDS and other immunodeficiencies. He has pioneered the field of human immunoregulation and developed effective therapies for formally fatal inflammatory and immune-mediated diseases. In the field of AIDS research, he has helped contribute to an understanding of how the AIDS virus destroys the body's defenses leading to its susceptibility to deadly infections.
He has also served as an editor of Harrison's Principles of Internal Medicine and has authored, coauthored or edited more than 1,100 scientific publications, including several textbooks. Dr. Fauci is a key advisor to the White House and Department of Health and Human Services on global AIDS issues and public health protections against emerging infectious disease threats, such as pandemic influenza. He was educated at Cornell University Medical College and holds 32 honorary doctorate degrees.
Question: Who are we?
Anthony Fauci: That’s a difficult question. I’ll start with the one that I’m very familiar with because it’s what I do. And I think that the whole issue of global health and health, if you look at history, how diseases have shaped societies going back from the Bubonic plague of the early centuries, to the pandemic influenza of 1918, to the total decimation of the Inca and Aztec populations by measles and small pox, I think that health issues have played a major role on how society has been shaped.
And then, as the era of understanding disease and being able to do something about disease has occurred, there has been a rather dramatic protection against the unavoidable decimation of disease; but mostly in the developed world.
And the thing that I see even now as an answer to your question is that we need to have a more global appreciation of the problems that other people have. Because it’s very interesting that, some years ago when I was first getting involved in medicine – and even in the arena of infectious diseases, which is my sub-specialty – there were very well placed people in this country [USA] who were actually saying that you can forget about infectious diseases because they’ve essentially been conquered. We’ve got vaccines. We’ve got anti-microbials. You can conquer infectious diseases.
Which means they weren’t paying attention to, as they were saying that; maybe in our own country, in the United States, or Europe, or Australia, or Canada that was going on; but in the developing world, more than a million people were dying of malaria. A million and a half people were dying of tuberculosis. Hundreds of thousands, if not a million people were dying of neglected tropical diseases [NTDs].
So really, disease has a major impact not only historically in the shaping of our society, but also even today where there are the “haves” and the “have nots” of the world. I would hope that an appreciation of that will have us continue to try and do more and more.
Science is telling us that we can do phenomenal things if we put our minds and our resources to it. I think science is probably the best example of you put resources into something, and you let the creativity and the brilliance of the minds throughout the world – and certainly not only in this country [USA], throughout the world – and phenomenally good things can happen.
You’ve got to make sure that there’s checks and balances on that, because science can also lead to things that are not so good. There’s ethical issues of manipulation at the genomic level. The whole issues of embryos and creating people to your own fashionable, boutique-liking. All those things you’ve got to be really, really careful of.
But science, at its most pure, where you’re looking for discovery, and you’re going to use discovery for the betterment of mankind; I think science stands out among some of the most important endeavors that humankind can pursue.
This is just only a somewhat provincial view. There was a period in my own discipline of infectious diseases back in the late 19th century when people were just starting to appreciate the germ theory of disease. Instead of the historical components, we had these plagues. We had these influenzas. We have ______. We have this. We have no idea where it comes from.
There were a group of people – Louie Pasture, Cook; all of the group from the Institute Pasteur [in French: Institut Pasteur de Lille; also known as, Pasteur-Lille], the German group, Matchnikoff and others – who were able to take a field that was completely bare bones and no one had any idea what was going on, to actually make those first initial discoveries that a microbe actually caused tuberculosis. You can actually take that microbe. You can inject it into someone or into an animal, and you can create the disease that you once thought was just some ______ from heaven that caused it.
So the heroes and the people that I look up to were those people who struggled against a complete, vast unknown.
Right now there’s so much known in science that when I and my colleagues do it – although we occasionally make transforming discoveries – we’re standing on the shoulders of giants who didn’t have what we have 100 or so years ago when they made those phenomenal discoveries.
Well I don’t know if it’s a universal truth, but I think that mankind evolves. There’s no doubt that we have evolved. The whole issue of evolving through carious lower species to our own species of the human.
But there’s also the continuing evolution that is associated with mankind. And a lot of that is using what specifically and particularly and peculiarly makes you a human being. And that is your intellect and your will. You have a choice. You can analyze things, and you can act in an intellectual manner.
And that is, to me, at the very foundation of what science is – how you can better your own lot, the lot of the other citizens of the world, while you’re paying attention to and preserving the world you live in, which is the reason why things like the environment are so important.
And we try and analyze are we doing things that are detrimental to the environment. And if so, how do we stop it? And if we have to stop it, how do we replace it with something that’s environmentally friendly?
And I think science is going t lead us there. And it’s the good will that you have to try and preserve your own species, as well as preserve the environment, i.e. our planet, so that we can have thousands of more years of people doing good things and leading good lives.
Recorded On: July 6, 2007
Anthony Fauci on the past, present and future battles against disease.
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Scientists do not know what is causing the overabundance of the gas.
- A new study looked to understand the source of methane on Saturn's moon Enceladus.
- The scientists used computer models with data from the Cassini spacecraft.
- The explanation could lie in alien organisms or non-biological processes.
Something is producing an overabundance of methane in the ocean hidden under the ice of Saturn's moon Enceladus. A new study analyzed if the source could be an alien life form or some other explanation.
The study, published in Nature Astronomy, was carried out by scientists at the University of Arizona and Paris Sciences & Lettres University, who looked at composition data from the water plumes erupting on Enceladus.
The particular chemistry, discovered by the Cassini spacecraft which flew through the plumes, suggested a high concentration of molecules that have been linked to hydrothermal vents on the bottom of Earth's oceans. Such vents are potential cradles of life on Earth, according to previous studies. The data from Cassini, which has been studying Saturn after entering its orbit in 2004, revealed the presence of molecular hydrogen (dihydrogen), methane, and carbon dioxide, with the amount of methane presenting a particular interest to the scientists."We wanted to know: Could Earthlike microbes that 'eat' the dihydrogen and produce methane explain the surprisingly large amount of methane detected by Cassini?" shared one of the study's lead authors Régis Ferrière, an associate professor in the department of Ecology and Evolutionary Biology at the University of Arizona.
Earth's hydrothermal vents feature microorganisms that use dihydrogen for energy, creating methane from carbon dioxide via the process of methanogenesis.
Searching for such microorganisms known as methanogens on the seafloor of Enceladus is not yet feasible. Likely, it would require very sophisticated deep diving operations that will be the objective of future missions.
So, Ferrière's team took a more available approach to pinpointing the origins of the methane, creating mathematical models that attempted to explain the Cassini data. They wanted to calculate the likelihood that particular processes were responsible for producing the amount of methane observed. For example, is the methane more likely the result of biological or non-biological processes?
They found that the data from Cassini was consistent with either microbial activity at hydrothermal vents or processes that have nothing to do with life but could be quite different from what happens on Earth. Intriguingly, models that didn't involve biological entities didn't seem to produce enough of the gas.
"Obviously, we are not concluding that life exists in Enceladus' ocean," Ferrière stated. "Rather, we wanted to understand how likely it would be that Enceladus' hydrothermal vents could be habitable to Earthlike microorganisms. Very likely, the Cassini data tell us, according to our models."
Still, the scientists think future missions are necessary to either prove or discard the "life hypothesis." One explanation for the methane that does not involve biological organisms is that the gas is the result of a chemical breakdown of primordial organic matter within Enceladus' core. This matter could have become a part of Saturn's moon from comets rich in organic materials.
It marks a breakthrough in using gene editing to treat diseases.
This article was originally published by our sister site, Freethink.
For the first time, researchers appear to have effectively treated a genetic disorder by directly injecting a CRISPR therapy into patients' bloodstreams — overcoming one of the biggest hurdles to curing diseases with the gene editing technology.
The therapy appears to be astonishingly effective, editing nearly every cell in the liver to stop a disease-causing mutation.
The challenge: CRISPR gives us the ability to correct genetic mutations, and given that such mutations are responsible for more than 6,000 human diseases, the tech has the potential to dramatically improve human health.
One way to use CRISPR to treat diseases is to remove affected cells from a patient, edit out the mutation in the lab, and place the cells back in the body to replicate — that's how one team functionally cured people with the blood disorder sickle cell anemia, editing and then infusing bone marrow cells.
Bone marrow is a special case, though, and many mutations cause disease in organs that are harder to fix.
Another option is to insert the CRISPR system itself into the body so that it can make edits directly in the affected organs (that's only been attempted once, in an ongoing study in which people had a CRISPR therapy injected into their eyes to treat a rare vision disorder).
Injecting a CRISPR therapy right into the bloodstream has been a problem, though, because the therapy has to find the right cells to edit. An inherited mutation will be in the DNA of every cell of your body, but if it only causes disease in the liver, you don't want your therapy being used up in the pancreas or kidneys.
A new CRISPR therapy: Now, researchers from Intellia Therapeutics and Regeneron Pharmaceuticals have demonstrated for the first time that a CRISPR therapy delivered into the bloodstream can travel to desired tissues to make edits.
We can overcome one of the biggest challenges with applying CRISPR clinically.
"While these are early data, they show us that we can overcome one of the biggest challenges with applying CRISPR clinically so far, which is being able to deliver it systemically and get it to the right place," she continued.
What they did: During a phase 1 clinical trial, Intellia researchers injected a CRISPR therapy dubbed NTLA-2001 into the bloodstreams of six people with a rare, potentially fatal genetic disorder called transthyretin amyloidosis.
The livers of people with transthyretin amyloidosis produce a destructive protein, and the CRISPR therapy was designed to target the gene that makes the protein and halt its production. After just one injection of NTLA-2001, the three patients given a higher dose saw their levels of the protein drop by 80% to 96%.
A better option: The CRISPR therapy produced only mild adverse effects and did lower the protein levels, but we don't know yet if the effect will be permanent. It'll also be a few months before we know if the therapy can alleviate the symptoms of transthyretin amyloidosis.
This is a wonderful day for the future of gene-editing as a medicine.
If everything goes as hoped, though, NTLA-2001 could one day offer a better treatment option for transthyretin amyloidosis than a currently approved medication, patisiran, which only reduces toxic protein levels by 81% and must be injected regularly.
Looking ahead: Even more exciting than NTLA-2001's potential impact on transthyretin amyloidosis, though, is the knowledge that we may be able to use CRISPR injections to treat other genetic disorders that are difficult to target directly, such as heart or brain diseases.
"This is a wonderful day for the future of gene-editing as a medicine," Fyodor Urnov, a UC Berkeley professor of genetics, who wasn't involved in the trial, told NPR. "We as a species are watching this remarkable new show called: our gene-edited future."
A global survey shows the majority of countries favor Android over iPhone.
- When Android was launched soon after Apple's own iPhone, Steve Jobs threatened to "destroy" it.
- Ever since, and across the world, the rivalry between both systems has animated users.
- Now the results are in: worldwide, consumers clearly prefer one side — and it's not Steve Jobs'.
A woman on her phone in Havana, Cuba. Mobile phones have become ubiquitous the world over — and so has the divide between Android and iPhone users.Credit: Yamil Lage / AFP via Getty Images.
Us versus them: it's the archetypal binary. It makes the world understandable by dividing it into two competing halves: labor against capital, West against East, men against women.
These maps are the first to show the dividing lines between one of the world's more recent binaries: Android vs. Apple. Published by Electronics Hub, they are based on a qualitative analysis of almost 350,000 tweets worldwide that presented positive, neutral, and negative attitudes toward Android and/or Apple.
Steve Jobs wanted to go "thermonuclear"
Feelings between Android and Apple were pretty tribal from the get-go. It was Steve Jobs himself who said, when Google rolled out Android a mere ten months after Apple launched the iPhone, "I'm going to destroy Android, because it's a stolen product. I'm willing to go thermonuclear war on this."
Buying a phone is like picking a side in the eternal feud between the Hatfields and the McCoys. Each choice for automatically comes with an in-built arsenal of arguments against.
If you are an iPhone person, you appreciate the sleekness and simplicity of its design, and you are horrified by the confusing mess that is the Android operating system. If you are an Android aficionado, you pity the iPhone user, a captive of an overly expensive closed ecosystem, designed to extract money from its users.
Even without resorting to those extremes, many of us will recognize which side of the dividing line that we are on. Like the American Civil War, that line runs through families and groups of friends, but that would be a bit confusing to chart geographically. To un-muddle the information, these maps zoom out to state and country level.
If the contest is based on the number of countries, Android wins. In all, 74 of the 142 countries surveyed prefer Android (in green on the map). Only 65 favor Apple (colored grey). That's a 52/48 split, which may not sound like a decisive vote, but it was good enough for Boris Johnson to get Brexit done (after he got breakfast done, of course).
And yes, math-heads: 74 plus 65 is three short of 142. Belarus, Fiji, and Peru (in yellow on the map) could not decide which side to support in the Global Phone War.
What about the United States, home of both the Android and the iPhone? Another victory for the former, albeit a slightly narrower one: 30.16 percent of the tweets about Android were positive versus just 29.03 percent of the ones about Apple.
United States: Texas surrounded!
Credit: Electronics Hub
There can be only one winner per state, though, and that leads to this preponderance of Android logos. Frankly, it's a relief to see a map showing a visceral divide within the United States that is not the coasts versus the heartland.
- Apple dominates in 19 states: a solid Midwestern bloc, another of states surrounding Texas, the Dakotas and California, plus North Carolina, New Hampshire, and Rhode Island.
- And that's it. The other 32 are the United States of Android. You can drive from Seattle to Miami without straying into iPhone territory. But no stopovers in Dallas or Houston – both are behind enemy lines!
North America: strongly leaning toward Android
Credit: Electronics Hub
Only eight of North America's 21 countries surveyed fall into the Apple category.
- The U.S. and Canada lean Android, while Mexico goes for the iPhone.
- Central America is divided, but here too Android wins hands down, 5-2.
Europe: Big Five divided
Credit: Electronics Hub
In Europe, Apple wins, with 20 countries preferring the iPhone, 17 going for Android, and Belarus sitting on the fence.
- Of Western Europe's Big Five markets, three (UK, Germany, Spain) are pro-Android, and two (France, Italy) are pro-Apple.
- Czechia and Slovakia are an Apple island in the Android sea that is Central Europe. Glad to see there is still something the divorcees can agree on.
South America: almost even
Credit: Electronics Hub
In South America, the divide is almost even.
- Five countries prefer Android, four Apple, and one is undecided.
- In Peru, both Android- and Apple-related tweets were 25 percent positive.
Africa: watch out for Huawei
Credit: Electronics Hub
In Africa, Android wins by 17 countries versus Apple's 15.
- There's a solid Android bloc running from South Africa via DR Congo all the way to Ethiopia.
- iPhone countries are scattered throughout the north (Algeria), west (Guinea), east (Somalia), and south (Namibia).
Huawei — increasingly popular across the continent — could soon dramatically change the picture in Africa. Currently still running on Android, the Chinese phone manufacturer has just launched its own operating system, called Harmony.
Middle East: Iran vs. Saudi Arabia (again)
Credit: Electronics Hub
In the Middle East and Central Asia, Android wins 8 countries to Apple's 6.
- But it's complicated. One Turkish tweeter wondered how it is that iPhones seem more popular in the Asian half of Istanbul, while Android phones prevailed in the European part of the city.
- The phone divide matches up with the region's main geopolitical one: Iran prefers Android, Saudi Arabia the iPhone.
Asia-Pacific: Apple on the periphery
Credit: Electronics Hub
Another wafer-thin majority for Android in the Asia-Pacific region: 13 countries versus 12 for Apple — and one abstention (Fiji).
- The two giants of the Asian mainland, India and China, are both Android countries. Apple countries are on the periphery.
- And if India is Android, its rival Pakistan must be Apple. Same with North and South Korea.
Experts point to the fact that both operating systems are becoming more alike with every new generation as a potential resolution to the conflict. But as any student of human behavior will confirm: smaller differences will only exacerbate the rivalry between both camps.
Maps taken from Electronics Hub, reproduced with kind permission.
Strange Maps #1096
Got a strange map? Let me know at firstname.lastname@example.org.
A new government report describes 144 sightings of unidentified aerial phenomena.
On June 25, 2021, the Office of the Director of National Intelligence released a much-anticipated report on UFOs to Congress.
The military has rebranded unidentified flying objects as unidentified aerial phenomena – UAPs – in part to avoid the stigma that has been attached to claims of aliens visiting the Earth since the Roswell incident in 1947. The report presents no convincing evidence that alien spacecraft have been spotted, but some of the data defy easy interpretation.
I'm a professor of astronomy who has written extensively on the search for life in the universe. I also teach a free online class on astrobiology. I do not believe that the new government report or any other sightings of UFOs in the past are proof of aliens visiting Earth. But the report is important because it opens the door for a serious look at UFOs. Specifically, it encourages the U.S. government to collect better data on UFOs, and I think the release of the report increases the chances that scientists will try to interpret that data. Historically, UFOs have felt off limits to mainstream science, but perhaps no more.
Three videos from the U.S. military sparked a recent surge in interest in UFOs.
What's in the UFO report?
The No. 1 thing the report focuses on is the lack of high-quality data. Here are the highlights from the slender nine-page report, covering a total of 144 UAP sightings from U.S. government sources between 2004 and 2021:
- “Limited data and inconsistent reporting are key challenges to evaluating UAP."
- Some observations “could be the result of sensor errors, spoofing, or observer misperception."
- “UAP clearly pose a safety of flight issue and may pose a challenge to U.S. national security."
- Of the 144 sightings, the task force was “able to identify one reported UAP with high confidence. In that case, we identified the object as a large, deflating balloon. The others remain unexplained."
- “Some UAP many be technologies deployed by China, Russia, another nation, or non-governmental entity."
UFOs are taboo among scientists
UFO means unidentified flying object. Nothing more, nothing less. You'd think scientists would enjoy the challenge of solving this puzzle. Instead, UFOs have been taboo for academic scientists to investigate, and so unexplained reports have not received the scrutiny they deserve.
One reason is that most scientists think there is less to most reports than meets the eye, and the few who have dug deeply have mostly debunked the phenomenon. Over half of sightings can be attributed to meteors, fireballs and the planet Venus.
Another reason for the scientific hesitance is that UFOs have been co-opted by popular culture. They are part of a landscape of conspiracy theories that includes accounts of abduction by aliens and crop circles. Scientists worry about their professional reputations, and the association of UFOs with these supernatural stories causes most researchers to avoid the topic.
But some scientists have looked. In 1968, Edward U. Condon at the University of Colorado published the first major academic study of UFO sightings. The Condon Report put a damper on further research when it found that “nothing has come from the study of UFOs in the past 21 years that has added to scientific knowledge."
However, a review in 1998 by a panel led by Peter Sturrock, a professor of applied physics at Stanford University, concluded that some sightings are accompanied by physical evidence that deserves scientific study. Sturrock also surveyed professional astronomers and found that nearly half thought UFOs were worthy of scientific study, with higher interest among younger and more well-informed astronomers.
If astronomers are intrigued by UFOs – and believe some cases deserve study with academic rigor – what's holding them back? A history of mistrust between ufologists and scientists hasn't helped. And while UFO research has employed some of the tools of the scientific method, it has not had the core of skeptical, evidence-based reasoning that demarcates science from pseudoscience.
A search of 90,000 recent and current grants awarded by the National Science Foundation finds none addressing UFOs or related phenomena. I've served on review panels for 35 years, and can imagine the reaction if such a proposal came up for peer review: raised eyebrows and a quick vote not to fund.
A decadeslong search for aliens
While the scientific community has almost entirely avoided engaging with UFOs, a much more mainstream search for intelligent aliens and their technology has been going on for decades.
The search is motivated by the fact that astronomers have, to date, discovered over 4,400 planets orbiting other stars. Called exoplanets, some are close to the Earth's mass and at just the right distance from their stars to potentially have water on their surfaces – meaning they might be habitable.
Astronomers estimate that there are 300 million habitable worlds in the Milky Way galaxy alone, and each one is a potential opportunity for life to develop and for intelligence and technology to emerge. Indeed, most astronomers think it very unlikely that humans are the only or the first advanced civilization.
This confidence has fueled an active search for extraterrestrial intelligence, known as SETI. It has been unsuccessful so far. As a result, researchers have recast the question “Are we alone?" to “Where are the aliens?" The absence of evidence for intelligent aliens is called the Fermi paradox. First articulated by the physicist Enrico Fermi, it's a paradox because advanced civilizations should be spread throughout the galaxy, yet we see no sign of their existence.
The SETI activity has not been immune from scientists' criticism. It was starved of federal funding for decades and recently has gotten most of its support from private sources. However, in 2020, NASA resumed funding for SETI, and the new NASA administrator wants researchers to pursue the topic of UFOs.
In this context, the intelligence report is welcome. The report draws few concrete conclusions about UFOs and avoids any reference to aliens or extraterrestrial spacecraft. However, it notes the importance of destigmatizing UFOs so that more pilots report what they see. It also sets a goal of moving from anecdotal observations to standardized and scientific data collection. Time will tell if this is enough to draw scientists into the effort, but the transparency to publish the report at all reverses a long history of secrecy surrounding U.S. government reports on UFOs.
I don't see any convincing evidence of alien spacecraft, but as a curious scientist, I hope the subset of UFO sightings that are truly unexplained gets closer study. Scientists are unlikely to weigh in if their skepticism generates attacks from “true believers" or they get ostracized by their colleagues. Meanwhile, the truth is still out there.
This article has been updated to clarify that the report was produced by the Office of the Director of National Intelligence.