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A Possible Cure for Ebola Virus Infection?
Editor's Note: This article was provided by our partner, RealClearScience. The original is here.
Ebola is one of the scariest viruses on Earth. Along with Marburg and a few other lesser known viruses, it is a member of the Filoviridae family, a nasty group of microbes that causes hemorrhagic fever. Like most viral diseases, patients with hemorrhagic fever will first present with flu-like symptoms. As the disease progresses, patients often bleed from their body orifices, such as their eyes and ears. Death, however, does not result from blood loss, but from shock or organ failure.
Hemorrhagic fevers are not easy to catch. Transmission generally requires prolonged contact with the patient or with his bodily fluids. Mortality rates depend on the particular viral strain. For Ebola, the deadliest strain is Zaire, which can kill up to 90% of those infected. The worst ever outbreak occurred in Congo in 1976. That year, 318 people were infected and 280 died, a mortality rate of 88%. Currently, an outbreak of Ebola has killed at least 135 people in west Africa. The virus resembles Zaire, but researchers have determined that it is a brand new strain.
Obviously, finding a treatment or cure for such a frightening disease is desirable. With our highly interconnected world, it is only a matter of time before a hemorrhagic fever shows up on our doorstep. (Actually, that's already happened.) Unfortunately, at the present time, there is little that can be done for a victim of Ebola or any other hemorrhagic fever. Mostly, patients are kept hydrated and symptoms are treated as they arise. Other than that, doctors cross their fingers and hope the patient doesn't die.
That may be about to change. In the journal Nature, scientists -- who conducted much of their work in the secretive, high-containment biological laboratory maintained by USAMRIID at Fort Detrick, Maryland -- have reported the discovery of a small molecule that rescues rodents and monkeys from various hemorrhagic fevers. Even more, the drug exhibited activity against a wide range of viruses.
The molecule, named BCX4430, resembles the famous "A" found in DNA: adenosine. (Recall that DNA is made of Adenosine, Thymidine, Cytidine and Guanosine.) The RNA-based filoviruses also use "A" in their genomes. BCX4430, because it resembles "A", can be accidentally used by the virus when it is trying to grow inside of our cells. For the virus, this is a fatal mistake. BCX4430 blocks further growth and reproduction.
Hold up a minute, you're probably thinking. Don't all cells use "A" too? Shouldn't this drug be expected to hurt not only the virus, but humans as well? That would be a reasonable expectation, but for some reason, BCX4430 appears to only hurt the virus. Human cells appear not to be fooled by BCX4430 and do just fine in its presence.
The most compelling experiment the research team ran involved the infection of cynomolgus macaque monkeys with deadly Marburg virus. Macaques were given twice daily doses of BCX4430 for 14 days beginning 1 hour, 24 hours, or 48 hours post-infection. (See graph. There were six monkeys in each treatment group.)
As shown above, all of the monkeys that did not receive BCX4430 (labeled "vehicle") died by day 12. However, every monkey (except for one) that received a dose of BCX4430 survived, even if the initial dose came 48 hours after infection. In total, 17 out of 18 treated monkeys lived.
Amazingly, in vitro experiments showed that BCX4430 could potentially work against a wide range of viruses, including SARS, MERS, influenza, dengue, and measles.
Because no human clinical trials have yet been conducted, it's still far too early to pop the cork on our champagne bottle. But this antiviral holds the greatest potential for curing nightmarish hemorrhagic fevers.
Source: TK Warren et al. "Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430." Nature 508: 402-405 (2014). doi:10.1038/nature13027
Sallie Krawcheck and Bob Kulhan will be talking money, jobs, and how the pandemic will disproportionally affect women's finances.
How can we promote the creation of new neurons - and why is it so important?
- Neurogenesis, the birth of neurons from stem cells, happens mostly before we are born - as we are formed in the womb, we are generating most of what we need after birth.
- After birth, neurogenesis is still possible in two parts of the brain: the olfactory bulb (which is responsible for our sense of smell) and the hippocampus (which is responsible for memory, spatial navigation, and emotional processing).
- Research from the 1960s proves creating new neurons as adults is possible, and modern-day research explains how (and why) we should promote new neuron growth.
Two parts of the brain can continue growing through neurogenesis<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMjkyMzk2NS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYwOTAwODc1MH0.4GDLlZmkwuD0-pJ0s0UWcUoYXMy95a-AM61a_QAlAeA/img.jpg?width=980" id="2e77e" class="rm-shortcode" data-rm-shortcode-id="4e23499fdf3b2185533979083fd02db7" data-rm-shortcode-name="rebelmouse-image" alt="brain made of twigs and plants concept of neurogenesis" />
Neurogenesis is still possible well into adulthood in two very important parts of the human brain.
Image by EtiAmmos on Shutterstock<p>Although most people are aware that aging or bad habits such as heavy alcohol use can contribute to the deterioration of our brains, not many of us give thought to how we can generate new brain cells.</p><p>Neurogenesis, the birth of neurons from stem cells, happens mostly before we are born - as we are formed in the womb, we are generating most of what we need after birth. </p><p><strong>After birth, however, neurogenesis is still possible in two parts of the brain:</strong></p><ul><li>The olfactory bulb, which is a structure of the forebrain that's responsible for our sense of smell. </li><li>The hippocampus, which is a structure of the brain located within the temporal lobe (just above your ears) - this area is important for learning, memory, regulation, of emotions and spatial navigation. </li></ul><p>Of course, when this information first came to light <a href="https://www.ncbi.nlm.nih.gov/pubmed/13860748" target="_blank">back in the 1960s</a>, the next natural question was: How do we promote neurogenesis in those areas where it's still possible? </p><p>Researchers today believe there are activities you can do (some of them may be things you already do on a daily basis) that can promote neurogenesis in your brain. </p><p><strong>Why is it important to promote the growth of new neurons in adulthood?</strong></p><p>We produce an estimated 700 million neurons per day in the hippocampus - this means by the time we reach the age of 50, we will have exchanged the neurons we were born within that area of the brain with new (adult-generated) neurons. </p><p>If we don't promote this exchange with the growth of new neurons, we may block certain abilities these new neurons help us with (such as keeping our memory sharp, for example). </p>
4 ways to promote neurogenesis in your brain<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMjkyMzk2Ni9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYyNTE3NjczNH0.qyzh_AIUPKfaQIa1QEq4yTNCAAK9nYkH3HFV9vWXwww/img.jpg?width=1245&coordinates=0%2C0%2C0%2C104&height=700" id="64a68" class="rm-shortcode" data-rm-shortcode-id="ee1307fe2dd61ae425552da56db3c5ff" data-rm-shortcode-name="rebelmouse-image" alt="child playing trumpet concept of learning a new instrument neurogenesis" />
Learning a new instrument helps promote neurogenesis.
Photo by DenisProduction.com on Shutterstock<p><strong>Intermittent fasting</strong></p><p><a href="https://law.stanford.edu/2015/01/09/lawandbiosciences-2015-01-09-intermittent-fasting-try-this-at-home-for-brain-health/" target="_blank">A 2015 Stanford study</a> examined the link between <a href="https://www.healthline.com/nutrition/6-ways-to-do-intermittent-fasting#section1" target="_blank">intermittent fasting</a> and neurogenesis. Calorie restriction and fasting can not only increase synaptic plasticity and promote neuron growth but it can also decrease your risk of developing neurodegenerative diseases and boost cognitive function. </p><p><u>Two of the most common ways you can intermittently fast are: </u></p><ul><li>16 hours per day every day - this is a method where you are able to eat for an 8 hour period of the day and fast for 16 hours of the day. Many people begin their "fast" after dinner, pushing their morning meal far enough towards lunch that most of their "off" eating time happens while they are asleep anyways. </li></ul><ul><li>24 hours every week - this is a method where once a week you fast for an entire day. Some people prefer this method because the rest of the week can resume as normal - but for many, this is a difficult way to fast. </li></ul><p><strong>Traveling to new places</strong></p><p>While traveling is something many of us enjoy — scenic routes and new fun experiences — these things also promote neurogenesis while we're on vacation. <a href="https://www.chicagotribune.com/travel/ct-xpm-2014-01-28-sc-trav-0128-travel-mechanic-20140128-story.html" target="_blank">Paul Nussbaum</a>, a clinical neuropsychologist at the University of Pittsburgh, explains that the mental benefits of traveling are very clear.<br></p><p><em>"When you expose your brain to an environment that's novel and complex or new and difficult, the brain literally reacts. Those new and challenging situations cause the brain to sprout dendrites (dangling extensions) which grow the brain's capacity." </em></p><p><strong>Learning a new instrument</strong></p><p>The mental health benefits of music have long been studied, but did you know that learning a new instrument can promote new neuron growth? </p><p>According to <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996135/" target="_blank">this 2010 study</a>, learning to play a new musical instrument is an intense, multisensory motor experience that requires that acquisition and maintenance of skills over your entire lifetime - which of course, promotes the new formation of new neural networks. </p><p>When is the best time to begin learning a new instrument? Childhood, of course. </p><p><em>"Learning to play a new musical instrument in childhood can result in long-lasting changes in brain organization," </em>according to the study mentioned above. </p><p>While learning an instrument in adulthood will also promote neurogenesis, children who began training with a musical instrument before the age of 7 have shown that they have a significantly larger corpus callosum (the area of the brain the allows communication between the two hemispheres of the brain) than many adults. </p><p><strong>Reading novels</strong></p><p>A study from <a href="http://esciencecommons.blogspot.com/2013/12/a-novel-look-at-how-stories-may-change.html" target="_blank">Emory University</a> showed there was an increase in ongoing connectivity in the brains of participants after reading the same (fiction) novel. </p><p>In this study, enhanced brain activity was observed in the region that control physical sensations and movement. Reading a novel, according to lead researcher Gregory Berns, can transport you into the body of the protagonist. </p><p>This ability to shift into another mental state is a vital skill that promotes healthy neurogenesis in those areas of the brain. </p>
The coronavirus pandemic has brought out the perception of selfishness among many.
- Selfish behavior has been analyzed by philosophers and psychologists for centuries.
- New research shows people may be wired for altruistic behavior and get more benefits from it.
- Crisis times tend to increase self-centered acts.
Paul Krugman on the Virtues of Selfishness<div class="rm-shortcode" data-media_id="7ZtAkm6C" data-player_id="FvQKszTI" data-rm-shortcode-id="828936bf6953080e9018307354c0c02b"> <div id="botr_7ZtAkm6C_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/7ZtAkm6C-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/7ZtAkm6C-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/7ZtAkm6C-FvQKszTI.js"></script> </div> The Nobel Prize-winning economist on the virtues of selfishness.
Evolution Is Moving Us Away from Selfishness. But Where Is It Taking ...<div class="rm-shortcode" data-media_id="cyeqmYCb" data-player_id="FvQKszTI" data-rm-shortcode-id="6c5efecb56456e9acc25cf36935b1826"> <div id="botr_cyeqmYCb_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/cyeqmYCb-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/cyeqmYCb-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/cyeqmYCb-FvQKszTI.js"></script> </div>
Exploring Morality and Selfishness in Modern Times<div class="rm-shortcode" data-media_id="02eX1Cag" data-player_id="FvQKszTI" data-rm-shortcode-id="45cc6180db791f32683988fb52faff26"> <div id="botr_02eX1Cag_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/02eX1Cag-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/02eX1Cag-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/02eX1Cag-FvQKszTI.js"></script> </div> Philosopher Peter Singer discusses the state of global ethics.
Parenting could be a distraction from what mattered most to him: his writing.
Ernest Hemingway was affectionately called “Papa," but what kind of dad was he?