Yet 80 percent of respondents want to reduce their risk of dementia.
- A new MDVIP/Ipsos survey found that only 35 percent of Americans know the symptoms of Alzheimer's disease.
- Eighty percent of respondents said they want to reduce their risks.
- An estimated 7.1 million Americans over the age of 65 will suffer from Alzheimer's by 2025.
Credit: logika600 / Shutterstock<p>Remaining healthy requires regular screenings. Here again we see a disassociation between risk reduction and proactivity. Seventy-seven percent of respondents don't talk to their doctors about lifestyle habits that support brain health; 51 percent have never been screened for depression; 44 percent have never had a neurological exam; and 32 percent have never been screened for hearing problems. </p><p>Common early warning signs of dementia, <a href="https://news.yahoo.com/americans-worry-alzheimers-disease-survey-140644803.html" target="_blank" rel="noopener noreferrer">according to</a> Dr. Jason Karlawish, co-director of the Penn Memory Center, include repetitive questions and stories, difficulties with complex daily tasks, and trouble with orientation. </p><p>In terms of intervention, <a href="https://bigthink.com/21st-century-spirituality/does-lack-of-exercise-lead-to-dementia" target="_self">exercise</a>, <a href="https://bigthink.com/surprising-science/obesity-dementia" target="_self">diet</a>, building a <a href="https://bigthink.com/mind-brain/brain-reserve" target="_self">brain reserve</a>, and challenging your brain (such as learning a new language or musical instrument) are all proven methods for staving off the ravages of Alzheimer's. Oxytocin has also <a href="https://bigthink.com/mind-brain/alzheimers-oxytocin" target="_self">showed promise</a> in brain-addled mice, while researchers found positive results for a <a href="https://bigthink.com/mind-brain/intermittent-fasting" target="_self">group of intermittent fasters</a> in promoting neurogenesis. </p><p>Epidemiologist Bryan James says that dementia is <a href="https://www.npr.org/sections/health-shots/2013/04/15/176920391/how-exercise-and-other-activities-beat-back-dementia" target="_blank">not an inevitable result</a> of aging. </p><p style="margin-left: 20px;">"It's simply not pre-destined for all human beings. Lots of people live into their 90s and even 100s with no symptoms of dementia." </p><p>Professor of neurology at Boston University School of Medicine, Andrew Budson, <a href="https://news.yahoo.com/americans-worry-alzheimers-disease-survey-140644803.html" target="_blank" rel="noopener noreferrer">recommends</a> aerobic exercise and the Mediterranean diet. As has long been known, whole grains, fruits and vegetables, fish and shellfish, and healthy fasts like nuts and olive oil seem to have brain-boosting properties. </p><p>To learn more, take the <a href="https://www.mdvip.com/brain-health-iq-quiz" target="_blank">Brain Health IQ quiz</a>.</p><p><span></span>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a>, <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank">Facebook</a> and <a href="https://derekberes.substack.com/" target="_blank" rel="noopener noreferrer">Substack</a>. His next book is</em> "<em>Hero's Dose: The Case For Psychedelics in Ritual and Therapy."</em></p>
A team of researchers have discovered the brain rhythmic activity that can split us from reality.
- Researchers have identified the key rhythmic brain activity that triggers a bizarre experience called dissociation in which people can feel detached from their identity and environment.
- This phenomena is experienced by about 2 percent to 10 percent of the population. Nearly 3 out of 4 individuals who have experienced a traumatic event will slip into a dissociative state either during the event or sometime after.
- The findings implicate a specific protein in a certain set of cells as key to the feeling of dissociation, and it could lead to better-targeted therapies for conditions in which dissociation can occur.
What is dissociation?<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="bd2f1f29418bd4805bf1282001dca814"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/XF2zeOdE5GY?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p>Dissociation is an experience commonly described as a feeling of sudden detachment from the individual's identity and environment, almost like an out-of-body experience. This mysterious phenomena is experienced by about 2 percent to 10 percent of the population.</p><p>"This state often manifests as the perception of being on the outside looking in at the cockpit of the plane that's your body or mind — and what you're seeing you just don't consider to be yourself," explained senior author Karl Deisseroth, MD, PhD, <a href="https://med.stanford.edu/news/all-news/2020/09/researchers-pinpoint-brain-circuitry-underlying-dissociation.html" target="_blank" rel="noopener noreferrer">in a Stanford Medicine news release</a>. Deisseroth is a professor of bioengineering and of psychiatry and behavioral sciences, as well as a Howard Hughes Medical Institute investigator.</p><p>Nearly three-quarters of individuals who have experienced a traumatic event will slip into a dissociative state either during the event or in the hours or even weeks that follow, according to Deisseroth. Most of the time, the dissociative experiences end on their own within a few weeks of the trauma. But the eerie experience can become chronic, such as in cases of post-traumatic stress disorder, and extremely disruptive in daily life. The state of dissociation can also occur in epilepsy and be invoked by certain drugs. </p><p>Until now, no one has known what exactly is going on inside the brain triggering and sustaining the feeling of dissociation — and so it has been a challenge to figure out how to stop it and develop effective treatments. </p>
New Research: The Molecular Underpinnings of Dissociation<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDQyNjk3My9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYwNTQ3MTI1NX0._nJoxm1eDcTsHsy1Y27JxNl2uR5hlbEYDWYoQlO0EAU/img.jpg?width=1245&coordinates=0%2C121%2C0%2C121&height=700" id="26e86" class="rm-shortcode" data-rm-shortcode-id="1094af23e35a498a8a6b691f1d0cbfaf" data-rm-shortcode-name="rebelmouse-image" alt="neurons" />
Neurons from a mouse spinal cord
Credit: NICHD on Flickr<p>Last week, in a study published in <a href="https://www.nature.com/articles/s41586-020-2731-9" target="_blank">Nature</a><a href="https://www.nature.com/articles/s41586-020-2731-9">,</a> Deisseroth and his colleagues at Stanford University uncovered a localized brain rhythm and molecule that underlies this state.</p><p>"This study has identified brain circuitry that plays a role in a well-defined subjective experience," said Deisseroth. "Beyond its potential medical implications, it gets at the question, 'What is the self?' That's a big one in law and literature, and important even for our own introspections."</p><p>The authors' findings implicate a specific protein existing in a particular set of cells as key to the feeling of dissociation. </p><p>The research team first used a technique called widefield calcium imaging to record brain-wide neuronal activity in lab mice. They observed and analyzed changes in those brain rhythms after the animals had been administered a range of drugs that are known to cause dissociative states: ketamine, phencyclidine (PCP), and dizocilpine (MK801). At a certain dosage of ketamine, the mice behaved in a way that suggested that they were likely experiencing dissociation. For example, when the animals were placed on an uncomfortably warm surface, they reacted to it by flicking their paws. However, they signaled that they didn't care enough about the unpleasantness to do what they would typically do in such a situation, which is to lick their paws to cool them off. This suggested a dissociation from the surrounding environment.</p><p>The drug produced oscillations in neuronal activity in a region of the mices' brain called the retrosplenial cortex, an area essential for various cognitive functions such as navigation and episodic memory (a unique memory of a specific event). The oscillations occurred at about 1-3 hertz (three cycles per second). The authors then examined the active cells in more detail by using two-photon imaging for higher resolution. This revealed that the oscillations were occurring only in layer 5 of the retrosplenial cortex. Next, the researchers recorded neuronal activity across other regions of the brain. </p><p>"Normally, other parts of the cortex and subcortex are functionally connected to neuronal activity in the retrosplenial cortex," Ken Solt and Oluwaseun Akeju wrote in <a href="https://www.nature.com/articles/d41586-020-02505-z#ref-CR1" target="_blank">Nature</a>. "However, ketamine caused a disconnect, such that many of these brain regions no longer communicated with the retrosplenial cortex."</p><p>The scientists then used optogenetics, a method of manipulating living tissue with light to control neural function, to stimulate neurons in the mice's retrosplenial cortex. When the scientists did this at a 2-hertz rhythm, they were able to cause dissociative behavior in the animals analogous to the behavior caused by ketamine without using drugs. The experiments conducted by the team displayed how a particular type of protein, an ion channel, was essential to the generation of the hertz signal that caused the dissociative behavior in mice. Scientists are hopeful that this protein could be a potential treatment target in the future. </p>
What about humans?<p>The researchers also recorded electrical activity from brain regions in an epilepsy patient who had reported experiencing dissociation immediately before each seizure. The sensations experienced right before a seizure is called an aura. This aura for the patient was like being "outside the pilot's chair, looking at, but not controlling, the gauges," Deisseroth said.</p><p>The researchers recorded electric signals from the patient's cerebral cortex and stimulated it electrically aiming to identify the origin point of the seizures. While that was happening, the patient responded to questions about how it felt. The authors found that whenever the patient was about to have a seizure, it was preceded by the dissociative aura and a particular pattern of electrical activity localized within the patient's posteromedial cortex. That patterned activity was characterized by an oscillating signal sparked by nerve cells firing in coordination at 3 hertz. When this region of the brain was stimulated electrically, the patient experienced dissociation without having a seizure. </p><p>This study will have far-reaching implications for neuroscience and could lead to better-targeted therapies for disorders in which dissociation can be triggered, such as PTSD, borderline personality, and epilepsy.</p>
A team at the University of Basel discovered a connection between antidepressants and REM sleep.
- Researchers at the University of Basel measured the efficacy of antidepressants by measuring brain waves during REM sleep.
- Antidepressants take weeks to begin working, and over 50 percent of users don't find success with the first prescription.
- This research could offer a powerful new diagnostic tool for psychiatrists and doctors.
Should you "hack" your sleep pattern? | Vanessa Hill | Big Think<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="af84e812903700afbdc0c73e6b7c619e"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/1Y-qLKZWyDs?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p>University of Basel's Dr Thorsten Mikoteit led the research. His team studied 37 volunteers suffering from major depression, with 15 in the control group. Everyone's brain waves were measured while asleep. By gazing at these waves, the researchers identified patterns that could predict whether or not the volunteer would benefit from an antidepressant.</p><p>Through their observations, the researchers were able to suggest a different medication if they did not seem to respond to the first. After five weeks, 87.5 percent of the patients in the treatment group showed an improved response to medication, compared to only 20 percent in the control group. </p><p>It should be noted that this is a pilot study and has not yet been peer reviewed. Still, Mikoteit sees hope in the protocol. </p><p style="margin-left: 20px;">"We have been able to show that by predicting the non-response to antidepressants we were able to adapt the treatment strategy more or less immediately: this enables us to significantly shorten the average duration between start of antidepressant treatment and response, which is vital especially for seriously depressed patients."</p><p>Poor sleep is an indicator of numerous health problems, including anxiety and depression. Getting an inside view of sleep patterns could be a game-changer for the hundreds of millions of people that regularly suffer from depression. If this research holds up, doctors could have a powerful new diagnostic tool at their fingertips. The time, money, and health risks associated with faulty prescriptions could be avoided—a win for patients and the health care system overall. </p><p>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a>, <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank" rel="noopener noreferrer">Facebook</a> and <a href="https://derekberes.substack.com/" target="_blank" rel="noopener noreferrer">Substack</a>. His next book is</em> "<em>Hero's Dose: The Case For Psychedelics in Ritual and Therapy."</em></p>
Does time exist? Here's what the debate is all about.
- Everything we do as living organisms is dependent, in some capacity, on time. The concept is so complex that scientists still argue whether it exists or if it is an illusion.
- In this video, astrophysicist Michelle Thaller, science educator Bill Nye, author James Gleick, and neuroscientist Dean Buonomano discuss how the human brain perceives of the passage of time, the idea in theoretical physics of time as a fourth dimension, and the theory that space and time are interwoven.
- Thaller illustrates Einstein's theory of relativity, Buonomano outlines eternalism, and all the experts touch on issues of perception, definition, and experience.
Christians and Muslims that pick out unconscious patterns are more likely to believe in a god.
- Georgetown researchers found strong implicit pattern learning implies belief in a god.
- The study included American Christians and Afghani Muslims, representing two different religious and cultural backgrounds.
- Further research on polytheistic religious believers could provide insights into a cognitive basis of religion.
Why religion is literally false and metaphorically true | Bret Weinstein | Big Think<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="bb748b6454d9ea27e58c41be9c4b50f6"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/c0_J998UD9s?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p>The answer, according to their research, is yes. As Green <a href="https://gumc.georgetown.edu/news-release/study-suggests-unconscious-learning-underlies-belief-in-god/" target="_blank">notes</a>,</p><p style="margin-left: 20px;">"This is not a study about whether God exists, this is a study about why and how brains come to believe in gods. Our hypothesis is that people whose brains are good at subconsciously discerning patterns in their environment may ascribe those patterns to the hand of a higher power." </p><p>Consciousness only provides a sliver of data that our brains pay attention to. Bottom-up processes operate below the conscious threshold, such as the biological operations that maintain our body's homeostasis. Threat detection and other forms of perception are also processed from the bottom-up, although, as the authors write, top-down processing is not an entirely separate domain. The two inform one another. </p><p><a href="https://bigthink.com/21st-century-spirituality/how-does-intuition-work" target="_self">Intuition</a> is another example of bottom-up processing that appears in consciousness. We pick up signals from our environment and process it unconsciously all the time.</p><p style="margin-left: 20px;">"Because individuals are not aware of such bottom-up influences, intuitions drawn from unconscious processing may instead be consciously interpreted via explicit belief narratives that provide a rationalized context for beliefs and behaviors."</p>
A general view of the beach and a surfer as photographed on March 20, 2014 in Marina del Rey, California.
Photo by Bruce Bennett/Getty Images<p>Face processing, implicit racial bias, and pathogen avoidance provide further context. In fact, cleansing rituals likely evolved from an unconscious fear of disease. Our ancestors applied a spiritual dimension to their bathing rituals to make sense out of unconscious drives.</p><p>For this study, 199 (mostly) Christian volunteers in Washington, D.C. and 149 Muslims in Kabul watched a sequence of dots on a computer screen. They were tasked to press a corresponding button every time a dot appeared. Participants with strong implicit learning abilities began to unconsciously recognize patterns in the appearance of the dots, preemptively hitting the corresponding button <em>before</em> they appeared. None of the volunteers claimed to have seen a pattern, suggesting their guesses were unconscious. </p><p>The team observed a link between the strongest implicit learners and religious belief. Recognizing patterns before they appear is correlated with belief in a god. The team was surprised to discover such a strong correlation between two disparate religious and cultural groups, suggesting the potential of a universal theme. As Green notes, </p><p style="margin-left: 20px;">"A brain that is more predisposed to implicit pattern learning may be more inclined to believe in a god no matter where in the world that brain happens to find itself, or in which religious context."</p><p>An interesting next step could be studying polytheistic groups, where pattern recognition is likely stronger. It's one thing to give credit to one god for everything, but quite another to assign a variety of divine figures for the relationships between natural phenomena. </p><p>The authors conclude that they cannot write off top-down processing as part of religious belief. Indeed, faith likes has multivariate influences. Still, this research details another cognitive basis of belief, highlighting common ground we all share regardless of the form of our deities. </p><p>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a>, <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank" rel="noopener noreferrer">Facebook</a> and <a href="https://derekberes.substack.com/" target="_blank" rel="noopener noreferrer">Substack</a>. His next book is</em> "<em>Hero's Dose: The Case For Psychedelics in Ritual and Therapy."</em></p>