In the 1990s, the two scientists made key discoveries that led to the development of promising new cancer-fighting immunotherapy drugs.
- The two researchers, from the U.S. and Japan, made key discoveries about the immune system's response to cancer.
- Their work showed how to block cancer cells from crippling white blood cells.
- Still in its early stages, immunotherapy is a promising field in cancer research.
How immunotherapy works<p>Immunotherapy effectively removes the 'brakes' on the body's immune system, allowing for a certain type of white blood cell, called T-cells, to hunt down and kill cancer cells. Without immunotherapy treatment, cancer cells can deactivate T-cells by taking advantage of a switch on the cells, called an immune checkpoint. This shuts down the body's immune response and allows the cancer to spread unchecked.</p><p><img src="https://assets.rbl.ms/18677569/980x.jpg"></p><p><em>Image: <a href="https://www.nobelprize.org/uploads/2018/10/press-medicine2018.pdf" target="_blank">Nobel committee</a></em><br></p><p>Immunotherapies keep cancer-fighting T-cells active by blocking the immune checkpoints. In the 1990s, Allison and Honjo made key discoveries about immune checkpoints that later led to the development of immunotherapies that have proven successful in humans; Allison identified a checkpoint called CTLA-4, Honjo found another called PD-1.</p><p>The development and testing of immunotherapy drugs is still in early stages. However, immunotherapy has shown promising signs in recent years in combating several types of cancer, particularly <a href="https://lungevity.org/about-lung-cancer/experts-blog/exploring-potential-of-immunotherapy-in-early-stage-lung-cancer" target="_blank">lung cancer</a>, even reversing the disease completely in some patients.</p>
Revolutionary work<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8xODY3ODE1Ny9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYzNDE3MzIwMn0.CSbeYCPDxvcd4c4hcMnTcTv9i16sNCpj3NVcGQ1kEuk/img.jpg?width=980" id="c729c" class="rm-shortcode" data-rm-shortcode-id="5efdb53b23943b0522381956efd0e6bd" data-rm-shortcode-name="rebelmouse-image" />
Photo: JONATHAN NACKSTRAND/AFP/Getty Images<p>Many scientists have helped develop the field of immunotherapy, but the work of Allison and Honjo helped build a foundation from which it could grow.</p><p>"I think they really deserve it," Jerome Galon, an immunologist at the Paris-based national biomedical research agency INSERM, told <em><a href="https://www.nature.com/articles/d41586-018-06751-0?utm_source=fbk_nnc&utm_medium=social&utm_campaign=naturenews&sf198900854=1&error=cookies_not_supported&code=5bcbcd42-c793-4440-b52e-58ec42a11478" target="_blank">Nature</a></em>. "You can always multiply and have many other people, but these are the obvious two first choices."</p><p>Their work "brought immunotherapy out from decades of skepticism" and has led to treatments that have improved an "untold number of people's health," Dr. Jedd Wolchok, a cancer specialist at Memorial Sloan Kettering Cancer Center in New York, told <em><a href="https://www.nytimes.com/2018/10/01/health/nobel-prize-medicine.html" target="_blank">The New York Times.</a></em></p><p>The Nobel committee wrote that scientists have been searching for ways to bolster the immune system against cancer for more than a century, but the progress was "<a href="https://www.nobelprize.org/uploads/2018/10/press-medicine2018.pdf" target="_blank">modest</a>" until the revolutionary work of Allison and Honjo.</p><p>"Allison's and Honjo's discoveries have added a new pillar in cancer therapy. It represents a completely new principle, because unlike previous strategies, it is not based on targeting the cancer cells, but rather the brakes — the checkpoints — of the host immune system," Klas Kärre, a member of the Nobel Committee and an immunologist at the Karolinska Institute in Stockholm, said in a statement. "The seminal discoveries by the two laureates constitutes a paradigmatic shift and a landmark in the fight against cancer."</p>
It neutralized not only the tumor it was injected into but malignancies all over the body.
Current cancer therapies have terrible side effects and aren’t always effective. And with things like radiotherapy and chemotherapy, the number of treatments one needs to endure makes side effects progressively worse over time. A new technique developed by researchers at Stanford University uses two agents which when combined, alert the body’s immune system to the presence of cancer, in order to eliminate it.