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Tiny parasite-like robots are the future of pain relief
Researchers design microdevices that can gradually deliver medicine by latching on to intestines.
- A research team from Johns Hopkins University designs microdevices that can deliver medicine.
- The tiny robots are based on parasite hookworms.
- The machines can latch on to the intestines and gradually release pain-relieving drugs.
Researchers created tiny devices that can deliver drugs to the body by attaching themselves to a person's intestines.
The research team was led by engineering professor David Gracias and gastroenterologist Florin M. Selaru from Johns Hopkins University. The scientists took inspiration from the hookworm – parasitic worm that is known to dig its sharp teeth into the intestines of the host. The scientists created shape-shifting microdevices called "theragrippers" that can mimic the worm and latch on to the intestinal mucosa of a patient.
The six-pointed devices, each as large as a dust speck, are made of metal and thin film that can allow them to change shapes. They are covered by a heat-sensitive paraffin wax and have the potential to release a drug gradually into the body. This method improves upon other extended-release drugs that tend to go all the way through the gastrointestinal tract before fully dispensing all medicine.
"Normal constriction and relaxation of GI tract muscles make it impossible for extended-release drugs to stay in the intestine long enough for the patient to receive the full dose," explained Selaru." We've been working to solve this problem by designing these small drug carriers that can autonomously latch onto the intestinal mucosa and keep the drug load inside the GI tract for a desired duration of time."
The scientists say that thousands such devices can be let loose in a GI tract. As the wax coating on tiny robots matches the body's inside temperature, theraggrippers automatically close and latch on to the wall of the colon. As they do so and dig into the mucosa, they start slowly releasing the stored medicine. In time, the devices lose their grip on the intestine tissue and leave the organ through usual gastrointestinal function.
March of the microscopic robots
The very small robots don't rely on electricity or wireless signals, and don't have room for batteries, antennas, or any external controls, explained Gracias. Instead, the grippers work like "small, compressed springs with a temperature-triggered coating" which releases the stored energy.
In the trial, the researchers managed to fit about 6,000 such devices on a 3-inch silicon wafer. Experiments on rats showed a successful dispersion of pain-relieving drugs into the bloodstreams.
Check out the new study published in Science Advances.
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Inventions with revolutionary potential made by a mysterious aerospace engineer for the U.S. Navy come to light.
- U.S. Navy holds patents for enigmatic inventions by aerospace engineer Dr. Salvatore Pais.
- Pais came up with technology that can "engineer" reality, devising an ultrafast craft, a fusion reactor, and more.
- While mostly theoretical at this point, the inventions could transform energy, space, and military sectors.
The U.S. Navy controls patents for some futuristic and outlandish technologies, some of which, dubbed "the UFO patents," came to life recently. Of particular note are inventions by the somewhat mysterious Dr. Salvatore Cezar Pais, whose tech claims to be able to "engineer reality." His slate of highly-ambitious, borderline sci-fi designs meant for use by the U.S. government range from gravitational wave generators and compact fusion reactors to next-gen hybrid aerospace-underwater crafts with revolutionary propulsion systems, and beyond.
Of course, the existence of patents does not mean these technologies have actually been created, but there is evidence that some demonstrations of operability have been successfully carried out. As investigated and reported by The War Zone, a possible reason why some of the patents may have been taken on by the Navy is that the Chinese military may also be developing similar advanced gadgets.
Among Dr. Pais's patents are designs, approved in 2018, for an aerospace-underwater craft of incredible speed and maneuverability. This cone-shaped vehicle can potentially fly just as well anywhere it may be, whether air, water or space, without leaving any heat signatures. It can achieve this by creating a quantum vacuum around itself with a very dense polarized energy field. This vacuum would allow it to repel any molecule the craft comes in contact with, no matter the medium. Manipulating "quantum field fluctuations in the local vacuum energy state," would help reduce the craft's inertia. The polarized vacuum would dramatically decrease any elemental resistance and lead to "extreme speeds," claims the paper.
Not only that, if the vacuum-creating technology can be engineered, we'd also be able to "engineer the fabric of our reality at the most fundamental level," states the patent. This would lead to major advancements in aerospace propulsion and generating power. Not to mention other reality-changing outcomes that come to mind.
Among Pais's other patents are inventions that stem from similar thinking, outlining pieces of technology necessary to make his creations come to fruition. His paper presented in 2019, titled "Room Temperature Superconducting System for Use on a Hybrid Aerospace Undersea Craft," proposes a system that can achieve superconductivity at room temperatures. This would become "a highly disruptive technology, capable of a total paradigm change in Science and Technology," conveys Pais.
High frequency gravitational wave generator.
Credit: Dr. Salvatore Pais
Another invention devised by Pais is an electromagnetic field generator that could generate "an impenetrable defensive shield to sea and land as well as space-based military and civilian assets." This shield could protect from threats like anti-ship ballistic missiles, cruise missiles that evade radar, coronal mass ejections, military satellites, and even asteroids.
Dr. Pais's ideas center around the phenomenon he dubbed "The Pais Effect". He referred to it in his writings as the "controlled motion of electrically charged matter (from solid to plasma) via accelerated spin and/or accelerated vibration under rapid (yet smooth) acceleration-deceleration-acceleration transients." In less jargon-heavy terms, Pais claims to have figured out how to spin electromagnetic fields in order to contain a fusion reaction – an accomplishment that would lead to a tremendous change in power consumption and an abundance of energy.
According to his bio in a recently published paper on a new Plasma Compression Fusion Device, which could transform energy production, Dr. Pais is a mechanical and aerospace engineer working at the Naval Air Warfare Center Aircraft Division (NAWCAD), which is headquartered in Patuxent River, Maryland. Holding a Ph.D. from Case Western Reserve University in Cleveland, Ohio, Pais was a NASA Research Fellow and worked with Northrop Grumman Aerospace Systems. His current Department of Defense work involves his "advanced knowledge of theory, analysis, and modern experimental and computational methods in aerodynamics, along with an understanding of air-vehicle and missile design, especially in the domain of hypersonic power plant and vehicle design." He also has expert knowledge of electrooptics, emerging quantum technologies (laser power generation in particular), high-energy electromagnetic field generation, and the "breakthrough field of room temperature superconductivity, as related to advanced field propulsion."
Suffice it to say, with such a list of research credentials that would make Nikola Tesla proud, Dr. Pais seems well-positioned to carry out groundbreaking work.
A craft using an inertial mass reduction device.
Credit: Salvatore Pais
The patents won't necessarily lead to these technologies ever seeing the light of day. The research has its share of detractors and nonbelievers among other scientists, who think the amount of energy required for the fields described by Pais and his ideas on electromagnetic propulsions are well beyond the scope of current tech and are nearly impossible. Yet investigators at The War Zone found comments from Navy officials that indicate the inventions are being looked at seriously enough, and some tests are taking place.
If you'd like to read through Pais's patents yourself, check them out here.
Laser Augmented Turbojet Propulsion System
Credit: Dr. Salvatore Pais
A study on charity finds that reminding people how nice it feels to give yields better results than appealing to altruism.
- A study finds asking for donations by appealing to the donor's self-interest may result in more money than appealing to their better nature.
- Those who received an appeal to self-interest were both more likely to give and gave more than those in the control group.
- The effect was most pronounced for those who hadn't given before.
Even the best charities with the longest records of doing great fundraising work have to spend some time making sure that the next donation checks will keep coming in. One way to do this is by showing potential donors all the good things the charity did over the previous year. But there may be a better way.
A new study by researchers in the United States and Australia suggests that appealing to the benefits people will receive themselves after a donation nudges them to donate more money than appealing to the greater good.
How to get people to give away free money
The postcards that were sent to different study subjects. The one on the left highlighted benefits to the self, while the one on the right highlighted benefits to others.List et al. / Nature Human Behaviour
The study, published in Nature Human Behaviour, utilized the Pick.Click.Give program in Alaska. This program allows Alaska residents who qualify for dividends from the Alaska Permanent Fund, a yearly payment ranging from $800 to $2000 in recent years, to donate a portion of it to various in-state non-profit organizations.
The researchers randomly assigned households to either a control group or to receive a postcard in the mail encouraging them to donate a portion of their dividend to charity. That postcard could come in one of two forms, either highlighting the benefits to others or the benefits to themselves.
Those who got the postcard touting self-benefits were 6.6 percent more likely to give than those in the control group and gave 23 percent more on average. Those getting the benefits-to-others postcard were slightly more likely to give than those receiving no postcard, but their donations were no larger.
Additionally, the researchers were able to break the subject list down into a "warm list" of those who had given at least once before in the last two years and a "cold list" of those who had not. Those on the warm list, who were already giving, saw only minor increases in their likelihood to donate after getting a postcard in the mail compared to those on the cold list.
Additionally, the researchers found that warm-list subjects who received the self-interest postcard gave 11 percent more than warm-list subjects in the control group. Amazingly, among cold-list subjects, those who received a self-interest postcard gave 39 percent more.
These are substantial improvements. At the end of the study, the authors point out, "If we had sent the benefits to self message to all households in the state, aggregate contributions would have increased by nearly US$600,000."
To put this into perspective, in 2017 the total donations to the program were roughly $2,700,000.
Is altruism dead?
Are all actions inherently self-interested? Thankfully, no. The study focuses entirely on effective ways to increase charitable donations above levels that currently exist. It doesn't deny that some people are giving out of pure altruism, but rather that an appeal based on self-interest is effective. Plenty of people were giving before this study took place who didn't need a postcard as encouragement. It is also possible that some people donated part of their dividend check to a charity that does not work with Pick.Click.Give and were uncounted here.
It is also important to note that Pick.Click.Give does not provide services but instead gives money to a wide variety of organizations that do. Those organizations operate in fields from animal rescue to job training to public broadcasting. The authors note that it is possible that a more specific appeal to the benefits others will receive from a donation might prove more effective than the generic and all-inclusive "Make Alaska Better For Everyone" appeal that they used.
In an ideal world, charity is its own reward. In ours, it might help to remind somebody how warm and fuzzy they'll feel after donating to your cause.
The 'Monkeydactyl' was a flying reptile that evolved highly specialized adaptations in the Mesozoic Era.
- The 'Monkeydactly', or Kunpengopterus antipollicatus, was a species of pterosaur, a group of flying reptiles that were the first vertebrates to evolve the ability of powered flight.
- In a recent study, a team of researchers used microcomputed tomography scanning to analyze the anatomy of the newly discovered species, finding that it was the first known species to develop opposable thumbs.
- As highly specialized dinosaurs, pterosaurs boasted unusual anatomy that gave them special advantages as aerial predators in the Mesozoic Era.
A newly discovered flying dinosaur nicknamed "Monkeydactyl" is the oldest known creature that evolved opposable thumbs, according to new research published in Current Biology.
The 160-million-year-old reptile is officially named Kunpengopterus antipollicatus. Discovered in China, the dinosaur was a darwinopteran pterosaur, a subgroup of pterosaurs, which first appeared 215 million years ago during the Triassic Period. Pterosaurs, like the pterodactyl, were the first vertebrates to evolve the ability of powered flight.
But unlike other pterosaurs, the Monkeydactyl was the only species in its group known to have opposable thumbs. It's a rare adaptation for non-mammals: The only extant examples are chameleons and some species of tree frogs. (Most birds have at least one opposable digit, though that digit is usually classified as a hallux, not a pollex, which means "thumb" in Latin.)
To analyze the anatomy of K. antipollicatus, an international team of researchers used microcomputed tomography scanning, which generates images of the inside of the body.
"The fingers of 'Monkeydactyl' are tiny and partly embedded in the slab," study co-author Fion Waisum Ma said in a press release. "Thanks to micro-CT scanning, we could see through the rocks, create digital models, and tell how the opposed thumb articulates with the other finger bones."
"This is an interesting discovery. It provides the earliest evidence of a true opposed thumb, and it is from a pterosaur — which wasn't known for having an opposed thumb."
As a tree-dwelling reptile, the Monkeydactyl probably evolved opposable thumbs so it could grasp tree branches, which would have helped it hang, avoid falls, and obtain food. This arboreal (tree-dwelling) locomotion would help the Monkeydactyl adapt to its home ecosystem, the subtropical forests of the Tiaojishan Formation in China during the Jurassic Period.
The researchers noted that the forests of the Tiaojishan Formation were likely warm and humid, thriving with "a rich and complex" diversity of tree-dwelling animals. But while the forests were home to multiple pterosaur species, the Monkeydactyl was likely the only one that was arboreal, spending most of its time in the treetops, while other pterosaurs occupied different levels of the forest.
K. antipollicatus and its phylogenetic position. (A and B) Holotype specimen BPMC 0042 (A) and a schematic skeletal drawing (B). Scale bars, 50 mm.Credit: Zhou et al.
This process — in which competing species manage to coexist by using the environment in different ways — is called "niche partitioning."
"Tiaojishan palaeoforest is home to many organisms, including three genera of darwinopteran pterosaurs," study author Xuanyu Zhou said in the press release. "Our results show that K. antipollicatus has occupied a different niche from Darwinopterus and Wukongopterus, which has likely minimized competition among these pterosaurs."
In general, pterosaurs are a prime example of how animals can evolve remarkably specialized adaptations. As pioneers of vertebrate flight, pterosaurs had strong and lightweight skeletons that ranged widely in size, with some boasting wingspans of more than 30 feet. The largest pterosaurs weighed more than 650 pounds and had jaws twice the length of Tyrannosaurus rex.
Unlike birds, which jump into the air using only their hind limbs, pterosaurs used their exceptionally strong hind limbs and forelimbs to push off the ground and gain enough launch power for flight. That these massive dinosaurs managed to fly, and did so successfully for about 80 million years, has long fascinated and puzzled scientists.The recent discovery shows that pterosaurs developed even more remarkable adaptations than previously thought, suggesting there's still more to learn about the "monsters of the Mesozoic skies."