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CBD makes glaucoma worse, researchers find
A new study reveals that it increases eye pressure, negating the effects of THC.
- For decades, marijuana has been touted as providing glaucoma relief.
- A study out of Indiana University shows that while THC reduces eye pressure, CBD does the opposite.
- Of the 18 mice tested, females were less responsive to marijuana than males.
While glaucoma has been the butt of many well-intentioned, wink-wink weed jokes for decades, the disease is quit serious. In fact, glaucoma is the leading cause of blindness in people above sixty. Glaucoma is insidious as well. Abnormally high pressure in your eyes gradually damage the optic nerve.
Vision loss is subtle until it reaches advanced stages, by which point there is little chance of slowing damage. By this point prevention is impossible.
It begins with patchy spots in your vision, mostly in the periphery or central vision. By the time glaucoma is in latter stages, tunnel vision results. Deterioration of the optic nerve is irreversible. Some treatments mitigate damage by lowering eye pressure, such as laser treatment and eye drops.
And, of course, there is marijuana, which does, in fact, lower eye pressure — specifically, THC lowers it. But there are trade-offs. Unlike other treatments, marijuana's effects last 3–4 hours, meaning you need to smoke continuously throughout the day. While pressure is reduced, the constant smoke creates other problems.
However, a new study out of Indiana University reveals that marijuana, specifically cannnabidiol (CBD), can make glaucoma worse.
The study, published in Investigative Ophthalmology & Visual Science on December 14, found that CBD — one of the hottest and, as I've previously written, suspect health trends being shoved into every product imaginable at a premium — actually creates a rise in eye pressure, the exact opposite effect a glaucoma sufferer desires.
Associate scientist Alex Straiker, who led the study, continues:
This study raises important questions about the relationship between the primary ingredients in cannabis and their effect on the eye. It also suggests the need to understand more about the potential undesirable side effects of CBD, especially due to its use in children.
As mentioned, THC indeed lowers eye pressure, which has been the mechanism by which treatment has been administered thus far. The problem is, according to Straiker's research, CBD blocks the pressure-reducing effects that THC offers.
Illustration of glaucoma treatment using ultrasound. The ultrasound beams enable the ciliary body, the gland which produces aqueous humour, to coagulate, reducing the secretion long-term. The optic nerve is no longer under pressure, sight is maintained. Image source: BSIP / UIG via Getty Images
Which makes the science even more paradoxical and troubling for patients: CBD is being advertised as the non-psychoactive wunder drug counterpart to THC, which is what makes you high. Those who crave the benefits of marijuana without the fuzzy feeling find relief in CBD oils, tinctures, and creams. These, however, apparently will not help those with glaucoma because its greatest bioavailability comes from smoking.
It should be noted that this study was conducted on 18 mice. Interestingly, female mice were less affected by THC, which also has implications for marijuana's role in treating glaucoma. More research will have to be conducted on humans, but as Straiker concludes, this research offers new avenues of inquiry.
There were studies over 45 years ago that found evidence that THC lowers pressure inside the eye, but no one's ever identified the specific neuroreceptors involved in the process until this study. These results could have important implications for future research on the use of cannabis as a therapy for intraocular pressure.
The rough beauty of the American West seems as far as you can get from the polished corridors of power in Washington DC.
The rough beauty of the American West seems as far as you can get from the polished corridors of power in Washington DC. Until you look at the title to the land. The federal government owns large tracts of the western states: from a low of 29.9% in Montana, already more than the national average, up to a whopping 84.5% in Nevada.
Researchers are using technology to make visual the complex concepts of racism, as well as its political and social consequences.
- Often thought of first as gaming tech, virtual reality has been increasingly used in research as a tool for mimicking real-life scenarios and experiences in a safe and controlled environment.
- Focusing on issues of oppression and the ripple affect it has throughout America's political, educational, and social systems, Dr. Courtney D. Cogburn of Columbia University School of Social Work and her team developed a VR experience that gives users the opportunity to "walk a mile" in the shoes of a black man as he faces racism at three stages in his life: as a child, during adolescence, and as an adult.
- Cogburn says that the goal is to show how these "interwoven oppressions" continue to shape the world beyond our individual experiences. "I think the most important and powerful human superpower is critical consciousness," she says. "And that is the ability to think, be aware and think critically about the world and people around you...it's not so much about the interpersonal 'Do I feel bad, do I like you?'—it's more 'Do I see the world as it is? Am I thinking critically about it and engaging it?'"
President Vladimir Putin announces approval of Russia's coronavirus vaccine but scientists warn it may be unsafe.
A new coronavirus vaccine on display at the Nikolai Gamaleya National Center of Epidemiology and Microbiology in Moscow, Russia.
Credit: Alexander Zemlianichenko Jr/ Russian Direct Investment Fund via AP
Medical workers draw blood from volunteers participating in a trial of a coronavirus vaccine at the Budenko Main Military Hospital outside Moscow, Russia.
Credit: Russian Defense Ministry Press Service via AP
A report from the New York Times raises questions over how the teletherapy startup Talkspace handles user data.