from the world's big
Deer antlers are a 'controlled' form of bone cancer growth
Future cancer research may come from studying antler growth.
- Antlers in ruminants (deer, moose, elk and reindeer) can grow up to half a meter in one month.
- Researchers studying their genomes have found how they do it.
- Genes that both activate and turn off cancer are important to this process.
Antlers are one of the most fascinating adaptations across a wide variation of related species. As striking secondary sexual characteristics, these bony protrusions evolved to help horned animals find a mate. The genes responsible for promoting this rapid growth are even more interesting, as new research suggests.
While sequencing the genomes of some 44 ruminants — among them cows, giraffes, and other mammals that have chambered stomachs for plant digestion — Chinese scientists closely studied those that sprouted antlers, horns, and other bony protrusions. In doing so, they discovered that all the genes that were related to the growth process were oncogenes — genes related to cancer.
These genes were responsible for accelerating cell creation and forming tumors in the bone and skin. What's more, alongside the ability to prolong cancer cell life, the genes also seem to be able to suppress or stop the growth entirely.
Geneticist Qiang Qiu and his team, from the Northwestern Polytechnical University in Xi'an, China started their research by mapping out the genes active in 16 live tissue samples from goats, sheep, and deer. Qiu and the research team found that genes responsible for bone formation and embryonic tissue development in the neural crest likely spearheaded the development of bony headgear for ruminants.
Furthermore they found — the study was published in Science on June 21 — that while the same mutation responsible for bone formation appeared across various types of deer, not all of them displayed them. For instance, in contrast to regular deer, two separate species of musk and Chinese water deer entirely lack antlers. Regular deer, the researchers found, possessed eight active genes that jumpstarted tumor formation and growth.
From these findings, Qui states that antler growth is more akin to bone cancer than regular bones. However, in the case of antler growth contrasted to bone cancer, tumors, in this exceptional case, do not grow unchecked but are part of the animal's highly regulated system of genes, which both suppress and inhibit tumor growth.
Edward D. Davis, an evolutionary paleobiologist at the University of Oregon, states that, "Deer antlers are essentially a controlled form of bone cancer growth." Although he wasn't part of the study, he found the results to be surprising. As tumor-promoting genes are expected in something like antler growth, the involvement of cancer-controlling genes is a surprising find.
But the surprises didn't stop there. Qiu says that the cancer-suppressing genes also protect against the disease in general. Documented cancer rates in deer are five times less than other mammals. Wang Wen, the study's lead author remarked about the amazing ability of deer to regrow antlers.
"Deer can completely regenerate an organ. No other mammal has that ability."
Antlers grow up to one inch per day. Wang's team found nine genes involved with this antler cell growth. There was an additional 19 genes that act as tumor suppressors.
The two different sets of genes work together to build thriving antler cells without developing into cancer on other parts of the body. Implications from this study could be substantial for future cancer research.
Using cancer mechanics for treatment
Professor Yunzhi Peter Yang from Stanford University and Dai Fei Elmer Ker from University of Hong Kong's Institute for Tissue Engineering and Regenerative Medicine, said that the discovery could help scientists regrow damaged or missing organs, as well as develop new drugs to fight cancer.
"Studies of deer antlers offer attractive approaches for tissue engineering and regenerative medicine. For instance, deer antlers have inspired a commercially promising prosthesis for amputees."
This is just the beginning, as the animal's ability to grow "innervated bone with low tumour and infection incidence," could help remedy skeletal defects and affect other bone growth issues.
Andy Samberg and Cristin Milioti get stuck in an infinite wedding time loop.
- Two wedding guests discover they're trapped in an infinite time loop, waking up in Palm Springs over and over and over.
- As the reality of their situation sets in, Nyles and Sarah decide to enjoy the repetitive awakenings.
- The film is perfectly timed for a world sheltering at home during a pandemic.
Richard Feynman once asked a silly question. Two MIT students just answered it.
Here's a fun experiment to try. Go to your pantry and see if you have a box of spaghetti. If you do, take out a noodle. Grab both ends of it and bend it until it breaks in half. How many pieces did it break into? If you got two large pieces and at least one small piece you're not alone.
But science loves a good challenge<p>The mystery remained unsolved until 2005, when French scientists <a href="http://www.lmm.jussieu.fr/~audoly/" target="_blank">Basile Audoly</a> and <a href="http://www.lmm.jussieu.fr/~neukirch/" target="_blank">Sebastien Neukirch </a>won an <a href="https://www.improbable.com/ig/" target="_blank">Ig Nobel Prize</a>, an award given to scientists for real work which is of a less serious nature than the discoveries that win Nobel prizes, for finally determining why this happens. <a href="http://www.lmm.jussieu.fr/spaghetti/audoly_neukirch_fragmentation.pdf" target="_blank">Their paper describing the effect is wonderfully funny to read</a>, as it takes such a banal issue so seriously. </p><p>They demonstrated that when a rod is bent past a certain point, such as when spaghetti is snapped in half by bending it at the ends, a "snapback effect" is created. This causes energy to reverberate from the initial break to other parts of the rod, often leading to a second break elsewhere.</p><p>While this settled the issue of <em>why </em>spaghetti noodles break into three or more pieces, it didn't establish if they always had to break this way. The question of if the snapback could be regulated remained unsettled.</p>
Physicists, being themselves, immediately wanted to try and break pasta into two pieces using this info<p><a href="https://roheiss.wordpress.com/fun/" target="_blank">Ronald Heisser</a> and <a href="https://math.mit.edu/directory/profile.php?pid=1787" target="_blank">Vishal Patil</a>, two graduate students currently at Cornell and MIT respectively, read about Feynman's night of noodle snapping in class and were inspired to try and find what could be done to make sure the pasta always broke in two.</p><p><a href="http://news.mit.edu/2018/mit-mathematicians-solve-age-old-spaghetti-mystery-0813" target="_blank">By placing the noodles in a special machine</a> built for the task and recording the bending with a high-powered camera, the young scientists were able to observe in extreme detail exactly what each change in their snapping method did to the pasta. After breaking more than 500 noodles, they found the solution.</p>
The apparatus the MIT researchers built specifically for the task of snapping hundreds of spaghetti sticks.
(Courtesy of the researchers)
What possible application could this have?<p>The snapback effect is not limited to uncooked pasta noodles and can be applied to rods of all sorts. The discovery of how to cleanly break them in two could be applied to future engineering projects.</p><p>Likewise, knowing how things fragment and fail is always handy to know when you're trying to build things. Carbon Nanotubes, <a href="https://bigthink.com/ideafeed/carbon-nanotube-space-elevator" target="_self">super strong cylinders often hailed as the building material of the future</a>, are also rods which can be better understood thanks to this odd experiment.</p><p>Sometimes big discoveries can be inspired by silly questions. If it hadn't been for Richard Feynman bending noodles seventy years ago, we wouldn't know what we know now about how energy is dispersed through rods and how to control their fracturing. While not all silly questions will lead to such a significant discovery, they can all help us learn.</p>
Finding a balance between job satisfaction, money, and lifestyle is not easy.
- When most of your life is spent doing one thing, it matters if that thing is unfulfilling or if it makes you unhappy. According to research, most people are not thrilled with their jobs. However, there are ways to find purpose in your work and to reduce the negative impact that the daily grind has on your mental health.
- "The evidence is that about 70 percent of people are not engaged in what they do all day long, and about 18 percent of people are repulsed," London Business School professor Dan Cable says, calling the current state of work unhappiness an epidemic. In this video, he and other big thinkers consider what it means to find meaning in your work, discuss the parts of the brain that fuel creativity, and share strategies for reassessing your relationship to your job.
- Author James Citrin offers a career triangle model that sees work as a balance of three forces: job satisfaction, money, and lifestyle. While it is possible to have all three, Citrin says that they are not always possible at the same time, especially not early on in your career.
The planet is making a lot less noise during lockdown.
- A team of researchers found that Earth's vibrations were down 50 percent between March and May.
- This is the quietest period of human-generated seismic noise in recorded history.
- The researchers believe this helps distinguish between natural vibrations and human-created vibrations.
Earth is quieter as coronavirus lockdowns reduce seismic vibration<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="cc871d5d88a79ecc6605ce488c26a7c1"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/_yFF2MziwPA?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p>The team investigated seismic data from a global network of 268 stations spread out across 117 countries. As lockdown measures in different regions began, they tracked the drop in vibrations. Singapore and New York City recorded some of the biggest drops, though even Germany's Black Forest—famous for its association with the Brothers Grimm fairy tales—went quieter than usual.</p><p>The researchers also relied on citizen-owned seismometers in Cornwall and Boston, which recorded a 20 percent reduction from relatively quiet stretches in these college towns, such as during school holidays. </p><p>The environmental impact of lockdown has been dramatic. Indian skylines are notoriously grey. This <a href="https://www.axios.com/coronavirus-lockdown-pollution-drops-india-156b4f1d-160b-44d9-885a-148960b9e469.html" target="_blank">collection of photos</a> shows how quickly nature recovers when humans limit travel and industry. Such photographs also make you wonder why we cannot control emissions to begin with, now that we know the stakes. </p><p>Lead author, Dr Thomas Lecocq, says their research could help seismologists suss out the difference between human-created vibrations and natural vibrations, potentially resulting in longer lead times when natural disasters are set to strike. </p><p style="margin-left: 20px;">"With increasing urbanisation and growing global populations, more people will be living in geologically hazardous areas. It will therefore become more important than ever to differentiate between natural and human-caused noise so that we can 'listen in' and better monitor the ground movements beneath our feet. This study could help to kick-start this new field of study."</p>
Stray puppies play in an abandoned, partially-completed cooling tower inside the exclusion zone at the Chernobyl nuclear power plant on August 18, 2017 near Chornobyl, Ukraine.
Photo by Sean Gallup/Getty Images<p>The Earth is much stronger than us; humans are its products. In his 2007 book, "The World Without Us," Alan Weisman details just how quickly nature recovers from our insults. Chernobyl offers a <a href="http://www.bbc.com/earth/story/20160421-the-chernobyl-exclusion-zone-is-arguably-a-nature-reserve" target="_blank">real-world example</a>, while <a href="https://www.scientificamerican.com/article/even-if-injection-of-fracking-wastewater-stops-quakes-wont/" target="_blank">earthquakes caused by fracking-related wastewater injection</a> in Oklahoma are evidence of how much damage human "vibrations" cause.</p><p>Weisman's poetic homage imagines a symbiotic relationship with nature. This relationship depends on our cooperation, however. Weisman knows we aren't long for this world, nor is this world long for this universe: in just five billion years, give or take, Earth will implode. We all live on borrowed time. How we live during that time defines our character. </p><p>While he strikes a hopeful tone, Weisman knows nature will eventually have her way with us.</p><p style="margin-left: 20px;">"After we're gone, nature's revenge for our smug, mechanized superiority arrives waterborne. It starts with wood-frame construction, the most widely used residential building technique in the developed world. It begins on the roof, probably asphalt, or slate shingle, warranted to last two or three decades—but that warranty doesn't count around the chimney, where the first leak occurs." </p><p>The play-by-play of our demise continues, though Weisman offers plenty of proactive advice. The question is, will we be able to live up to it? Sadly, nothing in modern society hints at the possibility. </p><p>The only way we seem willing to pause our relentless pursuit of "progress" is when we're forced to do so, as in the current pandemic. The results, as the team in Belgium shows, are measurable. Whether or not we heed the call to slow our impact remains to be seen. Given precedent, it's unlikely, though as Weisman concludes, one can always dream. </p><p>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a>, <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank">Facebook</a> and <a href="https://derekberes.substack.com/" target="_blank">Substack</a>. His next book is</em> "<em>Hero's Dose: The Case For Psychedelics in Ritual and Therapy."</em></p>