Supercentenarian DNA May Hold the Ultimate Secret to Longevity

Find the right genes and we’ll have a way to prolong life and good health, perhaps indefinitely.

A senior being kissed by another old woman.
Credit: Getty Images.

Better food, healthcare, working conditions, and safety protocols have allowed humans to live longer and healthier than ever before. In most developed countries today, the average lifespan is 80 years, while in 1906, a little more than 100 years ago, it was 48. Projections moving forward look so good that there’s a debate in the medical community on whether or not we can increase human longevity indefinitely.


There are far more centenarians than ever, or those who’ve lived to 100, and more supercentenarians or those 110 or above. A study published last year in the journal Nature proposes that 122 may be the human lifespan's ceiling. Most of those in the upper reaches of our lifespan assign their longevity to lifestyle choices or healthy habits, which of course play an enormous role. But many scientists believe important secrets to longevity lie within our genes as well.

Moreover, quite a number of studies suggest a strong genetic link. For instance, a 1996 study published in the journal Human Genetics, looked at thousands of Danish twins. It concluded that 20-26% of longevity is up to one’s genetic code. Meanwhile, a Boston University study found that a centenarians’ siblings have about a 3½ times higher chance of reaching 100, over non-centenarians’ siblings.

What’s more, supercentenarians don’t often experience any of the serious diseases people succumb to in old age, such as heart disease or cancer. Turns out, the longest living among us carry fewer of the genetic variations involved with such diseases.


While lifestyle plays an enormous role, certain genes or gene combinations add significantly to longevity and good health later in life. Credit: Getty Images.

To find out what all those who’ve reached 110 have in common, a nonprofit known as Betterhumans is studying the DNA of those who have shown impressive longevity. It bills itself as “the world's most comprehensive genomic study of supercentenarians and their families.” DNA samples collected will not only be sequenced, the data produced will be made available to the public. In fact, a series of genomes are to be released this week.

The idea is to find out what genes gives people an exceptional lifespan, synthesize those genes, and from there develop a way to prolong life and health in others. So far, the project has collected over 30 samples from people in North America, Europe, and the Caribbean. Those who qualify can donate their saliva, a blood sample, or if their long-lived relative is deceased, a tissue sample, to the project. Then the samples are analyzed by Betterhumans and their research partners.


It may be more than being devoid of disease causing mutations that keep those over 110 in good health. Credit: Getty Images.

Supercentenarians live more healthy, disease-free lives in their autumn years than even centenarians. Their genomes are not just devoid of disease causing mutations, they must also contain actively protective genes. Previous work has been stunted however by a lack of supercentenarian DNA to work with. Betterhumans is hoping to overcome this problem.

The nonprofit says it uses a specific identification system, assigning a proprietary number to each sample, so that the subject can remain anonymous. Once a large number of samples have been processed, they’re sent to a lab for sequencing. Both proprietary and public-domain software is used. Besides sequencing, Betterhumans is comparing and contrasting supercentenarian DNA with non-supercentenarian DNA. It takes three months total from the time they take the sample to the time it’s turned into data.

2,500 differences in supercentenarian DNA have been tagged thus far, but it’s hard to discern which are significant. Extremely rare mutations might be difficult to detect using standard methods. Scanning procedures are set to look at places that are already known to harbor mutations.


A significant number of variants for supercentenarians have been found so far. Deciphering them is another matter. Credit: Getty Images.

So will we all be living to 110 in a decade or two? There’s still a contentious debate on whether or not there's a limit to the human lifespan or if science can eventually make it limitless. But let’s say for the sake of argument that we can, should we?

The project has natural limitations. To understand all the phenotypes or combination of genes involved, tens of thousands of genomes would need to be sequenced. Yet, there are only about 150 supercentenarians worldwide. Just one in five million Americans is one. Also, some of them are hard to find. They may be living in rural areas in developing countries and did not receive a birth certificate when they were born.

Those who have a supercentenarian in their life or are one and want to contribute, contact Betterhumans and donate a sample. Contact them by phone at: (509) 987-5282, email: supercentenarian@betterhumans.org, or by filling out an enrollment form here.

To learn about another significant breakthrough in the quest for longevity, click here:

Live on Monday: Does the US need one billion people?

What would happen if you tripled the US population? Join Matthew Yglesias and Charles Duhigg at 1pm ET on Monday, September 28.

‘Time is elastic’: Why time passes faster atop a mountain than at sea level

The idea of 'absolute time' is an illusion. Physics and subjective experience reveal why.

ESA
Surprising Science
  • Since Einstein posited his theory of general relativity, we've understood that gravity has the power to warp space and time.
  • This "time dilation" effect occurs even at small levels.
  • Outside of physics, we experience distortions in how we perceive time — sometimes to a startling extent.
Keep reading Show less

Learn innovation with 3-star Michelin chef Dominique Crenn

Dominique Crenn, the only female chef in America with three Michelin stars, joins Big Think Live.

Big Think LIVE

Having been exposed to mavericks in the French culinary world at a young age, three-star Michelin chef Dominique Crenn made it her mission to cook in a way that is not only delicious and elegant, but also expressive, memorable, and true to her experience.

Keep reading Show less

Universe works like a cosmological neural network, argues new paper

Controversial physics theory says reality around us behaves like a computer neural network.

Synapses in space.

Credit: sakkmesterke
Surprising Science
  • Physicist proposes that the universe behaves like an artificial neural network.
  • The scientist's new paper seeks to reconcile classical physics and quantum mechanics.
  • The theory claims that natural selection produces both atoms and "observers".
Keep reading Show less

We studied what happens when guys add their cats to their dating app profiles

43% of people think they can get a sense of someone's personality by their picture.

Photo by Luigi Pozzoli on Unsplash
Sex & Relationships

If you've used a dating app, you'll know the importance of choosing good profile pics.

Keep reading Show less
Coronavirus

Quarantine rule breakers in 17th-century Italy partied all night – and some clergy condemned the feasting

17th-century outbreaks of plague in Italy reveal both tensions between religious and public health authorities.

Scroll down to load more…
Quantcast