New Drug First Major Breakthrough for Alzheimer’s in the Past Decade
This drug combined with antibody therapies could prevent or even cure the neurodegenerative disorder.
Amyloid beta plaques are gooey globs that clump together, stick to neurons inside the brain and kill them off, outright. The slow but steady accumulation of these plaques leads to Alzheimer’s disease. Tau protein tangles aid them by cutting off the brain’s supply lines, as the plaques march across white and gray matter, taking out the memory and cognitive ability, and wreaking havoc on the patient and their family. No treatment can halt this invasion once it occurs. But now, a small trial for an experimental drug is lending patients and loved ones hope.
This drug inhibits the production of these plaques, according to a small study. Scientists at Merck Research Laboratories have announced the drug Verubecestat. In a small, phase I trial it “switched off” the production of the amyloid proteins that form these plaques. This in turn slowed the progression of the disease.
University College London neuroscientist John Hardy, who played a role in amyloid plaque’s implication in Alzheimer’s, warned in an interview with The Guardian, that it is too soon to start breaking out the champagne. The results are from this phase I clinical trial including a mere 32 participants.
Even so, team leader for the Merck project, Matthew Kennedy, told Scientific American that this was the first effective BACE1 inhibitor that also maintained a good safety profile. Two follow-up trials, currently ongoing, including together 3,500 participants, should give us more insight into its efficacy and safety profile, long-term. Each will last 18 months or longer. One includes 1,500 prodromal patients, where the disease is in its seminal stages, and the other with 2,000 patients who each have mild-to-moderate disease. The first trial ends in 2019, while the second will show results next year.
Enzyme snipping amyloid precursor proteins.
If effective, Verubecestat will be the first breakthrough treatment for Alzheimer’s in a decade. For the phase I trial, each participant took the medication in pill form, once a day for a week. A control group who did not have Alzheimer’s, took the drug daily for two weeks. No side effects were reported.
Enzymes in the body produce proteins. This drug is designed to inhibit the enzyme BACE1. By doing so, the production of amyloid proteins is halted. BACE1 is thought to slice amyloid precursor proteins (APP) to bits, which go on and form globules that gunk up the gray and white matter. These two trials should also help solve a longstanding debate among the Alzheimer’s research community. There is a split over whether amyloid beta protein or tau tangles are the primary driver of the disease. Most believe amyloid protein is.
These findings arrived at an auspicious time. President Barack Obama recently dubbed November national Alzheimer’s awareness month. The administration has set the lofty goal of preventing or curing Alzheimer’s by 2025. Several treatments in the works may reap results. This BACE1 inhibitor is among the most promising.
On another front, in a study published in the journal Nature, antibody therapies were shown to break up existing amyloid plaque buildup. In that study, the drug Aducanumab was used. Researchers speculate that this could be combined with a BACE1 inhibitor like Verubecestat in order to recoup areas of the brain already affected, while at the same time, blocking the production of amyloid protein. Though dead neurons cannot be revived, living ones can be salvaged.
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Antimicrobial resistance is growing worldwide, rendering many "work horse" medicines ineffective. Without intervention, drug-resistant pathogens could lead to millions of deaths by 2050. Thankfully, companies like Pfizer are taking action.
- Antimicrobial-resistant pathogens are one of the largest threats to global health today.
- As we get older, our immune systems age, increasing our risk of life threatening infections. Without reliable antibiotics, life expectancy could decline for the first time in modern history.
- If antibiotics become ineffective, common infections could result in hospitalization or even death. Life-saving interventions like cancer treatments and organ transplantation would become more difficult, more often resulting in death. Routine procedures would become hard to perform.
- Without intervention, resistant pathogens could result in 10 million annual deaths by 2050.
- By taking a multi-faceted approach—inclusive of adherence to good stewardship, surveillance and responsible manufacturing practices, as well as an emphasis on prevention and treatment—companies like Pfizer are fighting to help curb the spread.
Entrepreneur and author Andrew Horn shares his rules for becoming an assured conversationalist.
- To avoid basing action on external validation, you need to find your "authentic voice" and use it.
- Finding your voice requires asking the right questions of yourself.
- There are 3-5 questions that you would generally want to ask people you are talking to.
Sarco assisted suicide pods come in three different styles, and allow you to die quickly and painlessly. They're even quite beautiful to look at.
Death: it happens to everyone (except, apparently, Keanu Reeves). But while the impoverished and lower-class people of the world die in the same ol' ways—cancer, heart disease, and so forth—the upper classes can choose hip and cool new ways to die. Now, there's an assisted-suicide pod so chic and so stylin' that peeps (young people still say peeps, right?) are calling it the "Tesla" of death... it's called... the Sarco!
Swiss researchers identify new dangers of modern cocaine.
- Cocaine cut with anti-worming adulterant levamisole may cause brain damage.
- Levamisole can thin out the prefrontal cortex and affect cognitive skills.
- Government health programs should encourage testing of cocaine for purity.
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