Heavy drinking increases the risk of Alzheimer’s, and now we know why

Drinking heavily over a long period of time has been known to cause early onset Alzheimer’s. But the forces behind this phenomenon have been a mystery, until now.

Man passed out on the ground. (Credit: Getty Images)
Man passed out on the ground. (Credit: Getty Images)

One in 14 people ages 65 and older develop Alzheimer’s. Experts say we are all at risk, although some of us are far more likely to develop it than others. Its origin is complex. The neurodegenerative disorder is thought to have both genetic and environmental components. New research shows that alcohol consumption is more weighty a cause than first thought, particularly heavy drinking on a consistent basis.


In a recent French study, containing 57,000 early onset dementia patients, 57% showed significant, alcohol-related brain damage. According to the CDC, booze remains the most abused intoxicant in America today. Alcohol use disorder is responsible for 88,000 deaths per year, whether it be alcoholism-related, from binge drinking, or some other form. Long-term, heavy drinking has been known to significantly increase the risk of early onset dementia.

Amyloid beta plaque buildup in the brain causes Alzheimer’s. These sticky globules of protein attach to neurons and choke them out. We’ve known that certain genes speed this process, and that alcohol somehow effects them. Now, a study by researchers at the University of Illinois at Chicago shows exactly what occurs and how heavy drinking affects this common form of dementia. The results of the study were published in the Journal of Neuroinflammation


Alcoholism leads to a significant number of deaths per year. It can also cause early-onset Alzheimer’s. (Credit: Getty Images.)

While there’s some evidence that light, occasional drinking may help prevent Alzheimer’s, heavy drinking has been shown to slow special immune cells, called microglial cells, whose job it is to clear amyloid plaque from the brain. Microglial cells are found in the brain and spine. They’re responsible for protecting neurons from damage. These cells do so by surrounding an amyloid beta plaque globule and absorbing it, a process called phagocytosis, which roughly means "the action of cells eating."

Consistent exposure to high levels of alcohol has been known to excite microglial cells and cause inflammation within them. But exactly why or how has not been known. To better understand the connection, lead author Dr. Douglas Feinstein and fellow researchers took rat microglial cells and exposed them to either alcohol, cytokines—which cause inflammation, or alcohol and cytokines. Each exposure lasted 24 hours, after which the scientists examined the cells’ genes. Had their expression changed? Could these cells still take out amyloid beta plaque?


Could alcohol intake recommendations based on risk help prevent Alzheimer’s later in life? (Credit: Getty Images)

Dr. Feinstein and colleagues showed that phagocytosis was inhibited by 15% an hour after exposure to high levels of alcohol. Such exposure changed the expression of 312 genes. 3,082 genes were expressed differently when exposed to cytokines alone. Both alcohol and cytokines together altered the expression of 3,552 genes. This is the first time alcohol exposure has been proven to inhibit phagocytosis. What’s more, the study shows exactly how heavy drinking and the inflammation it causes inhibits microglial cells from clearing amyloid plaque from the brain.

Dr. Feinstein told Newsweek, "There is a large literature supporting the idea that low amounts of alcohol can be beneficial, not only peripherally but in the brain. However, it might be prudent that if someone is at risk to develop AD, they should consider to reduce their alcohol intake and certainly avoid binge or heavy drinking."

While no one should take part in such drinking more research might fine-tune exactly how much is safe to consume at a sitting and over time, for those with a high risk of Alzheimer’s. These results, though insightful, are preliminary. Much more research will be needed to gain a greater understanding of all the complexities involved.

To learn more about heavy drinking and its impact on the brain, click here:

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7 most notorious and excessive Roman Emperors

These Roman Emperors were infamous for their debauchery and cruelty.

Nero's Torches. A group of early Christian martyrs about to be burned alive during the reign of emperor Nero in 64 AD.

1876. Painted by Henryk Siemiradzki.
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  • Roman Emperors were known for their excesses and violent behavior.
  • From Caligula to Elagabalus, the emperors exercised total power in the service of their often-strange desires.
  • Most of these emperors met violent ends themselves.

We rightfully complain about many of our politicians and leaders today, but historically speaking, humanity has seen much worse. Arguably no set of rulers has been as debauched, ingenious in their cruelty, and prone to excess as the Roman Emperors.

While this list is certainly not exhaustive, here are seven Roman rulers who were perhaps the worst of the worst in what was one of the largest empires that ever existed, lasting for over a thousand years.

1. Caligula

Officially known as Gaius (Gaius Caesar Augustus Germanicus), Caligula was the third Roman Emperor, ruling from 37 to 41 AD. He acquired the nickname "Caligula" (meaning "little [soldier's] boot") from his father's soldiers during a campaign.

While recognized for some positive measures in the early days of his rule, he became famous throughout the ages as an absolutely insane emperor, who killed anyone when it pleased him, spent exorbitantly, was obsessed with perverse sex, and proclaimed himself to be a living god.

Caligula gives his horse Incitatus a drink during a banquet. Credit: An engraving by Persichini from a drawing by Pinelli, from "The History of the Roman Emperors" from Augustus to Constantine, by Jean Baptiste Louis Crevier. 1836.

Among his litany of misdeeds, according to the accounts of Caligula's contemporaries Philo of Alexandria and Seneca the Younger, he was accused of sleeping with other men's wives and publicly talking about it, as well as killing for mere amusement. Supposedly, during one competition he was presiding over, he got so bored that he had his guards throw a whole section of the audience into the arena during the intermission so they would be eaten by wild beasts as no prisoners were available. He also allegedly executed two consuls who forgot his birthday.

Further atrocities of his character were relayed by the historian Suetonius, who wrote that Caligula "frequently had trials by torture held in his presence while he was eating or otherwise enjoying himself; and kept an expert headsman in readiness to decapitate the prisoners brought in from gaol." One particular form of torture associated with Caligula involved having people sawed in half.

He caused mass starvation and purposefully wasted money and resources, like making his troops stage fake battles just for theater. If that wasn't enough, he turned his palace into a brothel and was accused of incest with his sisters, Agrippina the Younger, Drusilla, and Livilla, whom he also prostituted to other men. Perhaps most famously, he was planning to appoint his favorite horse Incitatus a consul and went as far as making the horse into a priest.

In early 41 AD, Caligula was assassinated by a conspiracy of Praetorian Guard officers, senators, and other members of the court.

2. Nero

Fully named Nero Claudius Caesar, Nero ruled from 54 to 68 AD and was arguably an even worse madman than his uncle Caligula. He had his step-brother Britannicus killed, his wife Octavia executed, and his mother Agrippina stabbed and murdered. He personally kicked to death his lover Poppeaea while she was pregnant with his child — a horrific action the Roman historian Tacitus depicted as "a casual outburst of rage."

He spent exorbitantly and built a 100-foot-tall bronze statue of himself called the Colossus Neronis.

He is also remembered for being strangely obsessed with music. He sang and played the lyre, although it's not likely he really fiddled as Rome burned in what is a popular myth about this crazed tyrant. As misplaced retribution for the fire which burned down a sizable portion of Rome in the year 64, he executed scores of early Christians, some of them outfitted in animal skins and brutalized by dogs, with others burned at the stake.

He died by suicide.

Roman Emperor Nero in the burning ruins of Rome. July 64 AD.Credit: From an original painting by S.J. Ferris. (Photo by Kean Collection / Getty Images)

3. Commodus

Like some of his counterparts, Commodus (a.k.a. Lucius Aelius Aurelius Commodus) thought he was a god — in his case, a reincarnation of the Greek demigod Hercules. Ruling from 176 to 192 AD, he was also known for his debauched ways and strange stunts that seemed designed to affirm his divine status. Numerous statues around the empire showed him as Hercules, a warrior who fought both men and beasts. He fought hundreds of exotic animals in an arena like a gladiator, confusing and terrifying his subjects. Once, he killed 100 lions in a single day.

Emperor Commodus (Joaquin Phoenix) questions the loyalty of his sister Lucilla (Connie Nielsen) In Dreamworks Pictures' and Universal Pictures' Oscar-winning drama "Gladiator," directed by Ridley Scott.Credit: Photo By Getty Images

The burning desire to kill living creatures as a gladiator for the New Year's Day celebrations in 193 AD brought about his demise. After Commodus shot hundreds of animals with arrows and javelins every morning as part of the Plebeian Games leading up to New Year's, his fitness coach (aptly named Narcissus), choked the emperor to death in his bath.

4. Elagabalus

Officially named Marcus Aurelius Antoninus II, Elagabalus's nickname comes from his priesthood in the cult of the Syrian god Elagabal. Ruling as emperor from 218 to 222 AD, he was so devoted to the cult, which he tried to spread in Rome, that he had himself circumcised to prove his dedication. He further offended the religious sensitivities of his compatriots by essentially replacing the main Roman god Jupiter with Elagabal as the chief deity. In another nod to his convictions, he installed on Palatine Hill a conical fetish made of black stone as a symbol of the Syrian sun god Sol Invictus Elagabalus.

His sexual proclivities were also not well received at the time. He was likely transgender (wearing makeup and wigs), had five marriages, and was quite open about his male lovers. According to the Roman historian (and the emperor's contemporary) Cassius Dio, Elagabalus prostituted himself in brothels and taverns and was one of the first historical figures on record to be looking for sex reassignment surgery.

He was eventually murdered in 222 in an assassination plot engineered by his own grandmother Julia Maesa.

5. Vitellius

Emperor for just eight months, from April 19th to December 20th of the year 69 AD, Vitellius made some key administrative contributions to the empire but is ultimately remembered as a cruel glutton. He was described by the Roman historian Suetonius as overly fond of eating and drinking, to the point where he would eat at banquets four times a day while sending out the Roman navy to get him rare foods. He also had little social grace, inviting himself over to the houses of different noblemen to eat at their banquets, too.

Vitellius dragged through the streets of Rome.Credit: Georges Rochegrosse. 1883.

He was also quite vicious and reportedly either had his own mother starved to death or approved a poison with which she committed suicide.

Vitellius was ultimately murdered in brutal fashion by supporters of the rival emperor Vespasian, who dragged him through Rome's streets, then likely beheaded him and threw his body into the Tiber river. "Yet I was once your emperor," were supposedly his last words, wrote historian Cassius Dio.

6. Caracalla

Marcus Aurelius Antoninus I ruled Rome from 211 to 217 AD on his own (while previously co-ruling with his father Septimius Severus from 198). "Caracalla"' was his nickname, referencing a hooded coat from Gaul that he brought into Roman fashion.

He started off his rise to individual power by murdering his younger brother Geta, who was named co-heir by their father. Caracalla's bloodthirsty tyranny didn't stop there. He wiped out Geta's supporters and was known to execute any opponents to his or Roman rule. For instance, he slaughtered up to 20,000 citizens of Alexandria after a local theatrical satire dared to mock him.

Geta Dying in His Mother's Arms.Credit: Jacques Pajou (1766-1828)

One of the positive outcomes of his rule was the Edict of Caracalla, which gave Roman citizenship to all free men in the empire. He was also known for building gigantic baths.

Like others on this list, Caracalla met a brutal end, being assassinated by army officers, including the Praetorian prefect Opellius Macrinus, who installed himself as the next emperor.

7. Tiberius

As the second emperor, Tiberius (ruling from 42 BC to 16 AD) is known for a number of accomplishments, especially his military exploits. He was one of the Roman Empire's most successful generals, conquering Pannonia, Dalmatia, Raetia, and parts of Germania.

He was also remembered by his contemporaries as a rather sullen, perverse, and angry man. In the chapter on his life from The Lives of the Twelve Caesars by the historian Suetonius, Tiberius is said to have been disliked from an early age for his personality by even his family. Suetonius wrote that his mother Antonia often called him "an abortion of a man, that had been only begun, but never finished, by nature."

"Orgy of the Times of Tiberius on Capri".Painting by Henryk Siemiradzki. 1881.

Suetonius also paints a damning picture of Tiberius after he retreated from public life to the island of Capri. His years on the island would put Jeffrey Epstein to shame. A horrendous pedophile, Tiberius had a reputation for "depravities that one can hardly bear to tell or be told, let alone believe," Suetonius wrote, describing how "in Capri's woods and groves he arranged a number of nooks of venery where boys and girls got up as Pans and nymphs solicited outside bowers and grottoes: people openly called this 'the old goat's garden,' punning on the island's name."

There's much, much more — far too salacious and, frankly, disgusting to repeat here. For the intrepid or morbidly curious reader, here's a link for more information.

After he died, Tiberius was succeeded in emperorship by his grandnephew and adopted grandson Caligula. How fitting.

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