from the world's big
Flu season is here. Researchers may have discovered a cure.
Ferrets are not humans, but this new drug is showing promise.
- Researchers at Georgia State University and Emory University tweaked an old drug and found great results.
- None of the ferrets given EIDD-2801 twelve hours after infection developed the flu.
- Those given the drug a day later developed less severe symptoms than the control group or those receiving Tamiflu.
Disease is part of the price we pay as biological organisms. Contemplating how many diseases we have not eradicated can be daunting, though in reality, since the discovery of vaccination in the late eighteenth century and widespread acceptance of germ theory in the nineteenth, researchers have made great strides in medicine. Formerly deadly diseases are now behind us.
Not every illness is easy to overcome, however. Cancer, as Siddhartha Mukherjee writes in his opus on the topic, is an inherent part of our biology; whether or not those cells get turned on is the grim game of change every one of us faces. Optimize all we like, the possibility is always lurking.
A disease we often overlook in this conversation due to its ubiquity is one most everyone has fallen victim to once (or many times) in their lives: influenza. The flu killed a record number of Americans in 2017-18: 80,000 citizens died that year, according to the CDC.
Even in an average year, the agency states that between 12,000 and 79,000 people die. Yet many more are struck ill—somewhere around nine million up to 50 million. That's nearly one-sixth of the population during especially bad seasons. Globally, over 600,000 people die every single year.
The flu isn't one disease, but a family of viruses. Knowing which will strike in any given year requires educated guessing. (Since Australia experiences its season earlier than America, our flu shots are based on what happens across the planet.) Three of the four influenza viruses affect humans, though there is speculation that the fourth might also make us sick.
It doesn't really matter which virus gets into your system. They're all terrible, and, for the youngest and oldest among us, potentially deadly. Sadly, as with antibiotics, flu drugs are showing less efficacy, as the virus has developed resistance to a popular remedy, oseltamivir (commonly known as Tamiflu).
Hope springs eternal, however. A new study, published in the journal, Science Translational Medicine, is showing promise—in ferrets. Researchers at Georgia State University and Emory University teamed up to test N-hydroxycytidine (NHC) on those polecats; previous research on macaques didn't go well: the medicine wasn't effective in preventing or treating flu symptoms because their bodies couldn't convert the drug.
This time, the researchers created a new compound, EIDD-2801, a minor tweaking of NHC. When the ferrets were infected with the flu and given a round of this new compound twelve hours later, not one of them got sick. Those given the drug a day after infection exhibited fewer symptoms than the control group or the group given Tamiflu.
Influenza - causes, symptoms, diagnosis, treatment, pathology
Andrew Pavia, an infectious disease expert at the University of Utah, breaks it down:
"It's important that they showed a reduction in symptoms in ferrets, because it gets much closer to predicting what happens in people. It's a major step towards developing a drug for humans."
Ferrets are not people, of course, so efficacy and dosage are up for debate. But it's an important potential breakthrough. The team writes,
"In conclusion, our data identify EIDD-2801 as a promising clinical candidate for monotherapy of seasonal and pandemic influenza. Although SI values defined by the human airway epithelia model are encouraging and no gross signs of toxicity were observed in the corresponding ferret efficacy studies, formal two-species multiday toxicity and adverse event testing will determine first-in-human dose concentrations."
Trials on humans are likely to begin next spring, so we'll have to make due with Tamiflu and that old cure-all, sleep and hydration, for a bit longer. Of course, getting your flu shot as soon as possible is also a good idea. Regardless of this season, this new research is an advancement in treating one of the world's most common diseases. Over a half-million lives every year depend on such a development.
Educators and administrators must build new supports for faculty and student success in a world where the classroom might become virtual in the blink of an eye.
- If you or someone you know is attending school remotely, you are more than likely learning through emergency remote instruction, which is not the same as online learning, write Rich DeMillo and Steve Harmon.
- Education institutions must properly define and understand the difference between a course that is designed from inception to be taught in an online format and a course that has been rapidly converted to be offered to remote students.
- In a future involving more online instruction than any of us ever imagined, it will be crucial to meticulously design factors like learner navigation, interactive recordings, feedback loops, exams and office hours in order to maximize learning potential within the virtual environment.
A leading British space scientist thinks there is life under the ice sheets of Europa.
- A British scientist named Professor Monica Grady recently came out in support of extraterrestrial life on Europa.
- Europa, the sixth largest moon in the solar system, may have favorable conditions for life under its miles of ice.
- The moon is one of Jupiter's 79.
Neil deGrasse Tyson wants to go ice fishing on Europa<div class="rm-shortcode" data-media_id="GLGsRX7e" data-player_id="FvQKszTI" data-rm-shortcode-id="f4790eb8f0515e036b24c4195299df28"> <div id="botr_GLGsRX7e_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/GLGsRX7e-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/GLGsRX7e-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/GLGsRX7e-FvQKszTI.js"></script> </div>
Water Vapor Above Europa’s Surface Deteced for First Time<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="9c4abc8473e1b89170cc8941beeb1f2d"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/WQ-E1lnSOzc?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span>
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Can thinking about the past really help us create a better present and future?
- There are two types of counterfactual thinking: upward and downward.
- Both upward and downward counterfactual thinking can be positive impacts on your current outlook - however, upward counterfactual thinking has been linked with depression.
- While counterfactual thinking is a very normal and natural process, experts suggest the best course is to focus on the present and future and allow counterfactual thinking to act as a motivator when possible.
“Upward” versus “downward” counterfactual thinking<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMzQ1NDYxOS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0NDM2MDY2OX0.njWs1qrV1vDBxU1V75tUduUW4TjJvEHglDWsK8ZF2l4/img.jpg?width=1245&coordinates=0%2C556%2C0%2C209&height=700" id="a15fa" class="rm-shortcode" data-rm-shortcode-id="98314d4d2b256ed08f42d369fe4ae080" data-rm-shortcode-name="rebelmouse-image" alt="concept of man thinking about the past one line drawing counterfactual thinking" />
What are upward and downward counterfactual thinking?
Image by one line man on Shutterstock<p><strong>What is upward counterfactual thinking?</strong></p><p>Upward counterfactual thinking happens when we look at a scenario and ask ourselves "what if" in terms of how our life could have turned out better. </p><p>Examples of upward counterfactual thinking are: </p><ul><li><em>"I wish I had taken that other job instead of this one 10 years ago - my life would be so much better if I had." </em></li><li><em>"I wish I would have gotten the part in that high school play, maybe I could have gotten into a theatre school and became an actor…"</em> </li></ul><p>Both of these examples have the ideology that if you had made different choices, your life right now would be improved. </p><p><strong>What is downward counterfactual thinking?</strong></p><p>Downward counterfactual thinking is, naturally, the opposite of upward counterfactual thinking in that we think about how things could have been worse if other decisions had been made. </p><p>Examples of downward counterfactual thinking are: </p><ul><li><em>"I'm so thankful I studied secondary education in university instead of psychology like I had originally planned - I love teaching high school kids and I never would have gotten to do that…" </em></li><li><em>"I'm so happy I left David when I got the chance, I can't imagine still being in an unhappy marriage with someone who doesn't support me…"</em> </li></ul><p>In these examples, we see the idea that if you had made different choices your life would not be as good as it is right now. </p>
How counterfactual thinking can impact your life<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMzQ1NDYxNy9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYyNjI2MDQxOX0.DIVQ-Yk0d6yE3tc743MH1Fz2pOg1TGHLmhp8dPp9UdY/img.jpg?width=1245&coordinates=0%2C0%2C0%2C0&height=700" id="522d7" class="rm-shortcode" data-rm-shortcode-id="da7df6ad916b043e3610223900d0f8df" data-rm-shortcode-name="rebelmouse-image" alt="man thinking what if written on chalkboard" />
How do upward and downward counterfactual thinking impact your life?
Photo by Brasil Creativo on Shutterstock<p>While many people don't see the point in "what if" scenarios, various studies have found that downward counterfactual thinking can be more associated with psychological health compared with upward counterfactual thinking. Not only that, but research has also shown upward counterfactual thinking can be linked with current and future depression.</p> <p><strong>Downward counterfactual thinking tends to be more associated with psychological health </strong></p><p>According to a <a href="http://journal.sjdm.org/jdm06136.pdf" target="_blank">2000 study</a>, downward counterfactual thinking can be linked with better psychological health compared to upward counterfactual thinking. More importantly, in cases where downward counterfactual thinking did lead to negative feelings, those feelings acted as something of a motivator for people to take productive actions to better their current situation. </p> <p><strong>Upward counterfactual thinking tends to be more associated with depression </strong></p><p><a href="https://www.sciencedirect.com/science/article/abs/pii/S0272735816301714#:~:text=An%20upward%20counterfactual%20(as%20opposed,Markman%20and%20McMullen%2C%202003)." target="_blank">According to a 2017 study</a> that pooled a sample of over 13,000 respondents, thoughts about "better outcomes" and regret (upward counterfactual thinking) were associated with current and future depression. </p> <p><strong>Downward counterfactual thinking can actually improve your relationships and is more often engaged in by women than men.</strong></p><p>In a <a href="https://dspace.sunyconnect.suny.edu/bitstream/handle/1951/67589/Studer_Thesis.pdf?sequence=1&isAllowed=y" target="_blank">2016 research paper submitted</a> to the Department of Psychology at the State University of New York at New Paltz, downward counterfactual thinking in regards to romantic relationships was associated with relatively positive relationship outcomes. Interestingly, women were more likely than men to engage in downward counterfactual thinking about their romantic life. </p> <p><strong>Upward counterfactual thinking can have some benefits in certain scenarios. </strong></p><p>When we look back after a failed test and think "I wish I would have studied more" - this motivates us to study harder the next time a test comes up. In this way, upward counterfactual thinking (or the negative version of "what if") can actually benefit us. </p> <p><strong>This can be difficult, though, because much of the time upward counterfactual thinking is more associated with a pessimistic outlook that can be unmotivating. </strong></p> <p>Thinking in the past tense can be motivational (and even healthy) at times, but the best thing to do is look forward. </p><p>While counterfactual thinking as a whole can be used to motivate us to make better choices or appreciate where we are in life, <a href="https://www.psychologytoday.com/us/blog/darwins-subterranean-world/201809/the-psychology-what-if" target="_blank">this Psychology Today</a> article suggests that we should come up with ways to move on and focus on the present and the future instead of the past. Using counterfactual thinking as a motivational tool can be very helpful if we don't get stuck in the "what if" mindset that tends to pull us out of the present and back into the past, where things will always remain the same. </p>
Despite fact check campaigns, anti-vaccination influence is growing.
- Despite announcing plans to combat disinformation, anti-vax groups continue to gain influence on Facebook.
- An analysis of over 1,300 Facebook pages with 100 million followers shows that anti-vaccination agendas are having a profound impact.
- Only 50 percent of Americans are certain they'll receive an approved COVID-19 vaccine.
Facebook announces plan to 'tackle vaccine misinformation'<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="997c512b8b8afcd4db98fdb7ece75680"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/ZTZ3Lq67yiY?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p>This trend is having real-world consequences. Only <a href="https://www.sciencemag.org/news/2020/06/just-50-americans-plan-get-covid-19-vaccine-here-s-how-win-over-rest" target="_blank">half of Americans</a> are willing to get a coronavirus vaccine, with a quarter wavering and a quarter against. While we should be confident of efficacy—gossip about a <a href="https://www.webmd.com/lung/news/20200511/covid-19_vaccine_by_fall_possible_but_at_what_cost" target="_blank">vaccine arriving in the Fall</a> is ambitious and potentially unsafe—the idea that a quarter of the country will refuse any vaccine is a potential public health disaster (as if we're not experiencing one now).</p><p>Making matters worse, we can't fight disinformation with data. No matter how many articles <a href="https://bigthink.com/coronavirus/the-plandemic" target="_self">debunk Plandemic</a>, Mikki Willis gains momentum. Do <a href="https://www.facebook.com/mikki.willis/posts/2875973472513592" target="_blank">27,000 doctors</a> really support his efforts to "reform our corrupt global healthcare systems?" There's no way to tell, but that's the thing about Facebook: it doesn't have to be true. Willis's claim, which he made in conjunction with a fundraising effort for the film, has been shared 4.4k times. Convincing his fanbase that perhaps tens of thousands of doctors aren't on board will be a Herculean task. </p><p>Media Matters notes the official-sounding National Vaccine Information Center (NVIC), which, though sounding governmental, opposes every effort to vaccinate children. Beginning in February, the organization's website started publishing a "<a href="https://www.nvic.org/vaccines-and-diseases/Reports/covid-19.aspx" target="_blank">special report</a>" on COVID-19, laying the groundwork for vaccination disinformation. </p><p style="margin-left: 20px;">"The first three installments of the 'special report' adopt right-wing themes unrelated to vaccines, such as the claim that public health orders that promote social distancing result in a 'loss of civil liberties' and subject Americans to 'quarantine shaming.' The fourth installment, published on March 29, includes the first attacks on vaccine development in the series … The fifth installment of the 'special report,' published on April 1, frames the vaccine development efforts of pharmaceutical companies and other entities as a cash grab."</p>
A truck with writing "JESUS IS MY VACCINE" drives by demonstrators rallying outside the Pennsylvania Capitol Building to protest the continued closure of businesses due to the coronavirus pandemic on May 15, 2020 in Harrisburg, Pennsylvania.
Photo by Mark Makela/Getty Images<p>The irony is that NVIC's Facebook page is listed as an "Educational Research Center." Just today the organization posted about the <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831678/" target="_blank">long-disproven link between the measles vaccine and autism</a> (via Robert F. Kennedy's anti-vax organization, Children's Health Defense), <a href="https://www.vice.com/en_ca/article/wxevj5/the-coronavirus-truthers-dont-believe-in-public-health" target="_blank">opportunist Joseph Mercola</a>'s questioning whether the COVID-19 surge in Texas has anything to do with the novel coronavirus, and conspiracy theory-rich GreenMedInfo, whose founder traffics in ridiculous ideas, such as <a href="https://www.facebook.com/watch/?v=1720256541450732" target="_blank">germ theory being false</a>. </p><p>And so here we are: instead of reporting on pressing global issues, Reuters has to <a href="https://www.reuters.com/article/uk-factcheck-metal-strip-medical-masks-5/fact-check-metal-strip-in-medical-masks-is-not-a-5g-antenna-idUSKBN24A2O1?fbclid=IwAR2nqo5OaXP3unV7v3jOhtdGY5JjivJgyBSqrKcW0pcEJfhdGWieDb1K5C8" target="_blank">fact check</a> whether the metal strip in face masks is really a 5G antenna or if Wayfair is <a href="https://www.reuters.com/article/uk-factcheck-wayfair-human-trafficking/fact-check-no-evidence-linking-wayfair-to-human-trafficking-operation-idUSKCN24E2M2" target="_blank">involved in human trafficking</a>. (The woman that posted the "medical doctor" video above is convinced Amazon is involved as well.) No matter how ridiculous these sound—and they should, to any functioning adult—common sense is losing ground: an <a href="https://www.sciencemag.org/news/2020/05/vaccine-opponents-are-gaining-facebook-battle-hearts-and-minds-new-map-shows" target="_blank">analysis</a> of over 1,300 Facebook pages with 100 million followers shows that anti-vax agendas are becoming more influential.</p><p>When the printing press was first invented, <a href="https://apple.news/Agz3WmeyWTEKLg-9yHo2BMA" target="_blank">anyone could hire a printer</a>. The idea of objective news took some time to work out, and it is questionable that it ever did get worked out. But we're in a truly disturbing place when one of the most effective therapeutics ever discovered—the <a href="https://www.tmrjournals.com/tmr/EN/abstract/abstract321.shtml" target="_blank">millennia-old idea</a> of allowing the body to build up immunity by introducing a small dose of an offending agent—is being used as, what? A political tool? An ideological battering ram? An apocalyptic battle song sung by the woke as they laugh at all the silly sheeple? </p><p>It's impossible to tell what the end game is. Being contrarian is now its own currency. Whether or not your agenda accomplishes anything is secondary to just being on the team—a participation trophy for simply showing up. Putting in the intellectual and emotional effort demanded by the complex and nuanced realm of science is proving too much for America to tolerate. When a nation descends into such intolerance, anything becomes possible. </p><p>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a>, <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank">Facebook</a> and <a href="https://derekberes.substack.com/" target="_blank">Substack</a>. His next book is</em> "<em>Hero's Dose: The Case For Psychedelics in Ritual and Therapy."</em></p>
Gender and sexual minority populations are experiencing rising anxiety and depression rates during the pandemic.