What is John Adams' legacy?
David McCullough is called the "citizen chronicler" by Librarian of Congress James Billington. His books have led a renaissance of interest in American history--from learning about a flood in Pennsylvania that without warning devastated an entire community to discovering the private achievements and frailties of an uncelebrated president. His biography of Harry Truman won him a Pulitzer, as did his most recent biography of another president, John Adams.
Meeting Thornton Wilder at Yale as an undergraduate inspired McCullough to become a writer--his first love, in fact, had been art. While at college he also met his wife, Rosalee. He learned his craft working at Sports Illustrated, at the United States Information Agency, and at American Heritage. McCullough researched and wrote his first book in the precious hours away from his job with American Heritage; The Johnstown Flood came out in 1968. It was a story and region familiar to McCullough, who was born and raised in nearby Pittsburgh. The book was a success and he became a full-time author.
Since then, McCullough has given us six more books--The Great Bridge, The Path between the Seas, Mornings on Horseback, Brave Companions, Truman, and John Adams--earning him two Pulitzer Prizes, two National Book Awards, and two Francis Parkman Prizes from the American Society of Historians. His other honors include a Charles Frankel Prize, a National Book Foundation Distinguished Contribution to American Letters Award, and a New York Public Library’s Literary Lion Award.
David McCullough: The legacy of John Adams is an example of a man who was willing to go through almost every conceivable kind of inconvenience hard ship and pain to achieve a Nobel objective, to create a nation her people would govern themselves, against the forces that wished otherwise. It had never happened before in history such a revolution had never been successful and he was working with others who had had no more experience in creating this dream come true then he had and they succeeded. I am not everybody of that revolutionary era was a hero, hundreds of people, went over to the other side, went over to the British side, where hundreds of them gave up, hundreds just sat back and watched and said well we will be on which ever side wins. Thousands of them, the estimates are that maybe as much as the 1/3rd of the country were simply waiting to see what happened, but this group this ragtag group very much of them many of them, if you saw them today you would think they look like homeless people, starving, hopeless looking army at one point, would not where and would not lose faith and any scenic, any skeptic, any self centered materialistic, keenest of the kind that would turn up his or her nose at such idealism was proven wrong, they did succeed, they succeeded against tremendous odds and we wouldn’t have what we have in the way of freedoms and idealism a body of the secular faith that you will, its the words so that, that’s his legacy and the legacy of the English. I think John Adams never failed to answer the call of his country to serve, John Adams is the only founding father who never owned a slave as a matter of principle. These were principled people and Abigail no less than John Adams.
Recorded on: 3/3/08
Adams was willing to suffer anything for a truly revolutionary ideal, McCullough says.
A new method promises to capture an elusive dark world particle.
- Scientists working on the Large Hadron Collider (LHC) devised a method for trapping dark matter particles.
- Dark matter is estimated to take up 26.8% of all matter in the Universe.
- The researchers will be able to try their approach in 2021, when the LHC goes back online.
Researchers hope the technology will further our understanding of the brain, but lawmakers may not be ready for the ethical challenges.
- Researchers at the Yale School of Medicine successfully restored some functions to pig brains that had been dead for hours.
- They hope the technology will advance our understanding of the brain, potentially developing new treatments for debilitating diseases and disorders.
- The research raises many ethical questions and puts to the test our current understanding of death.
The image of an undead brain coming back to live again is the stuff of science fiction. Not just any science fiction, specifically B-grade sci fi. What instantly springs to mind is the black-and-white horrors of films like Fiend Without a Face. Bad acting. Plastic monstrosities. Visible strings. And a spinal cord that, for some reason, is also a tentacle?
But like any good science fiction, it's only a matter of time before some manner of it seeps into our reality. This week's Nature published the findings of researchers who managed to restore function to pigs' brains that were clinically dead. At least, what we once thought of as dead.
What's dead may never die, it seems
The researchers did not hail from House Greyjoy — "What is dead may never die" — but came largely from the Yale School of Medicine. They connected 32 pig brains to a system called BrainEx. BrainEx is an artificial perfusion system — that is, a system that takes over the functions normally regulated by the organ. The pigs had been killed four hours earlier at a U.S. Department of Agriculture slaughterhouse; their brains completely removed from the skulls.
BrainEx pumped an experiment solution into the brain that essentially mimic blood flow. It brought oxygen and nutrients to the tissues, giving brain cells the resources to begin many normal functions. The cells began consuming and metabolizing sugars. The brains' immune systems kicked in. Neuron samples could carry an electrical signal. Some brain cells even responded to drugs.
The researchers have managed to keep some brains alive for up to 36 hours, and currently do not know if BrainEx can have sustained the brains longer. "It is conceivable we are just preventing the inevitable, and the brain won't be able to recover," said Nenad Sestan, Yale neuroscientist and the lead researcher.
As a control, other brains received either a fake solution or no solution at all. None revived brain activity and deteriorated as normal.
The researchers hope the technology can enhance our ability to study the brain and its cellular functions. One of the main avenues of such studies would be brain disorders and diseases. This could point the way to developing new of treatments for the likes of brain injuries, Alzheimer's, Huntington's, and neurodegenerative conditions.
"This is an extraordinary and very promising breakthrough for neuroscience. It immediately offers a much better model for studying the human brain, which is extraordinarily important, given the vast amount of human suffering from diseases of the mind [and] brain," Nita Farahany, the bioethicists at the Duke University School of Law who wrote the study's commentary, told National Geographic.
An ethical gray matter
Before anyone gets an Island of Dr. Moreau vibe, it's worth noting that the brains did not approach neural activity anywhere near consciousness.
The BrainEx solution contained chemicals that prevented neurons from firing. To be extra cautious, the researchers also monitored the brains for any such activity and were prepared to administer an anesthetic should they have seen signs of consciousness.
Even so, the research signals a massive debate to come regarding medical ethics and our definition of death.
Most countries define death, clinically speaking, as the irreversible loss of brain or circulatory function. This definition was already at odds with some folk- and value-centric understandings, but where do we go if it becomes possible to reverse clinical death with artificial perfusion?
"This is wild," Jonathan Moreno, a bioethicist at the University of Pennsylvania, told the New York Times. "If ever there was an issue that merited big public deliberation on the ethics of science and medicine, this is one."
One possible consequence involves organ donations. Some European countries require emergency responders to use a process that preserves organs when they cannot resuscitate a person. They continue to pump blood throughout the body, but use a "thoracic aortic occlusion balloon" to prevent that blood from reaching the brain.
The system is already controversial because it raises concerns about what caused the patient's death. But what happens when brain death becomes readily reversible? Stuart Younger, a bioethicist at Case Western Reserve University, told Nature that if BrainEx were to become widely available, it could shrink the pool of eligible donors.
"There's a potential conflict here between the interests of potential donors — who might not even be donors — and people who are waiting for organs," he said.
It will be a while before such experiments go anywhere near human subjects. A more immediate ethical question relates to how such experiments harm animal subjects.
Ethical review boards evaluate research protocols and can reject any that causes undue pain, suffering, or distress. Since dead animals feel no pain, suffer no trauma, they are typically approved as subjects. But how do such boards make a judgement regarding the suffering of a "cellularly active" brain? The distress of a partially alive brain?
The dilemma is unprecedented.
Setting new boundaries
Another science fiction story that comes to mind when discussing this story is, of course, Frankenstein. As Farahany told National Geographic: "It is definitely has [sic] a good science-fiction element to it, and it is restoring cellular function where we previously thought impossible. But to have Frankenstein, you need some degree of consciousness, some 'there' there. [The researchers] did not recover any form of consciousness in this study, and it is still unclear if we ever could. But we are one step closer to that possibility."
She's right. The researchers undertook their research for the betterment of humanity, and we may one day reap some unimaginable medical benefits from it. The ethical questions, however, remain as unsettling as the stories they remind us of.
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