A Message From Aliens in Our DNA?
Davies’s research focuses on the “big questions” of existence, ranging from the origin of the universe to the origin of life, and include the nature of time, the search for life in the universe, and foundational questions in quantum mechanics. He helped create the theory of quantum fields in curved spacetime, with which he provided explanations for how black holes can radiate energy, and what caused the ripples in the cosmic afterglow of the Big Bang. In astrobiology, he was a forerunner of the theory that life on Earth may have come from Mars. He is currently championing the theory that Earth may host a shadow biosphere of alternative life forms.
Davies has lectured on scientific topics at institutions as diverse as The World Economic Forum, the United Nations, the Commission of the European Union, Google, Windsor Castle, The Vatican and Westminster Abbey, as well as mainstream academic establishments such as The Royal Society, The Smithsonian Institution, and the New York Academy of Sciences. Davies devised and presented a series of 45 minute BBC Radio 3 science documentaries and a one-hour television documentary about his work in astrobiology, entitled "The Cradle of Life." Among his bestselling books are "The Mind of God," "How to Build a Time Machine," and "The Goldilocks Enigma." His latest book, "The Eerie Silence," was published by Houghton Mifflin Harcourt in 2010.
Question: What future technologies might \r\nenhance the search\r\nfor extraterrestrials?\r\n\r\n
Paul\r\nDavies: I think we need to\r\nget away from the idea of leaving this to a small and heroic band of \r\nradio\r\nastronomers and try and spread the burden across the entire scientific\r\ncommunity. I think all the\r\nsciences can contribute, and I’ll give you some examples. \r\n One of the things that is baffling\r\nabout ET, and this is an idea that goes back to Enrico Fermi at the end \r\nof the\r\nSecond World War is, why haven’t the alien civilizations spread across \r\nthe\r\ngalaxy and colonized it or at the very least visited? “Where is \r\neverybody?” is\r\nthe way Fermi put it, and so he took that as evidence that there is \r\nnobody out\r\nthere, the fact that Earth has not been visited or colonized, that the \r\naliens\r\nhaven’t come here a long time ago is evidence that they’re not out there\r\neither, but I think one can put a spin on this particular story and say,\r\n well\r\nhow do we know that the aliens didn’t come and it doesn’t have to be \r\nflesh and\r\nblood aliens literally stepping out of a spacecraft. It\r\n could be their machines or their probes or robots or\r\nsomething of that sort that they could well have come a very long time \r\nago, and\r\nin this game you’ve got to think not in thousands or even millions of \r\nyears, but hundreds of millions or billions of years, so \r\nit's that sort of timescale we have to think on, and the question is, \r\nwould any trace remain of alien activity, say in our solar system, \r\nafter—let's pluck a figure out of midair—100 million years? If \r\nyou came back in another 100 million\r\nyears from now would any trace of human activity remain? \r\n The answer is not very much, but there\r\nare some things that we could look for. \r\nIf ET did pass through the solar system obviously didn’t stop for\r\n 100\r\nmillion years what would we find? \r\nWell there are some things like nuclear waste. If\r\n you dumped nuclear waste that will certainly survive for\r\nthat length of time. We could go\r\nlook for that. Any sort of large\r\nscale mining or quarrying activities would leave scars although they \r\nmight be\r\nburied beneath rock strata would still be discernible to a geologist \r\ndoing a\r\nsurvey. We could look for that\r\ntoo.\r\n\r\n
And then there is one other idea that is crazy, but\r\n it’s\r\ndear to my heart and this comes back to the message in the bottle \r\nconcept, so\r\nup to now SETI has been involved in looking for messages that are being\r\ndeliberately beamed at us and as I’ve explained that’s pretty unlikely, \r\nbut\r\nthere is another type of messaging of which the beacon is an example. It’s a one way message. When \r\nyou put a message in a bottle and\r\nthrow it into the sea you don’t think to yourself "Well, I expect a \r\nreply." It’s you don’t know if anybody is ever\r\ngoing to find it and certainly don’t know who is going to find it, so \r\nit’s just\r\nsort of left to its own devices. \r\nWell in the same way we might imagine that an alien civilization \r\nmight\r\nhave put a message in a bottle for anyone who might find it and that \r\nanyone\r\ncould be us, could be human beings, so where is the bottle and where is \r\nthe\r\nmessage? I’m open to\r\nsuggestions. One idea I’ve had is\r\nthat maybe the bottles are living cells, terrestrial organisms and that \r\nthe\r\nmessage is encoded in DNA. Viruses\r\nare continually infecting organisms on Earth and uploading their DNA \r\ninto the\r\ngenomes of those organisms, so there is a well understood pathway for \r\ngetting\r\ninformation into DNA. We’re\r\nlittered with it. Our own genomes\r\nhave got huge amounts of this junk that has climbed onboard from viruses\r\n over\r\nevolutionary history, so if viruses can to it ET can do it and it seems \r\nto me\r\nthat we could in addition to scouring the skies for radio waves with a \r\nmessage\r\nencoded we could scour terrestrial genomes, which are being sequenced \r\nanyway, to\r\nsee if there is a message from ET encoded in it. You\r\n know, it could be some striking string of nucleotide\r\nbases, the famous four letter alphabet that is the language of life, the\r\n A’s,\r\nG’s, C’s and T’s in the DNA. It\r\nmight just spell out some sort of message that would attract our\r\nattention. Now of course this is a\r\ncrazy idea. I’m not actually\r\nsuggesting that there really is a message from ET in genomes. What I’m saying is that is the type of\r\nthinking we need. Maybe it is no\r\nmore crazy than expecting it to be etched into radio waves coming from \r\nthe sky.
Recorded April 15, 2010
\r\nInterviewed by Austin Allen
OK, Paul Davies admits it’s a "crazy idea." But if we want to improve our search for ET, it’s the kind of idea we might need.
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Scientists are using bioelectronic medicine to treat inflammatory diseases, an approach that capitalizes on the ancient "hardwiring" of the nervous system.
- Bioelectronic medicine is an emerging field that focuses on manipulating the nervous system to treat diseases.
- Clinical studies show that using electronic devices to stimulate the vagus nerve is effective at treating inflammatory diseases like rheumatoid arthritis.
- Although it's not yet approved by the US Food and Drug Administration, vagus nerve stimulation may also prove effective at treating other diseases like cancer, diabetes and depression.
The nervous system’s ancient reflexes<p>You accidentally place your hand on a hot stove. Almost instantaneously, your hand withdraws.</p><p>What triggered your hand to move? The answer is <em>not</em> that you consciously decided the stove was hot and you should move your hand. Rather, it was a reflex: Skin receptors on your hand sent nerve impulses to the spinal cord, which ultimately sent back motor neurons that caused your hand to move away. This all occurred before your "conscious brain" realized what happened.</p><p>Similarly, the nervous system has reflexes that protect individual cells in the body.</p><p>"The nervous system evolved because we need to respond to stimuli in the environment," said Dr. Tracey. "Neural signals don't come from the brain down first. Instead, when something happens in the environment, our peripheral nervous system senses it and sends a signal to the central nervous system, which comprises the brain and spinal cord. And then the nervous system responds to correct the problem."</p><p>So, what if scientists could "hack" into the nervous system, manipulating the electrical activity in the nervous system to control molecular processes and produce desirable outcomes? That's the chief goal of bioelectronic medicine.</p><p>"There are billions of neurons in the body that interact with almost every cell in the body, and at each of those nerve endings, molecular signals control molecular mechanisms that can be defined and mapped, and potentially put under control," Dr. Tracey said in a <a href="https://www.youtube.com/watch?v=AJH9KsMKi5M" target="_blank">TED Talk</a>.</p><p>"Many of these mechanisms are also involved in important diseases, like cancer, Alzheimer's, diabetes, hypertension and shock. It's very plausible that finding neural signals to control those mechanisms will hold promises for devices replacing some of today's medication for those diseases."</p><p>How can scientists hack the nervous system? For years, researchers in the field of bioelectronic medicine have zeroed in on the longest cranial nerve in the body: the vagus nerve.</p>
The vagus nerve<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNTYyOTM5OC9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0NTIwNzk0NX0.UCy-3UNpomb3DQZMhyOw_SQG4ThwACXW_rMnc9mLAe8/img.jpg?width=1245&coordinates=0%2C0%2C0%2C0&height=700" id="09add" class="rm-shortcode" data-rm-shortcode-id="f38dbfbbfe470ad85a3b023dd5083557" data-rm-shortcode-name="rebelmouse-image" data-width="1245" data-height="700" />
Electrical signals, seen here in a synapse, travel along the vagus nerve to trigger an inflammatory response.
Credit: Adobe Stock via solvod<p>The vagus nerve ("vagus" meaning "wandering" in Latin) comprises two nerve branches that stretch from the brainstem down to the chest and abdomen, where nerve fibers connect to organs. Electrical signals constantly travel up and down the vagus nerve, facilitating communication between the brain and other parts of the body.</p><p>One aspect of this back-and-forth communication is inflammation. When the immune system detects injury or attack, it automatically triggers an inflammatory response, which helps heal injuries and fend off invaders. But when not deployed properly, inflammation can become excessive, exacerbating the original problem and potentially contributing to diseases.</p><p>In 2002, Dr. Tracey and his colleagues discovered that the nervous system plays a key role in monitoring and modifying inflammation. This occurs through a process called the <a href="https://www.nature.com/articles/nature01321" target="_blank" rel="noopener noreferrer">inflammatory reflex</a>. In simple terms, it works like this: When the nervous system detects inflammatory stimuli, it reflexively (and subconsciously) deploys electrical signals through the vagus nerve that trigger anti-inflammatory molecular processes.</p><p>In rodent experiments, Dr. Tracey and his colleagues observed that electrical signals traveling through the vagus nerve control TNF, a protein that, in excess, causes inflammation. These electrical signals travel through the vagus nerve to the spleen. There, electrical signals are converted to chemical signals, triggering a molecular process that ultimately makes TNF, which exacerbates conditions like rheumatoid arthritis.</p><p>The incredible chain reaction of the inflammatory reflex was observed by Dr. Tracey and his colleagues in greater detail through rodent experiments. When inflammatory stimuli are detected, the nervous system sends electrical signals that travel through the vagus nerve to the spleen. There, the electrical signals are converted to chemical signals, which trigger the spleen to create a white blood cell called a T cell, which then creates a neurotransmitter called acetylcholine. The acetylcholine interacts with macrophages, which are a specific type of white blood cell that creates TNF, a protein that, in excess, causes inflammation. At that point, the acetylcholine triggers the macrophages to stop overproducing TNF – or inflammation.</p><p>Experiments showed that when a specific part of the body is inflamed, specific fibers within the vagus nerve start firing. Dr. Tracey and his colleagues were able to map these relationships. More importantly, they were able to stimulate specific parts of the vagus nerve to "shut off" inflammation.</p><p>What's more, clinical trials show that vagus nerve stimulation not only "shuts off" inflammation, but also triggers the production of cells that promote healing.</p><p>"In animal experiments, we understand how this works," Dr. Tracey said. "And now we have clinical trials showing that the human response is what's predicted by the lab experiments. Many scientific thresholds have been crossed in the clinic and the lab. We're literally at the point of regulatory steps and stages, and then marketing and distribution before this idea takes off."<br></p>
The future of bioelectronic medicine<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNTYxMDYxMy9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYzNjQwOTExNH0.uBY1TnEs_kv9Dal7zmA_i9L7T0wnIuf9gGtdRXcNNxo/img.jpg?width=980" id="8b5b2" class="rm-shortcode" data-rm-shortcode-id="c005e615e5f23c2817483862354d2cc4" data-rm-shortcode-name="rebelmouse-image" data-width="2000" data-height="1125" />
Vagus nerve stimulation can already treat Crohn's disease and other inflammatory diseases. In the future, it may also be used to treat cancer, diabetes, and depression.
Credit: Adobe Stock via Maridav<p>Vagus nerve stimulation is currently awaiting approval by the US Food and Drug Administration, but so far, it's proven safe and effective in clinical trials on humans. Dr. Tracey said vagus nerve stimulation could become a common treatment for a wide range of diseases, including cancer, Alzheimer's, diabetes, hypertension, shock, depression and diabetes.</p><p>"To the extent that inflammation is the problem in the disease, then stopping inflammation or suppressing the inflammation with vagus nerve stimulation or bioelectronic approaches will be beneficial and therapeutic," he said.</p><p>Receiving vagus nerve stimulation would require having an electronic device, about the size of lima bean, surgically implanted in your neck during a 30-minute procedure. A couple of weeks later, you'd visit, say, your rheumatologist, who would activate the device and determine the right dosage. The stimulation would take a few minutes each day, and it'd likely be unnoticeable.</p><p>But the most revolutionary aspect of bioelectronic medicine, according to Dr. Tracey, is that approaches like vagus nerve stimulation wouldn't come with harmful and potentially deadly side effects, as many pharmaceutical drugs currently do.</p><p>"A device on a nerve is not going to have systemic side effects on the body like taking a steroid does," Dr. Tracey said. "It's a powerful concept that, frankly, scientists are quite accepting of—it's actually quite amazing. But the idea of adopting this into practice is going to take another 10 or 20 years, because it's hard for physicians, who've spent their lives writing prescriptions for pills or injections, that a computer chip can replace the drug."</p><p>But patients could also play a role in advancing bioelectronic medicine.</p><p>"There's a huge demand in this patient cohort for something better than they're taking now," Dr. Tracey said. "Patients don't want to take a drug with a black-box warning, costs $100,000 a year and works half the time."</p><p>Michael Dowling, president and CEO of Northwell Health, elaborated:</p><p>"Why would patients pursue a drug regimen when they could opt for a few electronic pulses? Is it possible that treatments like this, pulses through electronic devices, could replace some drugs in the coming years as preferred treatments? Tracey believes it is, and that is perhaps why the pharmaceutical industry closely follows his work."</p><p>Over the long term, bioelectronic approaches are unlikely to completely replace pharmaceutical drugs, but they could replace many, or at least be used as supplemental treatments.</p><p>Dr. Tracey is optimistic about the future of the field.</p><p>"It's going to spawn a huge new industry that will rival the pharmaceutical industry in the next 50 years," he said. "This is no longer just a startup industry. [...] It's going to be very interesting to see the explosive growth that's going to occur."</p>
"The Expanse" is the best vision I've ever seen of a space-faring future that may be just a few generations away.
- Want three reasons why that headline is justified? Characters and acting, universe building, and science.
- For those who don't know, "The Expanse" is a series that's run on SyFy and Amazon Prime set about 200 years in the future in a mostly settled solar system with three waring factions: Earth, Mars, and Belters.
- No other show I know of manages to use real science so adeptly in the service of its story and its grand universe building.
Credit: "The Expanse" / Syfy<p>Now, I get it if you don't agree with me. I love "Star Trek" and I thought "Battlestar Galactica" (the new one) was amazing and I do adore "The Mandalorian". They are all fun and important and worth watching and thinking about. And maybe you love them more than anything else. But when you sum up the acting, the universe building, and the use of real science where it matters, I think nothing can beat "The Expanse". And with a <a href="https://www.rottentomatoes.com/tv/the_expanse" target="_blank">Rotten Tomato</a> average rating of 93%, I'm clearly not the only one who feels this way.</p><p>Best.</p><p>Show.</p><p>Ever. </p>
Contrary to what some might think, the brain is a very plastic organ.
As with many other physicians, recommending physical activity to patients was just a doctor chore for me – until a few years ago. That was because I myself was not very active.
The first rule of Vulture Club: stay out of Portugal.
So you're a vulture, riding the thermals that rise up over Iberia. Your way of life is ancient, ruled by needs and instincts that are way older than the human civilization that has overtaken the peninsula below, and the entire planet.
By 2050, there may be more plastic than fish in the sea.
- 2050 is predicted to be a bleak milestone for the oceans - but it's not too late to avert disaster.
- Here are 10 actions the world can take to strengthen and preserve our oceans for generations to come.