from the world's big
Always tired? Your immune system may be overactive.
A new study provides strong evidence that chronic fatigue syndrome is linked to abnormal reactions in the immune system.
- Chronic fatigue syndrome affects millions of people worldwide, but scientists still aren't quite sure what causes it.
- A new study tracked people suffering from Hepatitis C (HCV) as they underwent a treatment course.
- The results showed that people with overactive immune responses developed chronic fatigue months following the treatment, and that the fatigue persisted even after their immune responses returned to normal.
A new study builds upon previous research showing that an overactive immune system might be a key cause of chronic fatigue syndrome.
Chronic fatigue syndrome (CFS), also called myalgic encephalomyelitis (ME), is a debilitating condition that leaves people feeling always tired and mentally foggy. Worse, sleep doesn't really help to alleviate the symptoms of CFS, which affects some 17 million people worldwide.
The causes of CFS remain unknown. In recent years, however, research has suggested that an overactive immune system might be to blame. But that hypothesis has been difficult to study because it's impossible to tell who's going to contract a virus, and researchers need to examine physiological conditions before, during and after an immune response occurs.
A recent study — it was published in the journal Psychoneuroendocrinology on December 17 — used a novel approach to get around that problem. Researchers at King's College London recruited 55 patients with chronic Hepatitis C (HCV) and gave them a six- to 12-month course of a drug called Interferon alpha, a common treatment for HCV. Then, the team tracked the participants as they recovered.
Six months after the treatment ended, 18 participants were more fatigued than before the course began. Before treatment, these participants showed relatively high levels of a protein linked to inflammation, called IL10, in their blood. These levels, including levels of another protein linked to inflammation, only increased after four weeks of treatment, reaching levels twice as high as people who recovered without chronic fatigue.
However, six months after the treatment, the 18 fatigued participants also showed immune-response levels that were no different from participants who hadn't developed post-treatment fatigue. What's more, the researchers took samples of these inflammation proteins from all the participants and compared them to those of 57 separate healthy participants who didn't have HCV or undergo the treatment. The results showed no difference between the two sets.
A possible cause
One theory is that a hyperactive immune response triggers CFS. Still, that doesn't explain exactly what role the immune system plays in the later stages of the condition, considering there appear to be no abnormal immune responses once symptoms emerge.
"In conclusion, findings from this study support the hypothesis that abnormal immune mechanisms are important in CFS, but only early in the course of the illness, around the time of the trigger, rather than when the syndrome is established," the authors wrote. "Moreover, our study confirms the importance of the acute fatigue response to the trigger, rather than of the recovery period preceding the illness."
The findings could give researchers "some clue down the line" as to the exact causes and possible treatments for CFS, Michael Sharpe, a professor of psychological medicine at the University of Oxford, told The Guardian.
"If the thing is triggered by an abnormal or excessive immune response, if we could find a way to reduce that immune response, we might stop incident cases," Sharpe said.
Sallie Krawcheck and Bob Kulhan will be talking money, jobs, and how the pandemic will disproportionally affect women's finances.
Got $55 million lying around? If so, you might be able to score a spot aboard the International Space Station starting 2024.
- NASA awarded a contract to startup Axiom Space to attach a "habitable commercial module" to the International Space Station.
- The project will also include a research and manufacturing module.
- The move is a major step in NASA's years-long push to privatize.
Image: Axiom Space<p>But first, space-tourist-hopefuls would have to pass through physical and medical exams, and 15 weeks of expert training. After that, the trip sounds pretty comfy:</p><p>"There will be wifi," Suffredini <a href="https://www.nytimes.com/2018/06/09/style/axiom-space-travel.html" target="_blank">told the New York Times</a> last year. "Everybody will be online. They can make phone calls, sleep, look out the window. [...] The few folks that have gone to orbit as tourists, it wasn't really a luxurious experience, it was kind of like camping. [...] Pretty soon we're going to be flying a butler with every crew."</p>
A render of the ISS tourist experience.
Image: Axiom Space<p>In a blog post, NASA wrote:</p><p>"Developing commercial destinations in low-Earth orbit is one of <a href="https://www.nasa.gov/press-release/nasa-opens-international-space-station-to-new-commercial-opportunities-private" target="_blank">five elements</a> of NASA's plan to open the International Space Station to new commercial and marketing opportunities. The other elements of the five-point plan include efforts to make station and crew resources available for commercial use through a new commercial use and pricing policy; enable private astronaut missions to the station; seek out and pursue opportunities to stimulate long-term, sustainable demand for these services; and quantify NASA's long-term demand for activities in low-Earth orbit."</p>
NASA's push to privatize the ISS<p>When a Russian rocket launched the first module of the ISS into space in 1998, NASA expected the space station to operate for about 15 years. But the agency has extended the life of the ISS twice, with funding currently set to expire in 2024. NASA spends between $3 and $4 billion per year operating and shuttling astronauts to and from the station. That's a decent chunk of the agency's $22.6 annual budget. What's more, the "major structural elements" of the ISS are certified only through 2028.</p><p>Meanwhile, NASA has been eyeing other projects, namely: putting humans back on the moon in 2024 and establishing a lunar presence. So, to save and redirect money, the agency has been starting to hand over the aging space station to the private sector, which could use it for commercial research and space tourism.</p><p>But some have questioned the move to privatize the ISS, including NASA's own inspector general, Paul K. Martin.</p><p>"An obvious alternative to privatization is to extend current ISS operations," Martin wrote in a <a href="https://oig.nasa.gov/docs/CT-18-001.pdf" target="_blank">2018 report</a>. "An extension to 2028 or beyond would enable NASA to continue critical on-orbit research into human health risks and to demonstrate the technologies that will be required for future missions to the Moon or Mars."</p>
Image: Axiom Space<p>Martin noted that "research into 2 other human health risks and 17 additional technology gaps is not scheduled to be completed until sometime in 2024," meaning that any slip-ups in the process would mean such research might go uncompleted. He also wrote that it's "questionable" whether the private sector could turn a profit on the ISS without "significant" government funding. The Institute for Defense Analyses, a federally funded research and development center, <a href="https://docs.house.gov/meetings/SY/SY00/20180517/108302/HHRG-115-SY00-Wstate-LalB-20180517.pdf" target="_blank">also found</a> that it "is unlikely that a commercially owned and operated space station will be economically viable by 2025."</p><p>The implication is that, if the ISS is handed over to the private sector, taxpayers could end up indirectly supporting space tourism for the ultra-rich. Whether that's worth any of the research benefits that might come from the ISS post-2024 is anybody's guess.</p><p>As the ISS enters its final years, China <a href="http://www.xinhuanet.com/english/2019-10/17/c_138479514.htm" target="_blank">plans</a> to complete construction of a manned space station in 2022.</p>
The coronavirus pandemic has brought out the perception of selfishness among many.
- Selfish behavior has been analyzed by philosophers and psychologists for centuries.
- New research shows people may be wired for altruistic behavior and get more benefits from it.
- Crisis times tend to increase self-centered acts.
Paul Krugman on the Virtues of Selfishness<div class="rm-shortcode" data-media_id="7ZtAkm6C" data-player_id="FvQKszTI" data-rm-shortcode-id="828936bf6953080e9018307354c0c02b"> <div id="botr_7ZtAkm6C_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/7ZtAkm6C-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/7ZtAkm6C-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/7ZtAkm6C-FvQKszTI.js"></script> </div> The Nobel Prize-winning economist on the virtues of selfishness.
Evolution Is Moving Us Away from Selfishness. But Where Is It Taking ...<div class="rm-shortcode" data-media_id="cyeqmYCb" data-player_id="FvQKszTI" data-rm-shortcode-id="6c5efecb56456e9acc25cf36935b1826"> <div id="botr_cyeqmYCb_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/cyeqmYCb-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/cyeqmYCb-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/cyeqmYCb-FvQKszTI.js"></script> </div>
Exploring Morality and Selfishness in Modern Times<div class="rm-shortcode" data-media_id="02eX1Cag" data-player_id="FvQKszTI" data-rm-shortcode-id="45cc6180db791f32683988fb52faff26"> <div id="botr_02eX1Cag_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/02eX1Cag-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/02eX1Cag-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/02eX1Cag-FvQKszTI.js"></script> </div> Philosopher Peter Singer discusses the state of global ethics.
Parenting could be a distraction from what mattered most to him: his writing.
Ernest Hemingway was affectionately called “Papa," but what kind of dad was he?