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How to vaccinate the world’s most vulnerable? Build global partnerships.
Pfizer's partnerships strengthen their ability to deliver vaccines in developing countries.
Pfizer Corporate Responsibility develops programs that help expand global access to medicines by providing direct assistance to underserved populations. Our initiatives include providing product donations and steep discounts that help patients access the medicine they need. We also collaborate with Pfizer business teams and nonprofit organizations to help shape sustainable business models that address affordability and the vast differences in economies around the world.
- Community healthcare workers face many challenges in their work, including often traveling far distances to see their clients
- Pfizer is helping to drive the UN's sustainable development goals through partnerships.
- Pfizer partnered with AMP and the World Health Organization to develop a training program for healthcare workers.
Community healthcare workers are often the only point of contact with the health system in many underserved areas in the developing world. These noble public servants work within the community to bring health coverage closer to people who need it. Millions of babies around the world are at risk every day from vaccine preventable diseases and many of them live in very remote communities. This means that health care workers must sometimes travel long distances over mountains, across desserts and through rivers while carrying vaccine coolers.
These are some of the reasons why Pfizer is proud to partner with organizations that share a vision of increasing the health and well-being of children around the world. Susan Silbermann, Global President of Pfizer Vaccines, recently sat down with Big Think to discuss how the company is helping to improve vaccine access in developing countries.
Pfizer is helping to improve vaccine access
The constraints people face in other countries requires companies to develop more novel and innovative approaches to help improve vaccine access.
So the question for Pfizer was: Tell us what innovating a vaccine means to you?
Silbermann brought a vial to show Big Think what innovation looks like.
"This tiny vial is an incredible testament to scientific innovation. Until 2017, it provided one dose to vaccinate one child. But now it provides four doses and can vaccinate four children. By combining multiple doses into one vial we have reduced the storage space and the shipping requirements."
Innovations like this multi-dose vial are just the beginning of making it easier to get vaccines to children. Here are a few facts that Pfizer wants to help change.
- Sub-saharan Africa bears nearly 25% of the disease burden in the world.
- It only has 3% of the global health workers.
The critical role of health care workers in the developing world
A health care worker administers a vaccine in Malawi.
Photo: Courtesy of Pfizer.
When Pfizer's new multi-dose vial (MDV) became available in 2017 in Gavi countries, it was a priority to ensure health care workers were properly trained. For this, Pfizer partnered up with the AMP and the World Health Organization to develop a pneumococcal conjugate refresher course and new training program for the multi-dose vial.
As part of the partnership program, Pfizer developed a "train the trainer" model that is a tiered system of training. For example, "master trainers" will go on to train the next round of health care workers.Last year, Pfizer trained over 27,000 health care workers across 15 different countries. And this year, it's extended the program to an additional nine countries with the goal of reaching an additional 17,000 new health care workers by the end of the year.
A future dedicated to vaccine development
The overall impact vaccines are having on global public health are astounding. It's been estimated that vaccinations have prevented 26 million cases of childhood infections in the last decade alone.
Right behind clean water, immunizations are the most important health investment we have. Pfizer employees are passionate about vaccine development because they know it will translate into a tremendous public health impact.
Once logistical barriers and other obstacles are overcome, Pfizer believes that we will be working toward building a better future in communities around the world. One the best ways to remove barriers is through working with and supporting partners.
Why partnerships matter
Pfizer supports many projects that work to empower and equip community health workers. It recognizes that supporting health care workers is a critical part of achieving universal health coverage.
Silbermann talked with Big Think about making sure vaccines get to where they are needed.
"We have to make sure that vaccines get to those who need it. I have often said that our job doesn't end when we make a vaccine and ship it to a distribution center. What good is a vaccine if it isn't reaching the people who need it the most?"
Pfizer is a strategic partner of AMP Health (Aspen Management Partnership for Health), a cross sector, public private partnership to strengthen healthcare systems. AMP Health partners with Ministries of Health to help grow community health and immunization programs by providing leadership and management training and has worked in Ghana, Kenya, Malawi, Sierra Leone, and Zambia.
National governments in Sub-Saharan Africa are committed to deploying thousands of community health workers, but often don't have the strategic, managerial, or financial skills to run a large-scale program.
Pfizer believes that professional, supported community health workers play a critical role in reaching underserved populations and that partnering with organizations like AMP Health advances this objective.
The unsung heroes
Vaccines must stay refrigerated as they travel and be stored at very specific temperatures until they are used. Health care workers often worry about the vaccine refrigerators which can be old and if they were to break down the quality of the vaccines could be at risk.
Silbermann told us a story about how a healthcare worker in Ghana ensured vaccines were available in her clinic.
"Let me tell you a story about a healthcare worker in Ghana that we recently met. She works in a clinic in a small village in the Ho region of Ghana which is approximately three hours north of the capital. In her clinic, there is no electricity or running water. These two elements are critical to ensure safe and effective use of medicines. For example, vaccines need to be stored at a specific temperature to maintain their effectiveness and therefore are stored in fridges which are powered by electricity.
"Instead of storing the vaccines in her clinic, the healthcare worker travels one hour each way on the bus to get fresh vaccines and transport them in a cooler. She then works all day at the clinic administering these vaccines and seeing mothers, children and babies. Without the dedication of healthcare workers like this one in Ghana it is very likely that communities of children would not have the opportunity to be vaccinated."
Why is Pfizer so committed to vaccines?
Pfizer colleagues are passionate about vaccine development and innovation because they know it can translate into a tremendous public health impact. Immunization not only saves lives and improves health, it also unlocks the potential of a community—a vaccinated community is not only healthier, research has shown it is stronger and more productive.
Silbermann left us with this thought:
"When I think about the future, I know we can make a significant difference by ensuring that no logistical issue is an obstacle to a child getting vaccinated. But we can't do it alone. We need to work together to build on our experiences and capabilities to make the world a healthier place to live."
Here's what it takes to get vaccines from the lab to the field
Join multiple Tony and Emmy Award-winning actress Judith Light live on Big Think at 2 pm ET on Monday.
How a study on worms pointed the way towards a treatment for dementia
- An increasing amount of research suggests that failures in phase transition within cells can cause a variety of aliments
- The mechanism is believed to involve the inability of moleclues to move from solid to liquid and back, inhibiting cellular function.
- The discoveries open the door to treatments for neurodegenerative disease, some cancers, and other illnesses.
All matter is just going through a phase.<p>Think of liquid water for a moment. If you put it in the freezer, it'll turn to solid ice. Leave it out, and it will melt again. Boil it or leave it outside on a hot day, and it will all turn into water vapor eventually. This change in state is called a "<a href="https://chem.libretexts.org/Bookshelves/Physical_and_Theoretical_Chemistry_Textbook_Maps/Supplemental_Modules_(Physical_and_Theoretical_Chemistry)/Physical_Properties_of_Matter/States_of_Matter/Phase_Transitions/Fundamentals_of_Phase_Transitions#:~:text=Phase%20transition%20is%20when%20a,combination%20of%20temperature%20and%20pressure." target="_blank">phase transition</a>" and is familiar to most people who took some physics or chemistry. </p><p>Phase transition sometimes takes place in cells. Molecules inside cells responsible for cellular metabolism can change from solid to liquid to carry out specific tasks. However, it occasionally happens that the process that allows this to happen breaks down, and the molecules remain a little more solid than is ideal. This means that the molecules are no longer able to move around the cell and do their jobs. <br> <br> When this happens in certain cells in the brain, toxins associated with Alzheimer's disease and various other conditions start to build up in and around the cells. This discovery, based on previous studies from 2009, is the foundation of a theory on how neurodegenerative diseases start in our brains. </p>
How did scientists develop this theory?<div class="rm-shortcode" data-media_id="aBJpp9J4" data-player_id="FvQKszTI" data-rm-shortcode-id="134616cefd3c5c6b756c407590ea3f91"> <div id="botr_aBJpp9J4_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/aBJpp9J4-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/aBJpp9J4-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/aBJpp9J4-FvQKszTI.js"></script> </div> <p>In 2009, a group of scientists discovered phase transitions and their importance in worms' reproductive cells<a href="https://science.sciencemag.org/content/324/5935/1729.full#otherarticles" target="_blank"></a>. For reasons which are probably clear to you, this study didn't garner much attention right away. After a few years, the idea that glitchy phase transitions could cause a variety of issues gained some traction, and studies on phase transition in human brain cells took <a href="https://www.nature.com/articles/s41582-019-0157-5" target="_blank">place</a>. Dr. J Paul Taylor even won the <a href="https://www.potamkinprize.org/" target="_blank">Potamkin Prize</a>, awarded for excellence in dementia research, for work concerning how faulty phase transition relates to neurodegenerative diseases.</p>
What directions does this point in?<div class="rm-shortcode" data-media_id="cRIAffgd" data-player_id="FvQKszTI" data-rm-shortcode-id="ae687302c209d641b6e6395a8d8bff74"> <div id="botr_cRIAffgd_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/cRIAffgd-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/cRIAffgd-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/cRIAffgd-FvQKszTI.js"></script> </div> <p><a href="https://www.npr.org/sections/health-shots/2020/07/08/888687912/new-clues-to-als-and-alzheimers-from-physics" target="_blank">In his NPR interview,</a> Dr. Taylor suggests that treatments for Alzheimer's and related diseases based on this new understanding could be available in a few years. In the same article, Dr. Clifford Brangwyane of Princeton explained that some experimental treatments have already shown promise in correcting the issues. He also suggests that phase transition treatments could be used against other illnesses and perhaps even some cancers.</p><p>Sometimes tremendous scientific advances are born out of the strangest studies. In this case, a potential treatment for a variety of terrible neurodegenerative diseases traces its roots to a study of worms. More bizarre things have happened in science.</p>
A new study lays out the case for the damaging effects of stress on orcas living in tanks.
- There are currently around 60 orcas living in concrete tanks globally.
- Orcas' brain structures and behaviors strongly suggest smart, emotional, self-aware beings.
- The study provides compelling evidence that the stresses inherent in captivity do damage to these naturally free-roaming cetaceans.
A study, "The harmful effects of captivity and chronic stress on the well-being of orcas (Orcinus orca)" recently published in Journal of Veterinary Behavior is the product of a unique collaboration of experts in marine mammal science, veterinary science, internal medicine and psychiatry. It makes the case for a careful consideration of the impacts of chronic stress on captive orcas, at least 60 of whom are currently in captivity. Most have spent years or decades of their lives in these conditions. 56.7% of these orcas were born in captivity, with 26 captured young. (Orcas are actually the third most commonly confined cetaceans — there are even more bottlenose dolphins and beluga whales held in tanks.)
The study explains how the continual, oppressive stress inherent to a captive orca's life is unhealthy and should be more thoughtfully addressed. Study lead author biopsychologist Lori Marino tells Big Think in an email:
"Our review shows that intelligence, complexity, and awareness are characteristics that make an animal more — not less — vulnerable to the effects of captivity. That seems counterintuitive because a lot of people think that the more mental resources you have the better you are able to cope with various situations. But it is also the case that the more mental capacity you have the greater your needs in order to thrive and the more extreme the impact of living in an artificial environment, that is, an environment outside your adaptive envelope."
While skeptics may consider it a leap to assume that orcas are intelligent and emotional enough to suffer the ill effects of stress, Marino responds, "That would be a claim in search of evidence. Stress is a common phenomenon in all mammals and many other organisms. The effects of chronic stress have been well-studied in mice, rats, dogs, etc." The study provides ample evidence that orcas are exceptionally intelligent, feeling creatures in any event.
The orca brain
Image source: FineShine/Shutterstock
The orca brain exhibits neurobiological traits that are considered prerequisites for complex psychology, emotion, and behavior:
- a large brain size
- an expanded neocortex
- a well-differentiated cortical cytoarchitecture
- an elaborated limbic system.
Even more important than sheer brain size is its size in relation to an animal's body. This is captured as the organism's encephalization quotient, or EQ. Says the study, "Odontocetes, and in particular Delphinoidea [the superfamily to which orcas belong], are the most highly encephalized nonhuman taxonomic group known … except modern humans."
Orcas also have the most highly convoluted, or folded, neocortical surface of all mammals including humans, and their ratio of neocortical surface to brain weight also exceeds the human brain's, suggesting an organ well-suited to higher-order functions.
Among a range of other clues presented by the study that suggest orcas are highly intelligent creatures are these:
- Areas associated in the human brain with high-level cognitive and social functions including attention, prediction, social awareness, and empathy are all highly developed in orcas.
- Orcas have a well-integrated mammalian limbic system that supports having emotions, memory, motivation, reasoning, learning, and abstraction.
Image source: Willyam Bradberry /Shutterstock
Observations of orca behavior richly supports the implications of their neurobiological structures. Marino says, "Free-ranging orcas live in tightly-knit social groups that are necessary during their long juvenile periods and afterwards. They support each other, help each other when in trouble, and grieve each other. Mothers and calves are very tightly bonded. In some groups, male orcas stay with their mom their whole life and if mom dies [the male offpsring] may go into a deep depression and die as well. Family and social group are everything."
Orcas also demonstrate culture, with vocalizations and even hunting methods unique within groups and passed from generation to generation.
"Orcas at Punta Norte, Argentina, hunt sea lion and elephant seal pups by beaching themselves and capturing the pups, typically in the surf zone," according to the study.
Image source: Peter Etchells/Shutterstock
In the wild, free-ranging female orcas live an average of 46 years — some live as long as 90 years — and males 31 years, or as long as 50-60 years. Captive orcas rarely live more than 30 years, with many dying in their teens or 20s. Their medical histories can be difficult to access due to facilities' desire for confidentiality. Nonetheless, some morbidities, or causes of death, have become clear over time.
One review from 1979 identified infectious disease as the culprit behind the death of 17 captive North American orcas who'd died since 1965 prior to the report's writing. The new study cites publicly available documentation revealing that between 1971 and 2017, SeaWorld parks alone have experienced 35 documented orca deaths, and that, "When causes of death were available, the most commonly implicated conditions were viral, bacterial and fungal infections, gastrointestinal disease, and trauma."
Infections such as these may not in and of themselves have necessarily been lethal, but when combined with orcas' "weakened immune system, chronic exposure to chemical irritants or trauma to the skin, excessive or improper use of antimicrobials, and an imbalance in the microbiota of the body or environment (which may exist in tanks)," they become deadly. Common fungal infections may also especially dangerous in this context "as a result of long-term and aggressive antibiotic treatment, overtreatment of water for purity, or both." The same is true for untreated dental infections.
Another frequent cause of orca death: gastrointestinal ulceration — ulcers — caused by prolonged exposure to stress.
The destructive power of stress
Image source: eldeiv/Shutterstock
"Importantly, the poor health and short lifespans of captive orcas are most clearly understood as connected elements in a cycle of maladaptiveness to the conditions of captivity that involves behavioral abnormalities, physical harm and vulnerability to disease."
The paper shows, says Marino, that "when you examine the totality of the welfare findings for captive orcas the whole picture fits best within a larger common framework of evidence on how stress effects captive animals. We know that, when confined, other animals show the same kinds of behavioral and physiological abnormalities that captive orcas do. This is not mysterious or even controversial. It is basic science."
Marino cites as especially damaging the manner in which captivity prevents orcas from making social connections. Tanks also deprive them of places to retreat, making conflicts inescapable even temporarily. Finally, captive orcas are likely to become bored and chronically demotivated by the frustration over their loss of autonomy.
The study also notes physical effects brought on by long-term stress, including:
- the release of too much cortisol by the hypothalamus-pituitary-adrenal, or HPA, axis, causing elevated blood sugar, suppression of the immune system, as well as metabolism and blood pressure issues.
- alterations of the hippocampus, amygdala, and prefrontal cortex due to prolonged stress, potentially leading to Increased anxiety, post-traumatic stress, cognitive impairment, depression, and mood dysregulation.
- organ degradation in response to unrelenting stress.
- a loss of natural sensory information, about which, says the study, "a growing body of research has found that exposure to excessive or unnatural levels or types of acoustic input can cause a number of impacts to cetaceans, including but not limited to … accelerated aging, suppression of the immune response, as well as premature hearing loss."
A valuable conversation
Marino explains why it was important to conduct this study, saying, "My co-authors and I wrote this review to bring all of the available information on captive orca well-being together in one place and to suggest that we might all best be able to understand the effects of captivity within a very familiar and well-researched model of how chronic stress effects all organisms. We want this paper to be a catalyst for dialogue and further scientific exploration based on data as to how we can better understand who orcas are and how we can identify the important elements needed in a captive environment for them to thrive."
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