Plant-grown vaccines: the next step in medicine?

Medicago is growing a SARS-CoV-2 vaccine candidate in a relative of the tobacco plant right now.

Plant-grown vaccines: the next step in medicine?
Credit: Quality Stock Arts / Adobe Stock
  • Canadian biotech company Medicago is growing a vaccine candidate in Nicotiana benthamiana.
  • An Australian relative to tobacco, plant-based vaccines could be cheaper and more reliable than current methods.
  • Medicago just completed phase 3 clinical trials of an influenza vaccine, which could be a game-changer for vaccine production.

One of the biggest fears around vaccines, however unwarranted, is that they're "unnatural." Adjuvants that help improve vaccine response, such as alum, squalene, and paraffin oil, have been demonized by the anti-vaxx movement. This trend has resulted in over one-third of Americans claiming they won't get a SARS-CoV-2 vaccine when one is produced.

With over 200 vaccine trials underway, chances that 2021 will result in a reliable vaccine are high. Those worried about the "unnatural" means by which vaccines are produced may take comfort in a groundbreaking new development.

In July, Canadian biotech company Medicago began phase 1 clinical trials using a vaccine candidate that's grown in Nicotiana benthamiana, an Australian plant that closely resembles tobacco. The plant's naturally poor immune system allows virus-like particles (VLPs) to flourish. Medicago CEO Bruce Clark says the plant acts like a "bioreactor" that produces usable material in a matter of weeks.

Many vaccines are traditionally incubated in chicken eggs. The annual influenza vaccination is a common example. The process is delicate, however: US government facilities are hidden and highly secure. This method is costly, as every dose requires at least one egg. Tens of millions of chicken eggs are used for this purpose in America every year.

There's another important cost: time. While a plant-developed VLP vaccine takes roughly two months to develop, egg vaccines take up to a half-year to produce. With plants, you get a vaccine quicker and without ethical concerns for the strain on chickens.

By contrast, Nicotiana benthamiana grows in rugged environments throughout Australia. It can grow up to five feet tall. The frail leaves have made it an exceptional candidate for plant research and have been used for decades in plant virology. An experimental drug, ZMapp, developed to treat Ebola, was designed using this plant. While not without risks, the WHO claims ZMapp's benefits outweigh the risks, and has approved its usage in cocktail treatments.

lab scientist in protective equipment

Credit: alphaspirit / Adobe Stock

Clark says it's important to attack the novel coronavirus from all sides.

"Creating a sufficient supply of COVID-19 vaccines within the next year is a challenge which will require multiple approaches, with different technologies. Our proven plant-based technology is capable of contributing to the collective solution to this public health emergency."

Unlike many common vaccines, VLP vaccines contain no genetic material. You won't get infected by it, which is always a risk in live vaccines.

This SARS-CoV-2 vaccine is not the only project on Medicago's hands. The company just completed phase 3 clinical trials on an influenza. While no plant-based vaccine has been approved for use, the company hopes to replace the more cumbersome and expensive egg-based model, or at least offset some of the costs of that model. The plant model could help researchers adapt more quickly to the ever-changing influenza strains each season.

Plants offer a wonderful alternative to the current vaccination model. Besides price, VLP vaccines scale much easier and faster. If the SARS-CoV-2 vaccine works, Medicago believes they can produce a billion doses a year, by far the most ambitious yield to date. At a time when speed, cost, and reliability are all essential factors in vaccine development, we should put tobacco to better use: healing instead of harming.


Stay in touch with Derek on Twitter and Facebook. His new book is "Hero's Dose: The Case For Psychedelics in Ritual and Therapy."

A brief history of human dignity

What is human dignity? Here's a primer, told through 200 years of great essays, lectures, and novels.

Credit: Benjavisa Ruangvaree / AdobeStock
Sponsored by the Institute for Humane Studies
  • Human dignity means that each of our lives have an unimpeachable value simply because we are human, and therefore we are deserving of a baseline level of respect.
  • That baseline requires more than the absence of violence, discrimination, and authoritarianism. It means giving individuals the freedom to pursue their own happiness and purpose.
  • We look at incredible writings from the last 200 years that illustrate the push for human dignity in regards to slavery, equality, communism, free speech and education.
Keep reading Show less

Mathematical model shows how the Nazis could have won WWII's Battle of Britain

With just a few strategical tweaks, the Nazis could have won one of World War II's most decisive battles.

Photo: Heinrich Hoffmann/ullstein bild via Getty Images
Politics & Current Affairs
  • The Battle of Britain is widely recognized as one of the most significant battles that occurred during World War II. It marked the first major victory of the Allied forces and shifted the tide of the war.
  • Historians, however, have long debated the deciding factor in the British victory and German defeat.
  • A new mathematical model took into account numerous alternative tactics that the German's could have made and found that just two tweaks stood between them and victory over Britain.
Keep reading Show less

We’ve mapped a million previously undiscovered galaxies beyond the Milky Way. Take the virtual tour here.

See the most detailed survey of the southern sky ever carried out using radio waves.

Photo by Štefan Štefančík on Unsplash
Surprising Science

Astronomers have mapped about a million previously undiscovered galaxies beyond the Milky Way, in the most detailed survey of the southern sky ever carried out using radio waves.

Keep reading Show less

New data reveals Earth closer to a black hole and 16,000 mph faster

A new study shows our planet is much closer to the supermassive black hole at the galaxy's center than previously estimated.

Position and velocity map of the Milky Way Galaxy.

Credit: NAOJ
Surprising Science
  • A Japanese radio astronomy project revealed Earth is 2,000 light years closer to the supermassive black hole at the Milky Way's center.
  • The data also showed the planet is moving 7 km/s or 16,000 mph faster in orbit around the Galactic Center.
  • The findings don't mean Earth is in more danger from the black hole but reflect better modeling of the galaxy.
  • Keep reading Show less
    Technology & Innovation

    How has technology changed — and changed us — in the past 20 years?

    Apple sold its first iPod in 2001, and six years later it introduced the iPhone, which ushered in a new era of personal technology.

    Scroll down to load more…