Scientists Discover Why Your Brain Can't Block Out Unwanted Thoughts

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“Try to pose for yourself this task: not to think of a polar bear, and you will see that the cursed thing will come to mind every minute.”

— Fyodor Dostoevsky, Winter Notes on Summer Impressions

Chances are you’ve heard this game before in some form, maybe with a pink elephant instead of a polar bear. And though it’s just a game, the similar phenomenon of being unable to rid your mind of intrusive thoughts can pose serious dangers to mental health, and it’s a hallmark symptom of psychiatric disorders like post-traumatic stress disorder, anxiety, depression, and schizophrenia.

What’s going on in the brain when you’re trying to clear unwanted thoughts from your mind?

Scientists just got much closer to the answer, it seems. A study published in the journal Nature by researchers at the University of Cambridge details how people with higher concentrations of the amino acid neurotransmitter GABA in their brain’s hippocampal region tend to be better at blocking unwanted thoughts, images and memories.

“What’s exciting about this is that now we’re getting very specific,” said study coauthor Michael Anderson to BBC News. “Before, we could only say ‘this part of the brain acts on that part’, but now we can say which neurotransmitters are likely to be important.”

In the study, participants were asked to memorize pairs of unrelated words — for example, moss/north or ordeal/roach. Then the researchers presented participants with two lights: one red, one green. Participants were asked to recall the associated memories when the light was green, and suppress memories when it was red without engaging in any distracting activity or thought pattern. “Whenever a memory intruded into awareness, they were asked to ‘push it out of mind.’,” write the study authors.

Meanwhile, participants’ brains were monitored with both functional magnetic resonance imaging (FMRI) and magnetic resonance spectroscopy, which measures chemical changes in the brain.

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Results showed that GABA plays a key role in people’s ability to stop thought patterns. functioning as an inhibitory neurotransmitter, GABA effectively tells the cells it comes in contact with not to fire. Without it, nerve cells can fire too often and too easily. Caffeine inhibits the release of GABA in the brain, so one way to conceptualize what a GABA deficiency might feel like is to imagine that jittery, hyperactive feeling when you drink too much coffee.

The study could help improve treatments for rumination and associated psychiatric disorders.

“Most of the focus has been on improving functioning of the prefrontal cortex,” Anderson said to BBC News. “Our study suggests that if you could improve GABA activity within the hippocampus, this may help people to stop unwanted and intrusive thoughts.”

The Game

The polar bear game listed at the top of the article is similar to a mind game played 24-7 around the world, known simply as The Game. According to its website, there are only three rules to The Game:

Rule 1: You are playing The Game. You, along with everyone else in the world, always is, always has been, and always will be playing The Game. Neither awareness nor consent is required to play.

Rule 2: Every time you think about The Game, you lose. Loss is temporary; as soon as you forget about The Game you stop losing. The objective of The Game is to forget that it exists. Good luck.

Rule 3: Loss of The Game must be announced. Every time you think about The Game, and hence lose, you must say so. This is the only rule that can be broken, but do you really need to cheat..?

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