What is Big Think?  

We are Big Idea Hunters…

We live in a time of information abundance, which far too many of us see as information overload. With the sum total of human knowledge, past and present, at our fingertips, we’re faced with a crisis of attention: which ideas should we engage with, and why? Big Think is an evolving roadmap to the best thinking on the planet — the ideas that can help you think flexibly and act decisively in a multivariate world.

A word about Big Ideas and Themes — The architecture of Big Think

Big ideas are lenses for envisioning the future. Every article and video on bigthink.com and on our learning platforms is based on an emerging “big idea” that is significant, widely relevant, and actionable. We’re sifting the noise for the questions and insights that have the power to change all of our lives, for decades to come. For example, reverse-engineering is a big idea in that the concept is increasingly useful across multiple disciplines, from education to nanotechnology.

Themes are the seven broad umbrellas under which we organize the hundreds of big ideas that populate Big Think. They include New World Order, Earth and Beyond, 21st Century Living, Going Mental, Extreme Biology, Power and Influence, and Inventing the Future.

Big Think Features:

12,000+ Expert Videos

1

Browse videos featuring experts across a wide range of disciplines, from personal health to business leadership to neuroscience.

Watch videos

World Renowned Bloggers

2

Big Think’s contributors offer expert analysis of the big ideas behind the news.

Go to blogs

Big Think Edge

3

Big Think’s Edge learning platform for career mentorship and professional development provides engaging and actionable courses delivered by the people who are shaping our future.

Find out more
Close

Scientists Get Cancer Cells to Commit Suicide

February 9, 2013, 4:00 PM
Cat_scan_2

What's the Latest Development?

Scientists have found a special molecule that activates the body's own tumor killing system, causing the death of cancerous tissue in mice while preserving the integrity of healthy cells. "The molecule, TIC10, activates the gene for a protein called TRAIL (tumour-necrosis-factor-related apoptosis-inducing ligand), which has long been a target for cancer researchers looking for drugs that would avoid the debilitating effects of conventional therapies." Experiments showed that TIC10 had potent effects against a variety of tumours, including breast, lymphatic, colon and lung cancer.

What's the Big Idea?

The TIC10 molecule has been shown to be especially effective at triggering cell suicide in gliobastoma, a kind of brain tumor that is notoriously difficult to treat. By activating the TRAIL gene in cancerous and healthy cells, cell suicide is induced in cancer cells immediatly next to healthy ones. Wafik El-Deiry, an oncologist at Pennsylvania State University in Hershey and lead author of the study, said "TRAIL is a part of our immune system: all of us with functional immune systems use this molecule to keep tumours from forming or spreading, so boosting this will not be as toxic as chemotherapy."

Photo credit: Shutterstock.com

Read it at Nature

 

Scientists Get Cancer Cells...

Newsletter: Share: