What is Big Think?  

We are Big Idea Hunters…

We live in a time of information abundance, which far too many of us see as information overload. With the sum total of human knowledge, past and present, at our fingertips, we’re faced with a crisis of attention: which ideas should we engage with, and why? Big Think is an evolving roadmap to the best thinking on the planet — the ideas that can help you think flexibly and act decisively in a multivariate world.

A word about Big Ideas and Themes — The architecture of Big Think

Big ideas are lenses for envisioning the future. Every article and video on bigthink.com and on our learning platforms is based on an emerging “big idea” that is significant, widely relevant, and actionable. We’re sifting the noise for the questions and insights that have the power to change all of our lives, for decades to come. For example, reverse-engineering is a big idea in that the concept is increasingly useful across multiple disciplines, from education to nanotechnology.

Themes are the seven broad umbrellas under which we organize the hundreds of big ideas that populate Big Think. They include New World Order, Earth and Beyond, 21st Century Living, Going Mental, Extreme Biology, Power and Influence, and Inventing the Future.

Big Think Features:

12,000+ Expert Videos

1

Browse videos featuring experts across a wide range of disciplines, from personal health to business leadership to neuroscience.

Watch videos

World Renowned Bloggers

2

Big Think’s contributors offer expert analysis of the big ideas behind the news.

Go to blogs

Big Think Edge

3

Big Think’s Edge learning platform for career mentorship and professional development provides engaging and actionable courses delivered by the people who are shaping our future.

Find out more
Close

Newly Discovered Platform Supports Turning Pain Off

July 28, 2012, 12:00 PM
Brainpain

Article written by guest writer Rin Mitchell

What’s the Latest Development?

According to researchers at Johns Hopkins University, a mass of proteins called group 1 metabotropic glutamate receptors (mGluRs) live on the outer walls of nerve cells. “When these receptors lock in glutamate, a chemical that neurons use to communicate, it encourages neurons to fire.”  Scientists were looking for ways to turn off the receptors because if not, they would remain active and prolong the suffering. Previous studies indicated mGluRs binded with another protein called Homer could turn it off. During a series of experiments in mice, researchers were able to see what other proteins bonded with mGlurs and Homer, this turned up a third protein called Preso1, which attracts protein kinases. According to Scientists, all of these things combined "coordinate the activation and deactivation of the mGluRs." 

What’s the Big Idea?

Researchers have discovered the protein framework necessary to deactivate the mGluRs, which is the culprit for many neurological problems. Based on various tests conducted on mice, scientist were able to see how a group of proteins work together to suppress the effects of the active protein. According to neuroscience profession Paul Worley, MD of the Johns Hopkins University School of Medicine, "Because mGluRs play so many important roles in the brain for so many different mental and neurological health conditions, knowledge of their regulatory mechanisms is extremely important." 


 

Newly Discovered Platform S...

Newsletter: Share: