"It’s possible to get financing from top tier investors if you’re located outside Silicon Valley, New York or Boston, but if you land venture or angel investments from remote investors, expect to go back to investors often for more rounds of cash. A recent study by Indiana University finance professor Xuan Tian found that entrepreneurs who raised capital from investors located more than 25 miles away were forced to raise smaller amounts, with a shorter duration between each fundraising round, than those with nearby investors. ... 'We saw that visiting a company day to day made a real difference, and investors were willing to write bigger checks if they could do that,' [Tian] says."