Interview Transcript
Question: Is the Y chromosome prone to mutations?
Marianne Legato: The Y chromosome is definitely unique among all the chromosomes. Over most of its extent, it can’t exchange with its partner the X chromosome to repair its deficiencies or mutations in DNA. It’s learned to repair itself in an interesting and unique way. The issues with the Y chromosome are that they are exposed to environmental toxins because they are housed outside the body in the scrotal sack. Many millions are produced every day and, therefore, mutations are far more frequent in the Y chromosome than in the X or indeed in any of the other chromosomes. So the male drives evolutionary development because of this extraordinary proliferation of mutations that are characteristic of sperm and the Y chromosome.
The Helpless Y Chromosome
Professor of Clinical Medicine, Columbia University
The masculine chromosome is unique in its inability to repair itself, making it exceptionally prone to mutation and pollution.
November 30, 2009 | In Environment, Health & Medicine
Discuss
Add a Comment
You must be logged in to comment. Log in or Register