Women Are Taking Too Many Drugs
Judy Norsigian: Well in industrialized countries there is no question that the encroachment of the pharmaceutical industry and its marketing practices has deleteriously affected the kind of medical care we get and the decisions that consumers are making. Many countries don’t allow something we call DTC or direct to consumer advertising. The United States does and what has happened is that the pharmaceutical industry can directly market its products to consumers.
Until late 1990s the pharmaceutical industry could only market prescription drugs to healthcare workers, to physicians and then there was a relaxing of those rules and they could market their product directly to consumers creating this clamor for the latest brand name product, which might not even necessarily be better or safer than the existing product on the market.
What we see too is that because R&D is so expensive there are a whole bunch of me too drugs and that the pharmaceutical industry is largely engaged in producing drugs that will come on the market to deal with the fact that something is off patent. It’s going to be cheap because it will be generic, so we need something new and different. Maybe minisculely different from a previous drug and I think the story of Prilosec and Nexium is probably one of the best stories you can tell about a product that comes on the market really not any markedly different from the first product, but that can be sold at ten times the cost of the first product, sometimes more. Then you’ve got the issue of whether or not you control pharmaceutical pricing. That is a huge problem in terms of access to medicines that we do need access to and in many countries there are government controls over pharmaceutical pricing, but in the United States the drug industry’s lobby has been so powerful that we don’t see those same controls over drug company pricing. We’ve had some efforts. The VA Administration of course is one place where we’re able to see some measure of control over the pricing of drugs and the VA system actually is one of the best systems that functions in our country today.
Question: How can women decipher the drug information they're getting?
Judy Norsigian: All of our materials emphasize for women the fact that commercial interests are producing much of the written material, the electronic material, the TV shows that they see now, that they can’t assume that they’re getting unbiased, uncompromised information, that conflicts of interest exist everywhere. So we say learn the source of your information. Is it a drug company producing the material? Sometimes it’s actually not bad information, but very often it is all about minimizing the harms, the risks and maximizing the benefits and exaggerating the benefits, so you have to look deeper beyond the sort of 20 second bullet points you see. Even physicians are inappropriately influenced by pharmaceutical advertising and educational programming, so you can’t always depend on your physician. One excellent example is the overuse of statin drugs in women for primary prevention of heart attacks, things like that that for secondary prevention we have very good studies that show benefit for women, but not for primary prevention, so now women who simply have an elevated cholesterol level, no other problems are told to go on statin drugs when in fact in many cases they stand to be hurt more than helped. Getting at the kind of data that evidence based folks have produced, those without conflicts of interest, these are physicians and researchers whom we try to work closely with, getting at that information is often hard because it doesn’t make it onto television. It is certainly in the medical literature, but there is no PR company getting that out to you, the public, so we are a voice for those sources of uncompromised information. We make sure it is in lay language and we get it out at our website, through our blog. We have a very popular blog, Our Bodies, Our Blog that many women read every day and we send our readers and our listeners to these other sources of more dependable information where there aren’t conflicts of interest and that is something every single woman has to think about and be concerned about is where is the conflict of interest here, am I getting information that is truly not tainted by commercial interest.
Another excellent example of where we saw this was in the recent new mammography guidelines produced by the US Preventive Services Taskforce. These are excellent guidelines. Those who have a lot to lose if women under 50 don’t get routine mammograms or if women over 50 do it maybe a little less frequently based upon their profile they have a lot to lose. Those are the ones critiquing this, not the evidence based folks. Those without conflicts of interest and there are many of them out there, have reviewed what the Preventive Services Taskforce has produced and certainly our experts, those for the National Women’s Health Network and several other wonderful organizations have to bat and said, “These are excellent guidelines.” “We should be following them.” It’s not about denying women care. And by the way, everyone should understand that mammography is a relatively weak tool for screening. We need better tools in the area of breast cancer. It’s not like pap tests where we have an excellent screening tool for cervical cancer. We’re not doing so well in the area of breast cancer, so there is an area where you would have seen the American Cancer Society. You would have seen some prominent folks in breast cancer treatment and people who have interests, in some cases in the equipment, the mammography equipment that is being sold. They have financial interest in it, so of course they don’t want to see the business go down. These are things the public doesn’t see very easily.
How women should think about their role in a society where prescriptions are everywhere.
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Every star we can see, including our sun, was born in one of these violent clouds.
This article was originally published on our sister site, Freethink.
An international team of astronomers has conducted the biggest survey of stellar nurseries to date, charting more than 100,000 star-birthing regions across our corner of the universe.
Stellar nurseries: Outer space is filled with clouds of dust and gas called nebulae. In some of these nebulae, gravity will pull the dust and gas into clumps that eventually get so big, they collapse on themselves — and a star is born.
These star-birthing nebulae are known as stellar nurseries.
The challenge: Stars are a key part of the universe — they lead to the formation of planets and produce the elements needed to create life as we know it. A better understanding of stars, then, means a better understanding of the universe — but there's still a lot we don't know about star formation.
This is partly because it's hard to see what's going on in stellar nurseries — the clouds of dust obscure optical telescopes' view — and also because there are just so many of them that it's hard to know what the average nursery is like.
The survey: The astronomers conducted their survey of stellar nurseries using the massive ALMA telescope array in Chile. Because ALMA is a radio telescope, it captures the radio waves emanating from celestial objects, rather than the light.
"The new thing ... is that we can use ALMA to take pictures of many galaxies, and these pictures are as sharp and detailed as those taken by optical telescopes," Jiayi Sun, an Ohio State University (OSU) researcher, said in a press release.
"This just hasn't been possible before."
Over the course of the five-year survey, the group was able to chart more than 100,000 stellar nurseries across more than 90 nearby galaxies, expanding the amount of available data on the celestial objects tenfold, according to OSU researcher Adam Leroy.
New insights: The survey is already yielding new insights into stellar nurseries, including the fact that they appear to be more diverse than previously thought.
"For a long time, conventional wisdom among astronomers was that all stellar nurseries looked more or less the same," Sun said. "But with this survey we can see that this is really not the case."
"While there are some similarities, the nature and appearance of these nurseries change within and among galaxies," he continued, "just like cities or trees may vary in important ways as you go from place to place across the world."
Astronomers have also learned from the survey that stellar nurseries aren't particularly efficient at producing stars and tend to live for only 10 to 30 million years, which isn't very long on a universal scale.
Looking ahead: Data from the survey is now publicly available, so expect to see other researchers using it to make their own observations about stellar nurseries in the future.
"We have an incredible dataset here that will continue to be useful," Leroy said. "This is really a new view of galaxies and we expect to be learning from it for years to come."
Tiny specks of space debris can move faster than bullets and cause way more damage. Cleaning it up is imperative.
- NASA estimates that more than 500,000 pieces of space trash larger than a marble are currently in orbit. Estimates exceed 128 million pieces when factoring in smaller pieces from collisions. At 17,500 MPH, even a paint chip can cause serious damage.
- To prevent this untrackable space debris from taking out satellites and putting astronauts in danger, scientists have been working on ways to retrieve large objects before they collide and create more problems.
- The team at Clearspace, in collaboration with the European Space Agency, is on a mission to capture one such object using an autonomous spacecraft with claw-like arms. It's an expensive and very tricky mission, but one that could have a major impact on the future of space exploration.
This is the first episode of Just Might Work, an original series by Freethink, focused on surprising solutions to our biggest problems.
Catch more Just Might Work episodes on their channel: https://www.freethink.com/shows/just-might-work
The finding is remarkably similar to the Dunning-Kruger effect, which describes how incompetent people tend to overestimate their own competency.
- Recent studies asked participants to rate the attractiveness of themselves and other participants, who were strangers.
- The studies kept yielding the same finding: unattractive people overestimate their attractiveness, while attractive people underrate their looks.
- Why this happens is unclear, but it doesn't seem to be due to a general inability to judge attractiveness.
There's no shortage of disparities between attractive and unattractive people. Studies show that the best-looking among us tend to have an easier time making money, receiving help, avoiding punishment, and being perceived as competent. (Sure, research also suggests beautiful people have shorter relationships, but they also have more sexual partners, and more options for romantic relationships. So call it a wash.)
Now, new research reveals another disparity: Unattractive people seem less able to accurately judge their own attractiveness, and they tend to overestimate their looks. In contrast, beautiful people tend to rate themselves more accurately. If anything, they underestimate their attractiveness.
The research, published in the Scandinavian Journal of Psychology, involved six studies that asked participants to rate the attractiveness of themselves and other participants, who were strangers. The studies also asked participants to predict how others might rate them.
In the first study, lead author Tobias Greitemeyer found that the participants who were most likely to overestimate their attractiveness were among the least attractive people in the study, based on average ratings.
Ratings of subjective attractiveness as a function of the participant's objective attractiveness (Study 1)
"Overall, unattractive participants judged themselves to be of about average attractiveness and they showed very little awareness that strangers do not share this view. In contrast, attractive participants had more insights into how attractive they actually are. [...] It thus appears that unattractive people maintain illusory self‐perceptions of their attractiveness, whereas attractive people's self‐views are more grounded in reality."
Why do unattractive people overestimate their attractiveness? Could it be because they want to maintain a positive self-image, so they delude themselves? After all, previous research has shown that people tend to discredit or "forget" negative social feedback, which seems to help protect a sense of self-worth.
To find out, Greitemeyer conducted a study that aimed to put participants in a positive, non-defensive mindset before rating attractiveness. He did that by asking participants questions that affirmed parts of their personality that had nothing to do with physical appearance, such as: "Have you ever been generous and selfless to another person?" Yet, this didn't change how participants rated themselves, suggesting that unattractive people aren't overestimating their looks out of defensiveness.
The studies kept yielding the same finding: unattractive people overestimate their attractiveness. Does that bias sound familiar? If so, you might be thinking of the Dunning-Kruger effect, which describes how incompetent people tend to overestimate their own competency. Why? Because they lack the metacognitive skills needed to discern their own shortcomings.
Greitemeyer found that unattractive people were worse at differentiating between attractive and unattractive people. But the finding that unattractive people may have different beauty ideals (or, more plainly, weaker ability to judge attractiveness) did "not have an impact on how they perceive themselves."
In short, it remains a mystery exactly why unattractive people overestimate their looks. Greitemeyer concluded that, while most people are decent at judging the attractiveness of others, "it appears that those who are unattractive do not know that they are unattractive."
Unattractive people aren't completely unaware
The results of one study suggested that unattractive people aren't completely in the dark about their looks. In the study, unattractive people were shown a set of photos of highly attractive and unattractive people, and they were asked to select photos of people with comparable attractiveness. Most unattractive people chose to compare themselves with similarly unattractive people.
"The finding that unattractive participants selected unattractive stimulus persons with whom they would compare their attractiveness to suggests that they may have an inkling that they are less attractive than they want it to be," Greitemeyer wrote.
Metal-like materials have been discovered in a very strange place.
- Bristle worms are odd-looking, spiky, segmented worms with super-strong jaws.
- Researchers have discovered that the jaws contain metal.
- It appears that biological processes could one day be used to manufacture metals.
The bristle worm, also known as polychaetes, has been around for an estimated 500 million years. Scientists believe that the super-resilient species has survived five mass extinctions, and there are some 10,000 species of them.
Be glad if you haven't encountered a bristle worm. Getting stung by one is an extremely itchy affair, as people who own saltwater aquariums can tell you after they've accidentally touched a bristle worm that hitchhiked into a tank aboard a live rock.
Bristle worms are typically one to six inches long when found in a tank, but capable of growing up to 24 inches long. All polychaetes have a segmented body, with each segment possessing a pair of legs, or parapodia, with tiny bristles. ("Polychaeate" is Greek for "much hair.") The parapodia and its bristles can shoot outward to snag prey, which is then transferred to a bristle worm's eversible mouth.
The jaws of one bristle worm — Platynereis dumerilii — are super-tough, virtually unbreakable. It turns out, according to a new study from researchers at the Technical University of Vienna, this strength is due to metal atoms.
Metals, not minerals
Fireworm, a type of bristle wormCredit: prilfish / Flickr
This is pretty unusual. The study's senior author Christian Hellmich explains: "The materials that vertebrates are made of are well researched. Bones, for example, are very hierarchically structured: There are organic and mineral parts, tiny structures are combined to form larger structures, which in turn form even larger structures."
The bristle worm jaw, by contrast, replaces the minerals from which other creatures' bones are built with atoms of magnesium and zinc arranged in a super-strong structure. It's this structure that is key. "On its own," he says, "the fact that there are metal atoms in the bristle worm jaw does not explain its excellent material properties."
Just deformable enough
Credit: by-studio / Adobe Stock
What makes conventional metal so strong is not just its atoms but the interactions between the atoms and the ways in which they slide against each other. The sliding allows for a small amount of elastoplastic deformation when pressure is applied, endowing metals with just enough malleability not to break, crack, or shatter.
Co-author Florian Raible of Max Perutz Labs surmises, "The construction principle that has made bristle worm jaws so successful apparently originated about 500 million years ago."
Raible explains, "The metal ions are incorporated directly into the protein chains and then ensure that different protein chains are held together." This leads to the creation of three-dimensional shapes the bristle worm can pack together into a structure that's just malleable enough to withstand a significant amount of force.
"It is precisely this combination," says the study's lead author Luis Zelaya-Lainez, "of high strength and deformability that is normally characteristic of metals.
So the bristle worm jaw is both metal-like and yet not. As Zelaya-Lainez puts it, "Here we are dealing with a completely different material, but interestingly, the metal atoms still provide strength and deformability there, just like in a piece of metal."
Observing the creation of a metal-like material from biological processes is a bit of a surprise and may suggest new approaches to materials development. "Biology could serve as inspiration here," says Hellmich, "for completely new kinds of materials. Perhaps it is even possible to produce high-performance materials in a biological way — much more efficiently and environmentally friendly than we manage today."