A Radical Theory of Autism
V.S. Ramachandran is a neurologist best known for his work in the fields of behavioral neurology and psychophysics. He is currently the Director of the Center for Brain and Cognition at the University of California, San Diego. He is also the author of several books including "Phantoms in the Brain: Probing the Mysteries of the Human Mind" (1998) and "The Tell-Tale Brain: A Neuroscientists Quest for What Makes Us Human" (2010).
Ramachandran initially obtained an M.D. at Stanley Medical College in Madras, India, and subsequently obtained a Ph.D. from Trinity College at the University of Cambridge. He has since been called “The Marco Polo of neuroscience” by Richard Dawkins and "the modern Paul Broca" by Eric Kandel. Newsweek magazine named him a member of "The Century Club", one of the "hundred most prominent people to watch" in the 21st century.
V.S. Ramachandran: Children with autism, they are lacking in empathy, emotional empathy, which enormously involve mirror neurons. They are unable to adopt somebody else’s point of view on a conceptual level, possible even on a perceptual level. And is also something that you ascribe, this function to mirror neurons, that’s missing in autism are impoverished in autism. So there's lack of emotional empathy.
There’s also a lack of pretend play. Pretend play by definition in normal children or non-autistic children, requires that you put yourself in the shoes of that doll or that action figure. Pretend you are Superman. Suspend reality for a short while and pretend you are Superman. This autistic children are incapable of doing is undoubtedly one of the functions of mirror neurons. You need to tap into the mirror neurons in order to put yourself in the shoes of the action figure.
And also, sophisticated imitation, which is missing in many autistic children, is another function of mirror neurons. Impoverished language is something that you see in autistic children.
So if you make a list of all the properties, emotional empathy, theory of other minds, imitation, pretend play and you look at all those functions of mirror neurons and make a tabular column of the functions that are deficient in autism, there’s almost a perfect fit. This is what led us to suggest over 10 years ago, or maybe about 10 years ago, that mirror neuron dysfunction might be the basis of autism, it might be one of the major causes of autism.
Now there are several groups which have shown this to be true doing brain imaging, but there’s one group who claims they don’t see a mirror neuron deficit. So what I’m arguing is—this is highly speculative at this point, I would say there are evidence that is suggestive, but not compelling or persuasive, but not compelling. So, we will have to wait and see.
Big Think: If this turns out to be the case, how will it impact the way autism is treated?
V.S. Ramachandran: The question is, is the mirror neuron system completely deranged or is there less than residual activity still there. And I suspect there is some residual activity. Can you tap into that activity using biofeedback? You know, there are EEG signals associated with mirror neurons and mirror neuron deficiency. So can the patient be taught to enhance by watching the computer screen and by using biofeedback, enhance the EEG signal, thereby indirectly recruiting more neurons and enhancing the activity of the mirror neurons? This is still very experimental, but people are trying it.
The other possibility is mirror neuron systems may have specific transmitters associated with them. It wouldn’t be surprising, for example, for we all know that “E” enhances… Ecstasy enhances empathy. It’s quite possible it is acting through the mirror neuron system. Especially parts of the mirror neuron system that are in the insular cortex and parts of the mirror neuron system that are concerned with the emotional empathy. Maybe if you knew what transmitters were involved you can engineer drugs that tap into that and enhance activity in the mirror neuron system.
Another way is to do exercises by synchronized dancing, like the Rockettes using multiple mirror reflections to enhance activity in mirror neurons. All of this is hypothetical and purely speculative, unlikely to work, but worth trying.
Mirror neurons, the cells in the brain that fire when watching others do actions, might be deficient in people with autism. Perhaps, drugs like ecstasy that enhance empathy, could be used to treat this deficiency.
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What is human dignity? Here's a primer, told through 200 years of great essays, lectures, and novels.
- Human dignity means that each of our lives have an unimpeachable value simply because we are human, and therefore we are deserving of a baseline level of respect.
- That baseline requires more than the absence of violence, discrimination, and authoritarianism. It means giving individuals the freedom to pursue their own happiness and purpose.
- We look at incredible writings from the last 200 years that illustrate the push for human dignity in regards to slavery, equality, communism, free speech and education.
The inherent worth of all human beings<p>Human dignity is the inherent worth of each individual human being. Recognizing human dignity means respecting human beings' special value—value that sets us apart from other animals; value that is intrinsic and cannot be lost.</p> <p>Liberalism—the broad political philosophy that organizes society around liberty, justice, and equality—is rooted in the idea of human dignity. Liberalism assumes each of our lives, plans, and preferences have some unimpeachable value, not because of any objective evaluation or contribution to a greater good, but simply because they belong to a human being. We are human, and therefore deserving of a baseline level of respect. </p> <p>Because so many of us take human dignity for granted—just a fact of our humanness—it's usually only when someone's dignity is ignored or violated that we feel compelled to talk about it. </p> <p>But human dignity means more than the absence of violence, discrimination, and authoritarianism. It means giving individuals the freedom to pursue their own happiness and purpose—a freedom that can be hampered by restrictive social institutions or the tyranny of the majority. The liberal ideal of the good society is not just peaceful but also pluralistic: It is a society in which we respect others' right to think and live differently than we do.</p>
From the 19th century to today<p>With <a href="https://books.google.com/ngrams/graph?year_start=1800&year_end=2019&content=human+dignity&corpus=26&smoothing=3&direct_url=t1%3B%2Chuman%20dignity%3B%2Cc0" target="_blank" rel="noopener noreferrer">Google Books Ngram Viewer</a>, we can chart mentions of human dignity from 1800-2019.</p><img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDg0ODU0My9vcmlnaW4ucG5nIiwiZXhwaXJlc19hdCI6MTY1MTUwMzE4MX0.bu0D_0uQuyNLyJjfRESNhu7twkJ5nxu8pQtfa1w3hZs/img.png?width=980" id="7ef38" class="rm-shortcode" data-rm-shortcode-id="9974c7bef3812fcb36858f325889e3c6" data-rm-shortcode-name="rebelmouse-image" />
American novelist, writer, playwright, poet, essayist and civil rights activist James Baldwin at his home in Saint-Paul-de-Vence, southern France, on November 6, 1979.
Credit: Ralph Gatti/AFP via Getty Images
The future of dignity<p>Around the world, people are still working toward the full and equal recognition of human dignity. Every year, new speeches and writings help us understand what dignity is—not only what it looks like when dignity is violated but also what it looks like when dignity is honored. In his posthumous essay, Congressman Lewis wrote, "When historians pick up their pens to write the story of the 21st century, let them say that it was your generation who laid down the heavy burdens of hate at last and that peace finally triumphed over violence, aggression and war."</p> <p>The more we talk about human dignity, the better we understand it. And the sooner we can make progress toward a shared vision of peace, freedom, and mutual respect for all. </p>
Researchers dramatically improve the accuracy of a number that connects fundamental forces.
- A team of physicists carried out experiments to determine the precise value of the fine-structure constant.
- This pure number describes the strength of the electromagnetic forces between elementary particles.
- The scientists improved the accuracy of this measurement by 2.5 times.
The process for measuring the fine-structure constant involved a beam of light from a laser that caused an atom to recoil. The red and blue colors indicate the light wave's peaks and troughs, respectively.
Scientists at Washington University are patenting a new electrolyzer designed for frigid Martian water.
- Mars explorers will need more oxygen and hydrogen than they can carry to the Red Planet.
- Martian water may be able to provide these elements, but it is extremely salty water.
- The new method can pull oxygen and hydrogen for breathing and fuel from Martian brine.
The WashU electrolyzer<iframe src='https://mars.nasa.gov/layout/embed/model/?s=6' width='800' height='450' scrolling='no' frameborder='0' allowfullscreen></iframe><p>The WashU electrolyzer—it has no snappy acronym yet—will not be the first device capable of extracting oxygen from Martian water. That honor goes to the Mars Oxygen In-Situ Resource Utilization Experiment, or <a href="https://mars.nasa.gov/mars2020/spacecraft/instruments/moxie/" target="_blank">MOXIE</a>, which is en route to Mars onboard NASA's <a href="https://mars.nasa.gov/mars2020/" target="_blank">Perseverance</a> rover. The rover was launched on July 30, 2020. It will arrive on February 18, 2021, and will perform high-temperature <a href="https://en.wikipedia.org/wiki/Electrolysis_of_water" target="_blank">electrolysis</a> to extract pure oxygen, but no hydrogen.</p><p>In addition to being able to capture hydrogen, the WashU system can even do a better job with oxygen than MOXIE can, extracting 25 times as much from the same amount of water.</p><p>The new system has no problem with Mars' magnesium perchlorate-laced water. On the contrary, the researchers say it ultimately makes their system work better since such high concentrations of salt keep water from freezing on such a cold a planet by lowering the liquid's freezing temperature to -60 °C. He adds it may "also improve the performance of the electrolyzer system by lowering the electrical resistance."</p><p>Cold itself is no issue for the WashU system. It's been tested in a sub-zero (-33 ⁰F, or -36 ⁰C) environment that simulates Mars'.</p><p>"Our novel brine electrolyzer incorporates a lead <a href="https://www.sciencedirect.com/science/article/abs/pii/S0926337318311299" target="_blank">ruthenate pyrochlore</a> <a href="https://en.wikipedia.org/wiki/Anode" target="_blank" rel="noopener noreferrer">anode</a> developed by our team in conjunction with a platinum on carbon <a href="https://en.wikipedia.org/wiki/Cathode" target="_blank">cathode</a>," explains Ramani. He adds, "These carefully designed components coupled with the optimal use of traditional electrochemical engineering principles has yielded this high performance."</p>
Back home<p>"This technology is equally useful on Earth where it opens up the oceans as a viable oxygen and fuel source," Ramani notes. His colleagues forsee potential applications such as producing oxygen in deep-sea habitats with ample water available, such as underwater research facilities and submarines.</p><p>The study's joint first author Pralay Gayen says that "having demonstrated these electrolyzers under demanding Martian conditions, we intend to also deploy them under much milder conditions on Earth to utilize brackish or salt water feeds to produce hydrogen and oxygen, for example, through seawater electrolysis."</p>
Scientists find that bursts of gamma rays may exceed the speed of light and cause time-reversibility.
- Astrophysicists propose that gamma-ray bursts may exceed the speed of light.
- The superluminal jets may also be responsible for time-reversibility.
- The finding doesn't go against Einstein's theory because this effect happens in the jet medium not a vacuum.
Jet bursting out of a blazar. Black-hole-powered galaxies called blazars are the most common sources detected by NASA's Fermi Gamma-ray Space Telescope.
Cosmic death beams: Understanding gamma ray bursts<div class="rm-shortcode" data-media_id="cu2knVEk" data-player_id="FvQKszTI" data-rm-shortcode-id="c6cfd20fdf31c82cb206ade8ce21ba3f"> <div id="botr_cu2knVEk_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/cu2knVEk-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/cu2knVEk-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/cu2knVEk-FvQKszTI.js"></script> </div>
Pfizer's vaccine needs to be kept at -100°F until it's administered. Can caregivers deliver?
- Fair distribution of the Moderna and Pfizer vaccines is especially challenging because they need to be stored at extremely cold temperatures.
- Back in 2018, the WHO reported that over half of all vaccines are wasted worldwide due to lack of cold storage, and they were only talking about vaccines that need to be chilled or kept at standard freezer temperatures.
- Real-time logistics data, location tracking, and information about movements are crucial to track shipment progress, product temperature and other conditions.