Today, Jim Allison is a name to be reckoned with throughout the scientific world — a 2018 Nobel Prize winner for discovering the immune system’s role in defeating cancer — but for decades he waged a lonely struggle against the skepticism of the medical establishment and the resistance of Big Pharma. Jim Allison: Breakthrough takes us into the inspiring and dramatic world of cutting-edge medicine, and into the heart of a true American pioneer, in a film that is both emotionally compelling and deeply entertaining.