This Week in Comments: November 12th—November 19th, 2017

Wow. Such comments. Much deep pondering. Witty banter and great points abounded this week. Did you make the cut? 

Another week, another sparkling selection of witticisms and bon mots from the Facebook audience. Pour another glass of brandy and sit by the fire and hunker down with this week's selection of comments. 


Why Panpsychism Fails to Solve the Mystery of Consciousness

Beverly HoschI don’t have the brain power to completely understand this. However humans are not the only conscious beings. Dogs, cats etc. display consciousness as well. In fact, I Wonder about ants, bees, and termites, and if they have a group consciousness. Electrons display particle behavior and wave behavior. We also can never know their position at a given time. Perhaps our pursuit of an explanation for consciousness must be done on an energy level as well as particulate. Am I way off base?

Andrew MerrittDepends on how one defines consciousness I suspect. After all one could argue that even a single cell has some level of consciousness as it interacts with it's environment.

 

North Korea Is Only a Threat if the U.S. Keeps Provoking Kim Jong-un

Arber KukajNorth Korea makes empty threats, on the other hand, the U.S actually enforces a rigid embargo on North Korea that ruins the lives of citizens in North Korea. If you want to talk about aggression, look no further than home.

The Universe’s Missing Atoms Have Finally Been Found, Scientists Announce

Chris Ryan: I was looking all over for them. 
 

Ronald Harder: They were behind the couch with the remote control, weren't they?

Does Quantum Physics Confirm The Occult?

David R. PhilpotThe question of whether physics confirms the occult is nonsensical in the same way that asking if an art book can confirm the laws of thermodynamics. Science cannot confirm or deny anything about a supernatural realm or how that realm operates because it deals with observable phenomenon in the natural world. If some event cannot be understood through natural processes after being studied by scientists then the only rational conclusion that can be reached is that we cannot identify the mechanism that caused the phenomenon, not that a supernatural agent was the cause. Scientific discovery is always tentative and subject to change when better evidence becomes available.

 

Could Your Favorite Stories Permanently Change Your Brain?

Eddie Duncan: I'll never understand why the religious always need to find a way to justify their own faith? And why does that justification always come in the form of finding fault in persons outside of their belief system? Have these people not read their own "sacred" text? And I mean in whole (front to back), not in part (a verse here or there).

 

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University of Cambridge
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Yale scientists restore brain function to 32 clinically dead pigs

Researchers hope the technology will further our understanding of the brain, but lawmakers may not be ready for the ethical challenges.

Still from John Stephenson's 1999 rendition of Animal Farm.
Surprising Science
  • Researchers at the Yale School of Medicine successfully restored some functions to pig brains that had been dead for hours.
  • They hope the technology will advance our understanding of the brain, potentially developing new treatments for debilitating diseases and disorders.
  • The research raises many ethical questions and puts to the test our current understanding of death.

The image of an undead brain coming back to live again is the stuff of science fiction. Not just any science fiction, specifically B-grade sci fi. What instantly springs to mind is the black-and-white horrors of films like Fiend Without a Face. Bad acting. Plastic monstrosities. Visible strings. And a spinal cord that, for some reason, is also a tentacle?

But like any good science fiction, it's only a matter of time before some manner of it seeps into our reality. This week's Nature published the findings of researchers who managed to restore function to pigs' brains that were clinically dead. At least, what we once thought of as dead.

What's dead may never die, it seems

The researchers did not hail from House Greyjoy — "What is dead may never die" — but came largely from the Yale School of Medicine. They connected 32 pig brains to a system called BrainEx. BrainEx is an artificial perfusion system — that is, a system that takes over the functions normally regulated by the organ. The pigs had been killed four hours earlier at a U.S. Department of Agriculture slaughterhouse; their brains completely removed from the skulls.

BrainEx pumped an experiment solution into the brain that essentially mimic blood flow. It brought oxygen and nutrients to the tissues, giving brain cells the resources to begin many normal functions. The cells began consuming and metabolizing sugars. The brains' immune systems kicked in. Neuron samples could carry an electrical signal. Some brain cells even responded to drugs.

The researchers have managed to keep some brains alive for up to 36 hours, and currently do not know if BrainEx can have sustained the brains longer. "It is conceivable we are just preventing the inevitable, and the brain won't be able to recover," said Nenad Sestan, Yale neuroscientist and the lead researcher.

As a control, other brains received either a fake solution or no solution at all. None revived brain activity and deteriorated as normal.

The researchers hope the technology can enhance our ability to study the brain and its cellular functions. One of the main avenues of such studies would be brain disorders and diseases. This could point the way to developing new of treatments for the likes of brain injuries, Alzheimer's, Huntington's, and neurodegenerative conditions.

"This is an extraordinary and very promising breakthrough for neuroscience. It immediately offers a much better model for studying the human brain, which is extraordinarily important, given the vast amount of human suffering from diseases of the mind [and] brain," Nita Farahany, the bioethicists at the Duke University School of Law who wrote the study's commentary, told National Geographic.

An ethical gray matter

Before anyone gets an Island of Dr. Moreau vibe, it's worth noting that the brains did not approach neural activity anywhere near consciousness.

The BrainEx solution contained chemicals that prevented neurons from firing. To be extra cautious, the researchers also monitored the brains for any such activity and were prepared to administer an anesthetic should they have seen signs of consciousness.

Even so, the research signals a massive debate to come regarding medical ethics and our definition of death.

Most countries define death, clinically speaking, as the irreversible loss of brain or circulatory function. This definition was already at odds with some folk- and value-centric understandings, but where do we go if it becomes possible to reverse clinical death with artificial perfusion?

"This is wild," Jonathan Moreno, a bioethicist at the University of Pennsylvania, told the New York Times. "If ever there was an issue that merited big public deliberation on the ethics of science and medicine, this is one."

One possible consequence involves organ donations. Some European countries require emergency responders to use a process that preserves organs when they cannot resuscitate a person. They continue to pump blood throughout the body, but use a "thoracic aortic occlusion balloon" to prevent that blood from reaching the brain.

The system is already controversial because it raises concerns about what caused the patient's death. But what happens when brain death becomes readily reversible? Stuart Younger, a bioethicist at Case Western Reserve University, told Nature that if BrainEx were to become widely available, it could shrink the pool of eligible donors.

"There's a potential conflict here between the interests of potential donors — who might not even be donors — and people who are waiting for organs," he said.

It will be a while before such experiments go anywhere near human subjects. A more immediate ethical question relates to how such experiments harm animal subjects.

Ethical review boards evaluate research protocols and can reject any that causes undue pain, suffering, or distress. Since dead animals feel no pain, suffer no trauma, they are typically approved as subjects. But how do such boards make a judgement regarding the suffering of a "cellularly active" brain? The distress of a partially alive brain?

The dilemma is unprecedented.

Setting new boundaries

Another science fiction story that comes to mind when discussing this story is, of course, Frankenstein. As Farahany told National Geographic: "It is definitely has [sic] a good science-fiction element to it, and it is restoring cellular function where we previously thought impossible. But to have Frankenstein, you need some degree of consciousness, some 'there' there. [The researchers] did not recover any form of consciousness in this study, and it is still unclear if we ever could. But we are one step closer to that possibility."

She's right. The researchers undertook their research for the betterment of humanity, and we may one day reap some unimaginable medical benefits from it. The ethical questions, however, remain as unsettling as the stories they remind us of.

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