from the world's big
New bandages turn color to identify an infected wound
Smart bandages quickly identify antibiotic-resistant bacteria, and normal bacteria, in owies.
- Judicious use of drugs for resistant bacteria requires time- and money-consuming tests until now.
- New smart bandages turn red for resistant bacteria and yellow for antibiotic-sensitive bacteria.
- The bandages also promote healing with the application of UV light.
The growing incidence of antibiotic-resistant bacteria was already a worrying problem before we all started washing our hands with anti-bacterial soaps in response to SARS-CoV-2. While necessary, we may also have provided even more bacteria the opportunity to develop resistance. Such uncooperative bacteria can often be treated, but before they can, they have to first be identified as antibiotic-resistant — each time the precious meds capable of defeating such bacteria are deployed, we risk bacteria developing resistance to them. This would obviously render them useless, and so they're administered only sparingly to bacteria that have tested as resistant. This testing takes time, and can be expensive.
Researchers at the Chinese Academy of Sciences, Changchun, Jilin province have a better idea: smart bandages that change color to indicate the nature of bacteria they cover. The study describing their research his published in ACS Central Science.
The idea behind the bandages
Image source: Alex Kondratiev/Unsplash
The smart coverings work by leveraging the chemistry of bacterial infections. Integrated into each covering is a metal organic framework (MOF), a structure that allows scientists to embed a few key chemicals in the bandages.
The bandages contain a chemical called nitrocefin that breaks down in the presence of the enzyme β-lactamase — β-lactamase is the enzyme that resistant bacteria produce and use to neutralize antibiotics. It's essentially the chemical source of antibiotic resistance. When the nitrocefin interacts with β-lactamase, it breaks down and turns red — as does the bandage— signifying the presence of an antibiotic-resistant bacteria.
For detecting normal, antibiotic-sensitive bacteria, the bandages leverage the fact that a bacterial infection on your skin causes a reduction in its pH, making the skin more acidic. Each smart bandage contains a chemical called bromophenol blue, and when it encounters a more acidic environment, it turns yellow. Thus, when a smart bandage turns yellow, it's telling you that bacteria is present, but that it's antibiotic-sensitive.
If there's no infection, the covering remains its original green color.
Tests and cures
Image source: Khamkhlai Thanet/Shutterstock
The bandages have so far been tested on mice who were infected with one of two different strains of E. Coli bacteria, one antibiotic-sensitive, and one antibiotic-resistant. The smart coverings over the mice's wounds behaved as designed, turning the hoped-for colors over the course of a day or two. After some tweaking, that time — and the identification of bacteria — was reduced to just 2-4 hours.
An additional feature is that the design of their MOF causes UV light shined on them to produce reactive oxygen species (ROS) that puncture the protective membranes surrounding the bacterial cells. This restores their susceptibility to standard antibiotics, meaning that the bandages are both diagnostic and curative.
Given the construction simplicity of the bandages, the researchers are hopeful that they can be easily manufactured at scale to join the fight against antibiotic-resistant bacteria, which is currently credited with 700,000 deaths annually.
Being able to quickly identify resistant bacteria can help prolong the effectiveness of available treatments. As the study puts it, "Because of the "auto-obsolescence" of antibacterial treatments, it is an important issue in the current antibacterial field how to rationally use of existing antibiotics and overcome tolerance."
Innovation in manufacturing has crawled since the 1950s. That's about to speed up.
Here's why you might eat greenhouse gases in the future.
- The company's protein powder, "Solein," is similar in form and taste to wheat flour.
- Based on a concept developed by NASA, the product has wide potential as a carbon-neutral source of protein.
- The man-made "meat" industry just got even more interesting.
Seriously sustainable<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8xOTk0MDIzNS9vcmlnaW4ucG5nIiwiZXhwaXJlc19hdCI6MTYyMjM4NTMzMX0.BCEfYnn6C3z1zUHIS38xOWjXktgamNBi5iyqklSMYK8/img.png?width=980" id="ea524" class="rm-shortcode" data-rm-shortcode-id="50533380eeb18eb5833b6b6aa3abec38" data-rm-shortcode-name="rebelmouse-image" />
Image source: Solar Foods<p>Solar Foods makes Solein by extracting CO₂ from air using <a href="https://www.fastcompany.com/90356326/we-have-the-tech-to-suck-co2-from-the-air-but-can-it-suck-enough-to-make-a-difference" target="_blank">carbon-capture technology</a>, and then combines it with water, nutrients and vitamins, using 100 percent renewable solar energy from partner <a href="https://www.fortum.com" target="_blank">Fortum</a> to promote a natural fermentation process similar to the one that produces yeast and lactic acid bacteria.</p><p>When the company claims its single-celled protein is "free from agricultural limitations," they're not kidding. Being produced indoors means Solar Foods is not dependent on arable land, water (i.e., rain), or favorable weather.</p><p>The company is already working with the European Space Agency to develop foods for off-planet production and consumption. (The idea for Solein actually began at NASA.) They also see potential in bringing protein production to areas whose climate or ground conditions make conventional agriculture impossible.</p><p>And let's not forget all those <a href="https://www.bk.com/menu-item/impossible-whopper" target="_blank">beef-free burgers</a> based on pea and soy proteins currently gaining popularity. The environmental challenge of scaling up the supply of those plants to meet their high demand may provide an opening for the completely renewable Solein — the company could provide companies that produce animal-free "meats," such as <a href="https://www.beyondmeat.com/products/" target="_blank">Beyond Meat</a> and <a href="https://impossiblefoods.com" target="_blank">Impossible Foods</a>, a way to further reduce their environmental impact.</p>
The larger promise<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8xOTk0MDI0MS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY1NjU4MTg2OX0.7dZZYT5WEV_EupBuLVFwHynarTiz8RYR9aJtC6Ts2C4/img.jpg?width=980" id="3415d" class="rm-shortcode" data-rm-shortcode-id="2e6eebe06d795f844752f9e9d30040d7" data-rm-shortcode-name="rebelmouse-image" />
Image source: Solar Foods<p>The impact of the beef — and for that matter, poultry, pork, and fish — industries on our planet is widely recognized as one of the main drivers behind climate change, pollution, habitat loss, and antibiotic-resistant illness. From the cutting down of rainforests for cattle-grazing land, to runoff from factory farming of livestock and plants, to the disruption of the marine food chain, to the overuse of antibiotics in food animals, it's been disastrous.</p><p>The advent of a promising source of protein derived from two of the most renewable things we have, CO₂ and sunlight, <a href="https://solarfoods.fi/environmental-impact/" target="_blank">gets us out of the planet-destruction business</a> at the same time as it offers the promise of a stable, long-term solution to one of the world's most fundamental nutritional needs.</p>
Solar Foods' timetable<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8xOTk0MTEzMS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTU5OTU1OTMwMn0.wnXh56iO_77x2XKV2uIPf78BKw4AJLUpmiyq_JBVGvo/img.jpg?width=1245&coordinates=172%2C146%2C62%2C135&height=700" id="0297c" class="rm-shortcode" data-rm-shortcode-id="125c9a98ec818f5c241fa28ef1423e67" data-rm-shortcode-name="rebelmouse-image" />
Image source: Lubsan / Shutterstock / Big Think<p>While company plans are always moderated by unforeseen events — including the availability of sufficient funding — Solar Foods plans a global commercial rollout for Solein in 2021 and to be producing two million meals annually, with a revenue of $800 million to $1.2 billion by 2023. By 2050, they hope to be providing sustenance to 9 billion people as part of a $500 billion protein market.</p><p>The project began in 2018, and this year, they anticipate achieving three things: Launching Solein (check), beginning the approval process certifying its safety as a Novel Food in the EU, and publishing plans for a 1,000-metric ton-per-year factory capable of producing 500 million meals annually.</p>
The protein powder Solein. Image source: SOLAR FOODS
SEAL training is the ultimate test of both mental and physical strength.
- The fact that U.S. Navy SEALs endure very rigorous training before entering the field is common knowledge, but just what happens at those facilities is less often discussed. In this video, former SEALs Brent Gleeson, David Goggins, and Eric Greitens (as well as authors Jesse Itzler and Jamie Wheal) talk about how the 18-month program is designed to build elite, disciplined operatives with immense mental toughness and resilience.
- Wheal dives into the cutting-edge technology and science that the navy uses to prepare these individuals. Itzler shares his experience meeting and briefly living with Goggins (who was also an Army Ranger) and the things he learned about pushing past perceived limits.
- Goggins dives into why you should leave your comfort zone, introduces the 40 percent rule, and explains why the biggest battle we all face is the one in our own minds. "Usually whatever's in front of you isn't as big as you make it out to be," says the SEAL turned motivational speaker. "We start to make these very small things enormous because we allow our minds to take control and go away from us. We have to regain control of our mind."
Pandemic-inspired housing innovation will collide with techno-acceleration.