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Scientists reactivate cells from 28,000-year-old woolly mammoth
"I was so moved when I saw the cells stir," said 90-year-old study co-author Akira Iritani. "I'd been hoping for this for 20 years."
- The team managed to stimulate nucleus-like structures to perform some biological processes, but not cell division.
- Unless better technology and DNA samples emerge in the future, it's unlikely that scientists will be able to clone a woolly mammoth.
- Still, studying the DNA of woolly mammoths provides valuable insights into the genetic adaptations that allowed them to survive in unique environments.
A team of Japanese and Russian scientists has successfully "reawakened" cells from a 28,000-year-old woolly mammoth, according to a study published Monday in Scientific Reports.
The cells came from an extraordinarily well-preserved woolly mammoth discovered in Siberian permafrost in 2012 and nicknamed "Yuka". Using a process called nuclear transfer, the scientists took nucleus-like structures from Yuka and implanted them into mouse oocytes, which are highly specialized cells that facilitate embryonic development. The scientists then used a live-cell imaging technique to observe how the structures reacted in their new environment. They saw traces of biological activity.
"I was looking under the microscope at night while I was alone in the laboratory," 90-year-old Akira Iritani, a co-author on the new study who's spent years working toward resurrecting the woolly mammoth, told CNN. "I was so moved when I saw the cells stir. I'd been hoping for this for 20 years."
Still, this cell activity wasn't significant enough to suggest it'll soon be possible to clone woolly mammoths, which went extinct about 4,000 years ago. For example, the scientists couldn't stimulate cell division in the mammoth cells, but did manage to induce activity that precedes it, such as getting the mammoth nuclei to perform a process called "spindle assembly," in which chromosomes are attached to spindle structures before a parent cell divides into two daughter cells.
Researchers observe biological activity after transplanting cell nuclei from Yuka the woolly mammoth (dead for 28,0… https://t.co/xlBKveguqN— Steve Hurst (@Steve Hurst)1552389024.0
Another roadblock is the quality of the DNA samples. Even though Yuka's was in relatively good condition, it was still significantly damaged. It seems vastly improved technology will be needed if scientists are ever going to clone a woolly mammoth, or create an elephant-mammoth hybrid — a more realistic possibility.
The study marks a "significant step toward bringing mammoths back from the dead," researcher Kei Miyamoto, one of the study's authors told Japan's Nikkei news outlet.
"We want to move our study forward to the stage of cell division," he said, adding "we still have a long way to go."
But that doesn't mean research like this is useless. For example, some scientists hope to learn more about the genetic adaptations of the woolly mammoth that enabled it to survive such cold conditions. The hope is that researchers might someday use gene-editing technologies like CRISPR to enable modern elephants to survive in the "mammoth steppe," a massive swath of cold, dry land that stretched across northern parts of globe where mammoths used to roam. Introducing elephants to these areas could actually help curb climate.
Photo credit: NATALIA KOLESNIKOVA / AFP / Getty Images
"The elephants that lived in the past — and elephants possibly in the future — knocked down trees and allowed the cold air to hit the ground and keep the cold in the winter, and they helped the grass grow and reflect the sunlight in the summer," George Church, a Harvard and MIT geneticist, told Live Science at the 2018 Liberty Science Center Genius Gala. "Those two [factors] combined could result in a huge cooling of the soil and a rich ecosystem."
But for some scientists, working to resurrect — or at least preserve — the woolly mammoth is more of a philosophical pursuit.
"It's because of people that certain animals have gone extinct," Iritani told CNN. "It's my duty to preserve species."
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Construction of the $500 billion dollar tech city-state of the future is moving ahead.
- The futuristic megacity Neom is being built in Saudi Arabia.
- The city will be fully automated, leading in health, education and quality of life.
- It will feature an artificial moon, cloud seeding, robotic gladiators and flying taxis.
The Red Sea area where Neom will be built:
Saudi Arabia Plans Futuristic City, "Neom" (Full Promotional Video)<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="c646d528d230c1bf66c75422bc4ccf6f"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/N53DzL3_BHA?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span>
Coronavirus layoffs are a glimpse into our automated future. We need to build better education opportunities now so Americans can find work in the economy of tomorrow.
- Outplacement is an underperforming $5 billion dollar industry. A new non-profit coalition by SkillUp intends to disrupt it.
- More and more Americans will be laid off in years to come due to automation. Those people need to reorient their career paths and reskill in a way that protects their long-term livelihood.
- SkillUp brings together technology and service providers, education and training providers, hiring employers, worker outreach, and philanthropies to help people land in-demand jobs in high-growth industries.
Source: McKinsey Global Institute analysis [PDF]<p>Work in understanding the skills at the heart of the new digital economy is leading to novel assessments that allow individuals to prove mastery to faithfully represent their abilities—but also to give weight and stackability to the emerging ecosystem of micro-credentials that make education more seamless across time and education providers. And we are seeing the beginnings of a renewal in the liberal arts, focused on building human skills in affordable ways that are accessible to many more individuals and far more effective.</p><p>Amidst these dark times, there is much opportunity to refresh the nation's education and training solutions to support the success of individuals and society writ large.</p>
Do we really know what we want in a romantic partner? If so, do our desires actually mean we match up with people who suit them?
- Two separate scientific studies suggest that our "ideals" don't really match what we look for in a romantic partner.
- Results of studies like these can change the way we date, especially in the online world.
- "You say you want these three attributes and you like the people who possess these attributes. But the story doesn't end there," says Paul Eastwick, co-author of the study and professor in the UC Davis Department of Psychology.
Do we really know what we want in love or are we just guessing?<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="204859156383d358652fda6f7eadda0f"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/vQgfx2iYlso?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p>More than 700 participants selected their top three qualities in a romantic partner (things like funny, attractive, inquisitive, kind, etc). They then reported their romantic desire for a series of people they knew personally. Some were blind date partners, others were romantic partners and some were simply platonic friends.</p><p>While participants did experience more romantic desire to the extent that these personal connections of theirs (people they knew) had the qualities they listed, there was more to the study. </p><p>Paul Eastwick, co-author and professor in the UC Davis Department of Psychology <a href="https://medicalxpress.com/news/2020-07-romantic-partner-random-stranger.html" target="_blank">explains</a>: "You say you want these three attributes and you like the people who possess these attributes. But the story doesn't end there." </p><p>The participants also considered the extent to which their personal acquaintances possessed three attributes nominated by some other random person in the study. For example, if Kris listed "down-to-earth", intelligent and thoughtful as her own top three attributes, Vanessa also experienced more desire for people with those specific traits. </p>
Does what we want really match up with what we find?<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMzQ0NDA4Ni9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTU5NjM3NzY5OX0.gdUo-UbjYhKUDOL39BDZseRynbwaK2H5dfJtbV0nw8Y/img.jpg?width=980" id="ff376" class="rm-shortcode" data-rm-shortcode-id="7c1e3a1bb9d576872ef5dce39b2e8e80" data-rm-shortcode-name="rebelmouse-image" alt="illustration of a man and woman matching on a dating app" />
What we claim to want and what we look for may be two separate things...
Image by GoodStudio on Shutterstock<p>So the question became: are we really listing what we want in an ideal partner or are we just listing vague qualities that people typically consider as positive?</p><p>"So in the end, we want partners who have positive qualities," Sparks explained, "but the qualities you specifically list do not actually have special predictive power for you." </p><p>In other words, the idea that we find certain things attractive in a person does not mean we actively seek out people who have those qualities, despite saying it's what we want in a love interest. The authors of this study suggest these findings could have implications for the way we approach online dating in the digital age. </p><p>This isn't the first study of its kind to suggest that what we find in love isn't really what we were looking for. The evidence suggests that we really are consistent in the abstract of it all: when asked to evaluate what you want on paper, you are more likely to suggest overall attractiveness in accordance with what you've stated are important ideals to you. But real life isn't so similar. </p><p>According to <a href="https://www.psychologytoday.com/us/blog/meet-catch-and-keep/201506/when-it-comes-love-do-you-really-know-what-you-want" target="_blank">Psychology Today,</a> who covered a 2015 study with similar results, initial face-to-face encounters have very little effect on our romantic desire. "When we initially meet someone, our level of romantic interest in the person is independent of our standards."</p><p>While you might have no immediate interest in John, he may fit your criteria of being kind, loyal, and intelligent. Similarly, someone may be attracted to Elaine even though she doesn't have any of the qualities they originally said were important to them. </p><p><strong>What does this all mean? </strong></p><p>The authors of both the 2015 and 2020 studies say the same thing: give someone a chance before writing them off as a poor match. If your initial attraction is independent of the standards you've set out, the qualities which you've listed as important to you, the first time you meet someone may not give you enough information to make an informed decision.</p><p>"It's really easy to spend time hunting around online for someone who seems to match your ideals," said Sparks, "But our research suggests an alternative approach: Don't be too picky ahead of time about whether a partner matches your ideals on paper. Or, even better, let your friends pick your dates for you." </p>