Social isolation is hard. New research identifies a potential intervention.

A team at Mount Sinai has discovered the neural mechanism behind social isolation.

man sitting alone at table
Photo by Andrew Neel from Pexels
  • Researchers at Mt. Sinai discovered the neural mechanism behind social isolation.
  • While the studies were conducted on mice, the team hopes this could lead to treatments in humans.
  • This could shed light on social difficulties experienced by autistic and schizophrenic populations.

Out of all the unforgettable lyrics by The Beatles, George Harrison's line, "Ah, look at all the lonely people," is one for the ages. How could you possibly live in a city surrounded by millions of people and be lonely? The paradox is stunning.

The world has changed quite a bit since 1966. Social isolation has gotten worse due to electronic communications—another paradox we must contend with. Loneliness is a leading indicator of depression; rates of anxiety and depression are quadruple 2019 levels. The pandemic has exploited a worrying trend.

Sadly, twenty-somethings appear to be suffering the worst, a trend that was in progress before lockdowns began. Children are also suffering. A recent report from the Anna Freud National Centre for Children and Families suggests that children might be suffering from PTSD due to quarantines.

We know isolation is especially damaging during childhood. Being separated from their peers predicts that children will have a difficult time acclimating to social situations as they age. A new study, published in Nature Neuroscience, has discovered the neural circuit mechanisms responsible for this phenomenon—in mice, at least.

A team at the Icahn School of Medicine at Mount Sinai identified brain cells in the prefrontal cortex that regulate social behavior as being responsible for also regulating social isolation. This particular role was previously unknown.

Male mice were isolated for two weeks. The researchers, led by senior author Hirofumi Morishita, Associate Professor of Psychiatry, Neuroscience, and Ophthalmology, noticed the mice were unable to activate these medial prefrontal cortex neurons after spending an extended period of time alone. They could no longer be social, even after being weaned back into society.

people practicing social distancing

Photo: eldar nurkovic / Shutterstock

The team used optogenetics (the use of light to control neurons) and chemogenetics (non-invasive chemical control of cells) to reacclimate the mice. As Morishita explains,

"We checked the presence of social behavior deficits just prior to stimulation and when we checked the behavior while the stimulation was ongoing, we found that the social behavior deficits were reversed."

The team writes that childhood may be a particularly sensitive time for behavioral plasticity. Once the mice become accustomed to social isolation, they may not learn the skills necessary for readjusting their social strategy later in life. They believe this is the first time the exact neural mechanisms for this process have been identified.

Of course, neurological correlation is not causation. Being alone is the condition that turned these neural connections off. That said, understanding the neuronal correlation could result in new therapies.

If this research can be replicated in humans, the team believes therapeutic interventions for autism and schizophrenia, disorders that involve difficulty with social integration, may be on the horizon.

As the team concludes, since these cells appear to be sensitive to "experience-dependent modulation, they are promising targets for treatments of social behavior deficits associated with psychiatric disorders that use noninvasive brain modulation techniques such as transcranial magnetic stimulation and/or transcranial direct current stimulation."

Behavioral problems are going to continue due to the current pandemic. For parents dealing with young children experiencing difficulty acclimating to these circumstances, Dr. Julie Pajek at Cleveland's MetroHealth Medical Center suggests the following methods.

  • Talk to your child about how they are feeling and validate their feelings.
  • Provide structure for them such as consistent bedtimes or playtimes.
  • Set up virtual or safe socially distanced playdates for them to help combat social isolation.
  • Make sure they are eating healthy and getting enough exercise.
-- --

Stay in touch with Derek on Twitter, Facebook and Substack. His next book is "Hero's Dose: The Case For Psychedelics in Ritual and Therapy."

U.S. Navy controls inventions that claim to change "fabric of reality"

Inventions with revolutionary potential made by a mysterious aerospace engineer for the U.S. Navy come to light.

U.S. Navy ships

Credit: Getty Images
Surprising Science
  • U.S. Navy holds patents for enigmatic inventions by aerospace engineer Dr. Salvatore Pais.
  • Pais came up with technology that can "engineer" reality, devising an ultrafast craft, a fusion reactor, and more.
  • While mostly theoretical at this point, the inventions could transform energy, space, and military sectors.
Keep reading Show less

The misguided history of female anatomy

From "mutilated males" to "wandering wombs," dodgy science affects how we view the female body still today.

Credit: Hà Nguyễn via Unsplash
Sex & Relationships
  • The history of medicine and biology often has been embarrassingly wrong when it comes to female anatomy and was surprisingly resistant to progress.
  • Aristotle and the ancient Greeks are much to blame for the mistaken notion of women as cold, passive, and little more than a "mutilated man."
  • Thanks to this dubious science, and the likes of Sigmund Freud, we live today with a legacy that judges women according to antiquated biology and psychology.
Keep reading Show less

Why do holidays feel like they're over before they even start?

People tend to reflexively assume that fun events – like vacations – will go by really quickly.

Mind & Brain

For many people, summer vacation can't come soon enough – especially for the half of Americans who canceled their summer plans last year due to the pandemic.

Keep reading Show less
Strange Maps

Android has won the phone world war

A global survey shows the majority of countries favor Android over iPhone.