Single algae cells can help deliver targeted medicine
Tiny and efficient, these biodegradable single cells show promise as a way to target hard-to-reach cancers.
- Scientists in Germany have found a potential improvement on the idea of bacteria delivering medicine.
- This kind of microtargeting could be useful in cancer treatments.
- The microswimmers are biodegradable and easy to produce.
Metin Sitti and colleagues at the Max Planck Institute in Germany recently demonstrated that tiny drugs could be attached to individual algae cells and that those algae cells could then be directed through body-like fluid by a magnetic field.
The results were recently published in Advanced Materials, and the paper as a whole offers up a striking portrait of precision and usefulness, perhaps loosely comparable in overall quality to recent work done by The Yale Quantum Institute. It begins by noting that medicine has been attached to bacteria cells before, but bacteria can multiply and end up causing more harm than good.
A potential solution to the problem seems to have been found in an algal cell: the intended object of delivery is given a different electrical charge than the algal cell, which helps attach the object to the cell. The movement of the algae was then tested in 2D and 3D. (The study calls this cell a 'microswimmer.') It would later be found that "3D mean swimming speed of the algal microswimmers increased more than twofold compared to their 2D mean swimming speed." The study continues —
More interestingly, 3D mean swimming speed of the algal microswimmers in the presence of a uniform magnetic field in the x-direction was approximately threefolds higher than their 2D mean swimming speed.
After the 2D and 3D speed of the algal was examined, it was then tested in something made to approximate human fluid, including what they call 'human tubal fluid' (think of the fallopian tubes), plasma, and blood. They then moved to test the compatibility of the microswimmer with cervical cancer cells, ovarian cancer cells, and healthy cells. They found that the microswimmer didn't follow the path of bacteria cells and create something toxic.
The next logical steps from the study include testing this inside a living organism in order to assess the safety of the procedure. Potential future research could include examining how effective this method of drug delivery could be in targeting "diseases in deep body locations," as in, the reproductive and gastrointestinal tracts.
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Tragedy in art, from Ancient Greece to Breaking Bad, resists all our efforts to tie reality up in a neat bow, to draw some edifying lesson from it. Instead it confronts us with our own limitations, leaving us scrabbling in the rubble of certainty to figure out what's next.
- Why democracy has been unpopular with philosophers
- Tragedy's reminder that the past isn't finished with us
- …and why we need art in the first place
We're talking Ghost in the Shell type of stuff.
Maybe you watched Ghost in the Shell and maybe afterwards you and your friend had a conversation about whether or not you would opt in for some bionic upgrades if that was possible - like a liver that could let you drink unlimitedly or an eye that could give you superhuman vision. And maybe you had differing opinions but you concluded that it's irrelevant because the time to make such choices is far in the future. Well, it turns out, it's two years away.
"Earth" features about 30 of the biggest names in entertainment.
- Lil Dicky is a rapper and comedian who released his debut album in 2015.
- His new music video, "Earth," features artists such as Justin Bieber, Ariana Grande, Ed Sheehan, Kevin Hart, and Leonardo DiCaprio.
- All proceeds of the music video will go to environmental causes, Dicky said.
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