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Ten “keys to reality” from a Nobel-winning physicist
To understand ourselves and our place in the universe, "we should have humility but also self-respect," Frank Wilczek writes in a new book.

At the University of Chicago, where Frank Wilczek was an undergraduate, regularly scheduled classes were "improvised and semivoluntary" amid the turmoil, as he recalls.
It was during this turbulent time that Wilczek found unexpected comfort, and a new understanding of the world, in mathematics. He had decided to sit in on a class by physics professor Peter Freund, who, with a zeal "bordering on rapture," led students through mathematical theories of symmetry and ways in which these theories can predict behaviors in the physical world.
In his new book, "Fundamentals: Ten Keys to Reality," published by Penguin Press, Wilczek writes that the lessons were a revelation: "To experience the deep harmony between two different universes — the universe of beautiful ideas and the universe of physical behavior — was for me a kind of spiritual awakening. It became my vocation. I haven't been disappointed."
Wilczek, who is the Herman Feshbach Professor of Physics at MIT, has since made groundbreaking contributions to our fundamental understanding of the physical world, for which he has been widely recognized, most notably in 2004 with the Nobel Prize in Physics, which he shared with physicists David Gross and David Politzer. He has also authored several popular science books on physics and the history of science.
In his new book, he distills scientists' collective understanding of the physical world into 10 broad philosophical themes, using the fundamental theories of physics, from cosmology to quantum mechanics, to reframe ideas of space, time, and our place in the universe.
"People wrestle with what the world is all about," Wilczek tells MIT News. "They're not concerned with knowing precisely what Coulomb's law is, but want to know more about questions like the ancient Greeks asked: What is space? What is time? So in the end, I came up with 10 assertions, at the levels of philosophy but backed up by very concrete facts, to organize what we know."
A rollercoaster reborn
Wilczek wrote the bulk of the book earlier this spring, in the midst of another tumultuous time, at the start of a global pandemic. His grandson had been born as Wilczek was laying out the structure for his book, and in the preface, the physicist writes that he watched as the baby began building up a model of the world, based on his observations and interactions with the environment, "with insatiable curiosity and few preconceptions."
Wilczek says that scientists may take a cue from the way babies learn — by building and pruning more detailed models of the world, with a similar unbiased, open outlook. He can recall times when he felt his own understanding of the world fundamentally shift. The college course on mathematical symmetry was an early instance. More recently, the rise of artificial intelligence and machine learning has prompted him to rethink "what knowledge is, and how it's acquired."
He writes: "The process of being born again can be disorienting. But, like a roller- coaster ride, it can also be exhilarating. And it brings this gift: To those who are born again, in the way of science, the world comes to seem fresh, lucid, and wonderfully abundant."
"Patterns in matter"
Wilczek's book contains ample opportunity for readers to reframe their view of the physical world. For instance, in a chapter entitled "There's Plenty of Space," he writes that, while the universe is vast, there is another scale of vastness in ourselves. To illustrate his point, he calculates that there are roughly 10 octillion atoms that make up the human body. That's about 1 million times the number of stars in the visible universe. The multitudes within and beyond us are not contradictory, he says, but can be explained by the same set of physical rules.
And in fact, the universe, in all its diversity, can be described by a surprisingly few set of rules, collectively known as the Standard Model of Physics, though Wilczek prefers to call it by another name.
"The so-called Standard Model is the culmination of millenia of investigation, allowing us to understand how matter works, very fully," Wilczek says. "So calling it a model, and standard, is kind of a lost opportunity to really convey to people the magnitude of what's been achieved by humanity. That's why I like to call it the 'Core.' It's a central body of understanding that we can build out from."
Wilczek takes the reader through many of the key experiments, theories, and revelations that physicists have made in building and validating the Standard Model, and its mathematical descriptions of the universe.
Included in this often joyful scientific tour are brief mentions of Wilczek's own contributions, such as his Nobel-winning work establishing the theory of quantum chromodynamics; his characterization of the axion, a theoretical particle that he named after a laundry detergent by the same name ("It was short, catchy, and would fit in nicely alongside proton, neutron, electron, and pion," he writes); and his introduction of the anyon — an entirely new kind of particle that is neither a fermion or a boson.
In April, and then separately in July, scientists made the first observations of anyons, nearly 40 years after Wilczek first proposed their existence.
"I was beginning to think it would never happen," says Wilczek, who was finishing up his book when the discoveries were made public. "When it finally did, it was a beautiful surprise."
The discovery of anyons opens possibilities for the particles to be used as building blocks for quantum computers, and marks another milestone in our understanding of the universe.
In closing his book, Wilczek writes about "complementarity" — a concept in physics that refers to two seemingly contrasting theories, such as the wave and particle theories of light, that can separately explain the same set of phenomena. He points to many complementary theories of physics throughout the book and extends the idea to philosophy and ways in which accepting contrasting views of the world can help us to expand our experience.
"With progress, we've come to consider people and creatures as having intrinsic value and being worthy of profound respect, just like ourselves," he writes. "When we see ourselves as patterns in matter, it is natural to draw our circle of kinship very wide indeed."
Reprinted with permission of MIT News. Read the original article.
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How tiny bioelectronic implants may someday replace pharmaceutical drugs
Scientists are using bioelectronic medicine to treat inflammatory diseases, an approach that capitalizes on the ancient "hardwiring" of the nervous system.
Left: The vagus nerve, the body's longest cranial nerve. Right: Vagus nerve stimulation implant by SetPoint Medical.
- Bioelectronic medicine is an emerging field that focuses on manipulating the nervous system to treat diseases.
- Clinical studies show that using electronic devices to stimulate the vagus nerve is effective at treating inflammatory diseases like rheumatoid arthritis.
- Although it's not yet approved by the US Food and Drug Administration, vagus nerve stimulation may also prove effective at treating other diseases like cancer, diabetes and depression.
The nervous system’s ancient reflexes
<p>You accidentally place your hand on a hot stove. Almost instantaneously, your hand withdraws.</p><p>What triggered your hand to move? The answer is <em>not</em> that you consciously decided the stove was hot and you should move your hand. Rather, it was a reflex: Skin receptors on your hand sent nerve impulses to the spinal cord, which ultimately sent back motor neurons that caused your hand to move away. This all occurred before your "conscious brain" realized what happened.</p><p>Similarly, the nervous system has reflexes that protect individual cells in the body.</p><p>"The nervous system evolved because we need to respond to stimuli in the environment," said Dr. Tracey. "Neural signals don't come from the brain down first. Instead, when something happens in the environment, our peripheral nervous system senses it and sends a signal to the central nervous system, which comprises the brain and spinal cord. And then the nervous system responds to correct the problem."</p><p>So, what if scientists could "hack" into the nervous system, manipulating the electrical activity in the nervous system to control molecular processes and produce desirable outcomes? That's the chief goal of bioelectronic medicine.</p><p>"There are billions of neurons in the body that interact with almost every cell in the body, and at each of those nerve endings, molecular signals control molecular mechanisms that can be defined and mapped, and potentially put under control," Dr. Tracey said in a <a href="https://www.youtube.com/watch?v=AJH9KsMKi5M" target="_blank">TED Talk</a>.</p><p>"Many of these mechanisms are also involved in important diseases, like cancer, Alzheimer's, diabetes, hypertension and shock. It's very plausible that finding neural signals to control those mechanisms will hold promises for devices replacing some of today's medication for those diseases."</p><p>How can scientists hack the nervous system? For years, researchers in the field of bioelectronic medicine have zeroed in on the longest cranial nerve in the body: the vagus nerve.</p>The vagus nerve
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNTYyOTM5OC9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0NTIwNzk0NX0.UCy-3UNpomb3DQZMhyOw_SQG4ThwACXW_rMnc9mLAe8/img.jpg?width=1245&coordinates=0%2C0%2C0%2C0&height=700" id="09add" class="rm-shortcode" data-rm-shortcode-id="f38dbfbbfe470ad85a3b023dd5083557" data-rm-shortcode-name="rebelmouse-image" data-width="1245" data-height="700" />Electrical signals, seen here in a synapse, travel along the vagus nerve to trigger an inflammatory response.
Credit: Adobe Stock via solvod
<p>The vagus nerve ("vagus" meaning "wandering" in Latin) comprises two nerve branches that stretch from the brainstem down to the chest and abdomen, where nerve fibers connect to organs. Electrical signals constantly travel up and down the vagus nerve, facilitating communication between the brain and other parts of the body.</p><p>One aspect of this back-and-forth communication is inflammation. When the immune system detects injury or attack, it automatically triggers an inflammatory response, which helps heal injuries and fend off invaders. But when not deployed properly, inflammation can become excessive, exacerbating the original problem and potentially contributing to diseases.</p><p>In 2002, Dr. Tracey and his colleagues discovered that the nervous system plays a key role in monitoring and modifying inflammation. This occurs through a process called the <a href="https://www.nature.com/articles/nature01321" target="_blank" rel="noopener noreferrer">inflammatory reflex</a>. In simple terms, it works like this: When the nervous system detects inflammatory stimuli, it reflexively (and subconsciously) deploys electrical signals through the vagus nerve that trigger anti-inflammatory molecular processes.</p><p>In rodent experiments, Dr. Tracey and his colleagues observed that electrical signals traveling through the vagus nerve control TNF, a protein that, in excess, causes inflammation. These electrical signals travel through the vagus nerve to the spleen. There, electrical signals are converted to chemical signals, triggering a molecular process that ultimately makes TNF, which exacerbates conditions like rheumatoid arthritis.</p><p>The incredible chain reaction of the inflammatory reflex was observed by Dr. Tracey and his colleagues in greater detail through rodent experiments. When inflammatory stimuli are detected, the nervous system sends electrical signals that travel through the vagus nerve to the spleen. There, the electrical signals are converted to chemical signals, which trigger the spleen to create a white blood cell called a T cell, which then creates a neurotransmitter called acetylcholine. The acetylcholine interacts with macrophages, which are a specific type of white blood cell that creates TNF, a protein that, in excess, causes inflammation. At that point, the acetylcholine triggers the macrophages to stop overproducing TNF – or inflammation.</p><p>Experiments showed that when a specific part of the body is inflamed, specific fibers within the vagus nerve start firing. Dr. Tracey and his colleagues were able to map these relationships. More importantly, they were able to stimulate specific parts of the vagus nerve to "shut off" inflammation.</p><p>What's more, clinical trials show that vagus nerve stimulation not only "shuts off" inflammation, but also triggers the production of cells that promote healing.</p><p>"In animal experiments, we understand how this works," Dr. Tracey said. "And now we have clinical trials showing that the human response is what's predicted by the lab experiments. Many scientific thresholds have been crossed in the clinic and the lab. We're literally at the point of regulatory steps and stages, and then marketing and distribution before this idea takes off."<br></p>The future of bioelectronic medicine
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNTYxMDYxMy9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYzNjQwOTExNH0.uBY1TnEs_kv9Dal7zmA_i9L7T0wnIuf9gGtdRXcNNxo/img.jpg?width=980" id="8b5b2" class="rm-shortcode" data-rm-shortcode-id="c005e615e5f23c2817483862354d2cc4" data-rm-shortcode-name="rebelmouse-image" data-width="2000" data-height="1125" />Vagus nerve stimulation can already treat Crohn's disease and other inflammatory diseases. In the future, it may also be used to treat cancer, diabetes, and depression.
Credit: Adobe Stock via Maridav
<p>Vagus nerve stimulation is currently awaiting approval by the US Food and Drug Administration, but so far, it's proven safe and effective in clinical trials on humans. Dr. Tracey said vagus nerve stimulation could become a common treatment for a wide range of diseases, including cancer, Alzheimer's, diabetes, hypertension, shock, depression and diabetes.</p><p>"To the extent that inflammation is the problem in the disease, then stopping inflammation or suppressing the inflammation with vagus nerve stimulation or bioelectronic approaches will be beneficial and therapeutic," he said.</p><p>Receiving vagus nerve stimulation would require having an electronic device, about the size of lima bean, surgically implanted in your neck during a 30-minute procedure. A couple of weeks later, you'd visit, say, your rheumatologist, who would activate the device and determine the right dosage. The stimulation would take a few minutes each day, and it'd likely be unnoticeable.</p><p>But the most revolutionary aspect of bioelectronic medicine, according to Dr. Tracey, is that approaches like vagus nerve stimulation wouldn't come with harmful and potentially deadly side effects, as many pharmaceutical drugs currently do.</p><p>"A device on a nerve is not going to have systemic side effects on the body like taking a steroid does," Dr. Tracey said. "It's a powerful concept that, frankly, scientists are quite accepting of—it's actually quite amazing. But the idea of adopting this into practice is going to take another 10 or 20 years, because it's hard for physicians, who've spent their lives writing prescriptions for pills or injections, that a computer chip can replace the drug."</p><p>But patients could also play a role in advancing bioelectronic medicine.</p><p>"There's a huge demand in this patient cohort for something better than they're taking now," Dr. Tracey said. "Patients don't want to take a drug with a black-box warning, costs $100,000 a year and works half the time."</p><p>Michael Dowling, president and CEO of Northwell Health, elaborated:</p><p>"Why would patients pursue a drug regimen when they could opt for a few electronic pulses? Is it possible that treatments like this, pulses through electronic devices, could replace some drugs in the coming years as preferred treatments? Tracey believes it is, and that is perhaps why the pharmaceutical industry closely follows his work."</p><p>Over the long term, bioelectronic approaches are unlikely to completely replace pharmaceutical drugs, but they could replace many, or at least be used as supplemental treatments.</p><p>Dr. Tracey is optimistic about the future of the field.</p><p>"It's going to spawn a huge new industry that will rival the pharmaceutical industry in the next 50 years," he said. "This is no longer just a startup industry. [...] It's going to be very interesting to see the explosive growth that's going to occur."</p>Smart vultures never, ever cross the Spain-Portugal border. Why?
The first rule of Vulture Club: stay out of Portugal.
So you're a vulture, riding the thermals that rise up over Iberia. Your way of life is ancient, ruled by needs and instincts that are way older than the human civilization that has overtaken the peninsula below, and the entire planet.
Best. Science. Fiction. Show. Ever.
"The Expanse" is the best vision I've ever seen of a space-faring future that may be just a few generations away.
- Want three reasons why that headline is justified? Characters and acting, universe building, and science.
- For those who don't know, "The Expanse" is a series that's run on SyFy and Amazon Prime set about 200 years in the future in a mostly settled solar system with three waring factions: Earth, Mars, and Belters.
- No other show I know of manages to use real science so adeptly in the service of its story and its grand universe building.
Credit: "The Expanse" / Syfy
<p>Now, I get it if you don't agree with me. I love "Star Trek" and I thought "Battlestar Galactica" (the new one) was amazing and I do adore "The Mandalorian". They are all fun and important and worth watching and thinking about. And maybe you love them more than anything else. But when you sum up the acting, the universe building, and the use of real science where it matters, I think nothing can beat "The Expanse". And with a <a href="https://www.rottentomatoes.com/tv/the_expanse" target="_blank">Rotten Tomato</a> average rating of 93%, I'm clearly not the only one who feels this way.</p><p>Best.</p><p>Show.</p><p>Ever. </p>How exercise changes your brain biology and protects your mental health
Contrary to what some might think, the brain is a very plastic organ.
As with many other physicians, recommending physical activity to patients was just a doctor chore for me – until a few years ago. That was because I myself was not very active.
Here's a 10-step plan to save our oceans
By 2050, there may be more plastic than fish in the sea.
