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Mini-brains may already be sentient and suffering, scientists warn
To prevent torturous experiments on organoids, some are calling for clearer definitions of consciousness.

- Mini-brains (also called organoids) are tiny lumps of tissue capable of generating rudimentary neural activity.
- Neuroscientists use mini-brains to conduct research and experiments that help them learn about the brain.
- As scientists generate increasingly complex mini-brains, however, some are concerned they might be experiencing pain.
Neuroscientists are "perilously close" to crossing serious ethical lines by experimenting with mini-brains that might be complex enough to feel pain. In fact, experiments with mini-brains (also called organoids) might have already crossed those lines.
"If there's even a possibility of the organoid being sentient, we could be crossing that line," Elan Ohayon, the director of the Green Neuroscience Laboratory in San Diego, California, told The Guardian. "We don't want people doing research where there is potential for something to suffer."
On Monday, Ohayon and his colleagues presented a computational study at Neuroscience 2019, the world's largest annual meeting of neuroscientists. The study aimed to establish guidelines for scientists to determine when exactly a mini-brain develops consciousness.
"Assessment informed by the models and associated dynamics suggests that current organoid research is perilously close to crossing this ethical Rubicon and may have already done so," the paper states. "Despite the field's perception that the complexity and diversity of cellular elements in vivo remains unmatched by today's organoids, current cultures are already isomorphic to sentient brain structure and activity in critical domains and so may be capable of supporting sentient activity and behavior."
Stand-ins for human brains
Mini-brains are tiny lumps of tissue made from stem cells that are capable of generating rudimentary neural activity, and researchers use them in neuroscience experiments. The main benefit of mini-brains is that scientists can conduct important research that sheds light on the human brain all without having to use actual human or animal brains.
As Big Think's Robby Berman noted in March, mini-brains are relatively rudimentary. The most advanced organoid possesses a couple million neurons — twice that of a cockroach, but far fewer than an adult zebrafish. The human brain, meanwhile, has some 100 billion neurons. But mini-brains are becoming more complex.
Smarter mini-brains
A 2018 study showed that organoids implanted in mouse brains are capable of attaching to the animal's blood supply and sprouting new connections. In another recent study, researchers created a mini-brain with retinal cells, which are the neurons that process visual information. In August, a paper published in Cell Stem Cell described how researchers developed an organoid that is capable of producing brain waves similar to those of premature human babies.
"We never had a brain organoid that can function like the human brain," biologist and researcher Alysson Muotri told Discover Magazine. "The electrical activity of these brain organoids are emitting something we see during normal human development. So, it's a strong indication that what we have should work and function like the human brain."
The need for clearer definitions of consciousness
Some scientists think that mini-brains are still too rudimentary to experience anything like what humans would call pain, and therefore the community doesn't need to worry about creating a nightmarish torture scenario for mini-brains. But others argue that scientists should establish clear guidelines for consciousness so can stop experiments before they effectively create new way for beings to suffer.
"We don't really know actually where this is all going," Patricia Churchland, a Salk Institute professor emerita who studies the linkage between philosophy and neuroscience, told the San Diego Union-Tribune. "It's very, very difficult to predict the future in science, as in baseball."
In the computational study presented on Monday, the researchers discussed five domains through which consciousness might be defined: [1] compositional (e.g., atomic, molecular), [2] causal (e.g., genetic, evolutionary), [3] anatomical (e.g., cellular, network geometry, brain regions), [4] physiological (e.g., cellular, network, whole brain activity), and [5] behavioral (e.g., embodied, virtual). But they also noted a strange and alarming possibility:
"It is important to note that the observations in this computational study point at minimal guidelines and undoubtedly would fail to identify alternate forms of sentience."
Archaeologists identify contents of ancient Mayan drug containers
Scientists use new methods to discover what's inside drug containers used by ancient Mayan people.
A Muna-type paneled flask with distinctive serrated-edge decoration from AD 750-900.
- Archaeologists used new methods to identify contents of Mayan drug containers.
- They were able to discover a non-tobacco plant that was mixed in by the smoking Mayans.
- The approach promises to open up new frontiers in the knowledge of substances ancient people consumed.
PARME staff archaeologists excavating a burial site at the Tamanache site, Mérida, Yucatan.
Credit: WSU
Why cities are critical to achieving a carbon-neutral world
In May 2018, the city of Paris set an ambition to be carbon-neutral by 2050.
- Countries, governments and companies are aligning on a need for net-zero - and this is an opportunity to rethink decarbonizing our cities.
- There is no "one-size-fits-all" solution – each city's needs must be at the heart of developing integrated energy solutions.
- A city can only decarbonize through collaboration between government, the private sector, and local communities.
Japanese government appoints new "Minister of Loneliness"
While not the first such minister, the loneliness epidemic in Japan will make this one the hardest working.
Minister Tetsushi Sakamoto
- The Japanese government has appointed a Minister of Loneliness to implement policies designed to fight isolation and lower suicide rates.
- They are the second country, after the U.K., to dedicate a cabinet member to the task.
- While Japan is famous for how its loneliness epidemic manifests, it isn't alone in having one.
The Ministry of Loneliness
<iframe width="730" height="430" src="https://www.youtube.com/embed/I5FIohjZT8o" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen></iframe><p><a href="https://www.jimin.jp/english/profile/members/114749.html" target="_blank" rel="noopener noreferrer">Tetsushi Sakamoto</a>, already in the government as the minister in charge of raising Japan's low birthrate and revitalizing regional economies, was appointed this <a href="https://www.japantimes.co.jp/news/2021/02/21/national/japan-tackles-loneliness/" target="_blank" rel="noopener noreferrer">month</a> to the additional role. He has already announced plans for an emergency national forum to discuss the issue and share the testimony of lonely <a href="https://www.japantimes.co.jp/news/2021/02/12/national/loneliness-isolation-minister/" target="_blank" rel="noopener noreferrer">individuals</a>.</p><p>Given the complexity of the problem, the minister will primarily oversee the coordination of efforts between different <a href="https://www.insider.com/japan-minister-of-loneliness-suicides-rise-pandemic-2021-2" target="_blank" rel="noopener noreferrer">ministries</a> that hope to address the issue alongside a task <a href="https://www.japantimes.co.jp/news/2021/02/21/national/japan-tackles-loneliness/" target="_blank" rel="noopener noreferrer">force</a>. He steps into his role not a moment too soon. The loneliness epidemic in Japan is uniquely well known around the world.</p><p><a href="https://en.wikipedia.org/wiki/Hikikomori" target="_blank" rel="noopener noreferrer"><em>Hikikomori</em></a><em>,</em> often translated as "acute social withdrawal," is the phenomenon of people completely withdrawing from society for months or years at a time and living as modern-day hermits. While cases exist in many <a href="https://www.frontiersin.org/articles/10.3389/fpsyt.2019.00247/full" target="_blank" rel="noopener noreferrer">countries</a>, the problem is better known and more prevalent in Japan. Estimates vary, but some suggest that one million Japanese live like this and that 1.5 million more are at <a href="https://www.nationalgeographic.com/photography/article/japan-hikikomori-isolation-society" target="_blank" rel="noopener noreferrer">risk</a> of developing the condition. Individuals practicing this hermitage often express contentment with their isolation at first before encountering severe symptoms of loneliness and <a href="https://www.sciencedaily.com/releases/2020/01/200110155241.htm" target="_blank" rel="noopener noreferrer">distress</a>.</p><p><a href="https://en.wikipedia.org/wiki/Kodokushi" target="_blank" rel="noopener noreferrer"><em>Kodokushi</em></a>, the phenomenon of the elderly dying alone and remaining undiscovered for some time due to their isolation, is also a widespread issue in Japan that has attracted national attention for decades.</p><p>These are just the most shocking elements of the loneliness crisis. As we've discussed before, loneliness can cause health issues akin to <a href="https://www.inc.com/amy-morin/americas-loneliness-epidemic-is-more-lethal-than-smoking-heres-what-you-can-do-to-combat-isolation.html" target="_blank" rel="noopener noreferrer">smoking</a>. A lack of interaction within a community can cause social <a href="https://bigthink.com/in-their-own-words/how-religious-neighbors-are-better-neighbors" target="_self">problems</a>. It is even associated with changes in the <a href="https://bigthink.com/mind-brain/loneliness-brain" target="_self">brain</a>. While there is nothing wrong with wanting a little time to yourself, the inability to get the socialization that many people need is a real problem with real <a href="https://bigthink.com/mind-brain/brain-loneliness-hunger" target="_self">consequences</a>.</p>The virus that broke the camel's back
<iframe width="730" height="430" src="https://www.youtube.com/embed/Hp-L844-5k8" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen></iframe><p> A global loneliness pandemic existed before COVID-19, and the two working in tandem has been catastrophic. </p><p>Japanese society has always placed a value on solitude, often associating it with self-reliance, which makes dealing with the problem of excessive solitude more difficult. Before the pandemic, 16.1 percent of Japanese seniors reported having nobody to turn to in a time of need, the highest rate of any nation <a href="https://www.japantimes.co.jp/news/2021/02/21/national/japan-tackles-loneliness/" target="_blank" rel="noopener noreferrer">considered</a>. Seventeen percent of Japanese men surveyed in 2005 said that they "rarely or never spend time with friends, colleagues, or others in social groups." This was three times the average rate of other <a href="http://www.oecd.org/sdd/37964677.pdf" target="_blank" rel="noopener noreferrer">countries</a>. </p><p>American individualism also creates a fertile environment for isolation to grow. About a month before the pandemic started, nearly<a href="https://www.npr.org/sections/health-shots/2020/01/23/798676465/most-americans-are-lonely-and-our-workplace-culture-may-not-be-helping" target="_blank" rel="noopener noreferrer"> 3 in 5</a> Americans reported being lonely in a <a href="https://www.cigna.com/about-us/newsroom/studies-and-reports/combatting-loneliness/" target="_blank" rel="noopener noreferrer">report</a> issued by Cigna. This is a slight increase over previous studies, which had been pointing in the same direction for years. </p><p>In the United Kingdom, the problem prompted the creation of the Jo Cox Commission on Loneliness. The commission's <a href="https://www.ageuk.org.uk/globalassets/age-uk/documents/reports-and-publications/reports-and-briefings/active-communities/rb_dec17_jocox_commission_finalreport.pdf" target="_blank" rel="noopener noreferrer">final report </a>paints a stark picture of the U.K.'s situation in 2017, with millions of people from all parts of British society reporting feeling regular loneliness at a tremendous cost to personal health, society, and the economy.</p><p>The report called for a lead minister to address the problem at the national level, incorporating government action with the insights provided by volunteer organizations, businesses, the NHS, and other organizations on the crisis's front lines. Her Majesty's Government acted on the report and appointed the first Minister for Loneliness in <a href="https://time.com/5248016/tracey-crouch-uk-loneliness-minister/" target="_blank" rel="noopener noreferrer">2018</a>, <a href="https://en.wikipedia.org/wiki/Tracey_Crouch" target="_blank" rel="noopener noreferrer">Tracey Crouch</a>, and dedicated millions of pounds to battling the problem. </p><p>The distancing procedures necessitated by the COVID-19 epidemic saved many lives but exacerbated an existing problem of loneliness in many parts of the world. While the issue had received attention before, Japan's steps to address the situation suggest that people are now willing to treat it with the seriousness it deserves.</p><p>--</p><p><em>If you or a loved one are having suicidal thoughts, help is available. The suicide prevention hotline can be reached at 1-800-273-8255.</em></p>How art and design can rebuild a community
MIT professor Azra Akšamija creates works of cultural resilience in the face of social conflict.
