New research suggests MDMA could be used to treat alcoholism
Yet another study shows the potential efficacy of psychedelics in treating addiction.
- MDMA could help alcoholics break their addiction (and not relapse) suggests a new study in the UK.
- Ketamine became the first FDA-sanctioned psychedelic for use in treating depression earlier this year.
- The Multidisciplinary Association for Psychedelic Studies (MAPS) organization hopes to have legally prescribed MDMA on the shelves by 2021.
When John Hopkins professor Roland Griffiths and NYU professor Stephen Ross brought a unique study on psilocybin's efficacy in treating cancer patients' existential distress to the FDA, they were surprised when the government agency asked them to expand their focus and ambition. Recognizing that SSRIs are not working in treating mental health disorders, the FDA was willing to explore other avenues — even a Schedule 1 drug like "magic mushrooms."
When Michael Pollan contacted the FDA while reporting for his book on psychedelics, How to Change Your Mind, the agency refused to confirm or deny this account due to its longstanding practice of not discussing substances under regulatory review. Still, this marks an important advancement in our broader understanding of the potential benefits of psychedelics.
Let's face it: until the twentieth century, these substances, predominantly used in ritual for all of recorded history (and likely longer), were generally not viewed as dangerous. In fact, it has been long been argued that they're necessary for personal and societal therapy.
Even more modern incarnations, such as LSD and MDMA, affect the same (or similar) serotonin circuits as psilocybin and DMT. Sanctioned drugs, such as alcohol, cigarettes, and sugar, have proven far more damaging to our health than the class of substances known as psychedelics.
MDMA is not always broadly considered a psychedelic, given that it does not provoke the same hallucinations or altered consciousness as other "trips." Yet MDMA binds to the same serotonin-2a receptor (the "mystical experience" receptor) as LSD and psilocybin, as well as dopamine receptors, accounting for the intense euphoria.
Is MDMA psychiatry’s antibiotic? | Ben Sessa | TEDxUniversityofBristol
All of these substances have been used recently in addiction treatment. As Pollan notes, MDMA specifically was being used to treat alcoholism back in the fifties and sixties, before sanctioned studies were commissioned. It was only due to Nixon's racist profiling that these class of drugs were deemed Schedule 1.
Now that the first study on MDMA's role in treating alcoholism is complete, it turns out that the longstanding anecdotal evidence might bear fruit. Led by Ben Sessa, a senior research fellow at Imperial College London, the team studied seven volunteers during an eight-week MDMA-assisted psychotherapy course to see if it would help curb their alcoholism. This preliminary paper focuses on four volunteers who have completed the course.
While this is an extremely small sample size, it does open the door for further studies, which is the general aim of such research. Given the tenuous nature of psychedelic research due to the drugs' illegality, governments (and the public) have to be brought in slowly, even as advocates can vouch for their value.
Simply put, we need better interventions. As the team notes, 6 percent of men and 2 percent of women in England are alcohol-dependent; a quarter of the population has an abusive relationship to alcohol. As a depressant, alcohol also heavily influences mental and emotional health. It is often a chicken-and-egg scenario in regards to mental health and alcoholism, but one thing is certain: drinking doesn't help.
Roland R. Griffiths, Ph.D., is a professor in the departments of Psychiatry and Neuroscience at Johns Hopkins University School of Medicine. He studies the effects of psychoactive drugs on the mind in his lab which is set up to look like a living room.
Photo by Andre Chung for The Washington Post via Getty Images
The total cost of alcohol-related problems in England, ranging from health disorders and domestic problems to crime and accidents, is £20 billion. Current treatment methods are insubstantial. Relapse rates there are 60 percent after one year, jumping to 80 percent after three years.
For this study, the patients received ten therapeutic sessions. Eight were non-drug psychotherapy sessions. The other two, administered during weeks three and six, included 125 mg doses of MDMA (with an optional 62.5 mg "booster" dose after two hours).
None of the volunteers experienced adverse effects during or after the course, nor did they return to drinking. Importantly, none felt any craving for MDMA after the study's conclusion. As one participant commented, the drug itself was more a mediator than anything:
It's not about the drinking, the MDMA healed me inside and the drinking looks after itself … I'm seeing things anew, nature for the first time … I'm in control of my decisions, I've got control back … Life is just good!
Comments from other participants include the feeling of a "weight being lifted off my shoulders" and "being under MDMA was beautiful. It showed me the real me; the me without alcohol."
Now the team is calling for twenty volunteers with alcohol dependency in order to conduct another study. Separating the actual efficacy of psychedelics and its sordid legal status and past fear-mongering will take time, but hopefully not too much. Earlier this year, ketamine became the first FDA-approved psychedelic to be legally prescribed.
The Multidisciplinary Association for Psychedelic Studies (MAPS) has trained its sights on legal MDMA by 2021. Given the emerging science on the topic, such a goal is within reach. That's good news for addicts that feel their time is running out.
- MDMA shows high efficacy rate in Phase 2 trials - Big Think ›
- MDMA and Psilocybin: The Future of Anxiety Medication? - Big Think ›
Meteorologists propose a stunning new explanation for the mysterious events in the Bermuda Triangle.
One of life's great mysteries, the Bermuda Triangle might have finally found an explanation. This strange region, that lies in the North Atlantic Ocean between Bermuda, Miami and San Juan, Puerto Rico, has been the presumed cause of dozens and dozens of mind-boggling disappearances of ships and planes.
Nazi supporters held huge rallies and summer camps for kids throughout the United States in the 1930s.
- During the 1930s, thousands of Americans sympathized with the Nazis, holding huge rallies.
- The rallies were organized by the American German Bund, which wanted to spread Nazi ideology.
- Nazi supporters also organized summer camps for kids to teach them their values.
A Bund parade in New York, October 30, 1939.
Credit: Library of Congress
Credit: Herald Tribune
Postcards from Camp Siegfried
Tea and coffee have known health benefits, but now we know they can work together.
Credit: NIKOLAY OSMACHKO from Pexels
- A new study finds drinking large amounts of coffee and tea lowers the risk of death in some adults by nearly two thirds.
- This is the first study to suggest the known benefits of these drinks are additive.
- The findings are great, but only directly apply to certain people.