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First Mars samples are headed to Earth. What are the risks?
A Mars Space Flight team member warns that people need to be prepared for what's coming.
- A mission to and from Mars aims to bring back signs or examples of life.
- Expect material direct from the Red Planet around 2031.
- A special lab to quarantine the samples is being designed.
With potentially habitable exoplanets continually being found, with water ice on the moon, and with verified military videos showing jaw-dropping who-knows-whats in our skies, it's seeming more and more likely that life exists elsewhere in the universe. In some form or another. The day feels increasingly imminent on which humankind will be called to accept a profound realignment. If and when this happens, it'll be a deeply-felt shock, forcing, among other things, a reassessment of human-centric faith systems as well the relevance of national/tribal loyalties.
If nothing else happens first, there's 2031 to consider if all goes according to plan. That's when NASA and ESI currently plan to return the first samples to Earth from Mars, samples that scientists hope will contain signs, if not examples, of Martian microbial life. Sheri Klug Boonstra of Arizona State University's Mars Space Flight Facility recently sounded an alarm: It's time to start consciously preparing the public to definitively learn we're not alone.
Bracing ourselves against anti-science attitudes and sound bites
Klug Boonstra is a science-education specialist and principal investigator of NASA's Lucy Student Pipeline and Competency Enabler Program. Speaking at the American Geophysical Unions' conference in December, she asserted that participants in the international Mars Sample Return Campaign (MSRC) should take seriously the ramifications of the project on society. She suggests this effort be considered equal in importance to the project's other objectives. "The public has to be a major part of the equation," Boonstra says. "We don't want to be in the position where we're just getting the information out when the public hears that the rocks are coming back."
No plague on mankind
Image source: science_photo/Shutterstock
Boonstra is concerned in particular with the possibility that laypeople may become terrified at the thought of bringing to Earth infectious new microbes or other biomaterials. With Ebola fresh in our minds, it's not an unreasonable concern, so Boonstra considers it important that the MSRC communicate the steps being taken to assure this doesn't happen.
While the likelihood of such an outcome is viewed as small — presuming we can predict with confidence the possible mechanisms of extraterrestrial contamination — MSRC plans to throughly vet the Mars samples at a Sample Receiving Facility (SRF) constructed for the purpose. The as-yet-unbuilt facility at a site not yet selected will guard against problems in both directions: Nothing would be able to contaminate the samples, and samples wouldn't be able to in any way leak out. The plan is to design and construct the SRF using to the standards of Biosafety Level 4 labs that safely house super-bugs such as Ebola as a baseline, according to Canadian Space Agency's Tim Haltigin.
The MSRC plan
Image source: ESA
While materials from Mars have been seen on Earth before, carried here in meteorites, this is the first time we'll have an up-close-and-personal look at pristine samples. MSRC is a joint effort of NASA and the European Space Agency. The preliminary plan is still being refined, but the probable broad strokes are clear.
In 2026, two launches will occur. The ESA's Earth Return Orbiter (ERO) will be sent into Mars orbit. NASA's Sample Retrieval Lander (SRL) will drop a craft into Jezero Crater, near the landing site of NASA's Mars 2020 rover. The lander will contain the ESA Sample Fetch Rover (SFR) as well as a small rocket, the Mars Ascent Vehicle (MAV).
As ERO orbits the red planet, the SRF will collect samples, packing them into sealed tubes and eventually carting them over to the MAV. The SRF will also have the option of stashing them on the 2020, which would also be able to bring them to the MAV.
When ready, the MAV will lift off with samples and jettison the container of them into orbit. ERO will catch the container, retrieve its contents and then dump the enclosure en route back to Earth, and us.
A new study finds that dogs fed fresh human-grade food don't need to eat—or do their business—as much.
- Most dogs eat a diet that's primarily kibble.
- When fed a fresh-food diet, however, they don't need to consume as much.
- Dogs on fresh-food diets have healthier gut biomes.
Four diets were tested<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNTU5ODI1MS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY1NjY0NjIxMn0._w0k-qFOC86AqmtPHJBK_i-9F5oVyVYsYtUrdvfUxWQ/img.jpg?width=980" id="1b1e4" class="rm-shortcode" data-rm-shortcode-id="87937436a81c700a8ab3b1d763354843" data-rm-shortcode-name="rebelmouse-image" data-width="1440" data-height="960" />
Credit: AntonioDiaz/Adobe Stock<p>The researchers tested refrigerated and fresh human-grade foods against kibble, the food most dogs live on. The <a href="https://frontierpets.com.au/blogs/news/how-kibble-or-dry-dog-food-is-made" target="_blank">ingredients</a> of kibble are mashed into a dough and then extruded, forced through a die of some kind into the desired shape — think a <a href="https://en.wikipedia.org/wiki/Food_extrusion" target="_blank">pasta maker</a>. The resulting pellets are sprayed with additional flavor and color.</p><p>For four weeks, researchers fed 12 beagles one of four diets:</p><ol><li>a extruded diet — Blue Buffalo Chicken and Brown Rice Recipe</li><li>a fresh refrigerated diet — Freshpet Roasted Meals Tender Chicken Recipe</li><li>a fresh diet — JustFoodforDogs Beef & Russet Potato Recipe</li><li>another fresh diet — JustFoodforDogs Chicken & White Rice Recipe.</li></ol><p>The two fresh diets contained minimally processed beef, chicken, broccoli, rice, carrots, and various food chunks in a canine casserole of sorts. </p><p>(One can't help but think how hard it would be to get finicky cats to test new diets. As if.)</p><p>Senior author <a href="https://ansc.illinois.edu/directory/ksswanso" target="_blank" rel="noopener noreferrer">Kelly S. Swanson</a> of U of I's Department of Animal Sciences and the Division of Nutritional Sciences, was a bit surprised at how much better dogs did on people food than even refrigerated dog chow. "Based on past research we've conducted I'm not surprised with the results when feeding human-grade compared to an extruded dry diet," he <a href="https://aces.illinois.edu/news/feed-fido-fresh-human-grade-dog-food-scoop-less-poop" target="_blank">says</a>, adding, "However, I did not expect to see how well the human-grade fresh food performed, even compared to a fresh commercial processed brand."</p>
Tracking the effect of each diet<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNTU5ODI1OC9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY3NjY1NTgyOX0.AdyMb8OEcjCD6iWYnXjToDmcnjfTSn-0-dfG96SIpUA/img.jpg?width=980" id="da892" class="rm-shortcode" data-rm-shortcode-id="880d952420679aeccd1eaf32b5339810" data-rm-shortcode-name="rebelmouse-image" data-width="1440" data-height="960" />
Credit: Patryk Kosmider/Adobe Stock<p>The researchers tracked the dogs' weights and analyzed the microbiota in their fecal matter.</p><p>It turned out that the dogs on kibble had to eat more to maintain their body weight. This resulted in their producing 1.5 to 2.9 times the amount of poop produced by dogs on the fresh diets.</p><p>Says Swanson, "This is consistent with a 2019 National Institute of Health study in humans that found people eating a fresh whole food diet consumed on average 500 less calories per day, and reported being more satisfied, than people eating a more processed diet."</p><p>Maybe even more interesting was the effect of fresh food on the gut biome. Though there remains much we don't yet know about microbiota, it was nonetheless the case that the microbial communities found in fresh-food poo was different.</p><p>"Because a healthy gut means a healthy mutt," says Swanson, "fecal microbial and metabolite profiles are important readouts of diet assessment. As we have shown in <a href="https://academic.oup.com/jas/article/92/9/3781/4702209#110855647" target="_blank">previous studies</a>, the fecal microbial communities of healthy dogs fed fresh diets were different than those fed kibble. These unique microbial profiles were likely due to differences in diet processing, ingredient source, and the concentration and type of dietary fibers, proteins, and fats that are known to influence what is digested by the dog and what reaches the colon for fermentation."</p>
How did kibble take over canine diets?<p>Historically, dogs ate scraps left over by humans. It has only been <a href="https://www.thefarmersdog.com/digest/the-history-of-commercial-pet-food-a-great-american-marketing-story/" target="_blank">since 1870</a>, with the arrival of the luxe Spratt's Meat Fibrine Dog Cakes—made from "the dried unsalted gelatinous parts of Prairie Beef", mmm—that commercial dog food began to take hold. Dog bone-shaped biscuits first appeared in 1907. Ken-L Ration dates from 1922. Kibble was first extruded in 1956. Pet food had become a great way to turn <a href="https://www.dogfoodadvisor.com/choosing-dog-food/animal-by-products/" target="_blank">human-food waste</a> into profit.</p><p>Commercial dog food became the norm for most household canines only after a massive marketing campaign led by a group of dog-food industry lobbyists called the Pet Food Institute in 1964. Over time, for most households, dog food was what dogs ate — what else? Human food? These days more than half of U.S. dogs are <a href="https://www.nytimes.com/2014/08/03/magazine/who-made-that-dog-biscuit.html" target="_blank">overweight or obese</a>, and certainly their diet is a factor.<span></span></p><p>We're not so special among animals after all. If something's healthy for us to eat—we're <em>not</em> looking at you, chocolate—maybe we should remember to share with our canine compatriots. Not from the table, though.</p>
New study suggests the placebo effect can be as powerful as microdosing LSD.
- New research from Imperial College London investigated the psychological effects of microdosing LSD in 191 volunteers.
- While microdosers experienced beneficial mental health effects, the placebo group performed statistically similar to those who took LSD.
- Researchers believe the expectation of a trip could produce some of the same sensations as actually ingesting psychedelics.
Psychedelics: The scientific renaissance of mind-altering drugs<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="92360c805fe66c11de38a75b0967f417"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/5T0LmbWROKY?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p>For the study published in eLife, the team recruited 191 citizen cosmonauts to microdose either LSD or a placebo over the course of several weeks and note the psychological effects. Volunteers were already microdosing LSD, so there was no true control. Each volunteer was given instructions on creating their own low-dose gel capsules, some containing LSD, others not. Then they mixed the capsules in envelopes so they didn't know if they were taking the real thing or not.</p><p>The trial design was ingenious: each capsule featured a QR code that was scanned after the addition of ingredients but before they were placed in the envelope so that researchers knew what they were ingesting.</p><p>The problem: volunteers sourced their own LSD. Lack of quality control could have had a profound effect on the results. </p><p>The results: LSD microdosers reported feeling more mindful, satisfied with life, and better overall; they also noticed a reduction in feelings of paranoia. </p><p>The catch: the control group felt the same thing, with no statistical difference between the groups. </p><p>Lead author Balázs Szigeti comments on the findings: "This suggests that the improvements may not be due to the pharmacological action of the drug but can instead be explained by the placebo effect." </p>
Credit: Alexander / Adobe Stock<p>Psychedelics are notoriously difficult to control for given the intensity of the experience. Yet there is precedent for the above findings. A <a href="https://link.springer.com/article/10.1007/s00213-020-05464-5" target="_blank">2019 study</a> found that 61 percent of volunteers that took a placebo instead of psilocybin felt some psychedelic effects, with a few volunteers experiencing full-on trips.</p><p style="margin-left: 20px;">"Several stated that they saw the paintings on the walls 'move' or 'reshape' themselves, others felt 'heavy. . . as if gravity [had] a stronger hold', and one had a 'come down' before another 'wave' hit her."</p><p>The Imperial team believes the expectation of a trip might have been enough to produce similar results. Senior author David Erritzoe is excited for future studies on the topic, believing they tapped into a new wave of citizen science that could push forward our knowledge of psychedelic substances.</p><p style="margin-left: 20px;">"Accounting for the placebo effect is important when assessing trends such as the use of cannabidiol oils, fad diets or supplements where social pressure or users' expectations can lead to a strong placebo response. Self-blinding citizen science initiatives could be used as an inexpensive, initial screening tool before launching expensive clinical studies."</p><p>As investments into the psychedelics market explode, with one company <a href="https://www.bloomberg.com/news/articles/2021-03-03/thiel-backed-magic-mushroom-firm-atai-hits-2-billion-valuation" target="_blank">reaching a $2 billion valuation</a>, a recurring irony appears in the long arc of psychedelics and research: the power of our minds might be enough to feel greater life satisfaction and a deeper sense of mindfulness. If that's possible with a placebo, we have to question why the rush to create more pharmacology is necessary. </p><p>This is, mind you, a separate conversation over the role of psychedelics and rituals for group bonding. The function of group cohesion around consciousness-altering substances will continue to play an important role in many communities. </p><p>Of course, we should continue to explore the efficacy of psychedelics on anxiety, depression, suicidal ideation, PTSD, and addiction. <a href="https://bigthink.com/surprising-science/antidepressant-effects" target="_self">Pharmacological dependence</a> is a stain on the psychiatry industry. Whether or not psychedelics can be prescribed for daily use remains to be seen, but we know a moneyed interest is expecting a return on investment—the above company, ATAI Life Sciences, raised $157 million in its Series D round. </p><p>When it comes to wellbeing, some things money just can't buy. How we navigate the tricky terrain of mainstreaming psychedelics remains to be seen. </p><p>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a> and <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank" rel="noopener noreferrer">Facebook</a>. His most recent book is</em> "<em><a href="https://www.amazon.com/gp/product/B08KRVMP2M?pf_rd_r=MDJW43337675SZ0X00FH&pf_rd_p=edaba0ee-c2fe-4124-9f5d-b31d6b1bfbee" target="_blank" rel="noopener noreferrer">Hero's Dose: The Case For Psychedelics in Ritual and Therapy</a>."</em></p>
What makes some people more likely to shiver than others?
Some people just aren't bothered by the cold, no matter how low the temperature dips. And the reason for this may be in a person's genes.