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Intermittent fasting and keto diet: Can you do both at the same time?
Hint: Both lead to the same metabolic state.
- The keto diet and intermittent fasting are two weight-loss methods that have gained popularity in recent years.
- Both can put the body in a state of ketosis, which leads to many of the same benefits.
- However, scientists are still researching both intermittent fasting and the keto diet, and it's best to consult a doctor before making any drastic changes to your dietary habits – especially two changes at same time.
The keto diet and intermittent fasting are two popular, effective ways to lose weight quickly. Both methods bring upon similar changes in the body: more ketones, lower blood sugar and, at least anecdotally, improved mood and mental clarity. Both also call for less snacks, though the keto diet restricts which snacks you eat while intermittent fasting restricts when you snack.
It's generally safe to experiment with either the keto diet or intermittent fasting (though it's always better to consult a doctor first). But how safe is it to combine the two? First, let's take a look at what both of these weight-loss approaches do to the body, and how those processes might interact.
The keto diet
In simple terms, ketosis is a metabolic process in which the body starts burning fat for fuel instead of sugar (glucose). Ketosis occurs naturally when the body doesn't have enough glucose to use as energy, so it instead turns to stored fats, which it converts into ketones that are distributed through blood to muscles and other tissue. The keto diet triggers this process by calling for a diet high in fat and low in carbohydrates, which results in lower levels of blood sugar and insulin.
Although scientists are still researching exactly how ketosis affects the body, some studies suggest keto diets can:
- Improve mood and mental clarity
- Improve heart health
- Decrease seizures among epilepsy patients
- Help in cancer treatments (potentially)
- Decrease acne
Cutting carbs is a sure way to put your body in a state of ketosis. Another way? Fasting.
Three square meals a day is the norm in the developed world, but in terms of human evolution it's a relatively new idea. The breakfast-lunch-dinner routine was likely established by Europeans, some of whom scoffed at the "uncivilized" Native Americans who didn't have rigid eating times and changed dietary habits with the seasons. But, as Yale University professor and author of Food: The History of Taste Paul Freedman argues, there's no biological reason for eating three meals a day at specific times.
Research shows that replacing rote eating habits with controlled fasting can be beneficial for your health, particularly through intermittent fasting, which can include fasting for several days at a time, fasting for 18 hours a day and eating only during the remaining six, and similar approaches.
Studies suggest intermittent fasting can:
- Increase longevity in animals and humans
- Increase levels of human growth hormone, promoting healthy muscle growth and fat loss
- Improve protection against cardiovascular diseases
- Gently stress your cells and neurons, strengthening them
- Promote autophagy — a natural process in which cells shed damaged cells, toxins
One particularly interesting benefit of intermittent fasting is that it seems to be effective at increasing insulin sensitivity, which refers to how cells respond to insulin – the hormone that tells cells to allow sugar to enter so it can be used as fuel.
"The food we eat is broken down by enzymes in our gut and eventually ends up as molecules in our bloodstream," Monique Tello, MD, MPH, wrote for Harvard Health Blog. "Carbohydrates, particularly sugars and refined grains (think white flours and rice), are quickly broken down into sugar, which our cells use for energy. If our cells don't use it all, we store it in our fat cells as, well, fat. But sugar can only enter our cells with insulin, a hormone made in the pancreas. Insulin brings sugar into the fat cells and keeps it there."
But for reasons scientists don't completely understand, our cells can become resistant to insulin, which can cause your pancreas to produce too much of the hormone and then, after it becomes fatigued, not enough. Intermittent fasting might break that cycle by putting your body in a fasting state in which it doesn't overproduce insulin, as Dr. Jason Fung told the Bulletproof Radio podcast:
"If you become very insulin resistant, then your insulin levels are up all the time, your body is always trying to shove the energy into the fat cells, and then you feel cold and tired and lousy. That's the real problem. Resistance really depends on two things. It's not simply the high levels, but it's the persistence of those levels. What people have realized is that the insulin resistance, because it depends on those two things, a period of time where you can get your insulin levels very low is going to break that resistance because it breaks that persistence. Not simply the levels, but the persistence of those levels."
Combining the keto diet with intermittent fasting
The major link between the keto diet and intermittent fasting is that they both can put the body into ketosis, generally resulting in lower levels of blood sugar and insulin, and therefore weight loss. But are they safe to do together?
Intermittent fasting will almost surely help you reach ketosis faster than a keto diet will alone, typically within 24 hours to three days. It's safe to say that, in terms of weight loss, combining these two approaches is likely to enhance the other's efficacy. But that's not to say everyone should do it.
Intermittent fasting and keto diets have been linked to mood problems in the weeks after beginning one or the other – irritability, anxiety, depressive symptoms. (For keto diets, this is often called the "keto flu.") It might be unsurprising that a drastic change in dietary habits would result in mood swings, and, to be sure, anecdotal reports suggest these symptoms tend to clear up eventually if people stick to their new routines. Still, it's best to consult your doctor before making such a drastic change – especially if you already suffer from a psychiatric condition, or a condition significantly affected by levels of blood sugar and insulin, like diabetes.
If you're going to move forward with combining intermittent fasting with the keto diet, consider these bits of advice from Perfect Keto:
"Make sure you still eat enough. Intermittent fasting does help you naturally eat less during the day, but be sure you're still eating nutritious ketogenic foods to avoid any deficiencies or metabolic issues. Use a website or app to calculate ideal caloric intake and your ketogenic macros for each day, then track them to make sure you're getting sufficient nutrition.
Measure your ketone levels. Even though fasting can really help you stay in ketosis, it's still important to make sure you aren't eating too many carbs or doing anything else to kick you out of ketosis. Track your ketones often to make sure you're actually in ketosis!"
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Andy Samberg and Cristin Milioti get stuck in an infinite wedding time loop.
- Two wedding guests discover they're trapped in an infinite time loop, waking up in Palm Springs over and over and over.
- As the reality of their situation sets in, Nyles and Sarah decide to enjoy the repetitive awakenings.
- The film is perfectly timed for a world sheltering at home during a pandemic.
Richard Feynman once asked a silly question. Two MIT students just answered it.
Here's a fun experiment to try. Go to your pantry and see if you have a box of spaghetti. If you do, take out a noodle. Grab both ends of it and bend it until it breaks in half. How many pieces did it break into? If you got two large pieces and at least one small piece you're not alone.
But science loves a good challenge<p>The mystery remained unsolved until 2005, when French scientists <a href="http://www.lmm.jussieu.fr/~audoly/" target="_blank">Basile Audoly</a> and <a href="http://www.lmm.jussieu.fr/~neukirch/" target="_blank">Sebastien Neukirch </a>won an <a href="https://www.improbable.com/ig/" target="_blank">Ig Nobel Prize</a>, an award given to scientists for real work which is of a less serious nature than the discoveries that win Nobel prizes, for finally determining why this happens. <a href="http://www.lmm.jussieu.fr/spaghetti/audoly_neukirch_fragmentation.pdf" target="_blank">Their paper describing the effect is wonderfully funny to read</a>, as it takes such a banal issue so seriously. </p><p>They demonstrated that when a rod is bent past a certain point, such as when spaghetti is snapped in half by bending it at the ends, a "snapback effect" is created. This causes energy to reverberate from the initial break to other parts of the rod, often leading to a second break elsewhere.</p><p>While this settled the issue of <em>why </em>spaghetti noodles break into three or more pieces, it didn't establish if they always had to break this way. The question of if the snapback could be regulated remained unsettled.</p>
Physicists, being themselves, immediately wanted to try and break pasta into two pieces using this info<p><a href="https://roheiss.wordpress.com/fun/" target="_blank">Ronald Heisser</a> and <a href="https://math.mit.edu/directory/profile.php?pid=1787" target="_blank">Vishal Patil</a>, two graduate students currently at Cornell and MIT respectively, read about Feynman's night of noodle snapping in class and were inspired to try and find what could be done to make sure the pasta always broke in two.</p><p><a href="http://news.mit.edu/2018/mit-mathematicians-solve-age-old-spaghetti-mystery-0813" target="_blank">By placing the noodles in a special machine</a> built for the task and recording the bending with a high-powered camera, the young scientists were able to observe in extreme detail exactly what each change in their snapping method did to the pasta. After breaking more than 500 noodles, they found the solution.</p>
The apparatus the MIT researchers built specifically for the task of snapping hundreds of spaghetti sticks.
(Courtesy of the researchers)
What possible application could this have?<p>The snapback effect is not limited to uncooked pasta noodles and can be applied to rods of all sorts. The discovery of how to cleanly break them in two could be applied to future engineering projects.</p><p>Likewise, knowing how things fragment and fail is always handy to know when you're trying to build things. Carbon Nanotubes, <a href="https://bigthink.com/ideafeed/carbon-nanotube-space-elevator" target="_self">super strong cylinders often hailed as the building material of the future</a>, are also rods which can be better understood thanks to this odd experiment.</p><p>Sometimes big discoveries can be inspired by silly questions. If it hadn't been for Richard Feynman bending noodles seventy years ago, we wouldn't know what we know now about how energy is dispersed through rods and how to control their fracturing. While not all silly questions will lead to such a significant discovery, they can all help us learn.</p>
The multifaceted cerebellum is large — it's just tightly folded.
- A powerful MRI combined with modeling software results in a totally new view of the human cerebellum.
- The so-called 'little brain' is nearly 80% the size of the cerebral cortex when it's unfolded.
- This part of the brain is associated with a lot of things, and a new virtual map is suitably chaotic and complex.
Just under our brain's cortex and close to our brain stem sits the cerebellum, also known as the "little brain." It's an organ many animals have, and we're still learning what it does in humans. It's long been thought to be involved in sensory input and motor control, but recent studies suggests it also plays a role in a lot of other things, including emotion, thought, and pain. After all, about half of the brain's neurons reside there. But it's so small. Except it's not, according to a new study from San Diego State University (SDSU) published in PNAS (Proceedings of the National Academy of Sciences).
A neural crêpe
A new imaging study led by psychology professor and cognitive neuroscientist Martin Sereno of the SDSU MRI Imaging Center reveals that the cerebellum is actually an intricately folded organ that has a surface area equal in size to 78 percent of the cerebral cortex. Sereno, a pioneer in MRI brain imaging, collaborated with other experts from the U.K., Canada, and the Netherlands.
So what does it look like? Unfolded, the cerebellum is reminiscent of a crêpe, according to Sereno, about four inches wide and three feet long.
The team didn't physically unfold a cerebellum in their research. Instead, they worked with brain scans from a 9.4 Tesla MRI machine, and virtually unfolded and mapped the organ. Custom software was developed for the project, based on the open-source FreeSurfer app developed by Sereno and others. Their model allowed the scientists to unpack the virtual cerebellum down to each individual fold, or "folia."
Study's cross-sections of a folded cerebellum
Image source: Sereno, et al.
A complicated map
Sereno tells SDSU NewsCenter that "Until now we only had crude models of what it looked like. We now have a complete map or surface representation of the cerebellum, much like cities, counties, and states."
That map is a bit surprising, too, in that regions associated with different functions are scattered across the organ in peculiar ways, unlike the cortex where it's all pretty orderly. "You get a little chunk of the lip, next to a chunk of the shoulder or face, like jumbled puzzle pieces," says Sereno. This may have to do with the fact that when the cerebellum is folded, its elements line up differently than they do when the organ is unfolded.
It seems the folded structure of the cerebellum is a configuration that facilitates access to information coming from places all over the body. Sereno says, "Now that we have the first high resolution base map of the human cerebellum, there are many possibilities for researchers to start filling in what is certain to be a complex quilt of inputs, from many different parts of the cerebral cortex in more detail than ever before."
This makes sense if the cerebellum is involved in highly complex, advanced cognitive functions, such as handling language or performing abstract reasoning as scientists suspect. "When you think of the cognition required to write a scientific paper or explain a concept," says Sereno, "you have to pull in information from many different sources. And that's just how the cerebellum is set up."
Bigger and bigger
The study also suggests that the large size of their virtual human cerebellum is likely to be related to the sheer number of tasks with which the organ is involved in the complex human brain. The macaque cerebellum that the team analyzed, for example, amounts to just 30 percent the size of the animal's cortex.
"The fact that [the cerebellum] has such a large surface area speaks to the evolution of distinctively human behaviors and cognition," says Sereno. "It has expanded so much that the folding patterns are very complex."
As the study says, "Rather than coordinating sensory signals to execute expert physical movements, parts of the cerebellum may have been extended in humans to help coordinate fictive 'conceptual movements,' such as rapidly mentally rearranging a movement plan — or, in the fullness of time, perhaps even a mathematical equation."
Sereno concludes, "The 'little brain' is quite the jack of all trades. Mapping the cerebellum will be an interesting new frontier for the next decade."
What happens if we consider welfare programs as investments?
- A recently published study suggests that some welfare programs more than pay for themselves.
- It is one of the first major reviews of welfare programs to measure so many by a single metric.
- The findings will likely inform future welfare reform and encourage debate on how to grade success.
Welfare as an investment<p>The <a href="https://scholar.harvard.edu/files/hendren/files/welfare_vnber.pdf" target="_blank">study</a>, carried out by Nathaniel Hendren and Ben Sprung-Keyser of Harvard University, reviews 133 welfare programs through a single lens. The authors measured these programs' "Marginal Value of Public Funds" (MVPF), which is defined as the ratio of the recipients' willingness to pay for a program over its cost.</p><p>A program with an MVPF of one provides precisely as much in net benefits as it costs to deliver those benefits. For an illustration, imagine a program that hands someone a dollar. If getting that dollar doesn't alter their behavior, then the MVPF of that program is one. If it discourages them from working, then the program's cost goes up, as the program causes government tax revenues to fall in addition to costing money upfront. The MVPF goes below one in this case. <br> <br> Lastly, it is possible that getting the dollar causes the recipient to further their education and get a job that pays more taxes in the future, lowering the cost of the program in the long run and raising the MVPF. The value ratio can even hit infinity when a program fully "pays for itself."</p><p> While these are only a few examples, many others exist, and they do work to show you that a high MVPF means that a program "pays for itself," a value of one indicates a program "breaks even," and a value below one shows a program costs more money than the direct cost of the benefits would suggest.</p> After determining the programs' costs using existing literature and the willingness to pay through statistical analysis, 133 programs focusing on social insurance, education and job training, tax and cash transfers, and in-kind transfers were analyzed. The results show that some programs turn a "profit" for the government, mainly when they are focused on children:
This figure shows the MVPF for a variety of polices alongside the typical age of the beneficiaries. Clearly, programs targeted at children have a higher payoff.
Nathaniel Hendren and Ben Sprung-Keyser<p>Programs like child health services and K-12 education spending have infinite MVPF values. The authors argue this is because the programs allow children to live healthier, more productive lives and earn more money, which enables them to pay more taxes later. Programs like the preschool initiatives examined don't manage to do this as well and have a lower "profit" rate despite having decent MVPF ratios.</p><p>On the other hand, things like tuition deductions for older adults don't make back the money they cost. This is likely for several reasons, not the least of which is that there is less time for the benefactor to pay the government back in taxes. Disability insurance was likewise "unprofitable," as those collecting it have a reduced need to work and pay less back in taxes. </p>