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What we know about the dangers of e-cigarettes

Compared to traditional cigarettes, e-cigarettes are extremely understudied. There is, however, some evidence on their negative effects on your health.

  • Traditional cigarettes have the benefit of decades' worth of research on their harmful effects. E-cigarettes are relatively new, and our understanding of their long-term effects is limited.
  • To fill this gap, researchers are conducting studies to identify exactly how e-cigarettes effect our bodies.
  • To date, it appears that e-cigarettes are better for you than traditional cigarettes, but that doesn't make them harmless.


E-cigarettes are, in all likelihood, better for your health than smoking cigarettes. There's a general agreement among the medical community that vaping exposes people to fewer toxic chemicals than cigarettes, but that doesn't mean they're consequence-free.

For one, e-cigarettes use a different cocktail of chemicals than cigarettes, which, even if they're fewer in number, may be of a more dangerous variety. But more importantly, cigarettes have had the benefit of many decades worth of research; e-cigarettes are simply too new for us to know what the long-term consequences will be.

That being said, there is some empirical evidence as to the negative health effects of e-cigarettes. Here's what we know so far.

Nicotine alone isn't harmless

The main appeal of e-cigarettes is that they deliver nicotine, which functions as a stimulant, ensuring both that e-cigarettes are enjoyable and addictive. However, even by itself, nicotine can do a number on your body.

It's been implicated in cardiovascular diseases such as coronary artery disease, atherosclerosis, and aortic aneurysms. Though nicotine is not a carcinogen in and of itself, new research suggests it promotes tumor growth, the formation of blood vessels that supply tumors with nutrients, and metastasis. Hopefully this doesn't need to be said, but it's also quite unhealthy for pregnant mothers and young children.

Exposure to metals from e-cigarette coils

Most e-cigarettes produce an aerosol by heating an e-liquid with a metal coil. These coils are made out of a variety of metals, with the majority made out of Kanthal (an alloy of iron, chromium, and aluminum) and nichrome (an alloy of nickel and chromium). A 2018 study found that the metals associated with these heating coils were leaching into the liquid solution — and, commensurately, into the bodies of the people inhaling them — at unsafe levels. Chronic exposure to such metals has been linked to lung, liver, heart, and brain damage, and may also depress immune function and increase cancer risk.

The cocktail of flavoring agents

E-liquids for use in vaporizers on display. Image source: Justin Sullivan / Getty Images

One of the biggest concerns with vaping is the chemicals used to flavor e-liquids. While many chemicals used in e-cigarettes are labelled as safe for human consumption by the FDA, typically, this labeling applies to their ingestion. Inhaling them may have very different consequences. While there are far too many to go through individually, a few stand out:

Cinnamaldehyde — which, as you may have guessed, has a cinnamon-like taste — has been found to be significantly toxic. Four very common flavoring agents — vanillin, ethyl maltol, ethyl vanillin, and methol — are either carcinogenic or toxic and contribute to cardiopulmonary and neurodegenerative diseases. In general, many of the sweeter flavorings tends to be more toxic. Diacetyl is sometimes found in flavored e-liquids, which provides a sort of buttery flavor. Originally, it was used in microwave popcorn, but manufacturers stopped including it when it was revealed to contribute to bronchiolitis obliterans, also known as popcorn lung.

Propylene glycol and vegetable glycerin

While flavoring chemicals can vary from e-liquid to e-liquid, propylene glycol (PG) and vegetable glycerin (VG) are essentially universal. As mentioned above, these are considered non-toxic when ingested, but their toxicity when inhaled is not clear. Some research, however, has been conducted on these chemicals.

One study, for instance, focused on testing a wide variety of e-liquid chemicals on cell cultures. Based off of the reduced rates at which the treated cells grew, the researchers could then evaluate the toxicity of e-liquid chemicals on those cells. In addition to testing a number of flavoring compounds, they also tested a pure PG/VG treatment, and found that it significantly impacted cell growth.

That being said, the evidence isn't entirely conclusive on PG/VG's toxicity. Another study, for instance, found no toxic effects in mice exposed to aerosolized PG/VG. Ultimately, the preliminary evidence seems to suggest that inhaling PG/VG over the short-term is not toxic, but there is a serious lack of data on their effects over the long-term.

There's another potential concern related to PG/VG in e-cigarettes: formaldehyde exposure. When PG/VG is heated, it can become oxidized to produce carbonyl compounds, such as glyoxal, acrolein, acetaldehyde, and formaldehyde, especially at higher wattages. However, a report by the Royal College of Physicians states that "In normal conditions of use [i.e., low wattages/temperatures], toxin levels in inhaled e-cigarette vapour are probably well below prescribed threshold limit values for occupational exposure."

Ultimately, vaping can be said to be safer than smoking traditional cigarettes, but it's clearly not harmless. If you use e-cigarettes and are concerned about the toxicity of the chemicals in your e-liquid, the Center for Tobacco Regulatory Science and Lung Health maintains a database on the toxicity of a variety of e-liquid brands at eliquidinfo.org

Neom, Saudi Arabia's $500 billion megacity, reaches its next phase

Construction of the $500 billion dollar tech city-state of the future is moving ahead.

Credit: Neom
Technology & Innovation
  • The futuristic megacity Neom is being built in Saudi Arabia.
  • The city will be fully automated, leading in health, education and quality of life.
  • It will feature an artificial moon, cloud seeding, robotic gladiators and flying taxis.
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Why do people believe in conspiracy theories?

Are we genetically inclined for superstition or just fearful of the truth?

Videos
  • From secret societies to faked moon landings, one thing that humanity seems to have an endless supply of is conspiracy theories. In this compilation, physicist Michio Kaku, science communicator Bill Nye, psychologist Sarah Rose Cavanagh, skeptic Michael Shermer, and actor and playwright John Cameron Mitchell consider the nature of truth and why some groups believe the things they do.
  • "I think there's a gene for superstition, a gene for hearsay, a gene for magic, a gene for magical thinking," argues Kaku. The theoretical physicist says that science goes against "natural thinking," and that the superstition gene persists because, one out of ten times, it actually worked and saved us.
  • Other theories shared include the idea of cognitive dissonance, the dangerous power of fear to inhibit critical thinking, and Hollywood's romanticization of conspiracies. Because conspiracy theories are so diverse and multifaceted, combating them has not been an easy task for science.

COVID-19 brain study to explore long-term effects of the virus

A growing body of research suggests COVID-19 can cause serious neurological problems.

Brain images of a patient with acute demyelinating encephalomyelitis.

Coronavirus
  • The new study seeks to track the health of 50,000 people who have tested positive for COVID-19.
  • The study aims to explore whether the disease causes cognitive impairment and other conditions.
  • Recent research suggests that COVID-19 can, directly or indirectly, cause brain dysfunction, strokes, nerve damage and other neurological problems.
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Sponsored by Charles Koch Foundation

Better reskilling can future-proof jobs in the age of automation. Enter SkillUp's new coalition.

Coronavirus layoffs are a glimpse into our automated future. We need to build better education opportunities now so Americans can find work in the economy of tomorrow.

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