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Scientists map great white shark genome, revealing clues about cancer and healing wounds

Can learning about the great white shark help protect us from cancer?

(Photo: Lalo Saidy / Barcroft Images / Barcroft Media via Getty Images)
  • Scientists have mapped the entire genome of the great white shark.
  • The team found genetic adaptations that seem to help the fish preserve and repair its genome, clues that may help us better understand why sharks rarely get cancer.
  • The team also identified several gene pathways that might also help explain the fish's extraordinary wound-healing capabilities.

An international team of scientists has decoded the entire genome of the great white shark, an achievement that could help us better fight cancer and learn more about the fish's extraordinary healing capabilities.

How could the great white shark – an apex predator that can reach 20 feet long and 7,000 pounds – provide humanity with potentially life-saving knowledge about cancer and other diseases? For one, the great white shark is a champion of evolution; its DNA has been fine-tuned by millions of years spent thriving in the world's oceans with no natural predators. Mapping the great white's genome could illuminate the keys to this evolutionary success.

The team, which published its findings in the Proceedings of the National Academy of Sciences, compared the great white's genome to that of humans and other vertebrates. The researchers found patterns of DNA sequence changes that indicated molecular adaptation in genes related to maintaining genome stability, through functions including DNA damage response, DNA repair and DNA damage tolerance – all of which can protect against cancer.

This might explain why sharks rarely suffer from the disease.

"Not only were there a surprisingly high number of genome stability genes that contained these adaptive changes, but there was also an enrichment of several of these genes, highlighting the importance of this genetic fine-tuning in the white shark," Mahmood Shivji, Ph.D., director of NSU's Save Our Seas Foundation Shark Research Center and GHRI, said in a statement.

The researchers also found that the great white's genome contains one of the highest proportions of transposons – also known as "jumping genes" – ever discovered among vertebrates.

"These LINEs are known to cause genome instability by creating double stranded breaks in DNA," study co-author Michael Stanhope said in a statement. "It's plausible that this proliferation of LINEs in the white shark genome could represent a strong selective agent for the evolution of efficient DNA repair mechanisms, and is reflected in the positive selection and enrichment of so many genome stability genes."

Rapid wound healing

A great white shark near The Neptune Islands, South Australia, sticks its head out of the water, baring its teeth.

Photo: Brad Leue / Barcroft Images / Barcroft Media via Getty Images

In addition to being able to preserve and repair genetic information, sharks are also known for their uncanny ability to recover from external injuries. For example, a 2015 study on blacktip reef sharks found they were able to heal wounds rapidly – sometimes within days – even when injuries were severe.

"We found positive selection and gene content enrichments involving several genes tied to some of the most fundamental pathways in wound healing, including in a key blood clotting gene," Stanhope said. "These adaptations involving wound healing genes may underlie the vaunted ability of sharks to heal efficiently from even large wounds."

Uncovering the 'tip of the iceberg' in shark genome research

The great white shark's ability to protect its genome may well help humans someday do the same, but it'll take years to incorporate these findings into approved treatments.

"Genome instability is a very important issue in many serious human diseases; now we find that nature has developed clever strategies to maintain the stability of genomes in these large-bodied, long-lived sharks," said Shivji. "There's still tons to be learned from these evolutionary marvels, including information that will potentially be useful to fight cancer and age-related diseases, and improve wound healing treatments in humans, as we uncover how these animals do it."

The “new normal” paradox: What COVID-19 has revealed about higher education

Higher education faces challenges that are unlike any other industry. What path will ASU, and universities like ASU, take in a post-COVID world?

Photo: Luis Robayo/AFP via Getty Images
Sponsored by Charles Koch Foundation
  • Everywhere you turn, the idea that coronavirus has brought on a "new normal" is present and true. But for higher education, COVID-19 exposes a long list of pernicious old problems more than it presents new problems.
  • It was widely known, yet ignored, that digital instruction must be embraced. When combined with traditional, in-person teaching, it can enhance student learning outcomes at scale.
  • COVID-19 has forced institutions to understand that far too many higher education outcomes are determined by a student's family income, and in the context of COVID-19 this means that lower-income students, first-generation students and students of color will be disproportionately afflicted.
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Mystery effect speeds up the universe – not dark energy, says study

Russian astrophysicists propose the Casimir Effect causes the universe's expansion to accelerate.

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Credits: NASA's Goddard Space Flight Center/Jeremy Schnittman
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  • Astrophysicists from Russia propose a theory that says dark energy doesn't exist.
  • Instead, the scientists think the Casimir Effect creates repulsion.
  • This effect causes the expansion of the universe to accelerate.
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How DNA revealed the woolly mammoth's fate – and what it teaches us today

Scientists uncovered the secrets of what drove some of the world's last remaining woolly mammoths to extinction.

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