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Ebola is now largely curable, new clinical trials suggest
A recent clinical trial shows that two new drugs are far more effective than current treatments.
- The Democratic Republic of Congo has been suffering a major Ebola outbreak since August 2018.
- In November 2018, a clinical trial began comparing the efficacy of four Ebola treatments.
- Two of those treatments — based on monoclonal antibodies — are nearly twice as effective as the standard treatment.
In August 2018, an Ebola outbreak struck a conflict zone in the Democratic Republic of Congo's North Kivu province. It soon spread elsewhere throughout the nation of 81.3 million people, many of whom are embroiled in battles over DRC's valuable minerals. By April, the outbreak had become the second worst ever recorded, and by June it had killed at least 1,357 Congolese.
But a recent clinical trial that compared the efficacy of four Ebola treatments brings good news.
"From now on, we will no longer say that Ebola is incurable," said Dr. Jean-Jacques Muyembe, the director general of the Institut National pour la Recherche Biomédicale in DRC, which has overseen the trial. "These advances will help save thousands of lives."
In November 2018, doctors in DRC began randomly assigning Ebola patients one of four treatments: an antiviral drug named remdesivir, or one of three drugs made of monoclonal antibodies, which are a set of immune cells cloned from a parent cell. ZMapp — one of the three drugs that use monoclonal antibodies — has long been considered the most effective treatment for Ebola. In the clinical trial, it helped lower mortality rates among Ebola patients to about 49 percent. (Patients who don't receive any treatment have a mortality rate of roughly 75 percent.)
But two other drugs of the same class — a cocktail of monoclonal antibodies made by a company named Regeneron, and an antibody called mAb114 made by the National Institute of Allergy and Infectious Diseases' Vaccine Research Center — were much more effective, yielding an overall mortality rate of 29 and 34 percent, respectively. These drugs were developed by giving mice Ebola and then extracting the antibodies that the mice produced. Scientists then tweaked those mice antibodies so the human body would accept them. The two drugs will now be administered in every treatment center in DRC.
An illustration depicting how to safely bury people who died from Ebola. Image source: CDC's Center for Global Health
The monoclonal antibodies-based drugs were especially successful at curing Ebola when patients took them soon after becoming sick, with Regeneron's drug lowering mortality rates to just 6 percent. But one problem is that most Ebola patients in DRC wait an average of four days before coming to the hospital, which decreases the odds of survival and increases the odds of transmitting the disease — through bodily fluids — to people near them.
But health experts are optimistic about the new drugs."The more we learn about these two treatments, and how they can complement the public health response, including contact tracing and vaccination, the closer we can get to turning Ebola from a terrifying disease to one that is preventable and treatable," Dr. Jeremy Farrar, the co-chair of the World Health Organization's Ebola therapeutics group, told The Guardian. "We won't ever get rid of Ebola but we should be able to stop these outbreaks from turning into major national and regional epidemics."
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A 2017 University of Wisconsin-Madison study was the first of it's kind to show structural differences in the psychopathic brain.
- According to a 2017 study led by the University of Wisconsin-Madison, psychopaths have reduced connections in the areas of the brain that control fear, anxiety, empathy and sentimentality.
- Psychopathy is typically diagnosed using a 20-item checklist called the Hare Psychopathy Checklist.
- Psychopathic tendencies could be considered "warning signs" of psychopathy, but it's important to note that not everyone who shows psychopathic tendencies becomes a psychopath.
Defining psychopathy<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMzQxMDkwMi9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYwNTk2MTAyOH0.yVAVp2AYmR0i5hPAhhY-R1jafU2y0shl5R35K2rOnCg/img.jpg?width=1245&coordinates=0%2C92%2C0%2C92&height=700" id="531fa" class="rm-shortcode" data-rm-shortcode-id="d45c27dc8187d30f709739ca98c9913f" data-rm-shortcode-name="rebelmouse-image" alt="concept of psychopathy split personality manipulation and deceit man showing half his true face" />
Psychopathy is typically diagnosed using a 20-item checklist called the Hare Psychopathy Checklist.
Photo by FGC on Shutterstock<p>Psychopathy, like many other conditions, is a spectrum. Common traits of psychopaths can include things like superficial charm, grandiose sense of self-worth, pathological lying, manipulation, lack of remorse or guilt, lack of empathy, behavioral problems in early life, impulsivity, and shallow affect (reduced emotional responses) to name a few.<br></p><p>Psychopathy is typically diagnosed using a 20-item checklist called the <a href="http://www.clintools.com/victims/resources/assessment/personality/psychopathy_checklist.html" target="_blank">Hare Psychopathy Checklist</a>. This list features questions that gauge common traits such as a lack of empathy, pathological lying, and impulsivity (among many others). </p><p>Each question on this scale is then scored on a three-point scale: The item doesn't apply (0), the item applies to a certain extend (1), or the question fully applies (2). The bar for "clinical psychopathy" is 30 points on this test. </p><p>For reference, here are some of the scores of notable evaluations: </p><p>Ted Bundy - 39/40<br>Richard Ramirez - 31/40<br>Brian David Mitchell - 34/40</p><p><strong>Differentiating psychopathy and sociopathy </strong></p><p>The terms "psychopath" and "sociopath" are often used interchangeably but they aren't the same - and the <a href="https://psychcentral.com/blog/differences-between-a-psychopath-vs-sociopath/#:~:text=Psychopaths%20tend%20to%20be%20more,much%20of%20a%20normal%20life." target="_blank">difference is quite important</a>. A sociopath is someone with antisocial tendencies that are specific to social or environmental factors. A psychopath is someone whose traits are more innate.</p><p>A psychopath will be more manipulative but can be seen by others to lead a charming, "normal" life - whereas sociopaths tend to be more erratic, rage-prone, and are unable to keep up the facade of normality. </p>
Psychopathic tendencies versus psychopathy<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMzQxMDkwNS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYzNjYzMTQ5OX0.IkfptXc5e1auSwTo_Bqpasjwbh4i1nLS8r8Xmm2EJEI/img.jpg?width=980" id="8b403" class="rm-shortcode" data-rm-shortcode-id="0581a77d5f1e4b73e07c019aeda5971d" data-rm-shortcode-name="rebelmouse-image" alt="concept of trying on many faces hiding your true personality psychopath" />
A psychopath may be able to create a seemingly typical personality and life to fool others. Psychopathic tendencies don't always extend into psychopathy.
Photo by FGC on Shutterstock<p><strong>What causes psychopathy?</strong></p><p>Brain anatomy, genetics, and the person's environment may all contribute to the development of psychopathic traits. However, it's important to note that not all psychopathic traits and tendencies mean the person will grow into a psychopath.</p><p><strong>What are psychopathic tendencies? </strong></p><p>Psychopathic tendencies could be considered warning signs of psychopathy, but it's important to note that not everyone who shows psychopathic tendencies becomes a psychopath. Some, with the intervention of various therapies and strong, nurturing relationships, can assimilate to a relatively normal way of life. </p><p>The most well-known case of this would be the case of Beth Thomas. The subject of a 1990 documentary entitled "Child of Rage," Beth began to show psychopathic tendencies extremely early in life after suffering physical neglect and sexual abuse at the hands of her birth father before the age of one. </p><p>Later moved into an adoptive family where she could get the help she needs, the documentary (<a href="https://www.bitchute.com/video/pr3tmwyZAn0f/" target="_blank">which you can view here</a>, be warned, this footage may be disturbing to some) showed the disturbing thought process of a young 6-year-old girl struggling with an attachment disorder that led to psychopathic tendencies. </p><p>However, Beth, with the help of her adoptive family and professionals, became a <a href="https://www.bitchute.com/video/pr3tmwyZAn0f/" target="_blank">relatively typical young woman</a> who works as a nurse and has co-authored a book called "More Than a Thread of Hope" with her adoptive mother.</p><p><strong>Psychopaths' brains show differences in structure and function</strong></p><p><a href="https://www.med.wisc.edu/news-and-events/2011/november/psychopaths-brains-differences-structure-function/" target="_blank">According to a 2017 study</a> led by the University of Wisconsin-Madison, psychopaths have reduced connections in their brains between the ventromedial prefrontal cortex (vmPFC) and the amygdala. </p><p>This is noteworthy because of the functions of both parts in play - the vmPFC is responsible for sentimentality, empathy and guilt and the amygdala mediates fear and anxiety. </p><p>Not only did the research here show there were differences in how these parts of the psychopathic brain functioned, but this was the first study of it's kind to show physical (structural) differences in the brains of psychopaths. </p><p><strong>How common is psychopathy? </strong></p><p>While there may never be a specific answer to this, there have been several studies that can give us insight into how common psychopathy is. <a href="https://www.livescience.com/16585-psychopaths-speech-language.html#:~:text=Psychopaths%20make%20up%20about%201,profoundly%20selfish%20and%20lack%20emotion." target="_blank">According to most research</a>, psychopaths make up about 1 percent of the general population. <a href="https://www.psychologytoday.com/us/blog/what-mentally-strong-people-dont-do/201602/5-traits-actual-psychopaths#:~:text=While%20about%20one%20percent%20of,the%20criteria%20for%20being%20psychopaths.)" target="_blank">Additional research</a> claims up to 15 percent of the U.S prison population may meet the criteria for being psychopaths. </p>
A new study looks at what would happen to human language on a long journey to other star systems.
- A new study proposes that language could change dramatically on long space voyages.
- Spacefaring people might lose the ability to understand the people of Earth.
- This scenario is of particular concern for potential "generation ships".
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Many of the most popular apps are about self-improvement.
Emotions are the newest hot commodity, and we can't get enough.