David Goggins
Former Navy Seal
Career Development
Bryan Cranston
Critical Thinking
Liv Boeree
International Poker Champion
Emotional Intelligence
Amaryllis Fox
Former CIA Clandestine Operative
Chris Hadfield
Retired Canadian Astronaut & Author
from the world's big
Start Learning

New study shows anti-inflammatories help alleviate depression

Move over SSRIs, Advil is on the way.

New study shows anti-inflammatories help alleviate depression

A woman walks through the park 'Tiergarten' on January 23, 2019 in Berlin, Germany.

Photo by Florian Gaertner/Photothek via Getty Images
  • A new study found that anti-inflammatory medications provide "reasonably safe" relief from depression.
  • The meta-analysis discovered that 26 out of 30 studies showed the efficacy of NSAIDs, omega-3s, and others help combat mental health issues.
  • While an important advancement in treating depression, root causes of inflammation, such as diet and stress, should be addressed first.

In his new book, The Body: A Guide for Occupants, Bill Bryson writes that during the initial stages of the technological revolution in the nineteenth century, medicine was moving backwards. Just as industrious civilizations were pushing boundaries in machinery, the understanding of biological machinery devolved. He writes,

"Until well into the nineteenth century most doctors approached diseases not as distinct afflictions, each requiring its own treatment, but as generalized imbalances affecting the whole body."

The humors were still considered real; bloodletting remained common even as death rates soared. Not until the twentieth century did the age of specialization take hold. Yet in many ways we seem to have overcorrected. Doctors and researchers became so fascinated on singular trees that they completely forget the interconnected nature of the forest.

As the gut microbiome is increasingly being implicated in mental health issues, we've had to reassess our understanding of mental health. We're now well aware how an inflamed digestive system throws your mental and emotional state out of balance. In that light, perhaps it should be unsurprising that a new study, published in the Journal of Neurology, Neurosurgery, and Psychiatry, has found that anti-inflammatory medication is seeing success in treating major depression.

How inflammation in the body could be causing depression

Inflammation is the body's response to a wide range of irritants and stress. When you cut yourself, the red region around the laceration is thanks to cytokines rushing in to defend the region, destroying bacteria before they spread. Yet it's not only a cut that send cytokines flooding into a region. Inflammatory diets, such as those high in carbohydrates and sugars, can keep your body in a constant state of inflammation—and inflammation has been linked to depression, as well as immune functioning, sleep, impulse control, and overall mood.

In fact, this is not the first study making this connection. Researchers were looking into the connection between anti-inflammatories and depression for at least five years.

For this meta-analysis, the group of researchers from China looked at 30 randomized controlled trials that included 1,610 participants. Of these, 26 suggested that a variety of anti-inflammatory agents, including NSAIDs, cytokine inhibitors, statins, and omega-3 fatty acids, reduced depressive symptoms better than placebos. They write,

"The overall analysis of 30 RCTs suggested a significant antidepressant effect of anti-inflammatory agents in comparison with placebo for patients with MDD in various efficacy outcomes. A significantly larger reduction in depressive rating scales was found in the intervention group, with moderate heterogeneity among studies. Similarly, the response and remission rates were significantly higher for patients taking anti-inflammatory drugs with low heterogeneity."

Packs of Advil Liqui-Gels Medicine on shelf, they are 200mg ibuprofen capsules, a nonsteroidal anti-inflammatory drug (NSAID) for relief in migraines, headaches, fever, muscle and joint pain.

Photo by Roberto Machado Noa/LightRocket via Getty Images

With an increasing number of mental health conditions afflicting humans, and with lackluster results from the common course of treatment, SSRIs—which, over the long-term, have a tendency to negatively affect the microbiome—new courses of treatment are necessary. The group of researchers from China concluded that the anti-inflammatory agents studied are "reasonably safe."

Of course, we also must question the advice of taking anti-inflammatory in certain situations, such as a means for countering a high-inflammatory diet. In such cases, the best advice would be to look for the root cause of the issue, and we know that there are links between depression and anxiety and diet. Medications should never take the place of better lifestyle decisions.

Diet is not the only cause of inflammation, although it has become an increasingly problematic one. Dependent upon condition, anti-inflammatory agents could be a relatively safe line of defense for both problems with inflammation and in the treatment of depression. More research is needed, but it's a solid start.


Stay in touch with Derek on Twitter and Facebook.

Radical innovation: Unlocking the future of human invention

Ready to see the future? Nanotronics CEO Matthew Putman talks innovation and the solutions that are right under our noses.

Big Think LIVE

Innovation in manufacturing has crawled since the 1950s. That's about to speed up.

Keep reading Show less

Swedish scientist advocates eating humans to combat climate change

A scientist in Sweden makes a controversial presentation at a future of food conference.

Surprising Science
  • A behavioral scientist from Sweden thinks cannibalism of corpses will become necessary due to effects of climate change.
  • He made the controversial presentation to Swedish TV during a "Future of Food" conference in Stockholm.
  • The scientist acknowledges the many taboos this idea would have to overcome.
Keep reading Show less

Russia claims world's first COVID-19 vaccine but skepticism abounds

President Vladimir Putin announces approval of Russia's coronavirus vaccine but scientists warn it may be unsafe.

Russian President Vladimir Putin announced coronavirus vaccine at the Novo-Ogaryovo residence outside Moscow, Russia, Tuesday, Aug. 11, 2020.

Credit: Alexei Nikolsky, Sputnik, Kremlin Pool Photo via AP
  • Vladimir Putin announced on Tuesday that a COVID-19 vaccine has been approved in Russia.
  • Scientists around the world are worried that the vaccine is unsafe and that Russia fast-tracked the vaccine without performing the necessary phase 3 trials.
  • To date, Russia has had nearly 900,000 registered cases of coronavirus.
  • Keep reading Show less

    Therapy app Talkspace mined user data for marketing insights, former employees allege

    A report from the New York Times raises questions over how the teletherapy startup Talkspace handles user data.
    Technology & Innovation
    • In the report, several former employees said that "individual users' anonymized conversations were routinely reviewed and mined for insights."
    • Talkspace denied using user data for marketing purposes, though it acknowledged that it looks at client transcripts to improve its services.
    • It's still unclear whether teletherapy is as effective as traditional therapy.
    Keep reading Show less
    Mind & Brain

    Viewing abstract art causes notable cognitive changes

    Viewing art that doesn't look like anything makes your brain take extra steps to try and get it.

    Scroll down to load more…