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Study: 'Mighty mice' stayed strong in space with gene treatment
Targeting a signaling pathway in mice helped them retain muscle and bone mass aboard the International Space Station, according to a new study.
- Losing bone and muscle mass in space is a major health concern for astronauts.
- In a recent study, scientists genetically altered mice and sent them to the International Space Station.
- The genetically altered mice retained — or even gained — muscle and bone mass, while a control group suffered significant losses.
Living in microgravity aboard the International Space Station (ISS) might seem like it'd be gentle on the human body, but it's not. Without gravity, the musculoskeletal system starts to atrophy because it no longer needs to support any weight. And even though regular exercise in space keeps astronauts in decent shape, bone and muscle loss remains a major health concern for long-term space missions.
A new study published in the Proceedings of the National Academy of Sciences suggests that targeting a specific signaling pathway in the body can help prevent bone and muscle loss in space.
The study involved sending 40 mice to the ISS for a month-long stay. Eight of the mice were missing the gene for myostatin, a protein known to inhibit muscle growth. Another eight mice were given a treatment that suppresses myostatin and the protein activin A, which also helps to regulate muscle mass. The rest of the mice (24) were left untreated as a control group.
Comparison of bone density loss between the mice groups.
(Image credit: Se-Jin Lee)
Upon return to Earth, the untreated mice showed significant losses in muscle mass and bone density. But the mice missing the myostatin gene retained almost all of their muscle and bone mass. What's more, the mice that received the gene-inhibiting treatment actually gained bone and muscle mass. The researchers observed similar results among a separate group of mice that were given the same set of treatments on Earth.
"These findings show that blocking the activities of these hormones does work to enhance both muscle and bone even when mice are unable to bear weight," study authors Se-Jin Lee and Emily L. Germain-Lee told CNN.
"One thing that we found somewhat surprising is how resilient mice are even when subjected to all of the stresses associated with space travel. We knew that mice had been sent to space in the past, but we still found it remarkable that after spending a month at the ISS, they seemed to resume normal activity very quickly after returning to Earth."
Treatments like these could protect astronauts on future long-term space missions. After all, studies show that spending just 16 to 28 weeks in space can cause a 3.5-percent loss in bone density, so space agencies are understandably concerned about the health risks of sending astronauts on a three-year mission to Mars.
Applications on Earth
The researchers also noted that "this strategy may be effective in preventing or treating muscle and bone loss not only in astronauts on prolonged missions but also in people with disuse atrophy on Earth, such as in older adults or in individuals who are bedridden or wheelchair-bound from illness."
Still, the experiment was done on mice, so it's not clear whether the treatment would have the same effects on humans. It's also unclear what other side effects the treatment might have on humans. Answering these questions will take some time.
"We're years away," Germain-Lee told Phys Org. "But that's how everything is when you go from mouse to human studies."
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The COVID-19 pandemic is making health disparities in the United States crystal clear. It is a clarion call for health care systems to double their efforts in vulnerable communities.
- The COVID-19 pandemic has exacerbated America's health disparities, widening the divide between the haves and have nots.
- Studies show disparities in wealth, race, and online access have disproportionately harmed underserved U.S. communities during the pandemic.
- To begin curing this social aliment, health systems like Northwell Health are establishing relationships of trust in these communities so that the post-COVID world looks different than the pre-COVID one.
COVID-19 deepens U.S. health disparities<p>Communities on the pernicious side of America's health disparities have their unique histories, environments, and social structures. They are spread across the United States, but they all have one thing in common.</p><p>"There is one common divide in American communities, and that is poverty," said <a href="https://www.northwell.edu/about/leadership/debbie-salas-lopez" target="_blank">Debbie Salas-Lopez, MD, MPH</a>, senior vice president of community and population health at Northwell Health. "That is the undercurrent that manifests poor health, poor health outcomes, or poor health prognoses for future wellbeing."</p><p>Social determinants have far-reaching effects on health, and poor communities have unfavorable social determinants. To pick one of many examples, <a href="https://www.npr.org/2020/09/27/913612554/a-crisis-within-a-crisis-food-insecurity-and-covid-19" target="_blank" rel="noopener noreferrer">food insecurity</a> reduces access to quality food, leading to poor health and communal endemics of chronic medical conditions. The U.S. Centers for Disease Control and Prevention has identified some of these conditions, such as obesity and Type 2 diabetes, as increasing the risk of developing a severe case of coronavirus.</p><p>The pandemic didn't create poverty or food insecurity, but it exacerbated both, and the results have been catastrophic. A study published this summer in the <em><a href="https://link.springer.com/article/10.1007/s11606-020-05971-3" target="_blank">Journal of General Internal Medicine</a></em> suggested that "social factors such as income inequality may explain why some parts of the USA are hit harder by the COVID-19 pandemic than others."</p><p>That's not to say better-off families in the U.S. weren't harmed. A <a href="https://voxeu.org/article/poverty-inequality-and-covid-19-us" target="_blank" rel="noopener noreferrer">paper from the Centre for Economic Policy Research</a> noted that families in counties with a higher median income experienced adjustment costs associated with the pandemic—for example, lowering income-earning interactions to align with social distancing policies. However, the paper found that the costs of social distancing were much greater for poorer families, who cannot easily alter their living circumstances, which often include more individuals living in one home and a reliance on mass transit to reach work and grocery stores. They are also disproportionately represented in essential jobs, such as retail, transportation, and health care, where maintaining physical distance can be all but impossible.</p><p>The paper also cited a positive correlation between higher income inequality and higher rates of coronavirus infection. "Our interpretation is that poorer people are less able to protect themselves, which leads them to different choices—they face a steeper trade-off between their health and their economic welfare in the context of the threats posed by COVID-19," the authors wrote.</p><p>"There are so many pandemics that this pandemic has exacerbated," Dr. Salas-Lopez noted.</p><p>One example is the health-wealth gap. The mental stressors of maintaining a low socioeconomic status, especially in the face of extreme affluence, can have a physically degrading impact on health. <a href="https://www.scientificamerican.com/index.cfm/_api/render/file/?method=inline&fileID=123ECD96-EF81-46F6-983D2AE9A45FA354" target="_blank" rel="noopener noreferrer">Writing on this gap</a>, Robert Sapolsky, professor of biology and neurology at Stanford University, notes that socioeconomic stressors can increase blood pressure, reduce insulin response, increase chronic inflammation, and impair the prefrontal cortex and other brain functions through anxiety, depression, and cognitive load. </p><p>"Thus, from the macro level of entire body systems to the micro level of individual chromosomes, poverty finds a way to produce wear and tear," Sapolsky writes. "It is outrageous that if children are born into the wrong family, they will be predisposed toward poor health by the time they start to learn the alphabet."</p>Research on the economic and mental health fallout of COVID-19 is showing two things: That unemployment is hitting <a href="https://www.pewsocialtrends.org/2020/09/24/economic-fallout-from-covid-19-continues-to-hit-lower-income-americans-the-hardest/" target="_blank" rel="noopener noreferrer">low-income and young Americans</a> most during the pandemic, potentially widening the health-wealth gap further; and that the pandemic not only exacerbates mental health stressors, but is doing so at clinically relevant levels. As <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413844/" target="_blank" rel="noopener noreferrer">the authors of one review</a> wrote, the pandemic's effects on mental health is itself an international public health priority.
Working to close the health gap<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDc5MDk1MS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYxNTYyMzQzMn0.KSFpXH7yHYrfVPtfgcxZqAHHYzCnC2bFxwSrJqBbH4I/img.jpg?width=980" id="b40e2" class="rm-shortcode" data-rm-shortcode-id="1b9035370ab7b02a0dc00758e494412b" data-rm-shortcode-name="rebelmouse-image" />
Northwell Health coronavirus testing center at Greater Springfield Community Church.
Credit: Northwell Health<p>Novel coronavirus may spread and infect indiscriminately, but pre-existing conditions, environmental stressors, and a lack of access to care and resources increase the risk of infection. These social determinants make the pandemic more dangerous, and erode communities' and families' abilities to heal from health crises that pre-date the pandemic.</p><p>How do we eliminate these divides? Dr. Salas-Lopez says the first step is recognition. "We have to open our eyes to see the suffering around us," she said. "Northwell has not shied away from that."</p><p>"We are steadfast in improving health outcomes for our vulnerable and underrepresented communities that have suffered because of the prevalence of chronic disease, a problem that led to the disproportionately higher death rate among African-Americans and Latinos during the COVID-19 pandemic," said Michael Dowling, Northwell's president and CEO. "We are committed to using every tool at our disposal—as a provider of health care, employer, purchaser and investor—to combat disparities and ensure the <a href="https://www.northwell.edu/education-and-resources/community-engagement/center-for-equity-of-care" target="_blank" rel="noopener noreferrer">equity of care</a> that everyone deserves." </p><p>With the need recognized, Dr. Salas-Lopez calls for health care systems to travel upstream and be proactive in those hard-hit communities. This requires health care systems to play a strong role, but not a unilateral one. They must build <a href="https://www.northwell.edu/news/insights/faith-based-leaders-are-the-key-to-improving-community-health" target="_blank" rel="noopener noreferrer">partnerships with leaders in those communities</a> and utilize those to ensure relationships last beyond the current crisis. </p><p>"We must meet with community leaders and talk to them to get their perspective on what they believe the community needs are and should be for the future. Together, we can co-create a plan to measurably improve [community] health and also to be ready for whatever comes next," she said.</p><p>Northwell has built relationships with local faith-based and community organizations in underserved communities of color. Those partnerships enabled Northwell to test more than 65,000 people across the metro New York region. The health system also offered education on coronavirus and precautions to curb its spread.</p><p>These initiatives began the process of building trust—trust that Northwell has counted on to return to these communities to administer flu vaccines to prepare for what experts fear may be a difficult flu season.</p><p>While Northwell has begun building bridges across the divides of the New York area, much will still need to be done to cure U.S. health care overall. There is hope that the COVID pandemic will awaken us to the deep disparities in the US.</p><p>"COVID has changed our world. We have to seize this opportunity, this pandemic, this crisis to do better," Dr. Salas-Lopez said. "Provide better care. Provide better health. Be better partners. Be better community citizens. And treat each other with respect and dignity.</p><p>"We need to find ways to unify this country because we're all human beings. We're all created equal, and we believe that health is one of those important rights."</p>
What’s Eminem doing in Missouri? Kanye West in Georgia? And Wiz Khalifa in, of all places, North Dakota?
This is a mysterious map. Obviously about music, or more precisely musicians. But what’s Eminem doing in Missouri? Kanye West in Georgia? And Wiz Khalifa in, of all places, North Dakota? None of these musicians are from those states! Everyone knows that! Is this map that stupid, or just looking for a fight? Let’s pause a moment and consider our attention spans, shrinking faster than polar ice caps.
Researchers make the case for "deep evidential regression."
- MIT researchers claim that deep learning neural networks need better uncertainty analysis to reduce errors.
- "Deep evidential regression" reduces uncertainty after only one pass on a network, greatly reducing time and memory.
- This could help mitigate problems in medical diagnoses, autonomous driving, and much more.
Credit: scharsfinn86 / Adobe Stock<p>On the road, 1 percent could be the difference between stopping at an intersection or rushing through just as another car runs a stop sign. Amini and colleagues wanted to produce a model that could better detect patterns in giant data sets. They named their solution "deep evidential regression."</p><p>Sorting through billions of parameters is no easy task. Amini's model utilizes uncertainly analysis—learning how much error exists within a model and supplying missing data. This approach in deep learning isn't novel, though it often takes a lot of time and memory. Deep evidential regression estimates uncertainty after only one run of the neural network. According to the team, they can assess uncertainty in both input data <em>and</em> the final decision, after which they can either address the neural network or recognize noise in the input data.</p><p>In real-world terms, this is the difference between trusting an initial medical diagnosis or seeking a second opinion. By arming AI with a built-in detection system for uncertainty, a new level of honesty with data is reached—in this model, with pixels. During a test run, the neural network was given novel images; it was able to detect changes imperceptible to the human eye. Ramini believes this technology can also be used to pinpoint <a href="https://www.theguardian.com/technology/2020/jan/13/what-are-deepfakes-and-how-can-you-spot-them" target="_blank">deepfakes</a>, a serious problem we must begin to grapple with.</p><p>Any field that uses machine learning will have to factor in uncertainty awareness, be it medicine, cars, or otherwise. As Amini says, </p><p style="margin-left: 20px;">"Any user of the method, whether it's a doctor or a person in the passenger seat of a vehicle, needs to be aware of any risk or uncertainty associated with that decision."</p><p>We might not have to worry about alien robots turning on us (yet), but we should be concerned with that new feature we just downloaded into our electric car. There will be many other issues to face with the emergence of AI in our world—and workforce. The safer we can make the transition, the better. </p><p>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a> and <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank" rel="noopener noreferrer">Facebook</a>. His new book is</em> "<em><a href="https://www.amazon.com/gp/product/B08KRVMP2M?pf_rd_r=MDJW43337675SZ0X00FH&pf_rd_p=edaba0ee-c2fe-4124-9f5d-b31d6b1bfbee" target="_blank" rel="noopener noreferrer">Hero's Dose: The Case For Psychedelics in Ritual and Therapy</a>."</em></p>
Can passenger airships make a triumphantly 'green' comeback?
Large airships were too sensitive to wind gusts and too sluggish to win against aeroplanes. But today, they have a chance to make a spectacular return.
Vegans and vegetarians often have nutrient deficiencies and lower BMI, which can increase the risk of fractures.