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Scientists teach birds new songs by implanting them with false memories
Groundbreaking neurological research on songbirds provides insight on human learned behavior and speech.
- Scientists recently implanted a false memory into the brains of young zebra finches, teaching them a melody they had never heard before.
- By stimulating certain neural circuits in the male birds' brains, researchers taught them courtship songs bypassing the lessons of an adult tutor.
- Scientists hope this research expands our knowledge of neurodevelopmental disorders such as autism.
"Monkey see, monkey do" has been the way we have historically understood the learning process for humans and animals. However, scientists at UT Southwestern recently implanted a false memory into the brains of young zebra finches, teaching them a melody they had never heard before.
The researchers identified the two regions of the brain responsible for encoding the memories through which the finch learn song-element durations. They were then able to manipulate the interactions between those regions of the brain using optogenetics, a method of manipulating living tissue with light to control neural function. This guided the birds in the development of courtship songs they had never heard.When one learns from observation, the memory of another individual doing something correctly guides you in learning to perform the behavior. How those "behavior-goal" memories are formed has been a mystery. Dina Lipkind, a biologist at York College, told The Scientist that the authors in this study were able to crack the first part of the process by discovering how a memory is initially formed that guides an individual to performing that behavior later on.
The anatomy of bird 'inception'
To test whether manipulating certain neural circuits could implant behavioral-goal memories, the researchers raised young male birds without any social or auditory experience gained through adult song tutors.
Typically, young male zebra finches learn to sing a mating song from their father or another adult tutor. The finches use their song to court female birds in a behavior that is called "directed singing." Naturally, the birds spend a great deal of time practicing their song in private so they are ready to swoop in and serenade a female when the opportunity arises.
Researchers optically tutored the finches using light pulses that stimulated certain neural circuits, which were designed to mimic short song elements. This "opto-tutoring" in the young birds shaped the temporal structure of their mating song in adulthood by imprinting "memories" of the song into the birds' brain, bypassing the tutor's lessons. The finches sang the courtship songs that corresponded to the duration of time light had kept the neurons active. Birds that received shorter pulses sang songs with a shorter duration, and those that received extended pulses held their melodies longer.
Interestingly, the researchers found that opto-tutored male birds grasped the social norms of singing. Like regularly tutored birds, they practiced their mating song when alone and, when presented with a female finch to woo, they performed using the shorter and extended notes they learned through the false memory implantation.
While the researchers were able to imprint the duration of syllables in the birds' memories, that isn't everything that they need to learn in the song. There are other important characteristics that a zebra finch needs to nail, including pitch and correctly ordering the syllables. Next the researchers want to identify the circuits that carry that other information, and investigate the ways to encode those memories.
Photo Source: Wikimedia Commons
The groundbreaking study could potentially serve as a blueprint for discovering how genetic and social environments influence neural circuits over time.
"This is the first time we have confirmed brain regions that encode behavioral-goal memories — those memories that guide us when we want to imitate anything from speech to learning the piano," said Dr. Todd Roberts, a neuroscientist with UT Southwestern's O'Donnell Brain Institute in a press release. "The findings enabled us to implant these memories into the birds and guide the learning of their song."
Because the zebra finches vocal development process is similar to humans, this knowledge might help us better understand the mechanisms of human speech and language learning. The hope is that someday it will be used to target certain speech genes that are disrupted in people with neurological conditions that affect vocalization, such as autism. Not only that, but it could be used to help kids understand other social patterns and cues.
Of course, the neural pathways of the human mind are a great deal more complex than the circuitry of a songbird's brain. While this research points us in the right direction on where to look for more information on neurodevelopmental disorders, it will be a while before science can imprint the human mind with false memories via light pulse.
Some evidence attributes a certain neurological phenomenon to a near death experience.
Time of death is considered when a person has gone into cardiac arrest. This is the cessation of the electrical impulse that drive the heartbeat. As a result, the heart locks up. The moment the heart stops is considered time of death. But does death overtake our mind immediately afterward or does it slowly creep in?
Some scientists have studied near death experiences (NDEs) to try to gain insights into how death overcomes the brain. What they've found is remarkable, a surge of electricity enters the brain moments before brain death. One 2013 study out of the University of Michigan, which examined electrical signals inside the heads of rats, found they entered a hyper-alert state just before death.
Scientists are beginning to think an NDE is caused by reduced blood flow, coupled with abnormal electrical behavior inside the brain. So the stereotypical tunnel of white light might derive from a surge in neural activity. Dr. Sam Parnia is the director of critical care and resuscitation research, at NYU Langone School of Medicine, in New York City. He and colleagues are investigating exactly how the brain dies.
Our cerebral cortex is likely active 2–20 seconds after cardiac arrest. Credit: Getty Images.
In previous work, he's conducted animal studies looking at the moments before and after death. He's also investigated near death experiences. “Many times, those who have had such experiences talk about floating around the room and being aware of the medical team working on their body," Dr. Parnia told Live Science. “They'll describe watching doctors and nurses working and they'll describe having awareness of full conversations, of visual things that were going on, that would otherwise not be known to them."
Medical staff confirm this, he said. So how could those who were technically dead be cognizant of what's happening around them? Even after our breathing and heartbeat stops, we're conscious for about 2–20 seconds, Dr. Parnia says. That's how long the cerebral cortex is thought to last without oxygen. This is the thinking and decision-making part of the brain. It's also responsible for deciphering the information gathered from our senses.
According to Parnia during this period, "You lose all your brain stem reflexes — your gag reflex, your pupil reflex, all that is gone." Brain waves from the cerebral cortex soon become undetectable. Even so, it can take hours for our thinking organ to fully shut down.
Usually, when the heart stops beating, someone performs CPR (cardiopulmonary resuscitation). This will provide about 15% of the oxygen needed to perform normal brain function. "If you manage to restart the heart, which is what CPR attempts to do, you'll gradually start to get the brain functioning again," Parnia said. “The longer you're doing CPR, those brain cell death pathways are still happening — they're just happening at a slightly slower rate."
CPR may help retain some brain function for longer. Credit: Getty Images.
Dr. Parnia's latest, ongoing study looks at large numbers of Europeans and Americans who have experienced cardiac arrest and survived. "In the same way that a group of researchers might be studying the qualitative nature of the human experience of 'love,'" he said, "we're trying to understand the exact features that people experience when they go through death, because we understand that this is going to reflect the universal experience we're all going to have when we die."
One of the objectives is to observe how the brain acts and reacts during cardiac arrest, through the process of death, and during revival. How much oxygen exactly does it take to reboot the brain? How is the brain affected after revival? Learning where the lines are drawn might improve resuscitation techniques, which could save countless lives per year.
"At the same time, we also study the human mind and consciousness in the context of death," Parnia said, “to understand whether consciousness becomes annihilated or whether it continues after you've died for some period of time — and how that relates to what's happening inside the brain in real time."
For more on the scientific perspective on a near death experience, click here:
The experience of life flashing before one's eyes has been reported for well over a century, but where's the science behind it?
At the age of 16, when Tony Kofi was an apprentice builder living in Nottingham, he fell from the third story of a building. Time seemed to slow down massively, and he saw a complex series of images flash before his eyes.
As he described it, “In my mind's eye I saw many, many things: children that I hadn't even had yet, friends that I had never seen but are now my friends. The thing that really stuck in my mind was playing an instrument". Then Tony landed on his head and lost consciousness.
When he came to at the hospital, he felt like a different person and didn't want to return to his previous life. Over the following weeks, the images kept flashing back into his mind. He felt that he was “being shown something" and that the images represented his future.
Later, Tony saw a picture of a saxophone and recognized it as the instrument he'd seen himself playing. He used his compensation money from the accident to buy one. Now, Tony Kofi is one of the UK's most successful jazz musicians, having won the BBC Jazz awards twice, in 2005 and 2008.
Though Tony's belief that he saw into his future is uncommon, it's by no means uncommon for people to report witnessing multiple scenes from their past during split-second emergency situations. After all, this is where the phrase “my life flashed before my eyes" comes from.
But what explains this phenomenon? Psychologists have proposed a number of explanations, but I'd argue the key to understanding Tony's experience lies in a different interpretation of time itself.
When life flashes before our eyes
The experience of life flashing before one's eyes has been reported for well over a century. In 1892, a Swiss geologist named Albert Heim fell from a precipice while mountain climbing. In his account of the fall, he wrote is was “as if on a distant stage, my whole past life [was] playing itself out in numerous scenes".
More recently, in July 2005, a young woman called Gill Hicks was sitting near one of the bombs that exploded on the London Underground. In the minutes after the accident, she hovered on the brink of death where, as she describes it: “my life was flashing before my eyes, flickering through every scene, every happy and sad moment, everything I have ever done, said, experienced".
In some cases, people don't see a review of their whole lives, but a series of past experiences and events that have special significance to them.
Explaining life reviews
Perhaps surprisingly, given how common it is, the “life review experience" has been studied very little. A handful of theories have been put forward, but they're understandably tentative and rather vague.
For example, a group of Israeli researchers suggested in 2017 that our life events may exist as a continuum in our minds, and may come to the forefront in extreme conditions of psychological and physiological stress.
Another theory is that, when we're close to death, our memories suddenly “unload" themselves, like the contents of a skip being dumped. This could be related to “cortical disinhibition" – a breaking down of the normal regulatory processes of the brain – in highly stressful or dangerous situations, causing a “cascade" of mental impressions.
But the life review is usually reported as a serene and ordered experience, completely unlike the kind of chaotic cascade of experiences associated with cortical disinhibition. And none of these theories explain how it's possible for such a vast amount of information – in many cases, all the events of a person's life – to manifest themselves in a period of a few seconds, and often far less.
Thinking in 'spatial' time
An alternative explanation is to think of time in a “spatial" sense. Our commonsense view of time is as an arrow that moves from the past through the present towards the future, in which we only have direct access to the present. But modern physics has cast doubt on this simple linear view of time.
Indeed, since Einstein's theory of relativity, some physicists have adopted a “spatial" view of time. They argue we live in a static “block universe" in which time is spread out in a kind of panorama where the past, the present and the future co-exist simultaneously.
The modern physicist Carlo Rovelli – author of the best-selling The Order of Time – also holds the view that linear time doesn't exist as a universal fact. This idea reflects the view of the philosopher Immanuel Kant, who argued that time is not an objectively real phenomenon, but a construct of the human mind.
This could explain why some people are able to review the events of their whole lives in an instant. A good deal of previous research – including my own – has suggested that our normal perception of time is simply a product of our normal state of consciousness.
In many altered states of consciousness, time slows down so dramatically that seconds seem to stretch out into minutes. This is a common feature of emergency situations, as well as states of deep meditation, experiences on psychedelic drugs and when athletes are “in the zone".
The limits of understanding
But what about Tony Kofi's apparent visions of his future? Did he really glimpse scenes from his future life? Did he see himself playing the saxophone because somehow his future as a musician was already established?
There are obviously some mundane interpretations of Tony's experience. Perhaps, for instance, he became a saxophone player simply because he saw himself playing it in his vision. But I don't think it's impossible that Tony did glimpse future events.
If time really does exist in a spatial sense – and if it's true that time is a construct of the human mind – then perhaps in some way future events may already be present, just as past events are still present.
Admittedly, this is very difficult to make sense of. But why should everything make sense to us? As I have suggested in a recent book, there must be some aspects of reality that are beyond our comprehension. After all, we're just animals, with a limited awareness of reality. And perhaps more than any other phenomenon, this is especially true of time.
Might as well face it, you're addicted to love.
- Many writers have commented on the addictive qualities of love. Science agrees.
- The reward system of the brain reacts similarly to both love and drugs
- Someday, it might be possible to treat "love addiction."
Since people started writing, they've written about love. The oldest love poem known dates back to the 21st century BCE. For most of that time, writers also apparently have been of two (or more) minds about it, announcing that love can be painful, impossible to quit, or even addictive — while also mentioning how nice it is.
The idea of love as an addiction is one that is both familiar and unsettling. Surely it can't be the case that our mutual love with our partner — a thing that can produce euphoria, consumes a great deal of our time, and which we fear losing — can be compared to a drug habit? But indeed, many scientists have turned their attention to the idea of "love addiction" and how your brain on drugs might resemble your brain in love.
Love and other drugs
In a 2017 article published in the journal Philosophy, Psychiatry, & Psychology, a team of neuroethicists considered the idea that love is addicting and held the idea up to science for scrutiny.
They point out that the leading model of addiction rests on the notion of a drug causing the brain to release an unnatural level of reward chemicals, such as dopamine, effectively hijacking the brain's reward system. This phenomenon isn't strictly limited to drugs, though they are more effective at this process than other things. Rats can get a similar rush from sugar as from cocaine, and they can have terrible withdrawal symptoms when the sugar crash kicks in.
On the structural level, there is a fair amount of overlap between the parts of the brain that handle love and pair-bonding and the parts that deal with addiction and reward processing. When inside an MRI machine and asked to think about the person they love romantically, the reward centers of people's brains light up like Broadway.
Love as an addiction
These facts lead the authors to consider two ideas, dubbed the "narrow" and "broad" views of love as an addiction.
The narrow view holds that addiction is the result of abnormal brain processes that simply don't exist in non-addicts. Under this paradigm, "food-seeking or love-seeking behaviors are not truly the result of addiction, no matter how addiction-like they may outwardly appear." It could be that abnormal processes cause the brain's reward system to misfire when exposed to love and to react to it excessively.
If this model is accurate, love addiction would be a rare thing — one study puts it around five to ten percent of the population — but could be considered a disorder similar to others and caused by faulty wiring in the brain. As with other addictions, this malfunction of the reward system could lead to an inability to fully live a typical life, difficulty having healthy relationships, and a number of other negative consequences.
The broad view looks at addiction differently, perhaps even radically.
It begins with the idea that addiction exists on a spectrum of motivations. All of our appetites, including those for food and water, exist on this spectrum and activate similar parts of the brain when satisfied. We can have appetites for anything that taps into our reward system, including food, gambling, sex, drugs, and love. For most people most of the time, our appetites are fairly temperate, if recurring. I might be slightly "addicted" to food — I do need some a few times per day — but that "addiction" doesn't have any negative effects on my health.
An appetite for cocaine, however, is rarely temperate and usually dangerous. Likewise, a person's appetite for love could reach addiction levels, and a person could be considered "hooked" on relationships (or on a particular person). This would put love addiction at the extreme end of the spectrum.
None of this is to say that the authors think that love is bad for you just because it can resemble an addiction. Love addiction is not the same as cocaine addiction at the neurological level: important differences, like how long it takes for the desire for another "hit" to occur, do exist. Rather, the authors see this as an opportunity to reconsider our approach to addiction in general and to think about how we can help the heartsick when they just can't seem to get over their last relationship.
Is "love addiction" a treatable disorder?
Hypothetically, a neurological basis for an addiction to love could point toward interventions that "correct" for it. If the narrow view of addiction is accurate, perhaps some people will be able to seek treatment for love addiction in the same way that others seek help to quit smoking. If the broad view of addiction is correct, the treatment of love addiction would be unlikely as it may be difficult to properly identify where the cutoff of acceptability on a spectrum should be.
Either way, since love is generally held in high regard by all cultures and doesn't quite seem to be in the same category as a bad cocaine habit in terms of social undesirability, the authors doubt we'll be treating anyone for "love addiction" anytime soon.
A brief passage from a recent UN report describes what could be the first-known case of an autonomous weapon, powered by artificial intelligence, killing in the battlefield.