An organism found in dirt may lead to an anxiety vaccine, say scientists

Can dirt help us fight off stress? Groundbreaking new research shows how.

  • New research identifies a bacterium that helps block anxiety.
  • Scientists say this can lead to drugs for first responders and soldiers, preventing PTSD and other mental issues.
  • The finding builds on the hygiene hypothesis, first proposed in 1989.


Are modern societies trying too hard to be clean, at the detriment to public health? Scientists discovered that a microorganism living in dirt can actually be good for us, potentially helping the body to fight off stress. Harnessing its powers can lead to a "stress vaccine".

Researchers at the University of Colorado Boulder found that the fatty 10(Z)-hexadecenoic acid from the soil-residing bacterium Mycobacterium vaccae aids immune cells in blocking pathways that increase inflammation and the ability to combat stress.

The study's senior author and Integrative Physiology Professor Christopher Lowry described this fat as "one of the main ingredients" in the "special sauce" that causes the beneficial effects of the bacterium.

The finding goes hand in hand with the "hygiene hypothesis," initially proposed in 1989 by the British scientist David Strachan. He maintained that our generally sterile modern world prevents children from being exposed to certain microorganisms, resulting in compromised immune systems and greater incidences of asthma and allergies.

Contemporary research fine-tuned the hypothesis, finding that not interacting with so-called "old friends" or helpful microbes in the soil and the environment, rather than the ones that cause illnesses, is what's detrimental. In particular, our mental health could be at stake.

"The idea is that as humans have moved away from farms and an agricultural or hunter-gatherer existence into cities, we have lost contact with organisms that served to regulate our immune system and suppress inappropriate inflammation," explained Lowry. "That has put us at higher risk for inflammatory disease and stress-related psychiatric disorders."

University of Colorado Boulder

Christopher Lowry

This is not the first study on the subject from Lowry, who published previous work showing the connection between being exposed to healthy bacteria and mental health. He found that being raised with animals and dust in a rural environment helps children develop more stress-proof immune systems. Such kids were also likely to be less at risk for mental illnesses than people living in the city without pets.

Lowry's other work also pointed out that the soil-based bacterium Mycobacterium vaccae acts like an antidepressant when injected into rodents. It alters their behavior and has lasting anti-inflammatory effects on the brain, according to the press release from the University of Colorado Boulder. Prolonged inflammation can lead to such stress-related disorders as PTSD.

The new study from Lowry and his team identified why that worked by pinpointing the specific fatty acid responsible. They showed that when the 10(Z)-hexadecenoic acid gets into cells, it works like a lock, attaching itself to the peroxisome proliferator-activated receptor (PPAR). This allows it to block a number of key pathways responsible for inflammation. Pre-treating the cells with the acid (or lipid) made them withstand inflammation better.

Lowry thinks this understanding can lead to creating a "stress vaccine" that can be given to people in high-stress jobs, like first responders or soldiers. The vaccine can prevent the psychological effects of stress.

What's more, this friendly bacterium is not the only potentially helpful organism we can find in soil.

"This is just one strain of one species of one type of bacterium that is found in the soil but there are millions of other strains in soils," said Lowry. "We are just beginning to see the tip of the iceberg in terms of identifying the mechanisms through which they have evolved to keep us healthy. It should inspire awe in all of us."

Check out the study published in the journal Psychopharmacology.

The key to ending online hate? Treat it like a virus.

It will take a crack team of scientists, programmers and philosophers to cure on the online hate pandemic.

Sponsored by Charles Koch Foundation
  • If online hate is a contagion, as suggested by neuroscientist Joel Finkelstein, then perhaps the most effective course of action will come from treating it as a virus: Gather an interdisciplinary team of minds to study the mechanics of the virus and treat it.
  • The internet is as big a disruption to society as the printing press was. Sarah Ruger sees the road toward social peace as one where neuroscientists, technologists, conflict resolution theorists and philosophers all work together to create a digital culture that brings out the best in humanity, not the worst.


Big Think Edge
  • Often times, interactions that we think are "zero-sum" can actually be beneficial for both parties.
  • Ask, What outcome will be good for both parties? How can we achieve that goal?
  • Afraid the win-win situation might not continue? Build trust by creating a situation that increases the probability you and your counterpart will meet again.

10 new things we’ve learned about death

If you don't want to know anything about your death, consider this your spoiler warning.

Culture & Religion
  • For centuries cultures have personified death to give this terrifying mystery a familiar face.
  • Modern science has demystified death by divulging its biological processes, yet many questions remain.
  • Studying death is not meant to be a morbid reminder of a cruel fate, but a way to improve the lives of the living.
Keep reading Show less
Videos
  • When it comes to moving forward, the slightly harder path — but in the long run, the way easier path — would be for us to develop the skill of grieving.
  • Elisabeth Kubler-Ross's theories about the five stages may be off, but she gave us a lens from which to come to understand the process of grieving.
  • The fact that you grieve is a testimony to your love.
Keep reading Show less