Scientists Have Just Worked Out How to Find the Best Eggs for In Vitro

Scientists can see a spark at fertilization that has serious implications for in vitro.

Scientists at Northwestern’s Feinberg School of Medicine have just witnessed something amazing that happens when a sperm connects with an egg: Sparks literally fly. Zinc sparks. This electric event has been witnessed before in mice, but it’s the first time anyone’s seen and photographed it during human fertilization, and it could represent a significant advance in the success rate of in vitro fertilization.


The team injected an egg with sperm enzyme. (The use of actual sperm in experiments is illegal.) Doing this triggers an increase in calcium within the egg that then causes zinc to be released. The zinc binds to small molecule probes, that emit light that can be seen under a fluorescence microscope as a spark. From there, millions of zinc molecules explode momentarily all around the outside of the egg.

 

  • Northwestern
  • Being able to observe all this, and non-invasively, is important because zinc is critical for the development of a healthy embryo, and Northwestern has previously established that zinc is actually what triggers an embryo to grow and change into a distinct new organism, that is, a new person. 

    “This means if you can look at the zinc spark at the time of fertilization, you will know immediately which eggs are the good ones to transfer in in vitro fertilization (IVF),” according to Teresa Woodruff, one of the study’s two senior authors. “It’s a way of sorting egg quality in a way we’ve never been able to assess before.”

    Study co-author Eve Feinberg adds, “There are no tools currently available that tell us if it’s a good quality egg. Often we don’t know whether the egg or embryo is truly viable until we see if a pregnancy ensues. That’s the reason this is so transformative. If we have the ability up front to see what is a good egg and what’s not, it will help us know which embryo to transfer, avoid a lot of heartache and achieve pregnancy much more quickly.” 

    The bottom line? Francesca Duncan, first author of the study and the person who first discovered the human zinc spark, says the breakthrough “will help us address one of the largest unanswered questions in reproductive medicine—what makes a good egg?”

     

  • Headline image: Northwestern
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    New fossils suggest human ancestors evolved in Europe, not Africa

    Experts argue the jaws of an ancient European ape reveal a key human ancestor.

    Surprising Science
    • The jaw bones of an 8-million-year-old ape were discovered at Nikiti, Greece, in the '90s.
    • Researchers speculate it could be a previously unknown species and one of humanity's earliest evolutionary ancestors.
    • These fossils may change how we view the evolution of our species.

    Homo sapiens have been on earth for 200,000 years — give or take a few ten-thousand-year stretches. Much of that time is shrouded in the fog of prehistory. What we do know has been pieced together by deciphering the fossil record through the principles of evolutionary theory. Yet new discoveries contain the potential to refashion that knowledge and lead scientists to new, previously unconsidered conclusions.

    A set of 8-million-year-old teeth may have done just that. Researchers recently inspected the upper and lower jaw of an ancient European ape. Their conclusions suggest that humanity's forebearers may have arisen in Europe before migrating to Africa, potentially upending a scientific consensus that has stood since Darwin's day.

    Rethinking humanity's origin story

    The frontispiece of Thomas Huxley's Evidence as to Man's Place in Nature (1863) sketched by natural history artist Benjamin Waterhouse Hawkins. (Photo: Wikimedia Commons)

    As reported in New Scientist, the 8- to 9-million-year-old hominin jaw bones were found at Nikiti, northern Greece, in the '90s. Scientists originally pegged the chompers as belonging to a member of Ouranopithecus, an genus of extinct Eurasian ape.

    David Begun, an anthropologist at the University of Toronto, and his team recently reexamined the jaw bones. They argue that the original identification was incorrect. Based on the fossil's hominin-like canines and premolar roots, they identify that the ape belongs to a previously unknown proto-hominin.

    The researchers hypothesize that these proto-hominins were the evolutionary ancestors of another European great ape Graecopithecus, which the same team tentatively identified as an early hominin in 2017. Graecopithecus lived in south-east Europe 7.2 million years ago. If the premise is correct, these hominins would have migrated to Africa 7 million years ago, after undergoing much of their evolutionary development in Europe.

    Begun points out that south-east Europe was once occupied by the ancestors of animals like the giraffe and rhino, too. "It's widely agreed that this was the found fauna of most of what we see in Africa today," he told New Scientists. "If the antelopes and giraffes could get into Africa 7 million years ago, why not the apes?"

    He recently outlined this idea at a conference of the American Association of Physical Anthropologists.

    It's worth noting that Begun has made similar hypotheses before. Writing for the Journal of Human Evolution in 2002, Begun and Elmar Heizmann of the Natural history Museum of Stuttgart discussed a great ape fossil found in Germany that they argued could be the ancestor (broadly speaking) of all living great apes and humans.

    "Found in Germany 20 years ago, this specimen is about 16.5 million years old, some 1.5 million years older than similar species from East Africa," Begun said in a statement then. "It suggests that the great ape and human lineage first appeared in Eurasia and not Africa."

    Migrating out of Africa

    In the Descent of Man, Charles Darwin proposed that hominins descended out of Africa. Considering the relatively few fossils available at the time, it is a testament to Darwin's astuteness that his hypothesis remains the leading theory.

    Since Darwin's time, we have unearthed many more fossils and discovered new evidence in genetics. As such, our African-origin story has undergone many updates and revisions since 1871. Today, it has splintered into two theories: the "out of Africa" theory and the "multi-regional" theory.

    The out of Africa theory suggests that the cradle of all humanity was Africa. Homo sapiens evolved exclusively and recently on that continent. At some point in prehistory, our ancestors migrated from Africa to Eurasia and replaced other subspecies of the genus Homo, such as Neanderthals. This is the dominant theory among scientists, and current evidence seems to support it best — though, say that in some circles and be prepared for a late-night debate that goes well past last call.

    The multi-regional theory suggests that humans evolved in parallel across various regions. According to this model, the hominins Homo erectus left Africa to settle across Eurasia and (maybe) Australia. These disparate populations eventually evolved into modern humans thanks to a helping dollop of gene flow.

    Of course, there are the broad strokes of very nuanced models, and we're leaving a lot of discussion out. There is, for example, a debate as to whether African Homo erectus fossils should be considered alongside Asian ones or should be labeled as a different subspecies, Homo ergaster.

    Proponents of the out-of-Africa model aren't sure whether non-African humans descended from a single migration out of Africa or at least two major waves of migration followed by a lot of interbreeding.

    Did we head east or south of Eden?

    Not all anthropologists agree with Begun and his team's conclusions. As noted by New Scientist, it is possible that the Nikiti ape is not related to hominins at all. It may have evolved similar features independently, developing teeth to eat similar foods or chew in a similar manner as early hominins.

    Ultimately, Nikiti ape alone doesn't offer enough evidence to upend the out of Africa model, which is supported by a more robust fossil record and DNA evidence. But additional evidence may be uncovered to lend further credence to Begun's hypothesis or lead us to yet unconsidered ideas about humanity's evolution.

    New study finds the egg may actually 'choose' the Sperm

    Here's the first evidence to challenge the "fastest sperm" narrative.

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