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The World’s 1st Molecular Robot Has Just Been Created by UK Scientists
One researcher called it “the ultimate in the miniaturization of machinery.”
We marvel at movies like Ant Man, Inner Space, and Fantastic Voyage, where someone or something can shrink down to the nanoscale and navigate a microscopic world. Although shrinking something down with some type of laser or energy field is all but impossible today, we are beginning to exact more and more control over tinier and tinier environments.
The new and growing branch of nanotechnology promises much. In the near future, experts predict that nanosensors will be used inside our bodies to monitor our health and alert us to disease or even an oncoming health crisis. Nanosensors could also monitor the environment. Another exciting application is creating the next generation of materials with novel properties.
These can include gaining electrical properties in fabric-based items. Consider clothing that can conduct electricity; your outfit could have electronics built into it, or even a wireless charger for your phone. Nanotech can also help create the next generation of bullet-proof and explosive-resistant materials. We will be able to imbue materials with other properties as well such as water-resistance, anti-corrosive properties, anti-fogging, anti-abrasion, and more.
Imagine self-healing materials. Tear your jacket? No problem. It just grows back. In the realm of energy, nanotech could be used to improve solar cells and develop ultra-capacitors for energy storage, which could help us embrace green energy and jettison fossil fuels. In total, scientists believe nanotech can help us to develop multi-component systems that are smart, autonomous, and adapt to the environment or changing circumstances.
Carbon nanotubes strung together can make some of the strongest material on Earth. Wikipedia Commons.
But what about actual machines? The field of nanorobotics is young but growing rapidly. One research team is working on self-aware nanobots that can deliver drugs inside the body, right where they’re needed. Another group at Rice University built a nanocar. A collaboration of several US universities recently announced the creation of a photodynamic nanodrill. When it encounters light or a laser, it spins and can drill right down into a cancer cell, killing it.
Now, a team at the University of Manchester in the UK has reached another milestone. It's developed a robot so small it operates on the molecular level. This is the world’s first molecular robot, and it has an arm which can manipulate individual molecules or move them in clusters.
The thing is a millionth of a millimeter in size. To give you an idea of the scale we’re talking about, one quintillion (a billion billion) of them piled together would be about equal to a few grains of salt. Each machine is comprised of 150 atoms. That includes carbon, hydrogen, oxygen, and nitrogen atoms. Though small, these machines could offer us incredible capabilities, such as to work in tiny, molecular factories, in order to manufacture the next generation of materials and products.
This 2016 Nobel Prize-winning Nanocar was created at Rice University. Edumol, Molecular Visualizations. Wikimedia Commons.
Certain biological processes move atoms individually or in clusters all the time to serve an organism’s needs. Previous to this study, some experts argued that doing so artificially was all but impossible. Professor David Leigh of University of Manchester's School of Chemistry led the study. He called this, “the ultimate in the miniaturization of machinery.” The chemist explained how he and his team approached the project.
Our robot is literally a molecular robot constructed of atoms just like you can build a very simple robot out of Lego bricks. The robot then responds to a series of simple commands that are programmed with chemical inputs by a scientist. It is similar to the way robots are used on a car assembly line. Those robots pick up a panel and position it so that it can be riveted in the correct way to build the bodywork of a car. So, just like the robot in the factory, our molecular version can be programmed to position and rivet components in different ways to build different products, just on a much smaller scale, at a molecular level.
Detailed visualization of the molecular robot. Credit: Nature.
While most nanobots are extremely complex to build, this one operates on simple, well understood chemical processes. Prof. Leigh said, “This is the science of how atoms and molecules react with each other and how larger molecules are constructed from smaller ones.” He added, “It is the same sort of process scientists use to make medicines and plastics from simple chemical building blocks. Then, once the nano-robots have been constructed, they are operated by scientists by adding chemical inputs which tell the robots what to do and when, just like a computer program.”
The cost of materials, particularly to make electronics, is going through the roof. The beauty in using such robots instead of life-sized equipment is that everything operates on such a small scale, once the price of the actual tech comes down, it’ll make the ability to create materials more cost-effective. It could also improve the quality of products. It may even help increase the rate of miniaturization. We’ll be able to make smaller, more agile devices more easily. Such a robot could also help improve the process of discovering new drugs as well.
“Our aim is to design and make the smallest machines possible,” Prof. Leigh said. “This is just the start but we anticipate that within 10 to 20 years molecular robots will begin to be used to build molecules and materials on assembly lines in molecular factories.”
The results of this study were published in the journal Nature.
To get an interesting look at the “nanobots” that already operate inside your body, click here:
This is the first successful DNA sequencing on ancient Egyptian mummies, ever.
Egyptologists, writers, scholars, and others, have argued the race of the ancient Egyptians since at least the 1970's. Some today believe they were Sub-Saharan Africans. We can see this interpretation portrayed in Michael Jackson's 1991 music video for “Remember the Time" from his "Dangerous" album. The video, a 10-minute mini-film, includes performances by Eddie Murphy and Magic Johnson.
Reactionaries, meanwhile, say that there's never been any significant black civilizations—an utter falsehood, of course. There were several in fact, highly advanced African empires and kingdoms throughout history. Curiously, some extreme Right groups have even used blood group data to proclaim a Nordic origin to King Tutankhamun and his brethren.
The problem, it was thought, is that mummy DNA couldn't be sequenced. But a group of international researchers, using unique methods, have overcome the barriers to do just that. They found that the ancient Egyptians were most closely related to the peoples of the Near East, particularly from the Levant. This is the Eastern Mediterranean which today includes the countries of Turkey, Iraq, Israel, Jordan, Syria, and Lebanon. The mummies used were from the New Kingdom and a later period, (a period later than the Middle Kingdom) when Egypt was under Roman rule.
Egyptian mummy. British Museum. Flikr.
Modern Egyptians share 8% of their genome with central Africans, far more than ancient ones, according to the study, published in the journal Nature Communications. The influx of Sub-Saharan genes only occurred within the last 1,500 years. This could be attributed to the trans-Saharan slave trade or just from regular, long distance trade between the two regions. Improved mobility on the Nile during this period increased trade with the interior, researchers claim.
Egypt over the span of antiquity was conquered many times including by Alexander the Great, by the Greeks, Romans, Arabs, and more. Researchers wanted to know if these constant waves of invaders caused any major genetic changes in the populace over time. Group leader Wolfgang Haak at the Max Planck Institute in Germany said, "The genetics of the Abusir el-Meleq community did not undergo any major shifts during the 1,300 year timespan we studied, suggesting that the population remained genetically relatively unaffected by foreign conquest and rule."
The study was led by archeogeneticist Johannes Krause, also of the Max Planck Institute. Historically, there's been a problem finding intact DNA from ancient Egyptian mummies. "The hot Egyptian climate, the high humidity levels in many tombs and some of the chemicals used in mummification techniques, contribute to DNA degradation and are thought to make the long-term survival of DNA in Egyptian mummies unlikely," Dr. Krause said.
The mummified remains of Queen Hatshepsut wet-nurse Sitre-In. Egyptian Museum, Cairo. 2007. Getty Images.
It was also thought that, even if genetic material were recovered, it may not be reliable. Despite this, Krause and colleagues have been able to introduce robust DNA sequencing and verification techniques, and completed the first successful genomic testing on ancient Egyptian mummies.
Each came from Abusir el-Meleq, an archaeological site situated along the Nile, 70 miles (115 km) south of Cairo. This necropolis there houses mummies which display aspects revealing a dedication to the cult of Osiris, the green-skinned god of the afterlife.
First, the mitochondrial genomes from 90 of mummies were taken. From these, Krause and colleagues found that they could get the entire genomes from just three of the mummies in all. For this study, scientists took teeth, bone, and soft tissue samples. The teeth and bones offered the most DNA. They were protected by the soft tissue which has been preserved through the embalming process.
Researchers took these samples back to a lab in Germany. They began by sterilizing the room. Then they put the samples under UV radiation for an hour to sterilize them. From there, they were able to perform DNA sequencing.
An Egyptian necropolis. Getty Images.
Scientists also gathered data on Egyptian history and archaeological data of northern Africa, to give their discoveries some context. They wanted to know what changes had occurred over time. To find out, they compared the mummies' genomes to that of 100 modern Egyptians and 125 Ethiopians. “For 1,300 years, we see complete genetic continuity," Krause said.
The oldest mummy sequenced was from the New Kingdom, 1,388 BCE, when Egypt was at the height of its power and glory. The youngest was from 426 CE, when the country was ruled from Rome. The ability to acquire genomic data on ancient Egyptians is a dramatic achievement, which opens up new avenues of research.
One limitation according to their report, “all our genetic data were obtained from a single site in Middle Egypt and may not be representative for all of ancient Egypt." In southern Egypt they say, the genetic makeup of the people may have been different, being closer to the interior of the continent.
Researchers in future want to determine exactly when Sub-Saharan African genes seeped into the Egyptian genome and why. They'll also want to know where ancient Egyptians themselves came from. To do so, they'll have to identify older DNA from, as Krause said, “Back further in time, in prehistory."
Using high-throughput DNA sequencing and cutting-edge authentication techniques, researchers proved they could retrieve reliable DNA from mummies, despite the unforgiving climate and damaging embalming techniques.
Further testing will likely contribute much knowledge to our understanding of the ancient Egyptians and perhaps even those from other places as well, helping to fill in the gaps in humanity's collective memory.
To learn about the latest Egyptian archaeological find, click here:
Seawater is raising salt levels in coastal woodlands along the entire Atlantic Coastal Plain, from Maine to Florida.
Permanent flooding has become commonplace on this low-lying peninsula, nestled behind North Carolina's Outer Banks. The trees growing in the water are small and stunted. Many are dead.
Throughout coastal North Carolina, evidence of forest die-off is everywhere. Nearly every roadside ditch I pass while driving around the region is lined with dead or dying trees.
As an ecologist studying wetland response to sea level rise, I know this flooding is evidence that climate change is altering landscapes along the Atlantic coast. It's emblematic of environmental changes that also threaten wildlife, ecosystems, and local farms and forestry businesses.
Like all living organisms, trees die. But what is happening here is not normal. Large patches of trees are dying simultaneously, and saplings aren't growing to take their place. And it's not just a local issue: Seawater is raising salt levels in coastal woodlands along the entire Atlantic Coastal Plain, from Maine to Florida. Huge swaths of contiguous forest are dying. They're now known in the scientific community as “ghost forests."
Deer photographed by a remote camera in a climate change-altered forest in North Carolina. Emily Ury, CC BY-ND
The insidious role of salt
Sea level rise driven by climate change is making wetlands wetter in many parts of the world. It's also making them saltier.
In 2016 I began working in a forested North Carolina wetland to study the effect of salt on its plants and soils. Every couple of months, I suit up in heavy rubber waders and a mesh shirt for protection from biting insects, and haul over 100 pounds of salt and other equipment out along the flooded trail to my research site. We are salting an area about the size of a tennis court, seeking to mimic the effects of sea level rise.
After two years of effort, the salt didn't seem to be affecting the plants or soil processes that we were monitoring. I realized that instead of waiting around for our experimental salt to slowly kill these trees, the question I needed to answer was how many trees had already died, and how much more wetland area was vulnerable. To find answers, I had to go to sites where the trees were already dead.
Rising seas are inundating North Carolina's coast, and saltwater is seeping into wetland soils. Salts move through groundwater during phases when freshwater is depleted, such as during droughts. Saltwater also moves through canals and ditches, penetrating inland with help from wind and high tides. Dead trees with pale trunks, devoid of leaves and limbs, are a telltale sign of high salt levels in the soil. A 2019 report called them “wooden tombstones."
As the trees die, more salt-tolerant shrubs and grasses move in to take their place. In a newly published study that I coauthored with Emily Bernhardt and Justin Wright at Duke University and Xi Yang at the University of Virginia, we show that in North Carolina this shift has been dramatic.
The state's coastal region has suffered a rapid and widespread loss of forest, with cascading impacts on wildlife, including the endangered red wolf and red-cockaded woodpecker. Wetland forests sequester and store large quantities of carbon, so forest die-offs also contribute to further climate change.
Researcher Emily Ury measuring soil salinity in a ghost forest. Emily Bernhardt, CC BY-ND
Assessing ghost forests from space
To understand where and how quickly these forests are changing, I needed a bird's-eye perspective. This perspective comes from satellites like NASA's Earth Observing System, which are important sources of scientific and environmental data.
A 2016 Landsat8 image of the Albemarle Pamlico Peninsula in coastal North Carolina. USGS
Since 1972, Landsat satellites, jointly operated by NASA and the U.S. Geological Survey, have captured continuous images of Earth's land surface that reveal both natural and human-induced change. We used Landsat images to quantify changes in coastal vegetation since 1984 and referenced high-resolution Google Earth images to spot ghost forests. Computer analysis helped identify similar patches of dead trees across the entire landscape.
Google Earth image of a healthy forest on the right and a ghost forest with many dead trees on the left. Emily Ury
The results were shocking. We found that more than 10% of forested wetland within the Alligator River National Wildlife Refuge was lost over the past 35 years. This is federally protected land, with no other human activity that could be killing off the forest.
Rapid sea level rise seems to be outpacing the ability of these forests to adapt to wetter, saltier conditions. Extreme weather events, fueled by climate change, are causing further damage from heavy storms, more frequent hurricanes and drought.
We found that the largest annual loss of forest cover within our study area occurred in 2012, following a period of extreme drought, forest fires and storm surges from Hurricane Irene in August 2011. This triple whammy seemed to have been a tipping point that caused mass tree die-offs across the region.
Should scientists fight the transition or assist it?
As global sea levels continue to rise, coastal woodlands from the Gulf of Mexico to the Chesapeake Bay and elsewhere around the world could also suffer major losses from saltwater intrusion. Many people in the conservation community are rethinking land management approaches and exploring more adaptive strategies, such as facilitating forests' inevitable transition into salt marshes or other coastal landscapes.
For example, in North Carolina the Nature Conservancy is carrying out some adaptive management approaches, such as creating “living shorelines" made from plants, sand and rock to provide natural buffering from storm surges.
A more radical approach would be to introduce marsh plants that are salt-tolerant in threatened zones. This strategy is controversial because it goes against the desire to try to preserve ecosystems exactly as they are.
But if forests are dying anyway, having a salt marsh is a far better outcome than allowing a wetland to be reduced to open water. While open water isn't inherently bad, it does not provide the many ecological benefits that a salt marsh affords. Proactive management may prolong the lifespan of coastal wetlands, enabling them to continue storing carbon, providing habitat, enhancing water quality and protecting productive farm and forest land in coastal regions.
A new study used functional near-infrared spectroscopy (fNIRS) to measure brain activity as inexperienced and experienced soccer players took penalty kicks.
- The new study is the first to use in-the-field imaging technology to measure brain activity as people delivered penalty kicks.
- Participants were asked to kick a total of 15 penalty shots under three different scenarios, each designed to be increasingly stressful.
- Kickers who missed shots showed higher activity in brain areas that were irrelevant to kicking a soccer ball, suggesting they were overthinking.
In a 2019 soccer match, Swansea City was down 1-0 against West Brom late in the first half. A penalty was called against West Brom. Swansea midfielder Bersant Celina was preparing to deliver a penalty kick. He scuttled up to the ball, but his foot only made partial contact, lobbing it weakly to the right.
Was it a simple mistake? Maybe. But there might be deeper explanations for why professional athletes choke under high-pressure situations.
A new study published in Frontiers in Computer Science used functional near-infrared spectroscopy (fNIRS) to analyze the brain activity of inexperienced and experienced soccer players as they missed penalty shots. Although past research has explored why soccer players miss penalty shots, the recent study is the first to do so using in-the-field fNIRS measurement.
The results showed that kickers who choked were activating parts of their brain associated with long-term thinking, self-instruction, and self-reflection. The chokers, in other words, were overthinking it.
The psychology of penalty kicks
Penalty shots offer an interesting case study of how mental pressure affects physical performance. After all, there's a lot at stake, not only because the kick can sometimes render a win or loss, but also because there are sometimes millions of people anxiously watching, some of whom might have a financial interest in the outcome.
That pressure is no joke. For example, research on Men's World Cup penalty shoot-outs has shown that when the score is tied and a goal means an immediate win, players score 92 percent of kicks. But when teams are facing elimination in a shootout, and the kick determines an immediate tie or loss, players only score 60 percent of the time.
"How can it be that football players with a near perfect control over the ball (they can very precisely kick a ball over more than 50 meters) fail to score a penalty kick from only 11 meters?" study co-author Max Slutter, of the University of Twente in the Netherlands, said in a press release.
"Obviously, huge psychological pressure plays a role, but why does this pressure cause a missed penalty? We tried to answer this by measuring the brain activity of football players during the physical execution of a penalty kick."
In the new study, the researchers aimed to answer two key questions about choking under pressure among both experienced and inexperienced players: (1) What is the difference in brain activity between success (scoring) and failure (missing) when taking a penalty kick? (2) What brain activity is associated with performing under pressure during a penalty kick situation?
To find out, the researchers asked ten experienced soccer players and twelve inexperienced players to participate in a penalty-kicking task. The task was divided into three rounds, each of which was designed to be increasingly stressful:
- Round 1 had no goalkeeper and was labeled as a practice round.
- Round 2 had a friendly goalkeeper who wasn't allowed to distract the kicker.
- Round 3 had a competitive goalkeeper who was allowed to distract the kicker, and kickers were also competing for a prize.
Participants kicked five shots in each round. They wore a fNIRS-equipped headset during the task that measured activity in various parts of the brain.
All participants performed worse in the second and third rounds and reported experiencing the most pressure in the third round. Inexperienced players performed worse than experienced players, which might suggest that they were less able to deal with the mental stress.
The locations in which experienced and inexperienced players kicked the ball in each round. Red dots represent missed penalties and green dots represent scored penalties.Slutter et al., Frontiers in Computer Science, 2021.
The neuroscience of choke artists
So, what types of brain activity were associated with missed shots?
The most noticeable result was that kickers missed more shots when they showed higher activity in their prefrontal cortex (PFC), an area of the brain associated with long-term planning. This was especially true among participants who reported higher levels of anxiety. More specifically, experienced soccer players who missed shots showed high activity in the left temporal cortex, which is related to self-instruction and self-reflection.
"By activating the left temporal cortex more, experienced players neglect their automated skills and start to overthink the situation," the researchers wrote. "This increase can be seen as a distracting factor."
Also, when players of all experience levels felt anxious and missed shots, they showed less activity in the motor cortex, which is the brain area most directly associated with kicking a penalty shot.
Don't overthink it
The results suggest that mental pressure can activate parts of the brain that are irrelevant to the task at hand. In general, expert athletes show more efficient brain activity — that is, more activity in relevant areas, and less activity in irrelevant areas — and therefore experience fewer distractions. This is likely one reason why they were more successful at penalties than inexperienced players in high-stress situations.
This principle is described by neural efficiency theory, and it applies not only to athletes but experts in any field. As you gain mastery over something, you can rely more on automatic brain processes rather than deliberate thinking, which can lead to distractions. The authors of the study concluded that their results provide supporting evidence for neural efficiency theory.
Still, as long our experts are human, it seems that high-pressure situations can turn anyone into a choke artist.