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Supercentenarian DNA May Hold the Ultimate Secret to Longevity
Find the right genes and we’ll have a way to prolong life and good health, perhaps indefinitely.
Better food, healthcare, working conditions, and safety protocols have allowed humans to live longer and healthier than ever before. In most developed countries today, the average lifespan is 80 years, while in 1906, a little more than 100 years ago, it was 48. Projections moving forward look so good that there’s a debate in the medical community on whether or not we can increase human longevity indefinitely.
There are far more centenarians than ever, or those who’ve lived to 100, and more supercentenarians or those 110 or above. A study published last year in the journal Nature proposes that 122 may be the human lifespan's ceiling. Most of those in the upper reaches of our lifespan assign their longevity to lifestyle choices or healthy habits, which of course play an enormous role. But many scientists believe important secrets to longevity lie within our genes as well.
Moreover, quite a number of studies suggest a strong genetic link. For instance, a 1996 study published in the journal Human Genetics, looked at thousands of Danish twins. It concluded that 20-26% of longevity is up to one’s genetic code. Meanwhile, a Boston University study found that a centenarians’ siblings have about a 3½ times higher chance of reaching 100, over non-centenarians’ siblings.
What’s more, supercentenarians don’t often experience any of the serious diseases people succumb to in old age, such as heart disease or cancer. Turns out, the longest living among us carry fewer of the genetic variations involved with such diseases.
While lifestyle plays an enormous role, certain genes or gene combinations add significantly to longevity and good health later in life. Credit: Getty Images.
To find out what all those who’ve reached 110 have in common, a nonprofit known as Betterhumans is studying the DNA of those who have shown impressive longevity. It bills itself as “the world's most comprehensive genomic study of supercentenarians and their families.” DNA samples collected will not only be sequenced, the data produced will be made available to the public. In fact, a series of genomes are to be released this week.
The idea is to find out what genes gives people an exceptional lifespan, synthesize those genes, and from there develop a way to prolong life and health in others. So far, the project has collected over 30 samples from people in North America, Europe, and the Caribbean. Those who qualify can donate their saliva, a blood sample, or if their long-lived relative is deceased, a tissue sample, to the project. Then the samples are analyzed by Betterhumans and their research partners.
It may be more than being devoid of disease causing mutations that keep those over 110 in good health. Credit: Getty Images.
Supercentenarians live more healthy, disease-free lives in their autumn years than even centenarians. Their genomes are not just devoid of disease causing mutations, they must also contain actively protective genes. Previous work has been stunted however by a lack of supercentenarian DNA to work with. Betterhumans is hoping to overcome this problem.
The nonprofit says it uses a specific identification system, assigning a proprietary number to each sample, so that the subject can remain anonymous. Once a large number of samples have been processed, they’re sent to a lab for sequencing. Both proprietary and public-domain software is used. Besides sequencing, Betterhumans is comparing and contrasting supercentenarian DNA with non-supercentenarian DNA. It takes three months total from the time they take the sample to the time it’s turned into data.
2,500 differences in supercentenarian DNA have been tagged thus far, but it’s hard to discern which are significant. Extremely rare mutations might be difficult to detect using standard methods. Scanning procedures are set to look at places that are already known to harbor mutations.
A significant number of variants for supercentenarians have been found so far. Deciphering them is another matter. Credit: Getty Images.
So will we all be living to 110 in a decade or two? There’s still a contentious debate on whether or not there's a limit to the human lifespan or if science can eventually make it limitless. But let’s say for the sake of argument that we can, should we?
The project has natural limitations. To understand all the phenotypes or combination of genes involved, tens of thousands of genomes would need to be sequenced. Yet, there are only about 150 supercentenarians worldwide. Just one in five million Americans is one. Also, some of them are hard to find. They may be living in rural areas in developing countries and did not receive a birth certificate when they were born.
Those who have a supercentenarian in their life or are one and want to contribute, contact Betterhumans and donate a sample. Contact them by phone at: (509) 987-5282, email: firstname.lastname@example.org, or by filling out an enrollment form here.
To learn about another significant breakthrough in the quest for longevity, click here:
Physicist Frank Wilczek proposes new methods of searching for extraterrestrial life.
- Nobel Prize-winning physicist Frank Wilczek thinks we are not searching for aliens correctly.
- Instead of sending out and listening for signals, he proposes two new methods of looking for extraterrestrials.
- Spotting anomalies in planet temperature and atmosphere could yield clues of alien life, says the physicist.
1. Atmosphere chemistry<p>Like we found out with our own effect on the Earth's atmosphere, making a <a href="https://ozonewatch.gsfc.nasa.gov/facts/hole_SH.html" target="_blank">hole in the ozone layer</a>, the gases around a planet can be impacted by its inhabitants. "Atmospheres are especially significant in the search for alien life," <a href="https://www.wsj.com/articles/looking-for-signs-of-alien-technology-11581605907" target="_blank">writes Wilczek</a> "because they might be affected by biological processes, the way that photosynthesis on Earth produces nearly all of our planet's atmospheric oxygen."</p><p>But while astrobiology can provide invaluable clues, so can looking for the signs of alien technology, which can also be manifested in the atmosphere. An advanced alien civilization might be colonizing other planets, turning their atmospheres to resemble the home planets. This makes sense considering our own plans to terraform other planets like Mars to allow us to breathe there. Elon Musk even <a href="https://www.space.com/elon-musk-serious-nuke-mars-terraforming.html" target="_blank">wants to nuke the red planet.</a></p>
The Most Beautiful Equation: How Wilczek Got His Nobel<div class="rm-shortcode" data-media_id="ijBZzuI2" data-player_id="FvQKszTI" data-rm-shortcode-id="061a3de613c45f42b05432a2949e7caa"> <div id="botr_ijBZzuI2_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/ijBZzuI2-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/ijBZzuI2-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/ijBZzuI2-FvQKszTI.js"></script> </div>
2. Planet temperatures<p>Wilczek also floats another idea - what if an alien civilization created a greenhouse effect to raise the temperature of a planet? For example, if extraterrestrials were currently researching Earth, they would likely notice the increased levels of carbon dioxide that are <a href="https://www.epa.gov/ghgemissions/overview-greenhouse-gases" target="_blank">heating up</a> our atmosphere. Similarly, we can looks for such signs around the exoplanets.</p><p>An advanced civilization might also be heating up planets to raise their temperatures to uncover resources and make them more habitable. Unfreezing water might be one great reason to turn up the thermostat. </p><p>Unusually high temperatures can also be caused by alien manufacturing and the use of artificial energy sources like nuclear fission or fusion, suggests the scientist. Structures like the hypothetical <a href="https://bigthink.com/paul-ratner/this-mind-bending-scale-predicts-the-power-of-advanced-civilizations" target="_self">Dyson spheres</a>, which could be used to harvest energy from stars, can be particularly noticeable. </p>
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Research reveals a new evolutionary feature that separates humans from other primates.
- Researchers find a new feature of human evolution.
- Humans have evolved to use less water per day than other primates.
- The nose is one of the factors that allows humans to be water efficient.
A model of water turnover for humans and chimpanzees who have similar fat free mass and body water pools.
Credit: Current Biology
Being skeptical isn't just about being contrarian. It's about asking the right questions of ourselves and others to gain understanding.