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Scientists Attempt to Reanimate the Brain Dead — What Could Go Wrong?
Scientists will combine stem cells, lasers, and other techniques to (hopefully) reanimate the brain stems of 20 brain dead patients. The technique has promise, and perhaps unforeseen pitfalls.
Imagine this, your loved one gets into a serious accident. You and your family gather at the hospital. In the I.C.U. the doctor makes a grim announcement, they‘re brain dead. It is highly unlikely they will ever come out of a vegetative state. Today, there is no way past such horror, save for a miracle. But if one biotech firm has its way, soon doctors would be able to regrow the person’s brain, using a new procedure and a host of technologies, which could theoretically restore them to who they were before. Even so, there are lots of questions and ethical dilemmas surrounding this procedure, and the advancements it may someday thrust upon the world.
The idea originates from nature, as certain fish and amphibians can actually heal whole sections of the brain, brain stem, and other portions of the central nervous system, even after significant injury. Scientists believe they can someday mimic this process in human patients.
This study surrounds Bioquark, Inc., a Philadelphia-based company, who has received ethical approval by a U.S. and Indian Institutional Review Board. Bioquark will collaborate with Revita Life Sciences, led by famed specialist Dr. Himanshu Bansaa. The team will run a pilot study of 20 clinically brain dead patients, each having suffered a traumatic brain injury (TBI). Taking place at Anupam Hospital in India, Bioquark is currently recruiting patients for the study, expected to take place over six weeks.
Traumatic brain injury under an MRI.
Known as the “Reanima Project,” several different therapies will be employed in combination, including stem cells injected into the brain to try and regrow damaged portions, lasers, nerve stimulation techniques—which have been successful in waking patients out of a coma, and a combination of different peptides. The peptides will be introduced daily through a spinal cord pump, and the stem cells injected every other week. The patients will be evaluated and monitored for months with brain imaging technology and an EEG to see if the brain, particularly the upper spinal cord or lower brain stem region, is regenerated. This is the oldest part of the brain which controls breathing and heartbeat.
The CEO of Bioquark Inc. Dr. Ira Pastor, said in a statement that this was the first step toward the “eventual reversal of death in our lifetime.” He believes they will achieve results within the first couple of months or so. This is the seminal stage, a “proof of concept” study. If you are afraid of the zombie apocalypse, Dr. Pastor says a common sense protocol, adopted industry-wide, should avoid any nasty scenarios from taking place. But every technology or advanced method is always thought ironclad at the onset. He believes this study will show that brain death is recoverable. Dr. Bansal has attempted a similar procedure on two brain dead patients, one in Europe and another in the Persian Gulf. They are currently in a “minimal conscious state,” but may still come out of it.
According to Dr. Bansal, "We are now trying to create a definitive study in 20 subjects and prove that the brain death is reversible. This will open the door for future research and especially for people who lose their dear ones suddenly." Brain stem death is defined as the loss of such functions as breathing and consciousness. When a person’s brain stem has stopped functioning, there is no chance for recovery, as it stands.
Model of the human brain. The Reanima Project aims to regrow parts of the brain stem.
Those on life support deemed brain dead still have active bodies which grow, mature, heal, digest, circulate blood, and excrete waste. A woman can even gestate and deliver a baby in this state. Some new studies suggest that even after brain death, blood flow and limited electrical activity take place inside the brain. But it isn’t enough to repair the damage, nor live without life support.
Dr. Sergei Paylian is the founder, president, and chief science officer of Bioquark Inc. He said that this experiment is not only important in developing our understanding of brain death, but also the vegetative and minimally conscious states, coma, and even neurodegenerative conditions, like Parkinson’s and Alzheimer’s. Critics urge that though these areas may not be irreparable, one pilot study is far from a complete neurological transformation. Truly it will take years or even decades for such a technique to be refined, should it even work.
Beyond that, advancements in science are always a mixed blessing. The splitting of the atom brought the microwave, the horrors of Hiroshima and Nagasaki, and generations afterward living under constant fear of nuclear annihilation. The internal combustion engine has wrought the transportation industry and climate change. What could reanimating a human brain after such trauma ultimately produce?
One wonders if neurons will grow back exactly as they were, or will the person be a blank slate? The attempt will try and engage a functional epimorphic event. Epimorphic cells are those that can wipe their memory banks clean and start anew. So is this what will happen with the brain dead, should their brains be neuro-regenerated? Think of the emotional trauma to families who aren’t recognized by a healed loved one, not to mention the trauma to the person themselves? Will adults be like walking babies and need to relearn everything over again? Will it be like with amnesia? There’s no way to tell at this point.
And what if it did restore one’s memory in total? Does this create a scenario which when coupled with other technologies, could usher in an age of immortality? Though fanciful, it could seal the planet’s doom, as without periodic segments dying off, resources would quickly be depleted, not to mention the vast implications for war, politics, the workforce, social justice, and many other sectors. Of course we can speculate good and bad scenarios, but no one knows for sure until the Reanima Project and its progeny are complete, perhaps decades from now. The seeds of utopia or an utter hellscape could soon be sitting in 20 heads in a hospital in India.
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Inventions with revolutionary potential made by a mysterious aerospace engineer for the U.S. Navy come to light.
- U.S. Navy holds patents for enigmatic inventions by aerospace engineer Dr. Salvatore Pais.
- Pais came up with technology that can "engineer" reality, devising an ultrafast craft, a fusion reactor, and more.
- While mostly theoretical at this point, the inventions could transform energy, space, and military sectors.
The U.S. Navy controls patents for some futuristic and outlandish technologies, some of which, dubbed "the UFO patents," came to life recently. Of particular note are inventions by the somewhat mysterious Dr. Salvatore Cezar Pais, whose tech claims to be able to "engineer reality." His slate of highly-ambitious, borderline sci-fi designs meant for use by the U.S. government range from gravitational wave generators and compact fusion reactors to next-gen hybrid aerospace-underwater crafts with revolutionary propulsion systems, and beyond.
Of course, the existence of patents does not mean these technologies have actually been created, but there is evidence that some demonstrations of operability have been successfully carried out. As investigated and reported by The War Zone, a possible reason why some of the patents may have been taken on by the Navy is that the Chinese military may also be developing similar advanced gadgets.
Among Dr. Pais's patents are designs, approved in 2018, for an aerospace-underwater craft of incredible speed and maneuverability. This cone-shaped vehicle can potentially fly just as well anywhere it may be, whether air, water or space, without leaving any heat signatures. It can achieve this by creating a quantum vacuum around itself with a very dense polarized energy field. This vacuum would allow it to repel any molecule the craft comes in contact with, no matter the medium. Manipulating "quantum field fluctuations in the local vacuum energy state," would help reduce the craft's inertia. The polarized vacuum would dramatically decrease any elemental resistance and lead to "extreme speeds," claims the paper.
Not only that, if the vacuum-creating technology can be engineered, we'd also be able to "engineer the fabric of our reality at the most fundamental level," states the patent. This would lead to major advancements in aerospace propulsion and generating power. Not to mention other reality-changing outcomes that come to mind.
Among Pais's other patents are inventions that stem from similar thinking, outlining pieces of technology necessary to make his creations come to fruition. His paper presented in 2019, titled "Room Temperature Superconducting System for Use on a Hybrid Aerospace Undersea Craft," proposes a system that can achieve superconductivity at room temperatures. This would become "a highly disruptive technology, capable of a total paradigm change in Science and Technology," conveys Pais.
High frequency gravitational wave generator.
Credit: Dr. Salvatore Pais
Another invention devised by Pais is an electromagnetic field generator that could generate "an impenetrable defensive shield to sea and land as well as space-based military and civilian assets." This shield could protect from threats like anti-ship ballistic missiles, cruise missiles that evade radar, coronal mass ejections, military satellites, and even asteroids.
Dr. Pais's ideas center around the phenomenon he dubbed "The Pais Effect". He referred to it in his writings as the "controlled motion of electrically charged matter (from solid to plasma) via accelerated spin and/or accelerated vibration under rapid (yet smooth) acceleration-deceleration-acceleration transients." In less jargon-heavy terms, Pais claims to have figured out how to spin electromagnetic fields in order to contain a fusion reaction – an accomplishment that would lead to a tremendous change in power consumption and an abundance of energy.
According to his bio in a recently published paper on a new Plasma Compression Fusion Device, which could transform energy production, Dr. Pais is a mechanical and aerospace engineer working at the Naval Air Warfare Center Aircraft Division (NAWCAD), which is headquartered in Patuxent River, Maryland. Holding a Ph.D. from Case Western Reserve University in Cleveland, Ohio, Pais was a NASA Research Fellow and worked with Northrop Grumman Aerospace Systems. His current Department of Defense work involves his "advanced knowledge of theory, analysis, and modern experimental and computational methods in aerodynamics, along with an understanding of air-vehicle and missile design, especially in the domain of hypersonic power plant and vehicle design." He also has expert knowledge of electrooptics, emerging quantum technologies (laser power generation in particular), high-energy electromagnetic field generation, and the "breakthrough field of room temperature superconductivity, as related to advanced field propulsion."
Suffice it to say, with such a list of research credentials that would make Nikola Tesla proud, Dr. Pais seems well-positioned to carry out groundbreaking work.
A craft using an inertial mass reduction device.
Credit: Salvatore Pais
The patents won't necessarily lead to these technologies ever seeing the light of day. The research has its share of detractors and nonbelievers among other scientists, who think the amount of energy required for the fields described by Pais and his ideas on electromagnetic propulsions are well beyond the scope of current tech and are nearly impossible. Yet investigators at The War Zone found comments from Navy officials that indicate the inventions are being looked at seriously enough, and some tests are taking place.
If you'd like to read through Pais's patents yourself, check them out here.
Laser Augmented Turbojet Propulsion System
Credit: Dr. Salvatore Pais
- The history of AI shows boom periods (AI summers) followed by busts (AI winters).
- The cyclical nature of AI funding is due to hype and promises not fulfilling expectations.
- This time, we might enter something resembling an AI autumn rather than an AI winter, but fundamental questions remain if true AI is even possible.
The dream of building a machine that can think like a human stretches back to the origins of electronic computers. But ever since research into artificial intelligence (AI) began in earnest after World War II, the field has gone through a series of boom and bust cycles called "AI summers" and "AI winters."
Each cycle begins with optimistic claims that a fully, generally intelligent machine is just a decade or so away. Funding pours in and progress seems swift. Then, a decade or so later, progress stalls and funding dries up. Over the last ten years, we've clearly been in an AI summer as vast improvements in computing power and new techniques like deep learning have led to remarkable advances. But now, as we enter the third decade of the 21st century, some who follow AI feel the cold winds at their back leading them to ask, "Is Winter Coming?" If so, what went wrong this time?
How to build an A.I. brain that can conceive of itself | Joscha Bach | Big Think www.youtube.com
A brief history of AI
To see if the winds of winter are really coming for AI, it is useful to look at the field's history. The first real summer can be pegged to 1956 and the famous Dartmouth University Workshop where one of the field's pioneers, John McCarthy, coined the term "artificial intelligence." The conference was attended by scientists like Marvin Minsky and H. A. Simon, whose names would go on to become synonymous with the field. For those researchers, the task ahead was clear: capture the processes of human reasoning through the manipulation of symbolic systems (i.e., computer programs).
Unless we are talking about very specific tasks, any 6-year-old is infinitely more flexible and general in his or her intelligence than the "smartest" Amazon robot.
Throughout the 1960s, progress seemed to come swiftly as researchers developed computer systems that could play chess, deduce mathematical theorems, and even engage in simple discussions with a person. Government funding flowed generously. Optimism was so high that, in 1970, Minsky famously proclaimed, "In three to eight years we will have a machine with the general intelligence of a human being."
By the mid 1970s, however, it was clear that Minsky's optimism was unwarranted. Progress stalled as many of the innovations of the previous decade proved too narrow in their applicability, seeming more like toys than steps toward a general version of artificial intelligence. Funding dried up so completely that researchers soon took pains not to refer to their work as AI, as the term carried a stink that killed proposals.
The cycle repeated itself in the 1980s with the rise of expert systems and the renewed interest in what we now call neural networks (i.e., programs based on connectivity architectures that mimic neurons in the brain). Once again, there was wild optimism and big increases in funding. What was novel in this cycle was the addition of significant private funding as more companies began to rely on computers as essential components of their business. But, once again, the big promises were never realized, and funding dried up again.
AI: Hype vs. reality
The AI summer we're currently experiencing began sometime in the first decade of the new millennium. Vast increases in both computing speed and storage ushered in the era of deep learning and big data. Deep learning methods use stacked layers of neural networks that pass information to each other to solve complex problems like facial recognition. Big data provides these systems with vast oceans of examples (like images of faces) to train on. The applications of this progress are all around us: Google Maps give you near-perfect directions; you can talk with Siri anytime you want; IBM's Deep Think computer beat Jeopardy's greatest human champions.
In response, the hype rose again. True AI, we were told, must be just around the corner. In 2015, for example, The Guardian reported that self-driving cars, the killer app of modern AI, was close at hand. Readers were told, "By 2020 you will become a permanent backseat driver." And just two years ago, Elon Musk claimed that by 2020 "we'd have over a million cars with full self-driving software."
The general intelligence — i.e., the understanding — we humans exhibit may be inseparable from our experiencing. If that's true, then our physical embodiment, enmeshed in a context-rich world, may be difficult if not impossible to capture in symbolic processing systems.
By now, it's obvious that a world of fully self-driving cars is still years away. Likewise, in spite of the remarkable progress we've made in machine learning, we're still far from creating systems that possess general intelligence. The emphasis is on the term general because that's what AI really has been promising all these years: a machine that's flexible in dealing with any situation as it comes up. Instead, what researchers have found is that, despite all their remarkable progress, the systems they've built remain brittle, which is a technical term meaning "they do very wrong things when given unexpected inputs." Try asking Siri to find "restaurants that aren't McDonald's." You won't like the results.
Unless we are talking about very specific tasks, any 6-year-old is infinitely more flexible and general in his or her intelligence than the "smartest" Amazon robot.
Even more important is the sense that, as remarkable as they are, none of the systems we've built understand anything about what they are doing. As philosopher Alva Noe said of Deep Think's famous Jeopardy! victory, "Watson answered no questions. It participated in no competition. It didn't do anything. All the doing was on our side. We played Jeapordy! with Watson." Considering this fact, some researchers claim that the general intelligence — i.e., the understanding — we humans exhibit may be inseparable from our experiencing. If that's true, then our physical embodiment, enmeshed in a context-rich world, may be difficult if not impossible to capture in symbolic processing systems.
Not the (AI) winter of our discontent
Thus, talk a of a new AI winter is popping up again. Given the importance of deep learning and big data in technology, it's hard to imagine funding for these domains drying up any time soon. What we may be seeing, however, is a kind of AI autumn when researchers wisely recalibrate their expectations and perhaps rethink their perspectives.
A new study explores how investors' behavior is affected by participating in online communities, like Reddit's WallStreetBets.
- The study found evidence that "hype" over assets is psychologically contagious among investors in online communities.
- This hype is self-perpetuating: A small group of investors hypes an asset, bringing in new investors, until growth becomes unsteady and a price crash ensues.
- The researchers suggested that these new kinds of self-organized, social media-driven investment behaviors are unlikely to disappear anytime soon.
Social media has reshaped human behavior in ways we're only starting to understand. The proliferation of online communities has helped spawn novel strategies for promoting political causes, conducting business, finding sex and love, and transforming culture.
Could online communities also transform behavior in the financial world?
That's one of the key questions explored in a new study published on the preprint server arXiv. Titled "Reddit's self-organised bull runs: Social contagion and asset prices," the study used discussion data from the subreddit WallStreetBets to analyze relationships between the price of stocks and "hype" among online retail investors.
Hype is nothing new in the investing world. But the researchers noted that there seems to be something novel about the short squeeze of GameStop's stock in January, when the price of the stock rose tenfold, thanks largely to self-organized retail investors from WallStreetBets.
"As academics and regulators alike grapple with the implications, many wonder whether large-scale coordination among retail investors is the new 'modus operandi,' or a one-off fluke," the researchers wrote. "We argue that this is a new manifestation of a well-established global phenomenon."
To better understand how online hype is associated with stock prices, the researchers focused on two social components of hype: contagion and consensus. Contagion refers to investors spreading interest in an asset among each other, while consensus refers to their ability to agree on whether to buy or sell an asset.
The analysis found empirical evidence that both contagion and consensus emerge in online communities like WallStreetBets. In other words, investors spread sentiments about future stock performance to other investors, and then they cohere around investment strategies.
Popularity over fundamentals
The findings suggest that an asset's popularity, not its fundamentals, is paramount to many investors.
"Our results consistently show that investors become interested in discussing an asset, not because of fundamentals, but because other users discuss it," the researchers wrote. "Subsequently, this paper tests whether an individual's sentiment about future asset performance [is] affected by those of others. We find that this is the case: people look to their peers to form an opinion about an asset's potential."
To find evidence for social contagion among online investors, the researchers compiled a large dataset of posts and comments submitted to WallStreetBets. The goal was to analyze whether investors' past comments or posts about a given stock, such as Tesla, had a predictable effect on future discussions of that asset within WallStreetBets.
After conducting a regression analysis, the results suggest that hype is socially contagious and cyclical. The cycle usually plays out like this: A small group of investors hypes an asset. This attracts a larger group of investors who join the discussions.
But eventually, too many investors have joined the discussion, and fewer new investors are buying into the hype. As investors lose interest, they spend less time discussing (or "spreading") the asset on the forum, and they turn to new opportunities. The process is similar to a virus: As enough people become infected, they reach herd immunity, and the virus (hype) dies out.
So, does this process affect the stock price, and if so, how? The researchers said it was difficult to establish causality between hype and actual market activity. After all, they didn't have access to the trading records of subscribers to WallStreetBets.
But their model did show that activity on WallStreetBets was able to explain "significant variance" in trading volumes for the most-discussed assets on the forum. This suggests that when social contagion is strong for a given asset, consensus is strong too.
On the stock chart, consensus may start off bullish (or positively): As hype spreads, there's a slow, steady run-up in price. But the growth eventually becomes unstable and is followed by a crash and a period of volatility.
"The price crash stems from panic selling, as investors turn nervous in the face of volatility," the researchers wrote.
Bad news spreads faster than good news
Interestingly, the analysis found that bearish (or negative) sentiments were significantly more contagious on WallStreetBets.
"The data demonstrates that authors who previously commented on a bearish post are 47.7% more likely to express bearish over neutral sentiments, and 18.1% less likely to express bullish sentiments over neutral sentiments. Similarly, but less markedly, authors who previously commented on at least one bullish submission are 9.4% more likely to write a bullish submission, yet 11.3% less likely to write a bearish one."
The researchers said that the changing investing climate and widely available online data offers "promising opportunities for future research."
"As social media galvanizes a larger pool of retail investors with the potential for exciting stock market gambles, it is crucial to understand how social dynamics can impact asset prices," the researchers wrote. "With the first publicly acclaimed victory of Main Street over Wall Street, in the form of the GameStop short squeeze, it is unlikely that socially-driven asset volatility will simply disappear."
A 19th-century surveying mistake kept lumberjacks away from what is now Minnesota's largest patch of old-growth trees.