Migraines Could Be the Body’s Way of Protecting the Brain
We don’t know what causes migraines. But this new theory ties a lot of things together.
Worldwide, a little over a billion people experience migraine headaches, or around 14% of the world population. Meanwhile, 13% of US adults are affected, which is around 37 million migraine sufferers. Besides the detrimental effect to a person’s health and quality of life, migraines account for a loss of $36 billion to the US economy each year. Yet, medical science has failed to locate the source of such headaches or how to cure them.
There isn’t even a consensus on what might be causing them. Today, we have two prevailing theories. One is something causes the blood vessels in the head to narrow, leading to brain ischemia or an insufficient blood supply, which in turn causes a migraine. The second is an electrical disturbance in the brain.
Now, one researcher in a review published in the journal Headache, offers an entirely different explanation. Dr. Jonathan M. Borkum of the University of Maine says, migraines are a protective mechanism meant to ward off oxidative stress, allowing the brain to protect and repair itself, and shielding it from functional decline.
One theory suggests migraines come from abnormal electrical activity in the brain. Credit: inabstracting (#86. Migraine), via Wikimedia Commons.
To understand oxidative stress, you first have to understand free radicals. These are damaging molecules inside the body that are a byproduct of certain metabolic processes. These oxygen-laden molecules have one or more unimpaired electrons. Antioxidants neutralize free radicals, which is why it’s so important to get them in your diet. A buildup of free radicals leads to oxidative stress, which can damage the body.
Free radicals steal electrons from the DNA of healthy cells. This damages them, and causes them to steal electrons from one another, which can lead to a chain reaction. Previous studies have shown that migraine sufferers have a high level of oxidative stress. Dr. Borkum reviewed a number of different studies on migraine triggers conducted between 199 and 2014. Triggers include bright lights, loud sounds, disrupted sleep, air pollution, and more. According to Dr. Borkum, such triggers worsen the imbalance between free radicals and the body’s defenses against them. In other words, each migraine trigger increases oxidative stress in the brain.
"Oxidative stress is a useful signal of impending harm because a number of unfavorable conditions in the brain can give rise to it," Dr. Borkum told Medical News Today. Usually, symptoms from a disease such as fever, cough, or pain, aren’t caused by the disorder or infection itself, but by the body’s defenses against it. Dr. Borkum approached migraines in the exact new way, saying that a migraine and the other symptoms that come with it, are actually the body’s reaction to oxidative stress.
A migraine may be a protective mechanism inside the brain. Credit: r. nial bradshaw. Flickr.
The process which occurs when a migraine strikes is similar to the body's reaction to a disease. This includes a buildup of antioxidants, a brain-wide release of serotonin, and a decrease in electric activity inside the brain or what’s called cortical spreading depression. These actions according to Dr. Bokum, lead to the release of antioxidant enzymes, decreases the production of oxidants, and releases growth factors to protect neurons and stimulate their growth. Dr. Bokum believes these are all protective responses that are part of the same biological mechanism.
He said, "There are feedback loops between these components of a migraine attack that tie them together into an integrated system. Thus, it seems likely that migraine attacks are not simply triggered by oxidative stress, they actively protect and repair the brain from it." Understanding what leads to oxidative stress inside the brain could help researchers come up with more effective methods to treat migraines, or even a cure.
The implications don’t stop there. "The existence of an integrated system for protecting and repairing the brain could turn out to be quite useful—for example, we might one day be able to learn from this mechanism how to prevent neurodegenerative diseases," Dr. Borkum said.
To learn more about migraines, click here:
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"Nothing but naked people: fat ones, thin ones, old, young…"
"The Yellow Sands", 1888, John Reinhard Weguelin; source: Wikimedia Commons<h3>Naked revolution</h3><p>Yet long before anyone knew about beach fashion, naturism was trendy. Bathing naked in the sea was going on in England as early as 1840. However, during the reign of Queen Victoria, this pleasure was outlawed. But it popped up again among the conservative Germans. In 1898, the first Naturist Club was founded in Essen and in 1900 the Wandering Birds group (<em>Wandervögel</em>) was scouring the country for uninhabited places and naked sunbathing. In the same year, Heinrich Pudor wrote <em>The C</em><em>ult of </em><em>the </em><em>Nud</em><em>e</em>, winning the hearts of contemporary supporters of naturism.</p><p>In the 1920s, on the back of this, members of the Movement for Natural Healing (<em>Naturheilbewegung</em>) organized naked sunbathing for the improvement of health. Persuaded by Pudor's theory of the healing properties of the sun and wind, which could be absorbed through the skin, they launched the naked revolution.</p><p>Pudor's book became the naturists' manifesto and soon after, not far from Hamburg, the Free Body Culture (<em>Freikörperkultur</em>, or FKK) movement was founded. This spread through other German centres and brought together thousands of people. The FKK still operates under the same name today.</p><p>The cult of the naked body even wrote itself into the ideology of fascist Germany, which advocated a pure, Aryan race. But in 1933, Hermann Göring issued an order that defined nudity as "the greatest threat to the German soul" and, with that, criminalized naturist organizations. But this wasn't the end of the movement. The naturists went underground, continuing their activities under the guise of improving physical fitness.</p><p>In 1936, the idea was even floated of having a naturist display to open the Berlin Olympic Games. It was quickly dropped. Despite this, in 1939 the naturists managed to organize their own Games in the Swiss village of Thielle.</p>
Would you ever have sex with a robot?
- In 2016, "Harmony", the world's first AI sex robot was designed by a tech firm called Realbotix.
- According to 2020 survey data, more than one in five Americans (22 percent) say they would consider having sex with a robot. This is an increase from a survey conducted in 2017.
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From homemade dildos to Harmony, the AI sex robot<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="3f7451615568e74c6a839f04329c9902"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/-cN8sJz50Ng?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p><em>"...amid an economic crisis, with restaurants and retailers closing their doors and larger companies laying off and furloughing employees, the sex tech industry is booming."</em><br></p><p>A Bustle <a href="https://www.bustle.com/wellness/the-sex-tech-industry-is-booming-amid-economic-crisis-22819801" target="_blank" rel="noopener noreferrer">article</a> published in April 2020, weeks after COVID-19 was declared a pandemic, explored the drastic boost in the sex tech industry. According to the research, <a href="https://www.dameproducts.com/" target="_blank" rel="noopener noreferrer">Dame Products</a> (a popular sex toy retailer) experienced a 30 percent increase in sales between the months of February to April, and popular sexual wellness brand <a href="https://unboundbabes.com/?utm_source=%7Bsource%7D&utm_medium=%7Bmedium%7D&utm_keyword=unbound%20babes&utm_matchtype=e&device=c&utm_campaign=%7Bcampaign%7D&utm_adgroup=%7Badgroup%7D&gclid=CjwKCAjw1v_0BRAkEiwALFkj5qYbdEwANUjCdRkCeVZ2HZzHjcGmpYbsOXYcMcNneLc2nySvrbaalBoChEsQAvD_BwE" target="_blank" rel="noopener noreferrer">Unbound</a> reported selling twice as many toys as normal in this period.</p><p>While the new coronavirus was crashing the economy in other ways, the sex tech industry was one of the few that actually saw improvements, likely due to people all over the world being advised, encouraged, and in some instances forced to stay at home.</p><p>Something similar happened in 2008, <a href="https://www.villagevoice.com/2010/08/23/the-great-recession-is-a-turn-on-for-the-sex-toy-industry/" target="_blank" rel="noopener noreferrer">during the recession</a>: the sex toy industry was one of the only industries at the time that didn't gravely suffer. </p><p><strong>The evolution of sex tech from stone dildos to artificial intelligence.</strong></p><p><a href="https://sofiagray.com/what-is-the-history-of-sex-toys-from-stone-to-silicone-and-beyond/" target="_blank" rel="noopener noreferrer">The history of sex toys</a> is quite interesting. A 28,000-year-old siltstone dildo was uncovered in Germany in 2005. Luxury bronze dildos have also been found in China that are at least 2,000 years old.</p><p>Aside from various materials being shaped into dildos, there has always been an interest in how to advance sex technology, even before it involved actual technology at all.</p><ul><li>The 1700s: Steam-powered vibrators (such as the Manipulator).</li><li>The 1800s—1900s: The invention of the first electric vibrator (the Pulsoson) and "beauty tools" being used for sexual satisfaction (such as the Polar Cub massager)</li><li>The 1920s—1940s: The introduction of hand-held massagers (the Andis Vibrator) and compact devices (such as the Oster Stim-U-Lax)</li><li>The 1940s—1960s: Japan introduced the "Cadillac of Vibrators" (The Hitachi Magic Wand), which eventually made it's way to America.</li><li>1965: The invention of silicone, which most modern sex toys are made of.</li><li>The 1980s—1990s: The invention of the rabbit-style vibrator, made more popular with one of the first showings of a sex toy on television ("Sex and the City"). </li><li>The 2000s: Visual porn website Pornhub launched and sex toys became increasingly popular. Erotic literature also became more common and popular, with "50 Shades of Grey" and others like it. </li><li>The 2010s and beyond: Sex toys and technology start to blend, and the world's first internet-controlled sex toy was launched in 2010 by Lovense.</li></ul><p>In 2016, "Harmony", <a href="https://www.youtube.com/watch?v=-cN8sJz50Ng" target="_blank" rel="noopener noreferrer">the world's first AI sex robot</a> was designed by a tech firm called Realbotix. </p>
From television shows to real-life applications, artificial intelligence (AI) is becoming more and more popular in all areas of human life.
Credit: Willyam Bradberry on Shutterstock<p>In 2020, more than one in five Americans (22 percent) say they would consider having sex with a robot. <a href="https://today.yougov.com/topics/science/articles-reports/2020/03/19/2020-both-men-and-women-are-more-likely-consider-h" target="_blank" rel="noopener noreferrer">YouGov conducted a study</a> in February 2020 that compared results from a similar study from 2017.<br></p><p>According to the results, 6 percent more people in 2020 are comfortable with the idea of having sex with a robot than in 2017.</p><p>YouGov points out that the increase in consideration is particularly significant among American adults between the ages of 18-34 years old. Additionally, how people feel about having sex with a robot has also changed. In 2020, 27 percent of Americans said they would consider it cheating if they had a partner who had sex with a robot during the relationship, compared to the 32 percent reported in 2017.</p><p><strong>"If you had a partner who had sex with a robot, would you consider it cheating?"</strong></p><p>The results from this interesting study also reveal that many people (42 percent) believe having sex with a robot is safer than having sex with a human stranger.</p><p>Robots (and robotic tech) already play a vital role in speeding up manufacturing, packaging, and processing across various industries. From television shows to real-life applications, artificial intelligence is becoming more and more popular in all areas of human life.</p><p>According to YouGov, "a <a href="https://www.bloomberg.com/news/articles/2019-07-12/amazon-plans-high-end-echo-ramps-up-work-on-alexa-home-robot" target="_blank">Bloomberg</a> report outlining Amazon's plans for an Alexa-powered robot that follows and helps you around the home may redefine how these machines service humans in the near future." </p>