Antimicrobial resistance is a growing threat to good health and well-being
Antimicrobial resistance is growing worldwide, rendering many "work horse" medicines ineffective. Without intervention, drug-resistant pathogens could lead to millions of deaths by 2050. Thankfully, companies like Pfizer are taking action.
Pfizer Corporate Responsibility develops programs that help expand global access to medicines by providing direct assistance to underserved populations. Our initiatives include providing product donations and steep discounts that help patients access the medicine they need. We also collaborate with Pfizer business teams and nonprofit organizations to help shape sustainable business models that address affordability and the vast differences in economies around the world.
- Antimicrobial-resistant pathogens are one of the largest threats to global health today.
- As we get older, our immune systems age, increasing our risk of life threatening infections. Without reliable antibiotics, life expectancy could decline for the first time in modern history.
- If antibiotics become ineffective, common infections could result in hospitalization or even death. Life-saving interventions like cancer treatments and organ transplantation would become more difficult, more often resulting in death. Routine procedures would become hard to perform.
- Without intervention, resistant pathogens could result in 10 million annual deaths by 2050.
- By taking a multi-faceted approach—inclusive of adherence to good stewardship, surveillance and responsible manufacturing practices, as well as an emphasis on prevention and treatment—companies like Pfizer are fighting to help curb the spread.
Antibiotics have revolutionized healthcare.
With the advent of modern medicine, life threatening diseases such as smallpox, pertussis (whooping cough), tetanus (lockjaw) and measles have essentially been eradicated. More importantly, complicated procedures that increase our risk of infections—including plastic surgery, joint replacement, cancer treatments, and organ transplant, among others—have become routine because any resulting infection can be treated effectively.
But modern medicine depends on antibiotics to treat and cure many kinds of infections—infections that could impact anyone from the premature baby to the elderly. Unfortunately, antimicrobial resistance (AMR) has made some infections impossible and others increasingly difficult to treat, threatening the progress we have worked so hard to achieve.
AMR causes 700,000 deaths annually across the globe, a number projected to skyrocket to 10 million by 2050 without intervention.
What is antimicrobial resistance?
Antimicrobial drugs target the microorganisms that cause infection, such as bacteria, viruses, fungi, and parasites, and either kills them or inhibits their growth.
Anytime an antibiotic is used, either appropriately or inappropriately, the 30 trillion or more bacteria that live in or on our bodies undergo selective pressure to become resistant. Any that are sensitive to the antibiotic are killed, while those that remain are resistant or immune from the effects of that antibiotic. This is called AMR. Once a bacterial pathogen has reached a state of resistance to several types of antibiotics, it is colloquially referred to as a "superbug."
The consequences of AMR can be stated simply: Commonly used antibiotics are rendered ineffective against that pathogen. If an infection caused by resistant bacteria is treated by that antibiotic, the bacteria are unaffected, resulting in disease persistence, worsening of the infection and/or even death. Treatments for both minor and serious infections are compromised, surgeries and other routine procedures become riskier, and the treatment of diseases like pneumonia and tuberculosis becomes very complicated. For example, according to the World Health Organization, resistance in Klebsiella pneumoniae—a common intestinal bacterium that is a major cause of hospital-acquired infections, bloodstream infections, and infections in newborns and intensive-care unit patients—has spread to all regions of the world. In some countries, because of resistance, carbapenem antibiotics (often the "last resort" treatments) do not work in more than half of people treated for these types of infections. This results in prolonged hospitalization, increased medical costs and higher rates of death for infections that were easily treated only a few years ago.
"What's more, AMR is a truly global issue—it can affect anyone, of any age, in any country," Jill Inverso, Pfizer's Vice President of Global Medical Affairs and Anti-Infectives, told Big Think.
AMR causes 700,000 deaths annually across the globe, a number projected to skyrocket to 10 million by 2050 without intervention. The rise of resistant pathogens is causing many countries to accrue significantly higher healthcare costs due to longer duration of illness, additional tests, and the need for different medicines to treat patients.
And these costs add up. The World Bank Group estimates that AMR could reduce annual global gross domestic product from 1.1–3.8 percent depending on severity, with up to $10.8 trillion in additional health expenditures.
At Pfizer, we take this growing threat very seriously and are driven by our desire to protect global public health and address the medical needs of people suffering from infectious diseases.
Giving antimicrobial resistance a helping hand
The development of bacterial resistance to antibiotics is a natural process. Unlike almost every other class of drugs, antibiotics drive their own obsolescence by selecting antibiotic-resistant bacteria, even when used appropriately according to guidelines. When this happens, resistant bacteria survive and continue to multiply, causing the infection to worsen. These resistant bacteria can then also spread to other patients, causing new infections with these bacteria that are difficult to treat.
Overuse and misuse of antibiotics accelerates this process without providing any benefit to the patient. This happens when patients take a drug without need, do not finish their dose or stop taking the medication mid-course; it could also happen when a drug is either overprescribed or prescribed for the wrong duration/type of illness. All of these misuses create environments in which pathogens are exposed to drugs more often, allowing them to acclimate and breed resistance without any benefit to the patient.
Hence, antibiotics must be used wisely and sparingly.
Fighting the resistance
WHO calls AMR an "increasingly serious threat to global public health" and one that "requires action across all government sectors and society." Its widespread growth is threatening the United Nations General Assembly's Sustainable Development Goal of Good Health and Well-Being.
Companies like Pfizer are heavily committed to the fight against AMR, taking action across a variety of areas such as surveillance, stewardship, and prevention and treatment.
On the surveillance front, Pfizer is proud to sponsor one of the largest AMR surveillance programs in the world, the Antimicrobial Testing Leadership and Surveillance (or ATLAS). ATLAS monitors real-time changes in bacterial resistance and tracks these trends in real-time. Gathering information from more than 760 hospitals across 73 countries in many underserved areas, ATLAS has generated 14 years of continuous global data on bacteria. Researchers and healthcare professionals can access ATLAS's data—free of charge—to study resistance trends, even in emerging market countries like Africa, Asia, and Latin America.
"At Pfizer, we take this growing threat very seriously," Inverso added, "and are driven by our desire to protect global public health and address the medical needs of people suffering from infectious diseases."
Pfizer also encourages good stewardship practices and supports education and training programs to help ensure patients receive the correct antibiotic only if needed, at the right dose and for the right duration.
"We believe that everybody can play a part in AMR stewardship by not taking an antibiotic unless provided by a healthcare professional, sticking to antibiotic regimens when prescribed, and keeping their vaccinations up to date," said Inverso. She added, "Vaccines are administered to help prevent infections from happening in the first place, thereby reducing the need for antibiotic usage that can lead to the development of resistance."
To date, several studies have demonstrated the beneficial role vaccines play in the reduction of AMR, such as reducing the use of antibiotics by preventing bacterial infections which may, in turn, prevent antimicrobial resistant infections from developing. Pfizer is committed to continue the development of new, innovative vaccines to help prevent infectious diseases globally.
We believe that everybody can play a part in AMR stewardship by not taking an antibiotic unless provided by a healthcare professional, sticking to antibiotic regimens when prescribed, and keeping their vaccinations up to date.
Given this, we should ask ourselves the following:
- Have I ever not finished an antibiotic given to me by my doctor?
- Have I ever used an antibiotic given to someone else?
- Am I up-to-date on my vaccinations that prevent infections that would need antibiotics?
- Have I ever demanded an antibiotic for myself or a child that the doctor thought was caused by a virus?
- Have I ever saved antibiotics given to me for one infection and used it at a different time?
The key takeaway? AMR is a pervasive, growing threat that cannot be tamed without the collective efforts of government, industry, health systems, society and others. Working together, we may have a fighting chance.
Shannon Lee shares lessons from her father in her new book, "Be Water, My Friend: The Teachings of Bruce Lee."
- Bruce Lee would have turned 80 years old on November 27, 2020. The legendary actor and martial artist's daughter, Shannon Lee, shares some of his wisdom and his philosophy on self help in a new book titled "Be Water, My Friend: The Teachings of Bruce Lee."
- In this video, Shannon shares a story of the fight that led to her father beginning a deeper philosophical journey, and how that informed his unique expression of martial arts called Jeet Kune Do.
- One lesson passed down from Bruce Lee was his use and placement of physical symbols as a way to help "cement for yourself this new way of being, or this new lesson you've learned." By working on ourselves (with the right tools), we can develop the skills necessary to rise and conquer new challenges.
How to deal with "epistemic exhaustion."
A strange object found in Utah desert has prompted worldwide speculation about its origins.
- A monolithic object found in a remote part of Utah caused worldwide speculation about its origins.
- The object is very similar to the famous monolith from Stanley Kubrick's "2001: Space Odyssey".
- The object could be work of an artist or even have extraterrestrial origins.
1. ART OBJECT<p>Chances are, this is an art object. The shiny "monolith" appears to be bolted to the ground and made of metal. It also seems to be fastened with rivets, rather being a uniform block of more unexplainable production origin. Deserts are great places for unusual art installations as has been evidenced by art projects you can discover wondering through the desert ghost towns and faraway canyons of Nevada, California, Utah and New Mexico. Certainly, an artist with a sense of humor and an appreciation of Kubrick's genius could have installed such "sculpture" in hopes of exactly what is happening right now – viral fame.</p><p>On the other hand, there is evidence, courtesy of eagle-eyed <a href="https://www.reddit.com/r/news/comments/jzkpad/helicopter_pilot_finds_strange_monolith_in_remote/gdg9qfi?utm_source=share&utm_medium=web2x&context=3" target="_blank">Google Earth sleuths</a>, that the object appeared in that location (somewhere near <a href="https://www.nps.gov/cany/index.htm" target="_blank" rel="noopener noreferrer">Canyonlands National Park</a>) in 2015-2016. So it's possibly been there for a few years. Would an artist have placed it there so long ago with the aim of having this type of success eventually?</p><p>A gallery owner <a href="https://www.9news.com.au/world/utah-monolith-desert-mystery-solved-john-mccracken-sculptor-artist-2001-a-space-odyssey/0bae1a27-5bd2-451e-90a6-393928d9ed02" target="_blank">claimed</a> the work may be a tribute to the art of the late artist John McCracken, who created similar-looking objects before he died in 2011. McCracken was part of the Light and Space movement with such artists as James Turrell, and was known to make his sculptures from plywood forms that were coated with fiberglass and polyester resin.</p><p>While the theory that the monolith was the work of a McCracken aficionado (or the artist himself) may hold some water due to the object's similarity, the fact that the artist died so long ago and the lack of clear incentive for anyone to have planted this years ago only to reveal it now work against this theory.</p>
John McCracken sculptures.
2. ALIEN EVOLUTIONARY DEVICE<p>Certainly, explaining the monolith as an art installation may make the most sense at this point but its resemblance to the famous object from Kubrick's epic "2001: A Space Odyssey" can't help but bring some science-fiction scenarios to our minds.</p><p>In the film, the perfect black slab was discovered by a group of prehistoric apes. After finding the slab, the apes seemed to have developed the ability to utilize found objects like bones as tools and weapons. The film suggests that finding the monolith had an evolutionary impact on the apes, perhaps serving as "the missing link" that propelled humans from being lower-end primates to the intellectual powerhouses they are today.</p><p><span></span>Later in the film, after fast-forwarding thousands of years into the future, such an object is discovered on the moon by human astronauts. Using the writer Arthur C. Clarke's short story <a href="https://en.wikipedia.org/wiki/The_Sentinel_(short_story)" target="_blank">"The Sentinel"</a> as its inspiration, the film's narrative suggests that alien civilizations are responsible for these objects which potentially serve as beacons that may still be transmitting signals back to whoever created them while possibly being responsible for fostering evolution throughout the Universe.</p><p>Could the Utah object be serving just such a function? While 2020 has offered very inconsistent evidence of human intelligence, a device from a benevolent alien race that can make us all smarter might be just what we need. </p><p>Or it could portend the exact opposite and be the one thing that will hasten our demise.</p>
2001: A Space Odyssey, black monolith<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="2178845abc1a10c7b869e2f6201d5db7"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/cHWs3c3YNs4?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span>
3. ALIEN PROBE<p>Besides having some specific impact on the inhabitants of planet Earth, the monolith could "just" be an extraterrestrial probe, sent here to learn about our ways. Would placing it in the middle of Utah desert be the best place to probe humanity? If the object was part of many such probes being sent all over the cosmos, it's possible the advanced alien overlord wannabes may not know specifically we are here and are just sending these everywhere they can. It's similar to when humans send probes to places like Mars and assume there's no life there just because the rover landed in the middle of a desert.</p>
A closer look: the Utah monolith<blockquote class="instagram-media" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/CH_212pAKpr/?utm_source=ig_embed&utm_campaign=loading" data-instgrm-version="13" style=" background:#FFF; border:0; border-radius:3px; box-shadow:0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width:540px; min-width:326px; padding:0; width:99.375%; width:-webkit-calc(100% - 2px); width:calc(100% - 2px);"><div style="padding:16px;"> <a href="https://www.instagram.com/p/CH_212pAKpr/?utm_source=ig_embed&utm_campaign=loading" style=" background:#FFFFFF; line-height:0; padding:0 0; text-align:center; text-decoration:none; width:100%;" target="_blank"> <div style=" display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #F4F4F4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"></div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style=" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"></div> <div style=" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"></div></div></div><div style="padding: 19% 0;"></div> <div style="display:block; height:50px; margin:0 auto 12px; width:50px;"></div><div style="padding-top: 8px;"> <div style=" color:#3897f0; font-family:Arial,sans-serif; font-size:14px; font-style:normal; font-weight:550; line-height:18px;"> View this post on Instagram</div></div><div style="padding: 12.5% 0;"></div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"><div> <div style="background-color: #F4F4F4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"></div> <div style="background-color: #F4F4F4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"></div> <div style="background-color: #F4F4F4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"></div></div><div style="margin-left: 8px;"> <div style=" background-color: #F4F4F4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"></div> <div style=" width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg)"></div></div><div style="margin-left: auto;"> <div style=" width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"></div> <div style=" background-color: #F4F4F4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"></div> <div style=" width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"></div></div></div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style=" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"></div> <div style=" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"></div></div></a><a href="https://www.instagram.com/p/CH_212pAKpr/?utm_source=ig_embed&utm_campaign=loading" style=" color:#c9c8cd; font-family:Arial,sans-serif; font-size:14px; font-style:normal; font-weight:normal; line-height:17px; text-decoration:none;" target="_blank">A post shared by Dave Sparks (@heavydsparks)</a><br></div></blockquote> <script async="" src="//www.instagram.com/embed.js"></script>
4. KUBRICK FAN INSTALLATION<p><span style="background-color: initial;">Stanley Kubrick (1928-1999) was one of the greatest film directors of all time, leaving behind a slate of films that are each considered a masterpiece </span><span style="background-color: initial;">– "Dr. Strangelove," "The Shining," "2001: A Space Odyssey," "A Clockwork Orange," "Spartacus," "Full Metal Jacket" and more.</span></p><p>The visionary American director left a profound legacy, garnering millions of fans around the world. As the monolith he devised for "2001: A Space Odyssey" is one of the most famous objects in movie history, it's not out of the question that one of the director's followers decided to recreate it.</p>
2001: A Space Odyssey - The Monolith On The Moon<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="79d90172390295c27e533be4cbbd24e7"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/oU4Rk0NATNs?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span>
5. GOVERNMENT CONTROL DEVICE<p>The American Southwest is rife with government military installations and mysterious bases like Area 51. Having the monolith be a part of some government (vast psychological?) experiment is a connection that's easy to make for any conspiracy-minded Internet dweller.</p><p>Of course, given the government's penchant for both secrecy and ineptitude, this last one may be the hardest to ever prove definitively. In any case, the Department of Public Safety is not releasing the exact location of the object and warns people against trying to find it:</p><p style="margin-left: 20px;">"It is in a very remote area and if individuals were to attempt to visit the area, there is a significant possibility they may become stranded and require rescue," DPS <a href="https://www.theguardian.com/us-news/2020/nov/24/monolith-utah-theories-what-is-it-mystery" target="_blank">said</a>.</p>
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