New study: It's not quackery—antidepressants work. Period.

Antidepressants actually do work for a majority of people who try them, a new study asserts.

Antidepressant happy sad
Happy and sad. Sisters Valerie and Maureen Clark, aged 4 and 5, from the Great Arthur Street Mission in London, drinking lemonade during a day's outing to Woodford, Essex, 1943. (Photo by Fred Morley/Fox Photos/Getty Images

Ever since medications for depression have been introduced, there has been debate about their effectiveness. The media, as well as social media, has weighed in on this, repeatedly—for decades.  


There’s a new study out, however, that is beginning to put some of those debates to bed. 

It’s a fairly large-scale sampling: 21 different types of antidepressants, involved in 522 randomized controlled trials, including just over 115,000 men and women ages 18 and older who had clinical depression and were treated for at least eight weeks. 

The results?

Across the board, antidepressants performed better for controlling depression than placebos did. In order to be considered “effective”, the drugs had to reduce depression symptoms by at least 50 percent. 


Photo Illustration by Christopher Furlong/Getty Images.

The team expected that some of the antidepressants would be superior to placebos, but not all of them. Lead researcher and study author Dr. Andrea Cipriano of the University of Oxford, UK put it this way in The Lancet: “We were open to any result. This is why we can say this is the final answer to the controversy.”

A study involving some of the primary members of this team was done in 2009; it compared 12 antidepressants to each other, finding some worked better than others.  

Now, in addition to finding benefits versus a placebo, this study also concluded that some pharmaceuticals worked better than others, notably Agomelatine, amitriptyline (brand name Elavil), escitalopram (Lexapro), mirtazapine (Remeron), paroxetine (Paxil), venlafaxine (Effexor XR), and vortioxetine (Trintellix). Included in the least effective is fluoxetine (Prozac). 

Still, there are challenges for those who suffer from depression. Fully one-third of patients do not respond to any of these drugs. Considering that—at a minimum—16 million people suffer from depression in the U.S. alone, that’s a lot of untreatable patients. Traditional psychotherapy can help some of those folks, however. 

Depression is the leading cause of disability in the world, which makes these findings even more significant; any progress in the field of treating it can make a difference for millions of people. 

 

U.S. Navy controls inventions that claim to change "fabric of reality"

Inventions with revolutionary potential made by a mysterious aerospace engineer for the U.S. Navy come to light.

U.S. Navy ships

Credit: Getty Images
Surprising Science
  • U.S. Navy holds patents for enigmatic inventions by aerospace engineer Dr. Salvatore Pais.
  • Pais came up with technology that can "engineer" reality, devising an ultrafast craft, a fusion reactor, and more.
  • While mostly theoretical at this point, the inventions could transform energy, space, and military sectors.
Keep reading Show less

Modern society is as unequal as 14th century Europe

As bad as this sounds, a new essay suggests that we live in a surprisingly egalitarian age.

"Philosophy Presenting the Seven Liberal Arts to Boethius"

Getty Open Content
Politics & Current Affairs
  • A new essay depicts 700 years of economic inequality in Europe.
  • The only stretch of time more egalitarian than today was the period between 1350 to approximately the year 1700.
  • Data suggest that, without intervention, inequality does not decrease on its own.
Keep reading Show less

You are suffering from “tab overload”

Our love-hate relationship with browser tabs drives all of us crazy. There is a solution.

Photo by Anna Shvets from Pexels
Technology & Innovation
  • A new study suggests that tabs can cause people to be flustered as they try to keep track of every website.
  • The reason is that tabs are unable to properly organize information.
  • The researchers are plugging a browser extension that aims to fix the problem.
Keep reading Show less
Personal Growth

Epicurus and the atheist's guide to happiness

Seek pleasure and avoid pain. Why make it more complicated?

Quantcast